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BR9916324A - 4,5-pirazinoxindóis como inibidores de proteìna quinase - Google Patents

4,5-pirazinoxindóis como inibidores de proteìna quinase

Info

Publication number
BR9916324A
BR9916324A BR9916324-1A BR9916324A BR9916324A BR 9916324 A BR9916324 A BR 9916324A BR 9916324 A BR9916324 A BR 9916324A BR 9916324 A BR9916324 A BR 9916324A
Authority
BR
Brazil
Prior art keywords
pyrazinoxindoles
kinase inhibitors
protein kinase
protein kinases
pirazinoxindóis
Prior art date
Application number
BR9916324-1A
Other languages
English (en)
Inventor
Kin-Chun Luk
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9916324A publication Critical patent/BR9916324A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: <B>"4,5-PIRAZINOXINDóIS COMO INIBIDORES DE PROTEìNA QUINASE"<D>. Apresenta-se 4,5-pirazinoxindóis com a fórmula (I), os quais inibem ou modulam proteína quinases, em particular proteína quinases JNK, de utilidade como agentes antiinflamatórios, particularmente no tratamento da artrite reumatóide.
BR9916324-1A 1998-12-17 1999-12-11 4,5-pirazinoxindóis como inibidores de proteìna quinase BR9916324A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17
PCT/EP1999/009806 WO2000035921A1 (en) 1998-12-17 1999-12-11 4,5-pyrazinoxindoles as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BR9916324A true BR9916324A (pt) 2001-10-02

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916324-1A BR9916324A (pt) 1998-12-17 1999-12-11 4,5-pirazinoxindóis como inibidores de proteìna quinase

Country Status (17)

Country Link
US (1) US6221867B1 (pt)
EP (1) EP1149105B1 (pt)
JP (1) JP2002532503A (pt)
KR (1) KR20010108024A (pt)
CN (1) CN1158283C (pt)
AR (1) AR021695A1 (pt)
AT (1) ATE387448T1 (pt)
AU (1) AU767138B2 (pt)
BR (1) BR9916324A (pt)
CA (1) CA2354402A1 (pt)
DE (1) DE69938258T2 (pt)
ES (1) ES2301255T3 (pt)
PE (1) PE20001385A1 (pt)
TR (1) TR200101756T2 (pt)
UY (1) UY25854A1 (pt)
WO (1) WO2000035921A1 (pt)
ZA (1) ZA200104505B (pt)

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GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
US7683078B2 (en) 2001-07-23 2010-03-23 Laboratoires Serono S.A. Arylsulfonamide derivatives as C-Jun-N-Terminal Kinases (JNK's) inhibitors
JP4388376B2 (ja) 2002-02-28 2009-12-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規な縮合環インダゾール化合物
IL164187A0 (en) 2002-03-28 2005-12-18 Eisai Co Ltd 7-Azaindole derivatives and pharmaceutical compositions containing the same
ATE457312T1 (de) 2002-03-28 2010-02-15 Eisai R&D Man Co Ltd Azaindole als hemmstoffe von c-jun n-terminalen kinasen
CA2486183C (en) * 2002-05-23 2012-01-10 Cytopia Pty Ltd. Protein kinase inhibitors
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
WO2003106455A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
AU2004242105B2 (en) * 2003-05-08 2009-05-28 Wyeth Protein kinase C zeta as a drug target for arthritis and other inflammatory diseases
WO2004101565A2 (en) 2003-05-16 2004-11-25 Eisai Co., Ltd. Jnk inhibitors
BRPI0415773A (pt) 2003-10-24 2006-12-26 Schering Ag derivados de indolinona e sua aplicação no tratamento de estados de doença tais como cáncer
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
AU2006298132A1 (en) 2005-10-03 2007-04-12 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
KR20080097190A (ko) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법

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US4556672A (en) 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3531678A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK0429685T3 (da) 1989-07-25 1997-12-15 Taiho Pharmaceutical Co Ltd Oxoindolderivat
WO1991009598A1 (en) 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
GB9004483D0 (en) 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
US5322950A (en) 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
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GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
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DE69718968T2 (de) 1996-01-17 2003-10-09 Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo 3-(bis-substituierte-phenylmethylen)oxindol-derivate
ES2201266T3 (es) * 1996-01-17 2004-03-16 Taiho Pharmaceutical Company Limited Inhibidores del espesamiento de la capa intima.
GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9611797D0 (en) 1996-06-06 1996-08-07 Pharmacia Spa Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors
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GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
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Also Published As

Publication number Publication date
ATE387448T1 (de) 2008-03-15
JP2002532503A (ja) 2002-10-02
DE69938258D1 (de) 2008-04-10
ZA200104505B (en) 2002-10-04
ES2301255T3 (es) 2008-06-16
AU1977300A (en) 2000-07-03
EP1149105B1 (en) 2008-02-27
PE20001385A1 (es) 2000-12-14
CN1330653A (zh) 2002-01-09
UY25854A1 (es) 2001-07-31
KR20010108024A (ko) 2001-12-07
AR021695A1 (es) 2002-07-31
CA2354402A1 (en) 2000-06-22
CN1158283C (zh) 2004-07-21
DE69938258T2 (de) 2009-02-26
TR200101756T2 (tr) 2001-10-22
AU767138B2 (en) 2003-10-30
US6221867B1 (en) 2001-04-24
WO2000035921A1 (en) 2000-06-22
EP1149105A1 (en) 2001-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA(S) 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009.