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PE20001385A1 - 4,5-pirazinoxindoles como inhibidores de proteinquinasas - Google Patents

4,5-pirazinoxindoles como inhibidores de proteinquinasas

Info

Publication number
PE20001385A1
PE20001385A1 PE1999001276A PE00127699A PE20001385A1 PE 20001385 A1 PE20001385 A1 PE 20001385A1 PE 1999001276 A PE1999001276 A PE 1999001276A PE 00127699 A PE00127699 A PE 00127699A PE 20001385 A1 PE20001385 A1 PE 20001385A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrrol
heteroaryl
cycloalkyl
aryl
Prior art date
Application number
PE1999001276A
Other languages
English (en)
Inventor
Kin-Chun Luk
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20001385A1 publication Critical patent/PE20001385A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A PIRAZINOXINDOLES DE FORMULA I, DONDE: R1 Y R2 SON H, OR4, COR4, COOR4, CONR5R6, NR5R6, ALQUILO, CICLOALQUILO, HETEROCICLO, ARILO, HETEROARILO O R1 Y R2 PUEDEN FORMAR UN ANILLO DE 5-7 MIEMBROS; R3 ES H, OR4, COR4, COOR4, OCOR4, CONR5R6, HALOGENO, CN, PERFLUOROALQUILO-NR5R6, ENTRE OTROS; R4 ES H, ALQUILO, CICLOALQUILO, HETEROCICLO, ARILO, HETEROARILO; R5 Y R6 SON H, COR7, COOR7, CONR7R9, ALQUILO, CICLOALQUILO, HETEROCILO, ARILO, HETEROARILO, NR5R6 FORMAN UN ANILLO DE 3-7 MIEMBROS; R7 ES H, ALQUILO; X ES N, C. SON COMPUESTOS PREFERIDOS (Z)-7,9-DIHIDRO-2,3-DIMETIL-9-[(3-METOXI-1H-PIRROL-2-IL)METILEN]-8H-PIRROLO[3,2-f]QUINOXALIN-8-ONA, (Z)-3-BUTIL-7,9-DIHIDRO-9-[(3-METOXI-1H-PIRROL-2-IL)METILEN]-2-METIL-8H-PIRROLO[3,2-f]QUINOXALIN-8-ONA, ENTRE OTROS. EL COMPUESTO I INHIBE O MODULA A LAS QUINASAS JNK Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA INFLAMACION Y ENFERMEDADES NEURODEGENERATIVAS COMO ARTRITIS REUMATOIDE, TUMORES SOLIDOS DE MAMA, COLON
PE1999001276A 1998-12-17 1999-12-16 4,5-pirazinoxindoles como inhibidores de proteinquinasas PE20001385A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
PE20001385A1 true PE20001385A1 (es) 2000-12-14

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001276A PE20001385A1 (es) 1998-12-17 1999-12-16 4,5-pirazinoxindoles como inhibidores de proteinquinasas

Country Status (17)

Country Link
US (1) US6221867B1 (es)
EP (1) EP1149105B1 (es)
JP (1) JP2002532503A (es)
KR (1) KR20010108024A (es)
CN (1) CN1158283C (es)
AR (1) AR021695A1 (es)
AT (1) ATE387448T1 (es)
AU (1) AU767138B2 (es)
BR (1) BR9916324A (es)
CA (1) CA2354402A1 (es)
DE (1) DE69938258T2 (es)
ES (1) ES2301255T3 (es)
PE (1) PE20001385A1 (es)
TR (1) TR200101756T2 (es)
UY (1) UY25854A1 (es)
WO (1) WO2000035921A1 (es)
ZA (1) ZA200104505B (es)

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GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
US7683078B2 (en) 2001-07-23 2010-03-23 Laboratoires Serono S.A. Arylsulfonamide derivatives as C-Jun-N-Terminal Kinases (JNK's) inhibitors
JP4388376B2 (ja) 2002-02-28 2009-12-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規な縮合環インダゾール化合物
IL164187A0 (en) 2002-03-28 2005-12-18 Eisai Co Ltd 7-Azaindole derivatives and pharmaceutical compositions containing the same
ATE457312T1 (de) 2002-03-28 2010-02-15 Eisai R&D Man Co Ltd Azaindole als hemmstoffe von c-jun n-terminalen kinasen
CA2486183C (en) * 2002-05-23 2012-01-10 Cytopia Pty Ltd. Protein kinase inhibitors
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
WO2003106455A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
AU2004242105B2 (en) * 2003-05-08 2009-05-28 Wyeth Protein kinase C zeta as a drug target for arthritis and other inflammatory diseases
WO2004101565A2 (en) 2003-05-16 2004-11-25 Eisai Co., Ltd. Jnk inhibitors
BRPI0415773A (pt) 2003-10-24 2006-12-26 Schering Ag derivados de indolinona e sua aplicação no tratamento de estados de doença tais como cáncer
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
AU2006298132A1 (en) 2005-10-03 2007-04-12 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
KR20080097190A (ko) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법

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GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
US5322950A (en) 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
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Also Published As

Publication number Publication date
ATE387448T1 (de) 2008-03-15
JP2002532503A (ja) 2002-10-02
DE69938258D1 (de) 2008-04-10
ZA200104505B (en) 2002-10-04
ES2301255T3 (es) 2008-06-16
AU1977300A (en) 2000-07-03
EP1149105B1 (en) 2008-02-27
CN1330653A (zh) 2002-01-09
UY25854A1 (es) 2001-07-31
KR20010108024A (ko) 2001-12-07
AR021695A1 (es) 2002-07-31
CA2354402A1 (en) 2000-06-22
BR9916324A (pt) 2001-10-02
CN1158283C (zh) 2004-07-21
DE69938258T2 (de) 2009-02-26
TR200101756T2 (tr) 2001-10-22
AU767138B2 (en) 2003-10-30
US6221867B1 (en) 2001-04-24
WO2000035921A1 (en) 2000-06-22
EP1149105A1 (en) 2001-10-31

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