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BR9916216A - 4.5-azolo-oxindóis - Google Patents

4.5-azolo-oxindóis

Info

Publication number
BR9916216A
BR9916216A BR9916216-4A BR9916216A BR9916216A BR 9916216 A BR9916216 A BR 9916216A BR 9916216 A BR9916216 A BR 9916216A BR 9916216 A BR9916216 A BR 9916216A
Authority
BR
Brazil
Prior art keywords
oxindols
azole
oxindóis
azolo
cdks
Prior art date
Application number
BR9916216-4A
Other languages
English (en)
Inventor
Kin-Chun Luk
Christophe Michoud
Steven Gregory Mischke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9916216A publication Critical patent/BR9916216A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"4.5-AZOLO-OXINDóIS"<D>. Novos 4,5-azolo-oxindóis tendo a fórmula (I), na qual R¹, R², Y, Z e têm o significado indicado na especificação, inibe cinases dependentes de ciclina (CDKs), em particular CDK2 e são úteis no tratamento ou controle de distúrbios proliferativos celulares, em particular câncer.
BR9916216-4A 1998-12-17 1999-12-10 4.5-azolo-oxindóis BR9916216A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11261198P 1998-12-17 1998-12-17
PCT/EP1999/009779 WO2000035920A2 (en) 1998-12-17 1999-12-10 4,5-azolo-oxindoles

Publications (1)

Publication Number Publication Date
BR9916216A true BR9916216A (pt) 2001-09-11

Family

ID=22344875

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916216-4A BR9916216A (pt) 1998-12-17 1999-12-10 4.5-azolo-oxindóis

Country Status (18)

Country Link
EP (1) EP1149106B1 (pt)
JP (1) JP2002532502A (pt)
KR (2) KR100723854B1 (pt)
CN (1) CN1159315C (pt)
AR (1) AR021693A1 (pt)
AT (1) ATE234839T1 (pt)
AU (1) AU770060B2 (pt)
BR (1) BR9916216A (pt)
CA (1) CA2354852C (pt)
DE (1) DE69906149T2 (pt)
DK (1) DK1149106T3 (pt)
ES (1) ES2192878T3 (pt)
PE (1) PE20001329A1 (pt)
PT (1) PT1149106E (pt)
TR (1) TR200101745T2 (pt)
UY (1) UY25855A1 (pt)
WO (1) WO2000035920A2 (pt)
ZA (1) ZA200104269B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
KR20060123184A (ko) 2003-10-24 2006-12-01 쉐링 악티엔게젤샤프트 인돌리논 유도체, 및 암과 같은 질환 상태의 치료에있어서의 이들의 용도
KR20070113286A (ko) 2005-04-14 2007-11-28 에프. 호프만-라 로슈 아게 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
US8993737B2 (en) 2010-08-25 2015-03-31 Pacific Biosciences, Inc. Phospholinked dye analogs with an amino acid linker
WO2013173844A1 (en) * 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
KR101668074B1 (ko) * 2015-02-12 2016-10-21 전북대학교산학협력단 Ｐｋｒ 저해제를 유효성분으로 포함하는 기관지 천식의 예방 또는 치료용 조성물
WO2021242790A1 (en) * 2020-05-26 2021-12-02 Baylor College Of Medicine Novel soluble epoxide hydrolase inhibitors and method of use thereof
IL308314A (en) 2021-05-07 2024-01-01 Kymera Therapeutics Inc CDK2 compounds and their uses
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0984930B1 (en) * 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
CA2354852C (en) 2008-09-23
PE20001329A1 (es) 2000-12-11
EP1149106B1 (en) 2003-03-19
UY25855A1 (es) 2001-08-27
CN1330654A (zh) 2002-01-09
KR20010080768A (ko) 2001-08-22
AU770060B2 (en) 2004-02-12
KR100723854B1 (ko) 2007-05-31
PT1149106E (pt) 2003-06-30
KR20060109360A (ko) 2006-10-19
DK1149106T3 (da) 2003-07-14
DE69906149T2 (de) 2003-12-18
WO2000035920A2 (en) 2000-06-22
EP1149106A2 (en) 2001-10-31
WO2000035920A3 (en) 2000-11-23
AR021693A1 (es) 2002-07-31
ATE234839T1 (de) 2003-04-15
TR200101745T2 (tr) 2002-05-21
KR100685192B1 (ko) 2007-02-22
AU3037200A (en) 2000-07-03
ZA200104269B (en) 2002-08-26
DE69906149D1 (de) 2003-04-24
CA2354852A1 (en) 2000-06-22
ES2192878T3 (es) 2003-10-16
JP2002532502A (ja) 2002-10-02
CN1159315C (zh) 2004-07-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.