BR9914368A - Processo para a preparação de composições farmacêuticas orais que compreendem bis-fosfonatos. - Google Patents
Processo para a preparação de composições farmacêuticas orais que compreendem bis-fosfonatos.Info
- Publication number
- BR9914368A BR9914368A BR9914368-2A BR9914368A BR9914368A BR 9914368 A BR9914368 A BR 9914368A BR 9914368 A BR9914368 A BR 9914368A BR 9914368 A BR9914368 A BR 9914368A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- preparation
- bisphosphonates
- oral pharmaceutical
- fluidized bed
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940122361 Bisphosphonate Drugs 0.000 title abstract 2
- 150000004663 bisphosphonates Chemical class 0.000 title abstract 2
- 239000008203 oral pharmaceutical composition Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000005340 bisphosphate group Chemical group 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
''PROCESSO PARA A PREPARAçãO DE COMPOSIçõES FARMACêUTICAS ORAIS QUE COMPREENDEM BIS-FOSFONATOS''. A invenção refere-se a um processo para a preparação de composições farmacêuticas que contêm bis-fosfanatos para aplicação oral, em que a substância ativa é granulada a úmido de uma maneira conhecida em si, em um granulador de leito fluidizado, usando adjuvantes que não têm qualquer ação abrasiva, e em que o granulado úmido é depois secado no leito fluidizado, peneirado através de uma peneira que tem uma malha apropriada, e processado adicionalmente por técnicas conhecidas em si, para formar composições farmacêuticas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98119103A EP0998933A1 (de) | 1998-10-09 | 1998-10-09 | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
| PCT/EP1999/007306 WO2000021541A1 (en) | 1998-10-09 | 1999-10-01 | Process for the preparation of oral pharmaceutical compositions comprising biphosphonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9914368A true BR9914368A (pt) | 2001-08-07 |
Family
ID=8232770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9914368-2A BR9914368A (pt) | 1998-10-09 | 1999-10-01 | Processo para a preparação de composições farmacêuticas orais que compreendem bis-fosfonatos. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6419955B1 (pt) |
| EP (2) | EP0998933A1 (pt) |
| JP (1) | JP3725427B2 (pt) |
| KR (1) | KR100496086B1 (pt) |
| CN (1) | CN1154498C (pt) |
| AR (2) | AR019242A1 (pt) |
| AT (1) | ATE314075T1 (pt) |
| AU (1) | AU744142B2 (pt) |
| BR (1) | BR9914368A (pt) |
| CA (1) | CA2345818C (pt) |
| DE (1) | DE69929219T2 (pt) |
| DK (1) | DK1117411T3 (pt) |
| ES (1) | ES2255301T3 (pt) |
| TR (1) | TR200100888T2 (pt) |
| WO (1) | WO2000021541A1 (pt) |
| ZA (1) | ZA200102273B (pt) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0998932A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| EP1455796A1 (en) * | 2001-12-21 | 2004-09-15 | The Procter & Gamble Company | Method for the treatment of bone disorders |
| RU2387451C2 (ru) * | 2002-05-10 | 2010-04-27 | Ф.Хоффманн-Ля Рош Аг | Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза |
| US20050026871A1 (en) * | 2002-07-17 | 2005-02-03 | Moshe Flashner-Barak | Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative |
| EP1790347B1 (en) | 2002-12-20 | 2014-12-24 | F. Hoffmann-La Roche AG | High dose ibandronate formulation |
| JP4601271B2 (ja) * | 2003-08-01 | 2010-12-22 | 大洋薬品工業株式会社 | 圧縮成形製剤およびその製造方法 |
| MX2007000087A (es) * | 2004-06-23 | 2007-11-06 | Teva Pharma | Acido ibandronico solido y cristalino. |
| JP4559431B2 (ja) * | 2004-08-23 | 2010-10-06 | テバ ファーマシューティカル インダストリーズ リミティド | 固体及び結晶イバンドロネートナトリウム及びその調製方法 |
| US20070191315A1 (en) * | 2006-02-16 | 2007-08-16 | Bengt Bergstrom | Method for administering ibandronate |
| GB0616794D0 (en) | 2006-08-24 | 2006-10-04 | Arrow Int Ltd | Solid dosage form |
| RU2009110253A (ru) * | 2006-08-24 | 2010-09-27 | БЁРИНГЕР ИНГЕЛЬХАЙМ ФАРМА ГМБХ УНД Ко. КГ (DE) | Способ приготовления таблеток прамипексолдигидрохлорида, обладающих высокой стабильностью при хранении |
| CA2704826A1 (en) * | 2007-11-27 | 2009-06-04 | Ohara Pharmaceutical Co., Ltd. | Method for producing granulated preparation |
| HRP20171755T1 (hr) | 2009-07-31 | 2017-12-29 | Grünenthal GmbH | Postupak kristalizacije i biološka raspoloživost |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101230178B1 (ko) | 2010-06-10 | 2013-02-06 | 주식회사 네비팜 | 골다공증 예방 또는 치료용 조성물 및 이의 제조방법 |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| WO2012093974A1 (en) | 2011-01-06 | 2012-07-12 | Mahmut Bilgic | Improved bisphosphonate formulations |
| US9949993B2 (en) | 2012-05-14 | 2018-04-24 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9795622B2 (en) | 2012-05-14 | 2017-10-24 | Antecip Bioventures Ii Llc | Neridronic acid for treating pain associated with a joint |
| US9827256B2 (en) | 2014-05-27 | 2017-11-28 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating lower back pain |
| US9289441B2 (en) | 2014-08-08 | 2016-03-22 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US9655908B2 (en) | 2012-05-14 | 2017-05-23 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US9211257B2 (en) | 2012-05-14 | 2015-12-15 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9877977B2 (en) | 2012-05-14 | 2018-01-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9669040B2 (en) | 2012-05-14 | 2017-06-06 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10004756B2 (en) | 2014-05-15 | 2018-06-26 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9867840B2 (en) | 2014-05-27 | 2018-01-16 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10016445B2 (en) | 2012-05-14 | 2018-07-10 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9999628B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9956234B2 (en) | 2012-05-14 | 2018-05-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for joint conditions |
| US9867839B2 (en) | 2012-05-14 | 2018-01-16 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for joint conditions |
| US9895383B2 (en) | 2012-05-14 | 2018-02-20 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9999629B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9827192B2 (en) | 2012-05-14 | 2017-11-28 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10080765B2 (en) | 2012-05-14 | 2018-09-25 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US10028969B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10111837B2 (en) | 2012-05-14 | 2018-10-30 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds |
| US9782421B1 (en) | 2012-05-14 | 2017-10-10 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US9943531B2 (en) | 2014-08-08 | 2018-04-17 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US9770457B2 (en) | 2012-05-14 | 2017-09-26 | Antecip Bioventures Ii Llc | Neridronic acid for treating bone marrow lesion |
| US9662343B2 (en) | 2012-05-14 | 2017-05-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10350227B2 (en) | 2012-05-14 | 2019-07-16 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9675626B2 (en) | 2012-05-14 | 2017-06-13 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9700570B2 (en) | 2014-05-27 | 2017-07-11 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10034890B2 (en) | 2012-05-14 | 2018-07-31 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10173986B2 (en) | 2012-05-14 | 2019-01-08 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US10493085B2 (en) | 2012-05-14 | 2019-12-03 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US9901589B2 (en) | 2012-05-14 | 2018-02-27 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US8865757B1 (en) | 2014-05-28 | 2014-10-21 | Antecip Bioventures Ii Llp | Therapeutic compositions comprising imidazole and imidazolium compounds |
| US9707245B2 (en) | 2012-05-14 | 2017-07-18 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US9427403B2 (en) | 2012-05-14 | 2016-08-30 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US9694023B2 (en) | 2012-05-14 | 2017-07-04 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US10028908B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US8802658B2 (en) | 2012-05-14 | 2014-08-12 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US10413561B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US9707247B2 (en) | 2012-05-14 | 2017-07-18 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9844559B2 (en) | 2012-05-14 | 2017-12-19 | Antecip Bioventures Ii Llc | Neridronic acid for treating bone marrow lesions |
| US10016446B2 (en) | 2012-05-14 | 2018-07-10 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating Paget's disease of bone |
| US9789128B2 (en) | 2012-05-14 | 2017-10-17 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10463682B2 (en) | 2012-05-14 | 2019-11-05 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating low back pain |
| US9861648B2 (en) | 2012-05-14 | 2018-01-09 | Antecip Boiventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9717747B2 (en) | 2012-05-14 | 2017-08-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9956237B2 (en) | 2012-05-14 | 2018-05-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9616078B2 (en) | 2012-05-14 | 2017-04-11 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US10039773B2 (en) | 2012-05-14 | 2018-08-07 | Antecip Bioventures Ii Llc | Neridronic acid for treating arthritis |
| US10092581B2 (en) | 2014-05-15 | 2018-10-09 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US10413560B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US9956238B2 (en) | 2014-05-15 | 2018-05-01 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9820999B2 (en) | 2012-05-14 | 2017-11-21 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9925203B2 (en) | 2012-05-14 | 2018-03-27 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| CN103110515A (zh) * | 2012-11-14 | 2013-05-22 | 江苏江山制药有限公司 | 氨基葡萄糖硫酸钾盐颗粒的生产方法 |
| US9127069B1 (en) | 2014-06-11 | 2015-09-08 | Antecip Bioventures LLC | Compositions comprising rank/rankl antagonists and related compounds for treating pain |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| EP3376308B1 (fr) * | 2017-03-17 | 2019-11-13 | Montres Jaquet Droz SA | Mécanisme de remontage d'une pièce d'horlogerie |
| CN112972400A (zh) * | 2021-03-09 | 2021-06-18 | 华侨大学 | 可快速崩解的米诺膦酸颗粒及制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0163836B1 (de) * | 1984-04-07 | 1988-10-12 | Bayer Ag | Verfahren und Vorrichtung zur Herstellung von Granulaten |
| US4639338A (en) | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| DE3434667A1 (de) | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| ATE72816T1 (de) | 1986-11-21 | 1992-03-15 | Ciba Geigy Ag | Neue substituierte alkandiphosphonsaeuren. |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| EP0275468B1 (de) * | 1986-12-20 | 1991-02-06 | Roche Diagnostics GmbH | Clodronat-haltige Arzneimittel und Verfahren zur Herstellung derselben |
| FR2629716B1 (fr) | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
| WO1993009785A1 (en) * | 1991-11-22 | 1993-05-27 | Procter & Gamble Pharmaceuticals, Inc. | Risedronate delayed-release compositions |
| US5534262A (en) * | 1992-01-10 | 1996-07-09 | Dobrotvorsky; Anatoly E. | Pharmaceutical granulated composition and method for preparing same |
| SE501389C2 (sv) * | 1992-04-24 | 1995-01-30 | Leiras Oy | Farmaceutiskt preparat och förfarande för dess framställning |
| US5358941A (en) | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| CA2221416A1 (en) * | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Bisphosphonate therapy for bone loss associated with rheumatoid arthritis |
| US5656288A (en) | 1995-06-08 | 1997-08-12 | Sanofi Winthrop, Inc. | Stable pharmaceutical compositions containing tiludronate hydrates and process for producing the pharmaceutical compositions |
-
1998
- 1998-10-09 EP EP98119103A patent/EP0998933A1/de not_active Withdrawn
-
1999
- 1999-10-01 AT AT99948919T patent/ATE314075T1/de active
- 1999-10-01 CA CA002345818A patent/CA2345818C/en not_active Expired - Fee Related
- 1999-10-01 JP JP2000575517A patent/JP3725427B2/ja not_active Expired - Lifetime
- 1999-10-01 AU AU61990/99A patent/AU744142B2/en not_active Ceased
- 1999-10-01 TR TR2001/00888T patent/TR200100888T2/xx unknown
- 1999-10-01 EP EP99948919A patent/EP1117411B1/en not_active Expired - Lifetime
- 1999-10-01 DE DE69929219T patent/DE69929219T2/de not_active Expired - Lifetime
- 1999-10-01 DK DK99948919T patent/DK1117411T3/da active
- 1999-10-01 CN CNB998112291A patent/CN1154498C/zh not_active Expired - Fee Related
- 1999-10-01 WO PCT/EP1999/007306 patent/WO2000021541A1/en not_active Ceased
- 1999-10-01 KR KR10-2001-7004311A patent/KR100496086B1/ko not_active Expired - Fee Related
- 1999-10-01 ES ES99948919T patent/ES2255301T3/es not_active Expired - Lifetime
- 1999-10-01 BR BR9914368-2A patent/BR9914368A/pt not_active Application Discontinuation
- 1999-10-07 AR ARP990105082A patent/AR019242A1/es not_active Application Discontinuation
- 1999-10-07 US US09/413,989 patent/US6419955B1/en not_active Expired - Lifetime
-
2001
- 2001-03-19 ZA ZA200102273A patent/ZA200102273B/en unknown
-
2007
- 2007-02-12 AR ARP070100583A patent/AR057636A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1319016A (zh) | 2001-10-24 |
| TR200100888T2 (tr) | 2001-07-23 |
| AU744142B2 (en) | 2002-02-14 |
| ZA200102273B (en) | 2002-06-19 |
| DK1117411T3 (da) | 2006-04-24 |
| JP2002527399A (ja) | 2002-08-27 |
| WO2000021541A1 (en) | 2000-04-20 |
| DE69929219T2 (de) | 2006-08-17 |
| CA2345818A1 (en) | 2000-04-20 |
| KR20010073202A (ko) | 2001-07-31 |
| JP3725427B2 (ja) | 2005-12-14 |
| US6419955B1 (en) | 2002-07-16 |
| DE69929219D1 (de) | 2006-02-02 |
| AR057636A2 (es) | 2007-12-12 |
| ES2255301T3 (es) | 2006-06-16 |
| ATE314075T1 (de) | 2006-01-15 |
| KR100496086B1 (ko) | 2005-06-20 |
| AR019242A1 (es) | 2001-12-26 |
| EP1117411A1 (en) | 2001-07-25 |
| CN1154498C (zh) | 2004-06-23 |
| EP0998933A1 (de) | 2000-05-10 |
| EP1117411B1 (en) | 2005-12-28 |
| CA2345818C (en) | 2006-01-03 |
| AU6199099A (en) | 2000-05-01 |
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