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BR9913991A - Subregulation methods of the immune response to therapeutic proteins - Google Patents

Subregulation methods of the immune response to therapeutic proteins

Info

Publication number
BR9913991A
BR9913991A BR9913991-0A BR9913991A BR9913991A BR 9913991 A BR9913991 A BR 9913991A BR 9913991 A BR9913991 A BR 9913991A BR 9913991 A BR9913991 A BR 9913991A
Authority
BR
Brazil
Prior art keywords
methods
therapeutic proteins
immune response
subregulation
agents
Prior art date
Application number
BR9913991-0A
Other languages
Portuguese (pt)
Inventor
Jiahua Qian
Leon W Hoyer
Mary Collins
Gary S Gray
Original Assignee
Genetics Inst
American Nat Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst, American Nat Red Cross filed Critical Genetics Inst
Publication of BR9913991A publication Critical patent/BR9913991A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Patente de Invenção: <B>"MéTODOS DE SUB-REGULAçãO DA RESPOSTA IMUNE A PROTEìNAS TERAPêUTICAS"<D>. Composições e métodos para o tratamento de um distúrbio hemostático usando-se agentes os quais promovem a hemostase e agentes os quais inibem um sinal co-estimulatório em uma célula T são proporcionados. As presentes composições e métodos possibilitam o tratamento de distúrbios hemostáticos usando-se proteínas terapêuticas estranhas, ao mesmo tempo em que submodula as respostas imunes às proteínas terapêuticas.Invention Patent: <B> "METHODS OF SUB-REGULATION OF THE IMMUNE RESPONSE TO THERAPEUTIC PROTEINS" <D>. Compositions and methods for the treatment of a hemostatic disorder using agents which promote hemostasis and agents which inhibit a costimulatory signal in a T cell are provided. The present compositions and methods enable the treatment of hemostatic disorders using foreign therapeutic proteins, while submodulating immune responses to therapeutic proteins.

BR9913991-0A 1998-09-21 1999-09-21 Subregulation methods of the immune response to therapeutic proteins BR9913991A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15817898A 1998-09-21 1998-09-21
PCT/US1999/021991 WO2000016801A1 (en) 1998-09-21 1999-09-21 Methods of downmodulating the immune response to therapeutic proteins

Publications (1)

Publication Number Publication Date
BR9913991A true BR9913991A (en) 2001-07-03

Family

ID=22566971

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913991-0A BR9913991A (en) 1998-09-21 1999-09-21 Subregulation methods of the immune response to therapeutic proteins

Country Status (21)

Country Link
EP (1) EP1115423A1 (en)
JP (1) JP2002526455A (en)
KR (1) KR20010085830A (en)
CN (1) CN1331602A (en)
AU (1) AU761206B2 (en)
BR (1) BR9913991A (en)
CA (1) CA2343916A1 (en)
CZ (1) CZ20011021A3 (en)
EA (1) EA005236B1 (en)
HK (1) HK1039059A1 (en)
HU (1) HUP0103960A3 (en)
IL (1) IL142069A0 (en)
LT (1) LT4920B (en)
LV (1) LV12768B (en)
MX (1) MXPA01002898A (en)
NO (1) NO20011412L (en)
NZ (1) NZ511034A (en)
PL (1) PL346796A1 (en)
SI (1) SI20626A (en)
WO (1) WO2000016801A1 (en)
ZA (1) ZA200103156B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
JP2003534291A (en) * 2000-05-19 2003-11-18 ザ センター フォー ブラッド リサーチ インク Methods for diagnosing and treating hemostatic disorders by modulating P-selectin activity
WO2005010483A2 (en) * 2003-06-10 2005-02-03 Smiths Detection Inc. Sensor arrangement
GB201508024D0 (en) * 2015-05-11 2015-06-24 Haemostatix Ltd Haemostatic compositions

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171569A (en) 1985-03-15 1992-12-15 National Research Development Corporation Factor IX preparations uncontaminated by plasma components or pox virus
US4868112A (en) 1985-04-12 1989-09-19 Genetics Institute, Inc. Novel procoagulant proteins
US5422260A (en) 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US4994371A (en) 1987-08-28 1991-02-19 Davie Earl W DNA preparation of Christmas factor and use of DNA sequences
FR2657884B1 (en) 1990-02-05 1994-09-02 Tm Innovation PROCESS FOR THE PREPARATION OF HUMAN FACTOR VIII AND FACTOR VIII ANALOGS.
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5770197A (en) 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
CA2110518C (en) 1991-06-27 2007-05-22 Peter S. Linsley Ctla4 receptor, fusion proteins containing it and uses thereof
WO1993009804A1 (en) 1991-11-18 1993-05-27 The Scripps Research Institute Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
US5744446A (en) 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5364771A (en) 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5663060A (en) 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
WO1996005860A1 (en) * 1994-08-19 1996-02-29 Novo Nordisk A/S A method of treating a patient with a biologically active compound
CA2200869A1 (en) * 1994-10-19 1996-05-02 Bruce C. Trapnell Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
JP4751493B2 (en) * 1996-03-20 2011-08-17 ブリストル−マイヤーズ スクイッブ カンパニー Methods of blocking immune responses by blocking the GP39 / CD40 and CTLA4 / CD28 / B7 pathways and compositions used therefor
ATE356634T1 (en) * 1997-01-10 2007-04-15 Biogen Idec Inc METHOD FOR THERAPEUTIC ADMINISTRATION OF ANTI-CD40L AGENTS
AU733062B2 (en) * 1997-06-20 2001-05-03 Biogen Idec Ma Inc. CD154 blockade therapy for therapeutic protein inhibitor syndrome
US8112896B2 (en) 2009-11-06 2012-02-14 Hexagon Metrology Ab Articulated arm

Also Published As

Publication number Publication date
AU6057899A (en) 2000-04-10
NO20011412D0 (en) 2001-03-20
CA2343916A1 (en) 2000-03-30
LT4920B (en) 2002-06-25
HUP0103960A2 (en) 2002-02-28
PL346796A1 (en) 2002-02-25
AU761206B2 (en) 2003-05-29
WO2000016801A9 (en) 2000-10-26
KR20010085830A (en) 2001-09-07
CZ20011021A3 (en) 2001-10-17
JP2002526455A (en) 2002-08-20
HUP0103960A3 (en) 2003-09-29
EP1115423A1 (en) 2001-07-18
EA005236B1 (en) 2004-12-30
NO20011412L (en) 2001-05-16
LT2001045A (en) 2002-01-25
SI20626A (en) 2002-02-28
IL142069A0 (en) 2002-03-10
LV12768A (en) 2001-12-20
MXPA01002898A (en) 2002-06-04
EA200100385A1 (en) 2001-10-22
NZ511034A (en) 2004-03-26
WO2000016801A1 (en) 2000-03-30
LV12768B (en) 2002-06-20
CN1331602A (en) 2002-01-16
ZA200103156B (en) 2002-07-18
HK1039059A1 (en) 2002-04-12

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Legal Events

Date Code Title Description
TC Change of name
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.