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BR9912671A - Antìgenos imunológicos para o vìrus de herpes simples e métodos para sua utilização - Google Patents

Antìgenos imunológicos para o vìrus de herpes simples e métodos para sua utilização

Info

Publication number
BR9912671A
BR9912671A BR9912671-0A BR9912671A BR9912671A BR 9912671 A BR9912671 A BR 9912671A BR 9912671 A BR9912671 A BR 9912671A BR 9912671 A BR9912671 A BR 9912671A
Authority
BR
Brazil
Prior art keywords
antigens
hsv
methods
specificity
cells
Prior art date
Application number
BR9912671-0A
Other languages
English (en)
Inventor
David M Koelle
Lawrence Corey
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of BR9912671A publication Critical patent/BR9912671A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"ANTìGENOS IMUNOLóGICOS PARA O VìRUS DE HERPES SIMPLES E MéTODOS PARA SUA UTILIZAçãO" A invenção fornece antígenos para o HSV que são úteis na prevenção e tratamento da infecção por HSV. Estão descritos aqui os antígenos e/ou seus epítopos constituintes confirmados por serem reorganizados por células T derivadas de lesões herpéticas do cérvix uterino. As células T que apresentam especificidade para os antígenos da invenção demonstraram atividade citotóxica contra células carregadas com epítopos com peptídeos codificados viralmente e em muitos casos, contra células infectadas pelo HSV. A identificação dos antígenos imunogênicos responsáveis pela especificidade da célula T fornece uma melhor terapêutica anti-viral e estratégica profilática. As composições contendo antígenos ou polinucleotídeos codificando antígenos da invenção fornecem efetivamente vacinas eficazes para prevenção e tratamento da infecção por HSV.
BR9912671-0A 1998-08-07 1999-08-05 Antìgenos imunológicos para o vìrus de herpes simples e métodos para sua utilização BR9912671A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9572498P 1998-08-07 1998-08-07
US9572398P 1998-08-07 1998-08-07
PCT/US1999/017803 WO2000008051A2 (en) 1998-08-07 1999-08-05 Immunological herpes simplex virus antigens and methods for use thereof

Publications (1)

Publication Number Publication Date
BR9912671A true BR9912671A (pt) 2001-05-02

Family

ID=26790525

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912671-0A BR9912671A (pt) 1998-08-07 1999-08-05 Antìgenos imunológicos para o vìrus de herpes simples e métodos para sua utilização

Country Status (16)

Country Link
US (5) US6375952B1 (pt)
EP (2) EP1102790B1 (pt)
JP (1) JP2002522451A (pt)
KR (1) KR20010085348A (pt)
CN (1) CN1348463A (pt)
AR (1) AR020134A1 (pt)
AU (1) AU5467899A (pt)
BR (1) BR9912671A (pt)
CA (1) CA2336523C (pt)
DK (1) DK2272859T3 (pt)
IL (1) IL141044A0 (pt)
NO (1) NO20010576L (pt)
NZ (1) NZ509974A (pt)
PL (1) PL346213A1 (pt)
TR (1) TR200100373T2 (pt)
WO (1) WO2000008051A2 (pt)

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DE60324678D1 (de) * 2002-07-18 2008-12-24 Univ Washington N t-lymphozyten und damit identifizierte hsv-antigene
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US7744903B2 (en) 2010-06-29
EP1102790B1 (en) 2014-05-07
CA2336523A1 (en) 2000-02-17
US20030118611A1 (en) 2003-06-26
KR20010085348A (ko) 2001-09-07
CN1348463A (zh) 2002-05-08
EP2272859B1 (en) 2014-10-22
WO2000008051A3 (en) 2000-08-03
EP2272859A3 (en) 2011-06-08
JP2002522451A (ja) 2002-07-23
NO20010576L (no) 2001-04-02
PL346213A1 (en) 2002-01-28
AU5467899A (en) 2000-02-28
CA2336523C (en) 2015-06-30
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TR200100373T2 (tr) 2001-09-21
US6855317B2 (en) 2005-02-15
US8067010B2 (en) 2011-11-29
IL141044A0 (en) 2002-02-10
NZ509974A (en) 2003-10-31
US20100215693A1 (en) 2010-08-26
US20050163794A1 (en) 2005-07-28
EP2272859A2 (en) 2011-01-12
US8852602B2 (en) 2014-10-07
AR020134A1 (es) 2002-04-10
NO20010576D0 (no) 2001-02-02
WO2000008051A2 (en) 2000-02-17
US20120027790A1 (en) 2012-02-02

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