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NO20010576L - Immunologiske herpes simplex virus antigener og fremgangsmÕter for anvendelse derav - Google Patents

Immunologiske herpes simplex virus antigener og fremgangsmÕter for anvendelse derav

Info

Publication number
NO20010576L
NO20010576L NO20010576A NO20010576A NO20010576L NO 20010576 L NO20010576 L NO 20010576L NO 20010576 A NO20010576 A NO 20010576A NO 20010576 A NO20010576 A NO 20010576A NO 20010576 L NO20010576 L NO 20010576L
Authority
NO
Norway
Prior art keywords
antigens
hsv
cells
immunological
methods
Prior art date
Application number
NO20010576A
Other languages
English (en)
Other versions
NO20010576D0 (no
Inventor
David M Koelle
Lawrence Corey
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of NO20010576D0 publication Critical patent/NO20010576D0/no
Publication of NO20010576L publication Critical patent/NO20010576L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Oppfinnelsen tilveiebringer HSV antigener som er nyttige for å forebygge og behandle HSV infeksjon. Angitt heri er antigener og/eller deres konstituente epitoper bekreftet å være gjenkjent av T-celler avledet fra herpes lesjoner eller fra livmorhalsen. T-celler som har spesifisitet for antigenene fra oppfinnelsen har vist cytotoksisk aktivitet mot celler som har viral-kodede peptid epitoper, og i mange tilfeller, mot celler infisert med HSV. Identifiseringen av immunogene antigener som er ansvarlig for T-celle spesifisitet tilveiebringer forbedret antiviral terapeutika og profylaktiske strategier. Sammensetninger som inneholder antigener eller polynukleotider som koder for antigener fra oppfinnelsen tilveiebringer effektive mål økende vaksiner for å forebygge og behandle HSV infeksjon.
NO20010576A 1998-08-07 2001-02-02 Immunologiske herpes simplex virus antigener og fremgangsmÕter for anvendelse derav NO20010576L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9572498P 1998-08-07 1998-08-07
US9572398P 1998-08-07 1998-08-07
PCT/US1999/017803 WO2000008051A2 (en) 1998-08-07 1999-08-05 Immunological herpes simplex virus antigens and methods for use thereof

Publications (2)

Publication Number Publication Date
NO20010576D0 NO20010576D0 (no) 2001-02-02
NO20010576L true NO20010576L (no) 2001-04-02

Family

ID=26790525

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010576A NO20010576L (no) 1998-08-07 2001-02-02 Immunologiske herpes simplex virus antigener og fremgangsmÕter for anvendelse derav

Country Status (16)

Country Link
US (5) US6375952B1 (no)
EP (2) EP1102790B1 (no)
JP (1) JP2002522451A (no)
KR (1) KR20010085348A (no)
CN (1) CN1348463A (no)
AR (1) AR020134A1 (no)
AU (1) AU5467899A (no)
BR (1) BR9912671A (no)
CA (1) CA2336523C (no)
DK (1) DK2272859T3 (no)
IL (1) IL141044A0 (no)
NO (1) NO20010576L (no)
NZ (1) NZ509974A (no)
PL (1) PL346213A1 (no)
TR (1) TR200100373T2 (no)
WO (1) WO2000008051A2 (no)

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CA2336523A1 (en) 2000-02-17
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US20030118611A1 (en) 2003-06-26
KR20010085348A (ko) 2001-09-07
CN1348463A (zh) 2002-05-08
EP2272859B1 (en) 2014-10-22
WO2000008051A3 (en) 2000-08-03
EP2272859A3 (en) 2011-06-08
JP2002522451A (ja) 2002-07-23
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AU5467899A (en) 2000-02-28
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US6855317B2 (en) 2005-02-15
US8067010B2 (en) 2011-11-29
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US20100215693A1 (en) 2010-08-26
US20050163794A1 (en) 2005-07-28
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US8852602B2 (en) 2014-10-07
AR020134A1 (es) 2002-04-10
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WO2000008051A2 (en) 2000-02-17
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