BR9910978A - Análogos de insulina com elevada ligação de zinco - Google Patents
Análogos de insulina com elevada ligação de zincoInfo
- Publication number
- BR9910978A BR9910978A BR9910978-6A BR9910978A BR9910978A BR 9910978 A BR9910978 A BR 9910978A BR 9910978 A BR9910978 A BR 9910978A BR 9910978 A BR9910978 A BR 9910978A
- Authority
- BR
- Brazil
- Prior art keywords
- insulin analogs
- high zinc
- zinc binding
- well
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 230000004572 zinc-binding Effects 0.000 title abstract 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 150000003751 zinc Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"ANáLOGOS DE INSULINA COM ELEVADA LIGAçãO DE ZINCO"<D>. A presente invenção refere-se a refere-se a análogos de insulina, os quais apresentam um elevado poder de ligação de zinco, bem como complexos de zinco estáveis dos mesmos, que em comparação com insulina humana apresentam um perfil de efeito retardado, um processo para a sua preparação e sua aplicação especialmente em preparados farmacêuticos para a terapia do diabete mellitus do tipo I como também do tipo II.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825447A DE19825447A1 (de) | 1998-06-06 | 1998-06-06 | Neue Insulinanaloga mit erhöhter Zinkbildung |
| PCT/EP1999/003490 WO1999064598A2 (de) | 1998-06-06 | 1999-05-21 | Neue insulinanaloga mit erhöhter zinkbindung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910978A true BR9910978A (pt) | 2001-02-13 |
Family
ID=7870213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910978-6A BR9910978A (pt) | 1998-06-06 | 1999-05-21 | Análogos de insulina com elevada ligação de zinco |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6686177B1 (pt) |
| EP (1) | EP1084248B1 (pt) |
| JP (1) | JP4402296B2 (pt) |
| KR (1) | KR100649339B1 (pt) |
| CN (1) | CN1304450B (pt) |
| AR (1) | AR019852A1 (pt) |
| AT (1) | ATE334201T1 (pt) |
| AU (1) | AU757275B2 (pt) |
| BR (1) | BR9910978A (pt) |
| CA (1) | CA2330183C (pt) |
| CZ (1) | CZ301377B6 (pt) |
| DE (2) | DE19825447A1 (pt) |
| DK (1) | DK1084248T3 (pt) |
| ES (1) | ES2268871T3 (pt) |
| HU (1) | HU228908B1 (pt) |
| MX (1) | MXPA00011456A (pt) |
| NO (1) | NO329956B1 (pt) |
| PL (1) | PL198190B1 (pt) |
| PT (1) | PT1084248E (pt) |
| RU (1) | RU2225723C2 (pt) |
| TR (1) | TR200003606T2 (pt) |
| WO (1) | WO1999064598A2 (pt) |
| ZA (1) | ZA200006835B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| US6852694B2 (en) | 2001-02-21 | 2005-02-08 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
| CN101027318B (zh) | 2004-07-19 | 2016-05-25 | 比奥孔有限公司 | 胰岛素-低聚物共轭物，制剂及其用途 |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| JP5868594B2 (ja) * | 2007-10-16 | 2016-02-24 | バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ | 経口投与可能な固形医薬組成物及びそのプロセス |
| DK2597103T3 (en) * | 2007-11-16 | 2017-02-13 | Novo Nordisk As | Stable pharmaceutical compositions comprising liraglutide and degludec |
| PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
| BRPI0916560A2 (pt) * | 2008-07-31 | 2015-11-10 | Univ Case Western Reserve | análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. |
| CA2790495A1 (en) * | 2010-02-22 | 2011-08-25 | Case Western Reserve University | Long-acting insulin analogue preparations in soluble and crystalline forms |
| PL222975B1 (pl) | 2012-05-23 | 2016-09-30 | Inst Biotechnologii I Antybiotyków | Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny |
| FR3013049B1 (fr) | 2013-11-14 | 2015-11-13 | You-Ping Chan | Analogue de l'insuline glargine |
| EP3268384B1 (en) * | 2015-03-10 | 2021-11-03 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| DE3326472A1 (de) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| SU1250303A1 (ru) * | 1983-12-30 | 1986-08-15 | Филиал По Разработке Готовых Лекарственных Средств Научно-Исследовательского Института По Биологическим Испытаниям Химических Соединений | Способ стабилизации суспензии цинк-инсулина кристаллического |
| DE3440988A1 (de) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
| US4569794A (en) | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
| US5008241A (en) | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DE3526995A1 (de) | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DE3541856A1 (de) | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
| DE3636903A1 (de) | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
| RU2104305C1 (ru) * | 1986-08-29 | 1998-02-10 | Ново Нордиск А.С. | Аналоги инсулина человека, способ их получения, раствор для инъекций |
| CA1340522C (en) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| DE3805150A1 (de) | 1987-04-11 | 1988-10-20 | Hoechst Ag | Gentechnologisches verfahren zur herstellung von polypeptiden |
| DE4012818A1 (de) | 1990-04-21 | 1991-10-24 | Hoechst Ag | Verfahren zur herstellung von fremdproteinen in streptomyceten |
| DE3726655A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
| DE3739347A1 (de) | 1987-11-20 | 1989-06-01 | Hoechst Ag | Verfahren zur selektiven spaltung von fusionsproteinen |
| DK257988D0 (da) * | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| DE58906966D1 (de) | 1988-06-23 | 1994-03-24 | Hoechst Ag | Mini-Proinsulin, seine Herstellung und Verwendung. |
| DE3827533A1 (de) | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| IL95495A (en) | 1989-08-29 | 1996-10-16 | Hoechst Ag | Fusion proteins their preparation and use |
| US5227293A (en) | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
| US5358857A (en) | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
| DE59305396D1 (de) | 1992-12-02 | 1997-03-20 | Hoechst Ag | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
| EP0705275B1 (en) * | 1993-06-21 | 1999-02-03 | Novo Nordisk A/S | Asp-b28 insulin crystals |
| KR100310122B1 (ko) * | 1993-09-17 | 2002-04-24 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 아실화된인슐린 |
| DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| DK0821006T3 (da) * | 1996-07-26 | 2004-08-16 | Aventis Pharma Gmbh | Insulinderivater med öget zinkbinding |
| DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
-
1998
- 1998-06-06 DE DE19825447A patent/DE19825447A1/de not_active Withdrawn
-
1999
- 1999-05-21 US US09/701,968 patent/US6686177B1/en not_active Expired - Lifetime
- 1999-05-21 AU AU41454/99A patent/AU757275B2/en not_active Ceased
- 1999-05-21 BR BR9910978-6A patent/BR9910978A/pt active Search and Examination
- 1999-05-21 PL PL345898A patent/PL198190B1/pl unknown
- 1999-05-21 CZ CZ20004525A patent/CZ301377B6/cs not_active IP Right Cessation
- 1999-05-21 RU RU2001101164/15A patent/RU2225723C2/ru not_active IP Right Cessation
- 1999-05-21 CN CN998070688A patent/CN1304450B/zh not_active Expired - Fee Related
- 1999-05-21 ES ES99925023T patent/ES2268871T3/es not_active Expired - Lifetime
- 1999-05-21 DE DE59913711T patent/DE59913711D1/de not_active Expired - Lifetime
- 1999-05-21 WO PCT/EP1999/003490 patent/WO1999064598A2/de not_active Ceased
- 1999-05-21 KR KR1020007013862A patent/KR100649339B1/ko not_active Expired - Fee Related
- 1999-05-21 MX MXPA00011456A patent/MXPA00011456A/es not_active IP Right Cessation
- 1999-05-21 CA CA002330183A patent/CA2330183C/en not_active Expired - Fee Related
- 1999-05-21 JP JP2000553588A patent/JP4402296B2/ja not_active Expired - Fee Related
- 1999-05-21 HU HU0102217A patent/HU228908B1/hu not_active IP Right Cessation
- 1999-05-21 AT AT99925023T patent/ATE334201T1/de active
- 1999-05-21 EP EP99925023A patent/EP1084248B1/de not_active Expired - Lifetime
- 1999-05-21 TR TR2000/03606T patent/TR200003606T2/xx unknown
- 1999-05-21 PT PT99925023T patent/PT1084248E/pt unknown
- 1999-05-21 DK DK99925023T patent/DK1084248T3/da active
- 1999-06-03 AR ARP990102631A patent/AR019852A1/es active IP Right Grant
-
2000
- 2000-11-22 ZA ZA200006835A patent/ZA200006835B/xx unknown
- 2000-12-05 NO NO20006177A patent/NO329956B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9910978A (pt) | Análogos de insulina com elevada ligação de zinco | |
| SE9502167L (sv) | Insulinanalog-kompositioner | |
| PT801649E (pt) | Derivados de hidroxilamina uteis para aumentar a producao de proteinas moleculares adventicias e sua preparacao | |
| BR9915247A (pt) | Compostos biaromáticos análogos da vitamina d,seus usos, composição farmacêutica e composiçãocosmética contendo os mesmos, e uso dacomposição cosmética | |
| BRPI0510394A (pt) | inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 | |
| BR0212512A (pt) | Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta | |
| BR0314799A (pt) | Controle glicêmico aperfeiçoado para pré-diabetes e/ou diabetes do tipo ii usando ácido docosahexaenóico | |
| DK1011653T3 (da) | Anvendelse af xanthophyller i medikamenter til forbedring af varigheden af muskelfunktion eller behandling af muskelforstyrrelser eller -lidelser | |
| BR0113251A (pt) | Compostos, composição cosmética, composição farmacêutica, uso cosmético de uma composição e uso de um composto | |
| BR0308196A (pt) | Composto, formulação farmacêutica, uso de um composto, métodos de prevenção e/ou tratamento de condições associadas com a glicogênio sintase cinase-3, e de doenças, e, processo para a preparação de um composto | |
| MXPA01006917A (es) | Composicion topica que comprende n-acetilaldosaminas o acidos n-acetilaminos. | |
| DK642587A (da) | Insulinpraeparat | |
| BR0214457A (pt) | métodos para o tratamento de cáncer | |
| BRPI0411674A (pt) | compostos, composição cosmética, uso cosmético de uma composição, uso de um composto, composição farmacêutica, e processo cosmético para o embelezamento da pele | |
| PT1047397E (pt) | Composicoes topicas para aumento da producao de glutationa | |
| BR0114092A (pt) | Guanididas de ácido cinámico substituìdas, processos para a sua preparação, sua aplicação como medicamento bem como o medicamento contendo as mesmas | |
| NZ335231A (en) | Human fragments of insulin C-peptides of the sequence ELGGGPGAG or EGSLQ that have Na/K ATPase stimulating activity | |
| CA2735844A1 (en) | Use of piperine and analogues thereof in the prevention of skin cancer | |
| ES2187125T3 (es) | Compuestos biciclicos-aromaticos y su utilizacion en medicina humana o veterinaria asi como en cosmetologia. | |
| BR0308316A (pt) | Sais de nateglinida | |
| BR0013175A (pt) | Derivados de vitamina d com sub-estruturas cìclicas na cadeias laterais, processos e produtos intermediários para a sua preparação e a utilização para a preparação de medicamentos | |
| AU587054B2 (en) | Novel pharmaceutical compositions intended to the treatment of neuropathies and insuring the nervous regeneration | |
| BR0113148A (pt) | Composições de 2-piridinamina e métodos relacionados | |
| BR9809637A (pt) | Glicoconjugados de 20(s)-camptotecina | |
| BR0311371A (pt) | Composições para uso terapêutico compreendendo uma vitamina, um sal de metal e insulina ou um hormÈnio de crescimento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |