BR9910715A - Método para a purificação da lipoproteìna ospa de borrelia - Google Patents
Método para a purificação da lipoproteìna ospa de borreliaInfo
- Publication number
- BR9910715A BR9910715A BR9910715-5A BR9910715A BR9910715A BR 9910715 A BR9910715 A BR 9910715A BR 9910715 A BR9910715 A BR 9910715A BR 9910715 A BR9910715 A BR 9910715A
- Authority
- BR
- Brazil
- Prior art keywords
- lipoprotein
- purification
- ospa
- borrelia
- borrelia ospa
- Prior art date
Links
- 241000589968 Borrelia Species 0.000 title abstract 3
- 208000016604 Lyme disease Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 108090001030 Lipoproteins Proteins 0.000 title abstract 2
- 102000004895 Lipoproteins Human genes 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 108700006640 OspA Proteins 0.000 abstract 2
- 239000003599 detergent Substances 0.000 abstract 2
- 101001086191 Borrelia burgdorferi Outer surface protein A Proteins 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Patente de Invenção: <B>"MéTODO PARA A PURIFICAçãO DA LIPOPROTEìNA OSPA DE BORRELIA"<D>. A presente invenção provê um método para a purificação da lipoproteína OspA de Borrelia adequada para uso clínico humano com o qual uma célula hospedeira expressando a lipoproteína OspA é lisada na presença de um detergente zwitteriónico seguido por várias etapas cromatográficas em um detergente não-iónico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811219.6A GB9811219D0 (en) | 1998-05-26 | 1998-05-26 | Novel process |
| PCT/EP1999/003602 WO1999061473A1 (en) | 1998-05-26 | 1999-05-25 | Method for purification of borrelia lipoprotein ospa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9910715A true BR9910715A (pt) | 2001-01-30 |
Family
ID=10832669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9910715-5A BR9910715A (pt) | 1998-05-26 | 1999-05-25 | Método para a purificação da lipoproteìna ospa de borrelia |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1080109B1 (pt) |
| JP (1) | JP2002516340A (pt) |
| KR (1) | KR20010043817A (pt) |
| CN (1) | CN1311795A (pt) |
| AT (1) | ATE244730T1 (pt) |
| AU (1) | AU752196B2 (pt) |
| BR (1) | BR9910715A (pt) |
| CA (1) | CA2333167A1 (pt) |
| DE (1) | DE69909469T2 (pt) |
| GB (1) | GB9811219D0 (pt) |
| HU (1) | HUP0102774A3 (pt) |
| IL (1) | IL139749A0 (pt) |
| NO (1) | NO20005951L (pt) |
| PL (1) | PL345273A1 (pt) |
| TR (1) | TR200003468T2 (pt) |
| WO (1) | WO1999061473A1 (pt) |
| ZA (1) | ZA200006873B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008057396A2 (en) | 2006-11-03 | 2008-05-15 | Schering-Plough Ltd. | Canine lyme disease vaccine |
| WO2008101667A1 (en) * | 2007-02-22 | 2008-08-28 | Baxter International Inc. | Method of purification of hydrophobic proteins |
| CN103118701B (zh) | 2010-05-14 | 2017-10-24 | 百深公司 | Ospa嵌合体及其在疫苗中的用途 |
| RU2015106742A (ru) | 2012-07-27 | 2016-09-20 | Бакстер Интернэшнл Инк. | Композиции, содержащие химерные молекулы ospa и способы их применения |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| US6221363B1 (en) * | 1991-07-11 | 2001-04-24 | Baxter Aktiengesellschaft | Vaccine for the prevention of lyme disease |
| PT100980B (pt) * | 1991-10-18 | 1999-07-30 | Connaught Lab | Proteinas recombinantes de borrelia, seu processo de producao, vacina contra infeccao por borrelia e agente de imunodiagnostico para a sua deteccao |
-
1998
- 1998-05-26 GB GBGB9811219.6A patent/GB9811219D0/en not_active Ceased
-
1999
- 1999-05-25 TR TR2000/03468T patent/TR200003468T2/xx unknown
- 1999-05-25 HU HU0102774A patent/HUP0102774A3/hu unknown
- 1999-05-25 KR KR1020007013255A patent/KR20010043817A/ko not_active Withdrawn
- 1999-05-25 AU AU43679/99A patent/AU752196B2/en not_active Ceased
- 1999-05-25 BR BR9910715-5A patent/BR9910715A/pt not_active IP Right Cessation
- 1999-05-25 CN CN99809060A patent/CN1311795A/zh active Pending
- 1999-05-25 WO PCT/EP1999/003602 patent/WO1999061473A1/en not_active Ceased
- 1999-05-25 EP EP99926409A patent/EP1080109B1/en not_active Expired - Lifetime
- 1999-05-25 AT AT99926409T patent/ATE244730T1/de not_active IP Right Cessation
- 1999-05-25 DE DE69909469T patent/DE69909469T2/de not_active Expired - Fee Related
- 1999-05-25 CA CA002333167A patent/CA2333167A1/en not_active Abandoned
- 1999-05-25 PL PL99345273A patent/PL345273A1/xx not_active Application Discontinuation
- 1999-05-25 JP JP2000550877A patent/JP2002516340A/ja active Pending
- 1999-05-25 IL IL13974999A patent/IL139749A0/xx unknown
-
2000
- 2000-11-23 ZA ZA200006873A patent/ZA200006873B/xx unknown
- 2000-11-24 NO NO20005951A patent/NO20005951L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4367999A (en) | 1999-12-13 |
| ZA200006873B (en) | 2001-07-05 |
| JP2002516340A (ja) | 2002-06-04 |
| CN1311795A (zh) | 2001-09-05 |
| EP1080109A1 (en) | 2001-03-07 |
| HUP0102774A3 (en) | 2003-04-28 |
| GB9811219D0 (en) | 1998-07-22 |
| DE69909469D1 (de) | 2003-08-14 |
| WO1999061473A1 (en) | 1999-12-02 |
| IL139749A0 (en) | 2002-02-10 |
| EP1080109B1 (en) | 2003-07-09 |
| NO20005951L (no) | 2001-01-24 |
| AU752196B2 (en) | 2002-09-12 |
| PL345273A1 (en) | 2001-12-03 |
| KR20010043817A (ko) | 2001-05-25 |
| DE69909469T2 (de) | 2004-04-15 |
| CA2333167A1 (en) | 1999-12-02 |
| TR200003468T2 (tr) | 2002-05-21 |
| NO20005951D0 (no) | 2000-11-24 |
| ATE244730T1 (de) | 2003-07-15 |
| HUP0102774A2 (hu) | 2001-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU5926598A (en) | Electronic-property probing of biological molecules at surfaces | |
| BR9908020A (pt) | Fórmula para polimento ótico | |
| BR9408407A (pt) | Uso de inibidores pla2 como tratamento para doença de alzheimer | |
| PT895087E (pt) | Aparelho universal para analises clinicas | |
| DE69423652D1 (de) | Elastische teile für absorbierende wegwerfartikel | |
| DK1037880T3 (da) | Anilider som retinsyremimetika | |
| NO984524D0 (no) | Amfipatiske molekyler som kolesterol- og andre lipoidopptaksinhibitorer | |
| BR0203902A (pt) | Composições de compostos bioquìmicos envolvidos no metabolismo bioenergético das células e método de uso da mesma | |
| BR9710735A (pt) | Processos para detec-Æo de atividade de heparanase de mamiferos em uma amostra e para purifa-Æo de heparanase de maniferos a partir de um material contendo heparanase kit para uso na detec-Æo da atividade da heparanase de mamiferos em uma amostra e heparanase de mamiferos substancialmente purificada e de plaquetas humanas | |
| AU5252698A (en) | Therapeutic compositions and methods and diagnostic assays for type ii diabetes involving hnf-1 | |
| NO971347L (no) | DNA som koder for humant papillomvirus type 6A | |
| FR2857263B1 (fr) | Nouvelle composition pharmaceutique solide comprenant de l'amisulpride | |
| BR9910715A (pt) | Método para a purificação da lipoproteìna ospa de borrelia | |
| NO963108D0 (no) | Substituerte kanelsyreguanidider, fremgangsmåte for fremstilling, anvendelse som medikament eller diagnostikum som inneholder disse | |
| GR3034573T3 (en) | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | |
| FI965094A0 (fi) | 2,4,6-trijodi-5-substituoituja aminoisoftalaattiestereitä, jotka ovat hyödyllisiä varjoaineina lääketieteellisessä diagnostisessa kuvauksessa | |
| NO963497D0 (no) | Fibrin-spesifikt antistoff for anvendelse som et antitrombotisk middel | |
| DK0928197T3 (da) | Anvendelse af proteiner som midler mod autoimmune sygdomme | |
| FR2845267B1 (fr) | Kit cutane de diagnostic de l'atopie | |
| IT1293067B1 (it) | Composizione farmaceutica per il trattamento di patologie causate da alterato metabolismo lipidico | |
| PT1069885E (pt) | Solucao oftalmica que compreende glicogenio | |
| BR0007183A (pt) | Isonipectoamidas para o tratamento de distúrbios mediados por integrina | |
| AU6509698A (en) | Methods for clinical diagnosis | |
| BR9807210A (pt) | Processo para a preparação de 3,3-dimetilbutiraldeìdo | |
| AU2001224009A1 (en) | Clinical examination precision guarantee system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009. |