BR9908964A - Processo para produção de derivados de purina e intermediários para os mesmos - Google Patents
Processo para produção de derivados de purina e intermediários para os mesmosInfo
- Publication number
- BR9908964A BR9908964A BR9908964-5A BR9908964A BR9908964A BR 9908964 A BR9908964 A BR 9908964A BR 9908964 A BR9908964 A BR 9908964A BR 9908964 A BR9908964 A BR 9908964A
- Authority
- BR
- Brazil
- Prior art keywords
- intermediates
- purine derivatives
- producing purine
- producing
- penciclovir
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960004396 famciclovir Drugs 0.000 abstract 1
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229960001179 penciclovir Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA PRODUçãO DE DERIVADOS DE PURINA E INTERMEDIáRIOS PARA OS MESMOS"<D>. Processo para produção de um composto de fórmula (I), onde X é H, OH ou halo; e R~ 1~ e R~ 2~ são selecionados, independentemente dentre C~ 1-12~ alquila, arila, C~ 1-12~ alquilarila, C~ 1-12~ alquilsilila, arilsilila e C~ 1-12~ alquilarilsilila ou R~ 1~ e R~ 2~ são considerados juntos para formar um acetal ou cetal cíclico; cujo processo compreende reagir um composto de fórmula (II) com um composto de fórmula (III), onde Y é um grupo de partida, na presença de um catalisador de paládio (0) e de um ligante. O processo propicia um novo método de produção de famciclovir e penciclovir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807114.5A GB9807114D0 (en) | 1998-04-02 | 1998-04-02 | Novel process |
| PCT/EP1999/002308 WO1999051603A1 (en) | 1998-04-02 | 1999-03-30 | Process for the production of purine derivatives and intermediates therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908964A true BR9908964A (pt) | 2000-12-05 |
Family
ID=10829763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908964-5A BR9908964A (pt) | 1998-04-02 | 1999-03-30 | Processo para produção de derivados de purina e intermediários para os mesmos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6555685B1 (pt) |
| EP (1) | EP1068209B1 (pt) |
| JP (1) | JP4524040B2 (pt) |
| KR (1) | KR100701114B1 (pt) |
| CN (1) | CN1153769C (pt) |
| AT (1) | ATE304541T1 (pt) |
| AU (1) | AU3420099A (pt) |
| BR (1) | BR9908964A (pt) |
| CA (1) | CA2322583A1 (pt) |
| DE (1) | DE69927251T2 (pt) |
| DK (1) | DK1068209T3 (pt) |
| ES (1) | ES2247793T3 (pt) |
| GB (1) | GB9807114D0 (pt) |
| IL (1) | IL138288A (pt) |
| WO (1) | WO1999051603A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1288215B8 (en) | 2001-08-30 | 2005-04-06 | Ajinomoto Co., Inc. | Production method of famciclovir and production and crystallization method of intermediate therefor |
| US20040097528A1 (en) * | 2002-08-26 | 2004-05-20 | Ben-Zion Dolitzky | Crystalline solid famciclovir forms I, II, III and preparation thereof |
| WO2004099208A1 (en) * | 2003-04-30 | 2004-11-18 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of famciclovir |
| WO2005026167A1 (en) * | 2003-09-04 | 2005-03-24 | Teva Pharmaceutical Industries Ltd. | Process for preparing famciclovir |
| WO2005103025A1 (en) * | 2004-04-21 | 2005-11-03 | Novogen Research Pty Ltd | Isoflavene synthetic method and catalyst |
| GB2426247A (en) * | 2005-05-20 | 2006-11-22 | Arrow Int Ltd | Methods of preparing purine derivatives such as famciclovir |
| TW201211007A (en) | 2010-08-27 | 2012-03-16 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| JP5837934B2 (ja) | 2010-08-27 | 2015-12-24 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換２−オキソ−および２−チオキソ−ジヒドロキノリン−３−カルボキサミド |
| BR112013004562A2 (pt) | 2010-08-27 | 2016-09-06 | Gruenenthal Gmbh | 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3 |
| EP2611780A1 (en) | 2010-09-01 | 2013-07-10 | Grünenthal GmbH | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| CN102070636B (zh) * | 2011-01-17 | 2012-05-23 | 浙江大学 | 喷昔洛韦的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL73682A (en) | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
| SE8406538D0 (sv) | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
| GB8817607D0 (en) | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
| JPH06279443A (ja) * | 1993-01-27 | 1994-10-04 | Asahi Chem Ind Co Ltd | ６’−ホモネプラノシンａ誘導体およびその製造法 |
| GB9407698D0 (en) | 1994-04-19 | 1994-06-15 | Smithkline Beecham Plc | Pharmaceuticals |
-
1998
- 1998-04-02 GB GBGB9807114.5A patent/GB9807114D0/en not_active Ceased
-
1999
- 1999-03-30 DE DE69927251T patent/DE69927251T2/de not_active Expired - Fee Related
- 1999-03-30 IL IL13828899A patent/IL138288A/xx not_active IP Right Cessation
- 1999-03-30 CN CNB998044008A patent/CN1153769C/zh not_active Expired - Fee Related
- 1999-03-30 WO PCT/EP1999/002308 patent/WO1999051603A1/en not_active Ceased
- 1999-03-30 US US09/623,662 patent/US6555685B1/en not_active Expired - Lifetime
- 1999-03-30 ES ES99915738T patent/ES2247793T3/es not_active Expired - Lifetime
- 1999-03-30 AT AT99915738T patent/ATE304541T1/de not_active IP Right Cessation
- 1999-03-30 JP JP2000542324A patent/JP4524040B2/ja not_active Expired - Fee Related
- 1999-03-30 DK DK99915738T patent/DK1068209T3/da active
- 1999-03-30 BR BR9908964-5A patent/BR9908964A/pt active Search and Examination
- 1999-03-30 KR KR1020007010707A patent/KR100701114B1/ko not_active Expired - Fee Related
- 1999-03-30 CA CA002322583A patent/CA2322583A1/en not_active Abandoned
- 1999-03-30 EP EP99915738A patent/EP1068209B1/en not_active Expired - Lifetime
- 1999-03-30 AU AU34200/99A patent/AU3420099A/en not_active Abandoned
-
2003
- 2003-02-19 US US10/369,841 patent/US6806375B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL138288A (en) | 2005-07-25 |
| CN1153769C (zh) | 2004-06-16 |
| GB9807114D0 (en) | 1998-06-03 |
| CA2322583A1 (en) | 1999-10-14 |
| JP4524040B2 (ja) | 2010-08-11 |
| WO1999051603A1 (en) | 1999-10-14 |
| HK1034512A1 (en) | 2001-10-26 |
| IL138288A0 (en) | 2001-10-31 |
| ATE304541T1 (de) | 2005-09-15 |
| KR100701114B1 (ko) | 2007-03-29 |
| AU3420099A (en) | 1999-10-25 |
| DE69927251T2 (de) | 2006-06-29 |
| CN1294589A (zh) | 2001-05-09 |
| ES2247793T3 (es) | 2006-03-01 |
| KR20010034702A (ko) | 2001-04-25 |
| US20030130512A1 (en) | 2003-07-10 |
| JP2002510691A (ja) | 2002-04-09 |
| DK1068209T3 (da) | 2005-11-14 |
| EP1068209B1 (en) | 2005-09-14 |
| US6555685B1 (en) | 2003-04-29 |
| DE69927251D1 (de) | 2005-10-20 |
| EP1068209A1 (en) | 2001-01-17 |
| US6806375B2 (en) | 2004-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD (BM) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |