DE69905181D1 - Antivirale purin-derivate - Google Patents

Antivirale purin-derivate

Info

Publication number: DE69905181D1
Authority: DE; Germany
Prior art keywords: purine derivatives; antiviral purine; antiviral; derivatives; purine
Prior art date: 1998-09-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69905181T

Other languages

English (en)

Other versions

DE69905181T2 (de

Inventor

Christopher Mcguigan

Jan Balzarini

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rega Foundation

University College Cardiff Consultants Ltd

Cardiff University

Original Assignee

Rega Foundation

University College Cardiff Consultants Ltd

Cardiff University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-28

Filing date

1999-09-27

Publication date

2003-03-06

1999-09-27 Application filed by Rega Foundation, University College Cardiff Consultants Ltd, Cardiff University filed Critical Rega Foundation

2003-03-06 Application granted granted Critical

2003-03-06 Publication of DE69905181D1 publication Critical patent/DE69905181D1/de

2003-06-26 Publication of DE69905181T2 publication Critical patent/DE69905181T2/de

2019-09-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Pulmonology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DE69905181T 1998-09-28 1999-09-27 Antivirale purin-derivate Expired - Fee Related DE69905181T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9821058.6A GB9821058D0 (en)	1998-09-28	1998-09-28	Chemical compound
PCT/GB1999/003207 WO2000018775A1 (en)	1998-09-28	1999-09-27	Antiviral purine derivatives

Publications (2)

Publication Number	Publication Date
DE69905181D1 true DE69905181D1 (de)	2003-03-06
DE69905181T2 DE69905181T2 (de)	2003-06-26

Family

ID=10839578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69905181T Expired - Fee Related DE69905181T2 (de)	1998-09-28	1999-09-27	Antivirale purin-derivate

Country Status (31)

Country	Link
US (1)	US6638919B2 (de)
EP (1)	EP1117669B1 (de)
JP (1)	JP2002525374A (de)
KR (1)	KR20010085855A (de)
CN (1)	CN1328565A (de)
AR (1)	AR042368A1 (de)
AT (1)	ATE231874T1 (de)
AU (1)	AU762757B2 (de)
BR (1)	BR9914097A (de)
CA (1)	CA2345672A1 (de)
DE (1)	DE69905181T2 (de)
DK (1)	DK1117669T3 (de)
ES (1)	ES2192081T3 (de)
GB (1)	GB9821058D0 (de)
GC (1)	GC0000174A (de)
GT (1)	GT199900166A (de)
HU (1)	HUP0103641A3 (de)
IL (1)	IL141959A0 (de)
MA (1)	MA26694A1 (de)
MY (1)	MY121839A (de)
NO (1)	NO20011198L (de)
NZ (1)	NZ510506A (de)
PA (1)	PA8483101A1 (de)
PE (1)	PE20001072A1 (de)
PL (1)	PL346905A1 (de)
PT (1)	PT1117669E (de)
TN (1)	TNSN99183A1 (de)
TR (1)	TR200100864T2 (de)
TW (1)	TWI243176B (de)
WO (1)	WO2000018775A1 (de)
ZA (1)	ZA200102170B (de)

Families Citing this family (46)

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IL144647A0 (en) *	1999-02-12	2002-05-23	Glaxo Group Ltd	Phosphoramidate, and mono-, di-, and tri-phosphate esters of (ir, cis)-4-(6-amino-9h-purin-9-yl) 2-cyclopentene-1-methanol as antiviral agents
AU774492B2 (en)	1999-07-22	2004-07-01	Celmed Oncology (Usa) Inc.	Methods for treating therapy-resistant tumors
PE20010915A1 (es) *	1999-12-10	2001-09-29	Glaxo Group Ltd	Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales
WO2001042255A1 (en) *	1999-12-10	2001-06-14	Glaxo Group Limited	(1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) &excl; PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
AU8294101A (en)	2000-07-21	2002-02-05	Gilead Sciences Inc	Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
US20030158532A1 (en)	2002-02-20	2003-08-21	Magee Luke R.	Disposable absorbent article designed to facilitate an easy intuitive change
US8716548B2 (en)	2002-02-20	2014-05-06	The Procter & Gamble Company	Disposable absorbent article designed to facilitate an easy change
JP2006505537A (ja)	2002-09-30	2006-02-16	ジェネラブステクノロジーズ，インコーポレイテッド	Ｃ型肝炎ウイルスの感染を治療するためのヌクレオシド誘導体
US7094768B2 (en)	2002-09-30	2006-08-22	Genelabs Technologies, Inc.	Nucleoside derivatives for treating hepatitis C virus infection
PL377342A1 (pl)	2002-11-15	2006-01-23	Idenix (Cayman) Limited	Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
GB0401088D0 (en)	2004-01-19	2004-02-18	Univ Cardiff	Phosphoramidate derivatives
JP5080973B2 (ja) *	2004-06-24	2012-11-21	メルク・シャープ・エンド・ドーム・コーポレイション	Ｒｎａ依存性ｒｎａウイルスの感染を処置するためのヌクレオシドアリールホスホルアミダート
CN1984903A (zh) *	2004-06-30	2007-06-20	伊莱利利公司	1－(吲哚－6－羰基－d－苯基甘氨酰基)－4－(1－甲基哌啶－4－基)哌嗪d－酒石酸盐
GB0505781D0 (en) *	2005-03-21	2005-04-27	Univ Cardiff	Chemical compounds
GB0623493D0 (en) *	2006-11-24	2007-01-03	Univ Cardiff	Chemical compounds
US7951789B2 (en)	2006-12-28	2011-05-31	Idenix Pharmaceuticals, Inc.	Compounds and pharmaceutical compositions for the treatment of viral infections
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
PL217694B1 (pl)	2010-10-19	2014-08-29	Inst Chemii Bioorg Polskiej Akademii Nauk	Analog nukleotydu, sposób otrzymywania analogu nukleotydu, zastosowanie analogu nukleotydu, pro-nukleotyd antywirusowy, kompozycja farmaceutyczna
CN103842369A (zh)	2011-03-31	2014-06-04	埃迪尼克斯医药公司	用于治疗病毒感染的化合物和药物组合物
US9403863B2 (en)	2011-09-12	2016-08-02	Idenix Pharmaceuticals Llc	Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
SG11201400664WA (en)	2011-09-16	2014-04-28	Gilead Pharmassett Llc	Methods for treating hcv
US8507460B2 (en)	2011-10-14	2013-08-13	Idenix Pharmaceuticals, Inc.	Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
WO2013177188A1 (en)	2012-05-22	2013-11-28	Idenix Pharmaceuticals, Inc.	3',5'-cyclic phosphoramidate prodrugs for hcv infection
CN104470939B (zh)	2012-05-22	2017-04-26	埃迪尼克斯医药有限责任公司	用于肝脏疾病的d型氨基酸化合物
US9296778B2 (en)	2012-05-22	2016-03-29	Idenix Pharmaceuticals, Inc.	3′,5′-cyclic phosphate prodrugs for HCV infection
CA2871547C (en)	2012-05-25	2021-05-25	Janssen R&D Ireland	Uracyl spirooxetane nucleosides
CN107312039B (zh)	2012-08-30	2019-06-25	江苏豪森药业集团有限公司	一种替诺福韦前药的制备方法
US9192621B2 (en)	2012-09-27	2015-11-24	Idenix Pharmaceuticals Llc	Esters and malonates of SATE prodrugs
EA030189B8 (ru)	2012-10-08	2018-10-31	Иденикс Фармасьютикалз Ллс	Аналоги 2'-хлоронуклеозидов для инфекции вгс
EP2909222B1 (de)	2012-10-22	2021-05-26	Idenix Pharmaceuticals LLC	2',4'-verbrückten nukleoside für hcv-infektion
WO2014099941A1 (en)	2012-12-19	2014-06-26	Idenix Pharmaceuticals, Inc.	4'-fluoro nucleosides for the treatment of hcv
US20140212491A1 (en)	2013-01-31	2014-07-31	Gilead Pharmasset Llc	Combination formulation of two antiviral compounds
US9339541B2 (en)	2013-03-04	2016-05-17	Merck Sharp & Dohme Corp.	Thiophosphate nucleosides for the treatment of HCV
WO2014137926A1 (en)	2013-03-04	2014-09-12	Idenix Pharmaceuticals, Inc.	3'-deoxy nucleosides for the treatment of hcv
US20140271547A1 (en)	2013-03-13	2014-09-18	Idenix Pharmaceuticals, Inc.	Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (de)	2013-04-01	2021-09-15	Idenix Pharmaceuticals LLC	2',4'-fluor-nukleoside zur behandlung von hcv
EP3004130B1 (de)	2013-06-05	2019-08-07	Idenix Pharmaceuticals LLC.	1',4'-thionukleoside zur behandlung von hcv
EP3027636B1 (de)	2013-08-01	2022-01-05	Idenix Pharmaceuticals LLC	D-amino acid phosphoramidate pronucleotide of halogenierte pyrimidine verbindungen für leber krankheiten
EP3131914B1 (de)	2014-04-16	2023-05-10	Idenix Pharmaceuticals LLC	3'-substituierte methyl- oder alkynylnukleoside zur behandlung von hcv
WO2016134058A1 (en)	2015-02-18	2016-08-25	Abbvie Inc.	Combinations useful to treat hepatitis c virus
CN113444046B (zh) *	2016-07-20	2023-10-27	纳莹(上海)生物科技有限公司	一种荧光探针及其制备方法和用途
AU2017314148A1 (en) *	2016-08-19	2019-02-28	Sandoz Ag	Sofosbuvir derivatives for the treatment of Hepatitis C
RU2659388C1 (ru) *	2017-02-28	2018-07-02	Васильевич Иващенко Александр	Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение
WO2020022487A1 (ja)	2018-07-27	2020-01-30	富士フイルム株式会社	シクロブチルプリン誘導体またはその塩
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NZ227104A (en)	1987-11-30	1991-11-26	Beecham Group Plc	Phosphorus-substituted purine derivatives and pharmaceutical compositions
CA2001715C (en) *	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
EP0468119A1 (de) *	1990-07-24	1992-01-29	Merrell Dow Pharmaceuticals Inc.	Neue Carbocyclische Analoge einiger Nukleoside
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
EP0618214A1 (de)	1993-04-01	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Ungesättigte Phosphonatderivate Purinen und Pyrimidinen
CA2171743C (en)	1993-09-17	2007-11-20	Norbert W. Bischofberger	Nucleotide analogs
GB9505025D0 (en) *	1995-03-13	1995-05-03	Medical Res Council	Chemical compounds
JP2001524936A (ja)	1996-10-16	2001-12-04	アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド	プリンｌ―ヌクレオシド類およびその用途

1998
- 1998-09-28 GB GBGB9821058.6A patent/GB9821058D0/en not_active Ceased
1999
- 1999-09-22 TW TW088116280A patent/TWI243176B/zh active
- 1999-09-24 MA MA25787A patent/MA26694A1/fr unknown
- 1999-09-27 MY MYPI99004169A patent/MY121839A/en unknown
- 1999-09-27 IL IL14195999A patent/IL141959A0/xx unknown
- 1999-09-27 JP JP2000572234A patent/JP2002525374A/ja not_active Withdrawn
- 1999-09-27 AU AU62138/99A patent/AU762757B2/en not_active Ceased
- 1999-09-27 NZ NZ510506A patent/NZ510506A/en unknown
- 1999-09-27 PT PT99949151T patent/PT1117669E/pt unknown
- 1999-09-27 CN CN99813577A patent/CN1328565A/zh active Pending
- 1999-09-27 DK DK99949151T patent/DK1117669T3/da active
- 1999-09-27 TR TR2001/00864T patent/TR200100864T2/xx unknown
- 1999-09-27 KR KR1020017003894A patent/KR20010085855A/ko not_active Ceased
- 1999-09-27 DE DE69905181T patent/DE69905181T2/de not_active Expired - Fee Related
- 1999-09-27 BR BR9914097-7A patent/BR9914097A/pt not_active IP Right Cessation
- 1999-09-27 PA PA19998483101A patent/PA8483101A1/es unknown
- 1999-09-27 PL PL99346905A patent/PL346905A1/xx unknown
- 1999-09-27 AT AT99949151T patent/ATE231874T1/de not_active IP Right Cessation
- 1999-09-27 WO PCT/GB1999/003207 patent/WO2000018775A1/en not_active Ceased
- 1999-09-27 TN TNTNSN99183A patent/TNSN99183A1/fr unknown
- 1999-09-27 HU HU0103641A patent/HUP0103641A3/hu unknown
- 1999-09-27 ES ES99949151T patent/ES2192081T3/es not_active Expired - Lifetime
- 1999-09-27 PE PE1999000978A patent/PE20001072A1/es not_active Application Discontinuation
- 1999-09-27 CA CA002345672A patent/CA2345672A1/en not_active Abandoned
- 1999-09-27 EP EP99949151A patent/EP1117669B1/de not_active Expired - Lifetime
- 1999-09-27 ZA ZA200102170A patent/ZA200102170B/en unknown
- 1999-09-28 GT GT199900166A patent/GT199900166A/es unknown
- 1999-09-28 AR ARP990104876A patent/AR042368A1/es not_active Application Discontinuation
- 1999-09-28 GC GCP1999302 patent/GC0000174A/en active
2001
- 2001-03-08 NO NO20011198A patent/NO20011198L/no unknown
- 2001-03-27 US US09/825,554 patent/US6638919B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TR200100864T2 (tr)	2001-07-23
PA8483101A1 (es)	2000-09-29
ATE231874T1 (de)	2003-02-15
HUP0103641A3 (en)	2002-10-28
EP1117669B1 (de)	2003-01-29
MA26694A1 (fr)	2004-12-20
GT199900166A (es)	2001-03-21
WO2000018775A1 (en)	2000-04-06
NZ510506A (en)	2003-08-29
CA2345672A1 (en)	2000-04-06
US6638919B2 (en)	2003-10-28
EP1117669A1 (de)	2001-07-25
DE69905181T2 (de)	2003-06-26
KR20010085855A (ko)	2001-09-07
PL346905A1 (en)	2002-03-11
HUP0103641A2 (hu)	2002-04-29
DK1117669T3 (da)	2003-05-26
ZA200102170B (en)	2002-03-15
NO20011198D0 (no)	2001-03-08
GB9821058D0 (en)	1998-11-18
US20010031745A1 (en)	2001-10-18
IL141959A0 (en)	2002-03-10
PT1117669E (pt)	2003-06-30
NO20011198L (no)	2001-05-28
CN1328565A (zh)	2001-12-26
JP2002525374A (ja)	2002-08-13
AU6213899A (en)	2000-04-17
GC0000174A (en)	2006-03-29
AR042368A1 (es)	2005-06-22
AU762757B2 (en)	2003-07-03
TWI243176B (en)	2005-11-11
TNSN99183A1 (fr)	2005-11-10
HK1036455A1 (en)	2002-01-04
ES2192081T3 (es)	2003-09-16
MY121839A (en)	2006-02-28
BR9914097A (pt)	2001-07-31
PE20001072A1 (es)	2000-11-20

Publication	Publication Date	Title
DE69905181D1 (de)	2003-03-06	Antivirale purin-derivate
DE60026861D1 (de)	2006-05-11	Purin-derivate
DE60002356D1 (de)	2003-05-28	Purin-derivate
EE200100681A (et)	2003-04-15	Puriinderivaadid
NO20010743D0 (no)	2001-02-14	Antivirale indoloksoacetyl-piperazin-derivater
ATE277941T1 (de)	2004-10-15	Adenosinderivate
DE60116260D1 (de)	2006-02-02	Antivirale azaindolderivate
PT1296996E (pt)	2004-08-31	Derivados de purina
NO20005795D0 (no)	2000-11-16	Antivirale forbindelser
ATE231508T1 (de)	2003-02-15	Azyklische nukleosidderivate
DK1140937T3 (da)	2004-03-22	Antivirale nucleosid-analoger
DK1054867T3 (da)	2004-08-09	Antivirale midler
NO20011358L (no)	2001-04-17	Antivirale kombinasjoner
SI1117669T1 (en)	2003-06-30	Antiviral purine derivatives
DK1090019T3 (da)	2005-02-07	Adenosinderivater

Legal Events

Date	Code	Title	Description
2004-02-26	8364	No opposition during term of opposition
2007-07-26	8339	Ceased/non-payment of the annual fee