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BR0017030A - Derivados de tiazolilamida - Google Patents

Derivados de tiazolilamida

Info

Publication number
BR0017030A
BR0017030A BR0017030-5A BR0017030A BR0017030A BR 0017030 A BR0017030 A BR 0017030A BR 0017030 A BR0017030 A BR 0017030A BR 0017030 A BR0017030 A BR 0017030A
Authority
BR
Brazil
Prior art keywords
thiazolylamide
derivatives
thiazolylamide derivatives
medicaments
novel
Prior art date
Application number
BR0017030-5A
Other languages
English (en)
Other versions
BR0017030B1 (pt
BR0017030B8 (pt
Inventor
Ruediger Fischer
Gerald Kleymann
Ulrich Betz
Judith Baumeister
Wolfgang Bender
Peter Eckenberg
Gabriele Handke
Martin Hendrix
Kerstin Henninger
Axel Jensen
Joerg Keldenich
Udo Schneider
Olaf Weber
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19962532A external-priority patent/DE19962532A1/de
Priority claimed from DE10039265A external-priority patent/DE10039265A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR0017030A publication Critical patent/BR0017030A/pt
Publication of BR0017030B1 publication Critical patent/BR0017030B1/pt
Publication of BR0017030B8 publication Critical patent/BR0017030B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE TIAZOLILAMIDA". A presente invenção refere-se a novos derivados de tiazolilamida, um processo para a sua preparação bem como seu emprego como medicamentos, especialmente como medicamentos antivirais.
BRPI0017030A 1999-12-23 2000-12-12 derivados de tiazolilamida, processo para sua preparação, composição farmacêutica que os compreende e uso dos mesmos BR0017030B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19962532A DE19962532A1 (de) 1999-12-23 1999-12-23 Thiazolylamid-Derivate
DE10039265A DE10039265A1 (de) 2000-08-11 2000-08-11 Thiazolylamid-Derivate
PCT/EP2000/012564 WO2001047904A1 (de) 1999-12-23 2000-12-12 Thiazolylamid-derivate

Publications (3)

Publication Number Publication Date
BR0017030A true BR0017030A (pt) 2003-01-07
BR0017030B1 BR0017030B1 (pt) 2013-10-01
BR0017030B8 BR0017030B8 (pt) 2021-05-25

Family

ID=26006669

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0017030A BR0017030B8 (pt) 1999-12-23 2000-12-12 derivados de tiazolilamida, processo para sua preparação, composição farmacêutica que os compreende e uso dos mesmos

Country Status (26)

Country Link
US (1) US7105553B2 (pt)
EP (1) EP1244641B1 (pt)
JP (1) JP4726175B2 (pt)
KR (1) KR100768361B1 (pt)
CN (1) CN1235890C (pt)
AR (1) AR029210A1 (pt)
AT (1) ATE293104T1 (pt)
AU (1) AU784286B2 (pt)
BR (1) BR0017030B8 (pt)
CA (1) CA2396720C (pt)
CO (1) CO5261491A1 (pt)
DE (1) DE50010060D1 (pt)
DK (1) DK1244641T3 (pt)
DO (1) DOP2000000109A (pt)
ES (1) ES2240233T3 (pt)
IL (2) IL149897A0 (pt)
MX (1) MXPA02006243A (pt)
MY (1) MY134880A (pt)
NZ (1) NZ519701A (pt)
PE (1) PE20010964A1 (pt)
PL (1) PL208707B1 (pt)
PT (1) PT1244641E (pt)
SV (1) SV2002000249A (pt)
TW (1) TWI256951B (pt)
UY (1) UY26495A1 (pt)
WO (1) WO2001047904A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000259734A1 (en) * 2000-06-15 2001-12-24 Gerald Kleymann Method for identifying compounds with anti-herpes activity
DE10129714A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
DE10131128A1 (de) * 2001-06-28 2003-01-16 Bayer Ag Sekundäre Sulfonamide
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
DK2578229T3 (da) * 2004-09-09 2013-10-07 Novartis Vaccines & Diagnostic Faldende potentielle iatrogene risici associeret med vaccine-antigener
DE102005014248A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
WO2007037898A2 (en) * 2005-08-29 2007-04-05 Housey Pharmaceuticals Inc Theramutein modulators
BRPI0611187A2 (pt) * 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
US20070032488A1 (en) * 2005-08-05 2007-02-08 Genelabs Technologies, Inc. 6-Membered aryl and heteroaryl derivatives for treating viruses
PL2489350T3 (pl) * 2006-03-17 2014-08-29 Cardioxyl Pharmaceuticals Inc Pochodne N-hydroksylosulfonamidu jako nowe, fizjologicznie użyteczne donory nitroksylu
US20100051879A1 (en) * 2006-11-22 2010-03-04 The Regents od the Univesity of California Functionalized Boron Nitride Nanotubes
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
MX2015010339A (es) * 2013-02-12 2015-11-16 Aicuris Gmbh & Co Kg Inhibidores de helicasa-primasa para su uso en un metodo para tratar la enfermedad de alzheimer.
BR112017000285A2 (pt) * 2014-07-07 2017-10-31 Prophylaxis LLC métodos de tratamento da profilaxia viral e kits de profilaxia de pré-exposição
EA035401B1 (ru) * 2016-04-06 2020-06-08 Инновейтив Молекьюлз Гмбх Производные аминотиазола, полученные в качестве противовирусных средств
WO2018095576A1 (en) 2016-11-28 2018-05-31 Aicuris Anti-Infective Cures Gmbh Topical pharmaceutical formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide
RS61905B1 (sr) * 2016-11-28 2021-06-30 Aicuris Gmbh & Co Kg Hemihidrat slobodne baze n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida, postupci njegove proizvodnje i upotrebe
CN117186085A (zh) * 2016-11-28 2023-12-08 艾库里斯有限及两合公司 普瑞利韦硫酸盐、其药物制剂、制造方法及治疗疱疹病毒的用途
CN110225781B (zh) * 2017-01-09 2022-05-17 辉诺生物医药科技（杭州）有限公司 噻唑衍生物及其应用
MD3692039T2 (ro) 2017-10-05 2023-05-31 Innovative Molecules Gmbh Enantiomerii tiazolilor substituiți ca compuși antivirali
AU2019297214B2 (en) 2018-07-06 2022-07-07 Phaeno Therapeutics Co., Ltd. Crystal forms of thiazole compound and application thereof
KR20220160024A (ko) 2020-03-26 2022-12-05 아이쿠리스 게엠베하 운트 코. 카게 N-[5-(아미노술포닐)-4-메틸-1,3-티아졸-2-일]-n-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 반수화물을 포함하는 안과용 제제
EP3925595A1 (en) 2020-06-17 2021-12-22 AiCuris GmbH & Co. KG Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide hemihydrate
WO2022090409A1 (en) 2020-10-29 2022-05-05 Innovative Molecules Gmbh Deuterated aminothiazole compounds as antiviral compounds
KR20240134979A (ko) 2022-01-17 2024-09-10 이노베이티브 몰리큘스 게엠베하 헬리카제-프라이마제 억제제의 고체 결정형 및 이의 제조 방법
CN119546574A (zh) 2022-05-20 2025-02-28 吉利德科学公司 抗病毒吲哚啉基化合物和其用途
PE20251667A1 (es) 2022-08-29 2025-06-30 Assembly Biosciences Inc Compuestos ciclicos de urea tiazolilo para el tratamiento del hsv
JP2025530762A (ja) 2022-08-29 2025-09-17 アセンブリー・バイオサイエンシーズ・インコーポレイテッド ヘルペスウイルス用医薬組成物
EP4581030A1 (en) 2022-08-29 2025-07-09 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
WO2024047507A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
WO2024224304A1 (en) 2023-04-26 2024-10-31 Assembly Biosciences, Inc. Oral pharmaceutical compositions
WO2025046457A1 (en) 2023-08-28 2025-03-06 Assembly Biosciences, Inc. A crystalline form of 2-(3-(2,,5'-difluoro-[1,1'-biphenyl]-4-yl)-2-oxotetrahydropyrimidin-1(2h)-yl)-4-methylthiazole-5-sulfonamide
WO2025046456A1 (en) 2023-08-28 2025-03-06 Assembly Biosciences, Inc. A crystalline form of 2-(3-(2,,5'-difluoro-[1,1'-biphenyl]-4-yl)-2-oxotetrahydropyrimidin-1(2h)-yl)-4-methylthiazole-5-sulfonamide
WO2025111598A1 (en) 2023-11-22 2025-05-30 Assembly Biosciences, Inc. Azetidine compounds for treatment of hsv
WO2025172927A1 (en) 2024-02-16 2025-08-21 Assembly Biosciences, Inc. Pharmaceutical compositions for herpes virus
WO2026015761A1 (en) 2024-07-12 2026-01-15 Assembly Biosciences, Inc. Cyclic urea thiazolyl compound for treatment of viral infections unresponsive to treatment with a first antiviral therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2075560A5 (pt) 1970-01-16 1971-10-08 Shell Int Research
US3658830A (en) 1970-01-16 1972-04-25 Shell Oil Co 5-(substituted mercapto sulfiny sulfonyl or sulfamoyl)
US3717651A (en) 1970-04-20 1973-02-20 Shell Oil Co Thiazoles
US3847588A (en) 1970-04-20 1974-11-12 Shell Oil Co Thiazoles herbicidal
DE69624728T2 (de) 1995-12-29 2003-07-10 Boehringer Ingelheim (Canada) Ltd., Laval Phenyl thiazol derivate mit antiherpesvirus eigenschaften
US5705344A (en) 1996-03-14 1998-01-06 Tularik, Inc. High-throughput screening assay for inhibitors of nucleic acid helicases
GB2311069A (en) 1996-03-14 1997-09-17 Merck & Co Inc Primase isolated from human cytomegalovirus (HCMV)
GB2311068A (en) 1996-03-14 1997-09-17 Merck & Co Inc Helicase isolated from human cytomegalovirus (HCMV)
CA2223032A1 (en) 1997-02-21 1998-08-21 Smithkline Beecham Corporation Use of hsv-1 ul-15 and vp5 in identifying anti-viral agents
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
WO1999042455A1 (en) 1998-02-19 1999-08-26 Tularik Inc. Antiviral agents
DK1064273T3 (da) 1998-03-19 2003-03-31 Upjohn Co 1,3,4-Thiadiazoler, som er nyttige til behandling af CMV-infektioner
WO2000053591A1 (de) 1999-03-08 2000-09-14 Bayer Aktiengesellschaft Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel

Also Published As

Publication number Publication date
IL149897A (en) 2008-08-07
JP2003519134A (ja) 2003-06-17
AU3157401A (en) 2001-07-09
JP4726175B2 (ja) 2011-07-20
BR0017030B1 (pt) 2013-10-01
KR100768361B1 (ko) 2007-10-18
CN1235890C (zh) 2006-01-11
SV2002000249A (es) 2002-06-07
DE50010060D1 (de) 2005-05-19
NZ519701A (en) 2004-05-28
PE20010964A1 (es) 2001-11-10
MY134880A (en) 2007-12-31
PL208707B1 (pl) 2011-05-31
HK1057552A1 (en) 2004-04-08
PL356484A1 (en) 2004-06-28
DK1244641T3 (da) 2005-07-11
PT1244641E (pt) 2005-08-31
MXPA02006243A (es) 2003-01-28
TWI256951B (en) 2006-06-21
ES2240233T3 (es) 2005-10-16
DOP2000000109A (es) 2002-08-30
KR20020067568A (ko) 2002-08-22
CA2396720C (en) 2009-09-22
US20040006076A1 (en) 2004-01-08
CA2396720A1 (en) 2001-07-05
CO5261491A1 (es) 2003-03-31
IL149897A0 (en) 2002-11-10
WO2001047904A1 (de) 2001-07-05
EP1244641A1 (de) 2002-10-02
ATE293104T1 (de) 2005-04-15
UY26495A1 (es) 2001-07-31
AR029210A1 (es) 2003-06-18
BR0017030B8 (pt) 2021-05-25
CN1434812A (zh) 2003-08-06
US7105553B2 (en) 2006-09-12
AU784286B2 (en) 2006-03-02
EP1244641B1 (de) 2005-04-13

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