BR9908380A - Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product - Google Patents
Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its productInfo
- Publication number
- BR9908380A BR9908380A BR9908380-9A BR9908380A BR9908380A BR 9908380 A BR9908380 A BR 9908380A BR 9908380 A BR9908380 A BR 9908380A BR 9908380 A BR9908380 A BR 9908380A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- dad1
- nucleic acid
- substantial part
- acid fragment
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 150000007523 nucleic acids Chemical group 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 title abstract 2
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 101150037150 DAD1 gene Proteins 0.000 title 2
- 125000003275 alpha amino acid group Chemical group 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 229940088872 Apoptosis inhibitor Drugs 0.000 abstract 2
- 102100039104 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Human genes 0.000 abstract 2
- 101000884921 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Proteins 0.000 abstract 2
- 239000000158 apoptosis inhibitor Substances 0.000 abstract 2
- 102100039986 Apoptosis inhibitor 5 Human genes 0.000 abstract 1
- 101710106450 Apoptosis inhibitor 5 Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 108091006086 inhibitor proteins Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
"FRAGMENTO DE áCIDO NUCLéICO ISOLADO CODIFICADOR DE TODA OU UMA PARTE SUBSTANCIAL DE UMA PROTEìNA DAD1 OU DE UMA PROTEìNA AAC-11, GENE QUIMéRICO, CéLULA HOSPEDEIRA TRANSFORMADA, POLIPEPTìDEO DAD1, MéTODO DE ALTERAçãO DO NìVEL DE EXPRESSãO DE UMA PROTEìNA INIBIDORA DE APOPTPOSE EM UMA CéLULA HOSPEDEIRA, MéTODO DE OBTENçãO DE UM FRAGMENTO DE áCIDO NUCLéICO CODIFICADOR DE UMA PARTE SUBSTANCIAL DE UMA SEQuêNCIA DE AMINOáCIDOS CODIFICADORA DE UMA PROTEìNA INIBIDORA DE APOPTOSE E SEU PRODUTO" A presente invenção refere-se a um fragmento de ácido nucléico isolado codificador de uma proteína inibidora de apoptose. A presente invenção também se refere à construção de um gene quimérico que codifique a proteína inibidora de apoptose, no todo ou em parte, em orientação de sentido favorável ou contrário, em que a expressão do gene quimérico resulte na produção de níveis alterados da proteína inibidora de apoptose em uma célula hospedeira transformada."ISOLATED NUCLEIC ACID FRAGMENT ENCODING ALL OR A SUBSTANTIAL PART OF A DAD1 PROTEIN OR AAC-11 PROTEIN, CHEMICAL GENE, TRANSFORMED HOST CELL, DAD1 POLYEPTIDE, AN ALTERNATIVE DETERMINATION METHOD. HOSTING CELL, METHOD OF OBTAINING A NUCLEIC ACID FRAGMENT ENCODING A SUBSTANTIAL PART OF AN AMINO ACID SEQUENCE ENCODING AN APOPTOSIS INHIBITOR PROTEIN AND ITS PRODUCT apoptosis inhibitor. The present invention also relates to the construction of a chimeric gene that encodes the apoptosis inhibiting protein, in whole or in part, in a favorable or opposite direction, in which the expression of the chimeric gene results in the production of altered levels of the inhibitory protein of apoptosis in a transformed host cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9908380-9A BR9908380A (en) | 1999-03-10 | 1999-03-10 | Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9908380-9A BR9908380A (en) | 1999-03-10 | 1999-03-10 | Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product |
| PCT/US1999/005227 WO1999047689A2 (en) | 1998-03-16 | 1999-03-10 | Inhibitors of apoptosis proteins in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908380A true BR9908380A (en) | 2001-10-02 |
Family
ID=4074585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908380-9A BR9908380A (en) | 1999-03-10 | 1999-03-10 | Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9908380A (en) |
-
1999
- 1999-03-10 BR BR9908380-9A patent/BR9908380A/en not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9908858A (en) | Isolated nucleic acid fragment, chimeric gene, transformed host cell, polypeptide, method of altering the level of expression of a protein, method of obtaining a fragment of nucleic acid and product. | |
| Koc et al. | A new face on apoptosis: death‐associated protein 3 and PDCD9 are mitochondrial ribosomal proteins | |
| Rice et al. | Sites of deamidation and methylation in Tsr, a bacterial chemotaxis sensory transducer | |
| BR9712077A (en) | High level protein expression | |
| Skehel et al. | NADH: ubiquinone oxidoreductase from bovine heart mitochondria: sequence of a novel 17.2‐kDa subunit | |
| BR9808545A (en) | isolated nucleic acid, expression vector, host cell, processes to produce an osteoprotegerin-binding protein, to detect the presence of an osteoprotegerin-binding protein in a biological sample, to assess the ability of a candidate compound to bind to an osteoprotegerin-binding protein and a test compound to increase or reduce the binding of the osteoprotegerin-binding protein to odar, to regulate the expression of an osteoprotegerin-binding protein in an animal and to prevent or treat bone disease in a mammal, polypeptide, purified and isolated osteroprotegerin binding protein, or its fragment, analogue or derivative, and, antibody or fragment | |
| DE69833670D1 (en) | HOMOLOGOUS OF TIE RECEPTORTYROSINE KINASE LIGANDEN | |
| Smales et al. | Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2 | |
| BR9908101A (en) | Isolated nucleic acid fragment encoding all or a substantial part of an anthranilate synthase alpha and/or beta subunit, chimeric gene, transformed host cell, anthranilate synthase alpha subunit polypeptide, level-altering method expression of a tryptophan biosynthetic enzyme in a host cell, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding a tryptophan biosynthetic enzyme, and method of evaluating the capacity of at least one compound in inhibit the activity of a tryptophan biosynthetic enzyme. | |
| Hortin et al. | Identification of the site of sulfation of the fourth component of human complement. | |
| BR9908025A (en) | Isolated nucleic acid fragment encoding all or a substantial part of a xiap-associated factor 1 protein, chimeric gene, transformed host cell, xiap-associated factor 1 polypeptide, method of altering the level of expression of an apoptosis-inhibiting protein in a host cell, a method of obtaining a nucleic acid fragment encoding all or a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product | |
| BR9909414A (en) | Isolated nucleic acid fragment encoding all or a substantial part of a flavanone-3-hydroxylase, chimeric gene, trans-formed host cell, flavanone-3-hydroxylase polypeptide, method of altering the level of expression of a flavanone-3-hydroxylase in a host cell, method of obtaining a nucleic acid fragment encoding all or a substantial part of the amino acid sequence encoding a flavanone-3-hydroxylase, its product and method of evaluating the ability of at least one compound to inhibit activity of a flavanone-3-hydroxylase | |
| Charbaut et al. | N‐terminal acetylation of ectopic recombinant proteins in Escherichia coli | |
| FI971896A7 (en) | cDNA encoding BMP type II receptor | |
| BR9908380A (en) | Isolated nucleic acid fragment encoding all or a substantial part of a dad1 protein or aac-11 protein, chimeric gene, transformed host cell, dad1 polypeptide, method of altering the level of expression of an apoptpose inhibiting protein in a cell host, method of obtaining a nucleic acid fragment encoding a substantial part of an amino acid sequence encoding an apoptosis-inhibiting protein and its product | |
| Allegrini et al. | Mechanistic studies on bovine cytosolic 5′‐nucleotidase II, an enzyme belonging to the HAD superfamily | |
| EP0815240A4 (en) | NOVEL KINASE-LIKE CYCLINE-LIKE PROTEINS AND METHODS OF APPLICATION THEREOF | |
| Rotoli et al. | Cysteine residues contribute to the dimerization and enzymatic activity of human nuclear dUTP nucleotidohydrolase (nDut) | |
| Helmerhorst | Whole saliva proteolysis: wealth of information for diagnostic exploitation | |
| BR9907720A (en) | Isolated nucleic acid fragment, chimeric gene, transporated host cell, elf-4e polypeptide, method of altering the expression level of an elf-4e protein, in a host cell, method of obtaining one of a coding nucleic acid fragment of all or a substantial part of the amino acid sequence encoding an elf-4e protein and product | |
| Banijamali et al. | Characterization of a new member of kunitz-type protein family from the venom of Persian false-horned viper, Pseudocerastes persicus | |
| BR9813919A (en) | Isolated nucleic acid fragment, chimeric gene, transformed host cell, sclb ^ r ^ polypeptide, method for altering the expression level of a sclb ^ r ^ protein, method for obtaining a nucleic acid fragment and product | |
| BR9815065A (en) | Nucleic acid fragment, chimeric gene, host cell, isocitrate dehydrogenase polypeptide, method of altering the level of expression of an isocitrate dehydrogenase in a host cell, method of obtaining nucleic acid fragment, product and method of evaluating a compound to its ability to inhibit the activity of an isocitrate dehydrogenase | |
| DE69635081D1 (en) | ENAMEL MATRIX-RELATED POLYPEPTIDES | |
| Schmidt et al. | Lysine and polyamines are substrates for transglutamination of Rho by the Bordetella dermonecrotic toxin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |