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BR9814622A - Processo para a preparação de derivados de tiazolidinadiona - Google Patents

Processo para a preparação de derivados de tiazolidinadiona

Info

Publication number
BR9814622A
BR9814622A BR9814622-0A BR9814622A BR9814622A BR 9814622 A BR9814622 A BR 9814622A BR 9814622 A BR9814622 A BR 9814622A BR 9814622 A BR9814622 A BR 9814622A
Authority
BR
Brazil
Prior art keywords
formula
pharmaceutically acceptable
group
compound
unsubstituted
Prior art date
Application number
BR9814622-0A
Other languages
English (en)
Inventor
Robert Gordon Giles
Norman John Lewis
John Kirby Quick
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10821570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9814622(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR9814622A publication Critical patent/BR9814622A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE TIAZOLIDINADIONA" Um processo para preparação de um composto de fórmula (I) ou uma sua forma tautomérica ou seu sal farmaceuticamente aceitável, ou um seu solvato farmaceuticamente aceítável, onde: A¹ representa um grupo hetero ciclila aromático substituído ou não-substituído; R¹ representa um átomo de hidrogênio, um grupo alquila, um grupo acila, um grupo aralquila, onde a metade arila pode estar substituída ou não-substituída, ou um grupo arila substituído ou não-substituído; A² representa um anel benzeno tendo no total até cinco substituintes; e n representa um inteiro na faixa de 2 a 6, cujo processo compreende redução catalítica de um composto de fórmula (II): onde A¹, R¹, A² e n são como definidos em relação a fórmula (I), caracterizado em que a reação de redução é realizada usando-se uma pressão de hidrogênio acima de 1,4 kgf/cm²; e a seguir, se requerido formando um sal farmaceuticamente aceitável e/ou um solvato farmaceuticamente aceitável do composto de fórmula (I).
BR9814622-0A 1997-11-04 1998-10-27 Processo para a preparação de derivados de tiazolidinadiona BR9814622A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723295.3A GB9723295D0 (en) 1997-11-04 1997-11-04 Novel process
PCT/EP1998/006997 WO1999023095A1 (en) 1997-11-04 1998-10-27 Process for the preparation of thiazolidinedione derivatives

Publications (1)

Publication Number Publication Date
BR9814622A true BR9814622A (pt) 2000-10-03

Family

ID=10821570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814622-0A BR9814622A (pt) 1997-11-04 1998-10-27 Processo para a preparação de derivados de tiazolidinadiona

Country Status (44)

Country Link
US (2) US20060106221A1 (pt)
EP (2) EP1219620A1 (pt)
JP (2) JP3723448B2 (pt)
KR (1) KR100602551B1 (pt)
CN (1) CN1160351C (pt)
AP (1) AP1519A (pt)
AR (1) AR016660A1 (pt)
AT (1) ATE238302T1 (pt)
AU (2) AU1559599A (pt)
BG (1) BG64559B1 (pt)
BR (1) BR9814622A (pt)
CA (1) CA2309461A1 (pt)
CO (1) CO5011075A1 (pt)
CZ (1) CZ297209B6 (pt)
DE (1) DE69813869T2 (pt)
DK (1) DK1028960T3 (pt)
DZ (1) DZ2637A1 (pt)
EA (1) EA002722B1 (pt)
EC (1) ECSP082712A (pt)
ES (1) ES2197519T3 (pt)
GB (1) GB9723295D0 (pt)
HK (1) HK1048804A1 (pt)
HR (1) HRP20000263B1 (pt)
HU (1) HU224547B1 (pt)
ID (1) ID24644A (pt)
IL (1) IL135898A (pt)
IN (1) IN192870B (pt)
MA (1) MA26560A1 (pt)
MY (1) MY118605A (pt)
NO (1) NO315557B1 (pt)
OA (1) OA11521A (pt)
PE (1) PE129399A1 (pt)
PL (1) PL192503B1 (pt)
PT (1) PT1028960E (pt)
RS (1) RS49793B (pt)
SA (1) SA98190820B1 (pt)
SI (1) SI1028960T1 (pt)
SK (1) SK285233B6 (pt)
TR (1) TR200001239T2 (pt)
TW (1) TW538037B (pt)
UA (1) UA56269C2 (pt)
UY (1) UY25227A1 (pt)
WO (1) WO1999023095A1 (pt)
ZA (1) ZA9810033B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
US7091359B2 (en) 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
HU225919B1 (en) * 1999-12-18 2007-12-28 Richter Gedeon Nyrt Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0023970D0 (en) * 2000-09-29 2000-11-15 Smithkline Beecham Plc Novel pharmaceutical
GB0023971D0 (en) * 2000-09-29 2000-11-15 Smithkline Beecham Plc Novel pharmaceutical
EP1465881A4 (en) * 2001-12-20 2005-04-13 Teva Pharma HYDROGENATION OF PRECURSORS OF ANTI-HYPERGLYCEMIATING THIAZOLIDINEDIONE SUBSTANCES
GB0307259D0 (en) * 2003-03-28 2003-05-07 Glaxo Group Ltd Process
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
AR047541A1 (es) * 2004-02-13 2006-01-25 Sandoz Ag Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
US20080064877A2 (en) * 2004-05-12 2008-03-13 Medichem S.A. Process for the preparation of rosiglitazone
CZ297266B6 (cs) * 2004-09-10 2006-10-11 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ297347B6 (cs) * 2004-09-21 2006-11-15 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
CN102727489A (zh) * 2012-07-18 2012-10-17 西南大学 5-芳(杂环)亚甲基噻唑烷-2，4-二酮在制备ppar激动剂中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
US4812570A (en) 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
US6288095B1 (en) * 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
US5521201A (en) * 1987-09-04 1996-05-28 Beecham Group P.L.C. Method for treatment of atherosclerosis
US5232925A (en) * 1987-09-04 1993-08-03 Beecham Group P.L.C. Compounds
US5260445A (en) * 1987-09-04 1993-11-09 Beecham Group P.L.C. 2,4-thiazolidinediones
US5194443A (en) * 1987-09-04 1993-03-16 Beecham Group P.L.C. Compounds
EP0306228B1 (en) * 1987-09-04 1999-11-17 Beecham Group Plc Substituted thiazolidinedione derivatives
US20020049240A1 (en) * 1994-12-19 2002-04-25 Beecham Group P.1.C. Novel compounds
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9124513D0 (en) * 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
US6462337B1 (en) * 2000-04-20 2002-10-08 Agilent Technologies, Inc. Mass spectrometer electrospray ionization
CA2122712C (en) 1991-12-20 1999-09-21 Joel Edward Huber A reduction method for substituted 5-methylene-thiazolidinediones
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) * 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
US6632947B2 (en) * 1997-02-18 2003-10-14 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
UY24886A1 (es) 1997-02-18 2001-08-27 Smithkline Beecham Plc Tiazolidindiona
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
US7091359B2 (en) * 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives

Also Published As

Publication number Publication date
DE69813869D1 (de) 2003-05-28
EA002722B1 (ru) 2002-08-29
BG104505A (en) 2001-01-31
CN1160351C (zh) 2004-08-04
CZ297209B6 (cs) 2006-10-11
HUP0100144A2 (hu) 2001-08-28
WO1999023095A1 (en) 1999-05-14
KR20010031720A (ko) 2001-04-16
US20070066662A1 (en) 2007-03-22
CA2309461A1 (en) 1999-05-14
HU224547B1 (hu) 2005-10-28
NO315557B1 (no) 2003-09-22
HK1048804A1 (en) 2003-04-17
US7351832B2 (en) 2008-04-01
AU2002300593B8 (en) 2006-05-04
DE69813869T2 (de) 2004-01-29
BG64559B1 (bg) 2005-07-29
SK6502000A3 (en) 2000-09-12
AP2000001808A0 (en) 2000-06-30
YU33800A (sh) 2002-10-18
NO20002174D0 (no) 2000-04-27
EP1028960A1 (en) 2000-08-23
MY118605A (en) 2004-12-31
HRP20000263A2 (en) 2000-12-31
AP1519A (en) 2005-12-20
US20060106221A1 (en) 2006-05-18
KR100602551B1 (ko) 2006-07-19
TW538037B (en) 2003-06-21
RS49793B (sr) 2008-06-05
OA11521A (en) 2004-02-09
AU2002300593B2 (en) 2006-03-23
HK1032046A1 (en) 2001-07-06
IL135898A0 (en) 2001-05-20
IL135898A (en) 2005-08-31
SA98190820B1 (ar) 2006-10-29
CO5011075A1 (es) 2001-02-28
AU1559599A (en) 1999-05-24
PT1028960E (pt) 2003-09-30
DZ2637A1 (fr) 2003-03-08
PL340366A1 (en) 2001-01-29
HRP20000263B1 (en) 2009-01-31
PL192503B1 (pl) 2006-10-31
PE129399A1 (es) 2000-02-24
JP2004339235A (ja) 2004-12-02
HUP0100144A3 (en) 2002-04-29
CN1278818A (zh) 2001-01-03
MA26560A1 (fr) 2004-12-20
CZ20001633A3 (cs) 2000-10-11
GB9723295D0 (en) 1998-01-07
JP3723448B2 (ja) 2005-12-07
NO20002174L (no) 2000-05-30
JP2001521937A (ja) 2001-11-13
AR016660A1 (es) 2001-07-25
UY25227A1 (es) 1999-05-14
ID24644A (id) 2000-07-27
SI1028960T1 (en) 2003-10-31
ES2197519T3 (es) 2004-01-01
UA56269C2 (uk) 2003-05-15
ZA9810033B (en) 2000-05-03
DK1028960T3 (da) 2003-08-11
ATE238302T1 (de) 2003-05-15
EP1028960B1 (en) 2003-04-23
SK285233B6 (sk) 2006-09-07
EP1219620A1 (en) 2002-07-03
ECSP082712A (es) 2008-08-29
IN192870B (pt) 2004-05-22
EA200000484A1 (ru) 2000-10-30
TR200001239T2 (tr) 2001-07-23

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTARADA DA INT. CL.: C07D 417/12; C07C 5/02; A61K 31/395; A61P 3/10.

Ipc: C07D 417/12 (2008.04), C07C 5/02 (2008.04), A61K 3

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE A MATERIA PLEITEADA NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ARTIGOS 8O E 13 DA LPI ) O RELATORIO NAO DESCREVE CLARA E SUFICIENTEMENTE O OBJETO, DE MODO A POSSIBILITAR SUA REALIZACAO POR UM TECNICO NO ASSUNTO ( ARTIGO 24 DA LPI ) AS REIVNIDICACOES NAO ESTAO FUNDAMENTADAS NO RELATORIO DESCRITIVO ( ARTIGO 25 DA LPI )

B12B Appeal against refusal [chapter 12.2 patent gazette]