PE129399A1 - Procedimiento para la preparacion de 5-{4-[2-(n-metil-n-(2-piridil)-amino)-etoxi]bencil}-2,4-tiazolidindiona - Google Patents
Procedimiento para la preparacion de 5-{4-[2-(n-metil-n-(2-piridil)-amino)-etoxi]bencil}-2,4-tiazolidindionaInfo
- Publication number
- PE129399A1 PE129399A1 PE1998001038A PE00103898A PE129399A1 PE 129399 A1 PE129399 A1 PE 129399A1 PE 1998001038 A PE1998001038 A PE 1998001038A PE 00103898 A PE00103898 A PE 00103898A PE 129399 A1 PE129399 A1 PE 129399A1
- Authority
- PE
- Peru
- Prior art keywords
- thiazolidindiona
- piridil
- amino
- methyl
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- 239000003245 coal Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA I, DONDE A1 ES UN GRUPO HETEROCICLO AROMATICO OPCIONALMENTE SUSTITUIDO; R1 ES H, ALQUILO, ACILO, ARALQUILO, ARILO OPCIONALMENTE SUSTITUIDO; A2 ES BENCENO CON 5 SUSTITUYENTES; n ES 2-6, QUE COMPRENDE: REDUCIR CATALITICAMENTE UN COMPUESTO DE FORMULA II, A UNA PRESION DE HIDROGENO EN EL INTERVALO DE 3,5 kg/cm2 A 105 kg/cm2. EL CATALIZADOR DE HIDROGENACION ES PALADIO AL 10% SOBRE CARBON. EL DISOLVENTE DE REACCION ES ACIDO ACETICO, ACIDO ACETICO ACUOSO, ALCANOL, ALCANOL MEZCLADO CON UN ACIDO MINERAL ACUOSO, TETRAHIDROFURANO, TETRAHIDROFURANO MEZCLADO CON UN ACIDO MINERAL ACUOSO. LA REACCION SE LLEVA A CABO A UNA TEMPERATURA ENTRE 80°C A 115°C. DE PREFERENCIA SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR 5-{4-[2-(N-METIL-N-(2-PIRIDIL)-AMINO)-ETOXI]BENCIL}-2,4-TIAZOLIDINDIONA A PARTIR DE 5{4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)-ETOXI]BENCILIDEN}-2,4-TIAZOLIDINDIONA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723295.3A GB9723295D0 (en) | 1997-11-04 | 1997-11-04 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE129399A1 true PE129399A1 (es) | 2000-02-24 |
Family
ID=10821570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001038A PE129399A1 (es) | 1997-11-04 | 1998-11-03 | Procedimiento para la preparacion de 5-{4-[2-(n-metil-n-(2-piridil)-amino)-etoxi]bencil}-2,4-tiazolidindiona |
Country Status (44)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| US7091359B2 (en) | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
| HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
| GB0023970D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0023971D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
| EP1465881A4 (en) * | 2001-12-20 | 2005-04-13 | Teva Pharma | HYDROGENATION OF PRECURSORS OF ANTI-HYPERGLYCEMIATING THIAZOLIDINEDIONE SUBSTANCES |
| GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
| GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
| AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
| US20080064877A2 (en) * | 2004-05-12 | 2008-03-13 | Medichem S.A. | Process for the preparation of rosiglitazone |
| CZ297266B6 (cs) * | 2004-09-10 | 2006-10-11 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
| CZ297347B6 (cs) * | 2004-09-21 | 2006-11-15 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| CN102727489A (zh) * | 2012-07-18 | 2012-10-17 | 西南大学 | 5-芳(杂环)亚甲基噻唑烷-2，4-二酮在制备ppar激动剂中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US4812570A (en) | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| US5521201A (en) * | 1987-09-04 | 1996-05-28 | Beecham Group P.L.C. | Method for treatment of atherosclerosis |
| US5232925A (en) * | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
| US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| US5194443A (en) * | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US20020049240A1 (en) * | 1994-12-19 | 2002-04-25 | Beecham Group P.1.C. | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
| CA2122712C (en) | 1991-12-20 | 1999-09-21 | Joel Edward Huber | A reduction method for substituted 5-methylene-thiazolidinediones |
| GB9218830D0 (en) | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
| UY24886A1 (es) | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
| GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
-
1997
- 1997-11-04 GB GBGB9723295.3A patent/GB9723295D0/en not_active Ceased
-
1998
- 1998-10-27 ID IDW20000822A patent/ID24644A/id unknown
- 1998-10-27 KR KR1020007004783A patent/KR100602551B1/ko not_active Expired - Fee Related
- 1998-10-27 WO PCT/EP1998/006997 patent/WO1999023095A1/en not_active Ceased
- 1998-10-27 AP APAP/P/2000/001808A patent/AP1519A/en active
- 1998-10-27 AU AU15595/99A patent/AU1559599A/en not_active Abandoned
- 1998-10-27 RS YUP-338/00A patent/RS49793B/sr unknown
- 1998-10-27 BR BR9814622-0A patent/BR9814622A/pt not_active Application Discontinuation
- 1998-10-27 EP EP02075969A patent/EP1219620A1/en not_active Withdrawn
- 1998-10-27 SK SK650-2000A patent/SK285233B6/sk not_active IP Right Cessation
- 1998-10-27 AT AT98959834T patent/ATE238302T1/de active
- 1998-10-27 PL PL340366A patent/PL192503B1/pl not_active IP Right Cessation
- 1998-10-27 PT PT98959834T patent/PT1028960E/pt unknown
- 1998-10-27 CZ CZ20001633A patent/CZ297209B6/cs not_active IP Right Cessation
- 1998-10-27 ES ES98959834T patent/ES2197519T3/es not_active Expired - Lifetime
- 1998-10-27 IL IL13589898A patent/IL135898A/xx unknown
- 1998-10-27 UA UA2000042451A patent/UA56269C2/uk unknown
- 1998-10-27 OA OA1200000131A patent/OA11521A/en unknown
- 1998-10-27 DK DK98959834T patent/DK1028960T3/da active
- 1998-10-27 CN CNB98810959XA patent/CN1160351C/zh not_active Expired - Fee Related
- 1998-10-27 HU HU0100144A patent/HU224547B1/hu not_active IP Right Cessation
- 1998-10-27 EP EP98959834A patent/EP1028960B1/en not_active Expired - Lifetime
- 1998-10-27 HR HR20000263A patent/HRP20000263B1/xx not_active IP Right Cessation
- 1998-10-27 JP JP2000518965A patent/JP3723448B2/ja not_active Expired - Fee Related
- 1998-10-27 EA EA200000484A patent/EA002722B1/ru not_active IP Right Cessation
- 1998-10-27 TR TR2000/01239T patent/TR200001239T2/xx unknown
- 1998-10-27 CA CA002309461A patent/CA2309461A1/en not_active Abandoned
- 1998-10-27 SI SI9830468T patent/SI1028960T1/xx unknown
- 1998-10-27 DE DE69813869T patent/DE69813869T2/de not_active Expired - Lifetime
- 1998-10-28 UY UY25227A patent/UY25227A1/es not_active IP Right Cessation
- 1998-11-02 AR ARP980105505A patent/AR016660A1/es active IP Right Grant
- 1998-11-02 MY MYPI98004975A patent/MY118605A/en unknown
- 1998-11-02 MA MA25328A patent/MA26560A1/fr unknown
- 1998-11-03 ZA ZA9810033A patent/ZA9810033B/xx unknown
- 1998-11-03 TW TW087118222A patent/TW538037B/zh not_active IP Right Cessation
- 1998-11-03 PE PE1998001038A patent/PE129399A1/es not_active Application Discontinuation
- 1998-11-03 IN IN3258DE1998 patent/IN192870B/en unknown
- 1998-11-03 DZ DZ980247A patent/DZ2637A1/xx active
- 1998-11-03 CO CO98064433A patent/CO5011075A1/es unknown
- 1998-11-25 SA SA98190820A patent/SA98190820B1/ar unknown
-
2000
- 2000-04-27 NO NO20002174A patent/NO315557B1/no not_active IP Right Cessation
- 2000-06-05 BG BG104505A patent/BG64559B1/bg unknown
-
2001
- 2001-02-02 HK HK02108713.7A patent/HK1048804A1/en unknown
-
2002
- 2002-07-09 AU AU2002300593A patent/AU2002300593B8/en not_active Ceased
-
2004
- 2004-08-04 JP JP2004228226A patent/JP2004339235A/ja active Pending
-
2006
- 2006-01-05 US US11/326,003 patent/US20060106221A1/en not_active Abandoned
- 2006-10-18 US US11/550,506 patent/US7351832B2/en not_active Expired - Fee Related
-
2008
- 2008-07-08 EC EC2008002712A patent/ECSP082712A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |