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BRPI0406500A - processo farmacêutico e compostos preparados pelo mesmo - Google Patents

processo farmacêutico e compostos preparados pelo mesmo

Info

Publication number
BRPI0406500A
BRPI0406500A BRPI0406500-0A BRPI0406500A BRPI0406500A BR PI0406500 A BRPI0406500 A BR PI0406500A BR PI0406500 A BRPI0406500 A BR PI0406500A BR PI0406500 A BRPI0406500 A BR PI0406500A
Authority
BR
Brazil
Prior art keywords
compounds prepared
alkoxy
group
pharmaceutical process
unsubstituted
Prior art date
Application number
BRPI0406500-0A
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Pathi L Srinivas
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of BRPI0406500A publication Critical patent/BRPI0406500A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCESSO FARMACêUTICO E COMPOSTOS PREPARADOS PELO MESMO. A presente invenção refere-se a um processo melhorado para a preparação de um composto de sulfinila de fórmula (1) ou um sal, hidrato ou solvato farmaceuticamente aceitável deste, com um sulfeto de fórmula (II), sendo que em ambas as fórmulas (I) e (II) R~ 1~ e R~ 3~ são selecionados do grupo consistindo de hidrogênio, metila ou alcóxi C~ 1-4~, substituído ou não substituído, R~ 2~ é selecionado do grupo consistindo de alcóxi C~ 1-4~, e R~ 4~ é selecionado do grupo consistindo de hidrogênio ou alcóxi C~ 1- 4~ substituído ou não substituído.
BRPI0406500-0A 2003-01-15 2004-01-12 processo farmacêutico e compostos preparados pelo mesmo BRPI0406500A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN58MU2003 2003-01-15
IN193MU2003 2003-02-14
PCT/GB2004/000064 WO2004063188A1 (en) 2003-01-15 2004-01-12 Paharmaceutical process and compounds prepared thereby

Publications (1)

Publication Number Publication Date
BRPI0406500A true BRPI0406500A (pt) 2008-07-22

Family

ID=32715253

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0406500-0A BRPI0406500A (pt) 2003-01-15 2004-01-12 processo farmacêutico e compostos preparados pelo mesmo

Country Status (14)

Country Link
US (1) US7439367B2 (pt)
EP (1) EP1587805B1 (pt)
JP (1) JP5031362B2 (pt)
KR (1) KR101180530B1 (pt)
AT (1) ATE429429T1 (pt)
AU (1) AU2004203958B9 (pt)
BR (1) BRPI0406500A (pt)
CA (1) CA2513555C (pt)
DE (1) DE602004020730D1 (pt)
ES (1) ES2324665T3 (pt)
NZ (1) NZ541373A (pt)
PL (1) PL378201A1 (pt)
RU (1) RU2345075C2 (pt)
WO (1) WO2004063188A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
WO2006040778A1 (en) * 2004-10-15 2006-04-20 Matrix Laboratories Ltd Process for preparations and purification of pantoprazole sesquihydrate
WO2006049486A1 (en) * 2004-11-08 2006-05-11 Dishman Pharmaceuticals And Chemicals Ltd. A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES
US8691995B2 (en) 2004-12-16 2014-04-08 Cipla Limited Process
AU2006242782B2 (en) 2005-02-21 2010-11-04 Cipla Limited New process for synthesis of proton pump inhibitors
GB0525710D0 (en) * 2005-12-17 2006-01-25 Pliva Hrvatska D O O An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
WO2008001392A2 (en) * 2006-06-30 2008-01-03 Msn Laboratories Limited An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts
CN1919844B (zh) * 2006-09-01 2010-05-12 武汉工程大学 水相氧化合成兰索拉唑的方法
ITMI20062449A1 (it) 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
WO2009066317A2 (en) * 2007-08-20 2009-05-28 Macleods Pharmaceuticals Limited Process for the preparation of pantoprazole sodium
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
WO2010146428A1 (en) * 2009-06-15 2010-12-23 Orchid Chemicals And Pharmaceuticals Ltd. An improved process for the preparation of rabeprazole
ES2445711T3 (es) 2009-07-07 2014-03-04 Council Of Scientific & Industrial Research Procedimiento de flujo continuo para la preparación de compuestos de sulfóxido
CN102675285A (zh) * 2012-06-02 2012-09-19 大连理工大学 一种纯水相制备雷贝拉唑钠的方法
CN102952119B (zh) * 2012-11-01 2014-05-07 江苏奥赛康药业股份有限公司 一种雷贝拉唑钠的制备方法
WO2014091450A1 (en) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Process for the preparation of rabeprazole
EP3187494A1 (en) 2015-12-30 2017-07-05 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of pantoprazole sodium sesquihydrate
CN107964005A (zh) * 2017-11-10 2018-04-27 扬子江药业集团江苏海慈生物药业有限公司 一种兰索拉唑的制备方法
CN110372667A (zh) * 2019-08-26 2019-10-25 浙江金华康恩贝生物制药有限公司 一种奥美拉唑合成工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
ZA854287B (en) * 1984-06-16 1986-02-26 Byk Gulden Lomberg Chem Fab Dialkoxypyridines,process for their preparation,their use and medicaments containing them
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
US5433959A (en) * 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
JPS62277322A (ja) * 1986-02-13 1987-12-02 Takeda Chem Ind Ltd 安定化された腸溶性抗潰瘍固形組成物
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
JP2718945B2 (ja) * 1987-06-17 1998-02-25 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
NZ288608A (en) 1994-06-10 1999-01-28 Byk Gulden Lomberg Chem Fab Substituted pyridinylmethyl-thio(or sulphinyl)-benzimidazole(or 1h-imidazo-[2,3-b]-pyridine) and medicaments to combat heliobacter bacteria
JP3926936B2 (ja) * 1998-11-16 2007-06-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホキシド誘導体・アセトン錯体およびその製造法

Also Published As

Publication number Publication date
DE602004020730D1 (de) 2009-06-04
RU2005125724A (ru) 2006-01-27
AU2004203958A1 (en) 2004-07-29
EP1587805A1 (en) 2005-10-26
PL378201A1 (pl) 2006-03-20
WO2004063188A1 (en) 2004-07-29
JP2006515353A (ja) 2006-05-25
ES2324665T3 (es) 2009-08-12
KR20050104349A (ko) 2005-11-02
RU2345075C2 (ru) 2009-01-27
EP1587805B1 (en) 2009-04-22
US20060205791A1 (en) 2006-09-14
NZ541373A (en) 2008-11-28
KR101180530B1 (ko) 2012-09-06
CA2513555A1 (en) 2004-07-29
ATE429429T1 (de) 2009-05-15
US7439367B2 (en) 2008-10-21
JP5031362B2 (ja) 2012-09-19
CA2513555C (en) 2012-09-11
AU2004203958B2 (en) 2009-11-19
AU2004203958B9 (en) 2010-07-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.