BR9814340B1 - compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica. - Google Patents

compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica.

Info

Publication number: BR9814340B1
Authority: BR; Brazil
Prior art keywords: preparing; pharmaceutical composition; indole derivatives; indole; derivatives
Prior art date: 1997-12-24

Application number

BRPI9814340-9A

Other languages

English (en)

Other versions

BR9814340A (pt

Inventor

Elizabeth Defossa

Uwe Heinelt

Otmar Klingler

Gerhard Zoller

Fahad Al-Obeidi

Armin Walser

Peter Wildgoose

Hans Matter

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-24

Filing date

1998-12-10

Publication date

2010-07-13

1998-12-10 Application filed filed Critical

2000-10-03 Publication of BR9814340A publication Critical patent/BR9814340A/pt

2010-07-13 Publication of BR9814340B1 publication Critical patent/BR9814340B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI9814340-9A 1997-12-24 1998-12-10 compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica. BR9814340B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97122901		1997-12-24
PCT/EP1998/008030 WO1999033800A1 (en)	1997-12-24	1998-12-10	Indole derivatives as inhibitors or factor xa

Publications (2)

Publication Number	Publication Date
BR9814340A BR9814340A (pt)	2000-10-03
BR9814340B1 true BR9814340B1 (pt)	2010-07-13

Family

ID=8227884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9814340-9A BR9814340B1 (pt)	1997-12-24	1998-12-10	compostos derivados de indol, processo para a preparação dos mesmo e composição farmacêutica.

Country Status (28)

Country	Link
US (1)	US6337344B1 (pt)
EP (1)	EP1042287B1 (pt)
JP (1)	JP4589529B2 (pt)
KR (1)	KR100608472B1 (pt)
CN (1)	CN1220681C (pt)
AR (1)	AR018031A1 (pt)
AT (1)	ATE293599T1 (pt)
AU (1)	AU743881B2 (pt)
BR (1)	BR9814340B1 (pt)
CA (1)	CA2316172C (pt)
CZ (1)	CZ298827B6 (pt)
DE (1)	DE69829879T2 (pt)
DK (1)	DK1042287T3 (pt)
ES (1)	ES2241194T3 (pt)
HU (1)	HU227568B1 (pt)
ID (1)	ID27044A (pt)
IL (1)	IL136954A0 (pt)
MY (1)	MY120064A (pt)
NO (1)	NO316912B1 (pt)
NZ (1)	NZ505370A (pt)
PL (1)	PL195682B1 (pt)
PT (1)	PT1042287E (pt)
RU (1)	RU2225397C2 (pt)
SI (1)	SI1042287T1 (pt)
TR (1)	TR200001954T2 (pt)
TW (1)	TWI241294B (pt)
WO (1)	WO1999033800A1 (pt)
ZA (1)	ZA9811759B (pt)

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1998
- 1998-12-10 ID IDW20001225A patent/ID27044A/id unknown
- 1998-12-10 DK DK98965244T patent/DK1042287T3/da active
- 1998-12-10 WO PCT/EP1998/008030 patent/WO1999033800A1/en not_active Ceased
- 1998-12-10 SI SI9830771T patent/SI1042287T1/xx unknown
- 1998-12-10 KR KR1020007007084A patent/KR100608472B1/ko not_active Expired - Fee Related
- 1998-12-10 HU HU0100723A patent/HU227568B1/hu not_active IP Right Cessation
- 1998-12-10 AU AU20528/99A patent/AU743881B2/en not_active Ceased
- 1998-12-10 CZ CZ20002310A patent/CZ298827B6/cs not_active IP Right Cessation
- 1998-12-10 RU RU2000119774/04A patent/RU2225397C2/ru not_active IP Right Cessation
- 1998-12-10 CA CA002316172A patent/CA2316172C/en not_active Expired - Fee Related
- 1998-12-10 ES ES98965244T patent/ES2241194T3/es not_active Expired - Lifetime
- 1998-12-10 PT PT98965244T patent/PT1042287E/pt unknown
- 1998-12-10 BR BRPI9814340-9A patent/BR9814340B1/pt not_active IP Right Cessation
- 1998-12-10 EP EP98965244A patent/EP1042287B1/en not_active Expired - Lifetime
- 1998-12-10 PL PL98341400A patent/PL195682B1/pl not_active IP Right Cessation
- 1998-12-10 TR TR2000/01954T patent/TR200001954T2/xx unknown
- 1998-12-10 NZ NZ505370A patent/NZ505370A/en not_active IP Right Cessation
- 1998-12-10 AT AT98965244T patent/ATE293599T1/de active
- 1998-12-10 JP JP2000526484A patent/JP4589529B2/ja not_active Expired - Fee Related
- 1998-12-10 DE DE69829879T patent/DE69829879T2/de not_active Expired - Lifetime
- 1998-12-10 CN CNB988126532A patent/CN1220681C/zh not_active Expired - Fee Related
- 1998-12-10 IL IL13695498A patent/IL136954A0/xx not_active IP Right Cessation
- 1998-12-10 US US09/582,344 patent/US6337344B1/en not_active Expired - Lifetime
- 1998-12-22 ZA ZA9811759A patent/ZA9811759B/xx unknown
- 1998-12-22 AR ARP980106607A patent/AR018031A1/es active IP Right Grant
- 1998-12-23 MY MYPI98005870A patent/MY120064A/en unknown
1999
- 1999-02-23 TW TW087121374A patent/TWI241294B/zh not_active IP Right Cessation
2000
- 2000-06-14 NO NO20003057A patent/NO316912B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1220681C (zh)	2005-09-28
PT1042287E (pt)	2005-08-31
HU227568B1 (en)	2011-08-29
CZ20002310A3 (cs)	2000-10-11
NO20003057D0 (no)	2000-06-14
SI1042287T1 (en)	2005-10-31
CN1283186A (zh)	2001-02-07
AU743881B2 (en)	2002-02-07
CA2316172C (en)	2010-02-02
DK1042287T3 (da)	2005-08-15
EP1042287A1 (en)	2000-10-11
US6337344B1 (en)	2002-01-08
ZA9811759B (en)	1999-07-28
EP1042287B1 (en)	2005-04-20
HUP0100723A3 (en)	2002-12-28
DE69829879D1 (de)	2005-05-25
KR100608472B1 (ko)	2006-08-09
PL195682B1 (pl)	2007-10-31
HK1033795A1 (en)	2001-09-21
ATE293599T1 (de)	2005-05-15
RU2225397C2 (ru)	2004-03-10
TR200001954T2 (tr)	2000-12-21
WO1999033800A1 (en)	1999-07-08
AR018031A1 (es)	2001-10-31
BR9814340A (pt)	2000-10-03
HUP0100723A2 (hu)	2001-08-28
NO20003057L (no)	2000-08-18
PL341400A1 (en)	2001-04-09
JP4589529B2 (ja)	2010-12-01
DE69829879T2 (de)	2006-03-02
IL136954A0 (en)	2001-06-14
KR20010033573A (ko)	2001-04-25
MY120064A (en)	2005-08-30
NO316912B1 (no)	2004-06-21
NZ505370A (en)	2002-06-28
CA2316172A1 (en)	1999-07-08
ID27044A (id)	2001-02-22
ES2241194T3 (es)	2005-10-16
AU2052899A (en)	1999-07-19
TWI241294B (en)	2005-10-11
CZ298827B6 (cs)	2008-02-20
JP2001527066A (ja)	2001-12-25

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ES1038634Y (es)	1999-01-01	Cortapuros perfeccionado.
BR9915708B1 (pt)	2010-07-13	processo para preparação de monoariloxi-metalocenos.
BR9912104B1 (pt)	2010-07-13	compostos derivados de quinolina, composições farmacêuticas, e, processo para a manufatura de um composto.
BR0011702B1 (pt)	2011-01-25	processo para preparação de derivados herbicidas.
BR9711311B1 (pt)	2009-01-13	derivado de 1,2,3,4-tetrahidroquinolina, composiÇço farmaceutica, uso de um derivado de 1,2,3,4-tetrahidroquinolina, e, processo para a preparaÇço de compostos.
BR9906373B1 (pt)	2010-11-16	compostos pirimidinona, composições farmacêuticas contendo os compostos e processos para a preparação dos mesmos.
BR9801120B1 (pt)	2009-12-01	unidade de dosagem sólida de rapamicina e processo para preparar um compimido de dosagem oral de rapamicina.
BR9915027B1 (pt)	2010-09-08	derivados de 1,3-diaril-2-piridin-2-il-3-(3-piridin-2-ilamino)-propanol susbtituìdos, medicamento contendo tais compostos, processo de preparação do mesmo, e aplicação dos mesmos.
EE04902B1 (et)	2007-10-15	Mikrograanul, selle valmistamismeetod ja farmatseutiline preparaat
PT1021442E (pt)	2002-06-28	Derivados de 8-azabiciclo¬3.2.1\|octano-3-metanamina como ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2
BR9809809B1 (pt)	2009-05-05	processo para a preparação de um composto (-)-trans-1-benzil-3-hidroximetil-4-(4-fluorofenil) piperidina, e, processo para a preparação de paroxetina.
BR0012329B1 (pt)	2013-03-19	derivados de benzofurano, processo para sua preparaÇço e uso dos mesmos.
TR199700729A3 (tr)	1998-05-21	Sabit arilpirol parçaciklari, bunlarin hazirlanmasi için usul.
BR9703403B1 (pt)	2010-06-29	compostos, processo para preparação de compostos, utilização de composto e processo para preparação de composição farmacêutica.
BR9803237B1 (pt)	2009-05-05	derivados de uréia, composição farmacêutica e processo para sua preparação.
ZA9810403B (en)	2000-05-15	New epothilon derivatives, process for their preparation and their pharmaceutical use.
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