AR024158A1 - Compuestos antibacterianos - Google Patents
Compuestos antibacterianosInfo
- Publication number
- AR024158A1 AR024158A1 ARP000102666A ARP000102666A AR024158A1 AR 024158 A1 AR024158 A1 AR 024158A1 AR P000102666 A ARP000102666 A AR P000102666A AR P000102666 A ARP000102666 A AR P000102666A AR 024158 A1 AR024158 A1 AR 024158A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- antibacterial compounds
- compounds
- cf3s
- sulfoxyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos de formula (1) que son inhibidores de Fab I y son utiles en el tratamiento de infecciones bacterianas en la cual R1 es Ar o Het; R2es H, alquilo C1-6 o Ar-alquilo C0-6; X es H, alquilo C1-4, OR. SR, alquilo C1-4-sulfonilo, alquilo C1-4-sulfoxilo, CN, N(R)2, NO2, CF3, CO2R, CON(R)2,COR, NRC(O)R, F, Cl, Br, I o CF3S(O)r; R es H,alquilo C1-6 o Ar-alquilo C0-6; y r es 0, 1 o 2; o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13700499P | 1999-06-01 | 1999-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024158A1 true AR024158A1 (es) | 2002-09-04 |
Family
ID=22475391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000102666A AR024158A1 (es) | 1999-06-01 | 2000-05-30 | Compuestos antibacterianos |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6573272B1 (es) |
| EP (1) | EP1180030B1 (es) |
| JP (1) | JP4733836B2 (es) |
| KR (1) | KR20020005767A (es) |
| CN (1) | CN1365280A (es) |
| AR (1) | AR024158A1 (es) |
| AT (1) | ATE283049T1 (es) |
| AU (1) | AU773550B2 (es) |
| BR (1) | BR0011121A (es) |
| CA (1) | CA2375630A1 (es) |
| CO (1) | CO5370679A1 (es) |
| CZ (1) | CZ20014290A3 (es) |
| DE (1) | DE60016198T2 (es) |
| HK (1) | HK1045644A1 (es) |
| HU (1) | HUP0201206A3 (es) |
| IL (1) | IL146514A0 (es) |
| MX (1) | MXPA01012326A (es) |
| NO (1) | NO20015722D0 (es) |
| NZ (1) | NZ515611A (es) |
| PL (1) | PL351959A1 (es) |
| TR (1) | TR200103485T2 (es) |
| WO (1) | WO2000072846A1 (es) |
| ZA (1) | ZA200109733B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR024158A1 (es) | 1999-06-01 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| DE60017180T2 (de) | 1999-10-08 | 2005-12-08 | Affinium Pharmaceuticals, Inc., Toronto | Fab i inhibitoren |
| EP1225894B1 (en) * | 1999-10-08 | 2006-07-05 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| JP2004532816A (ja) | 2000-12-08 | 2004-10-28 | スミスクライン・ビーチャム・コーポレイション | 抗菌性化合物 |
| ATE402693T1 (de) * | 2000-12-21 | 2008-08-15 | Rima W Mcleod | Fab i und hemmung von apicomplexan-parasiten |
| AU2002246728A1 (en) * | 2001-02-12 | 2002-08-28 | Lilly Icos Llc | Carboline derivatives |
| JP4387804B2 (ja) * | 2001-04-06 | 2009-12-24 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | ＦａｂＩ阻害剤 |
| SI1575951T1 (sl) * | 2002-12-06 | 2014-10-30 | Debiopharm International Sa Forum "Apres-Demain" | Heterociklične spojine, postopki za njihovo izdelavo in njihova uporaba v terapiji |
| DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
| US20060273819A1 (en) * | 2003-04-29 | 2006-12-07 | Timothy Opperman | Antibiotic tetrahydro-beta-carboline derivatives |
| EP2848614A3 (en) * | 2004-06-04 | 2015-07-29 | Debiopharm International SA | Acrylamide derivatives as antibiotic agents |
| US20090156578A1 (en) * | 2005-12-05 | 2009-06-18 | PAULS Henry | 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents |
| EP2687533B1 (en) * | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| US7854963B2 (en) * | 2006-10-13 | 2010-12-21 | Solopower, Inc. | Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| EP2225250A2 (en) | 2007-11-30 | 2010-09-08 | Biota Scientific Management Pty Ltd | Bicyclic ppat inhibitors as antibacterial agents |
| KR101135179B1 (ko) * | 2009-02-20 | 2012-04-16 | 한국생명공학연구원 | ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물 |
| US9353113B2 (en) | 2011-03-18 | 2016-05-31 | Ono Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| LT2861608T (lt) | 2012-06-19 | 2019-07-10 | Debiopharm International Sa | (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-nafthidrin-3-il)akrilamido provaisto dariniai |
| AU2017223037B2 (en) | 2016-02-26 | 2022-04-14 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
| JP2021534246A (ja) * | 2018-08-16 | 2021-12-09 | レクレオ ファーマシューティカルス アイエヌシー | １，３，４，９−テトラヒドロ−２ｈ−ピリド［３，４−ｂ］インドール誘導体化合物及びその使用 |
| CN116327781A (zh) | 2019-02-14 | 2023-06-27 | 德彪药业国际股份公司 | 阿法比星制剂及其制备方法 |
| MX2021015513A (es) | 2019-06-14 | 2022-04-20 | Debiopharm Int Sa | Medicamento y uso del mismo para tratar infecciones bacterianas que involucran una biopelicula. |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3828068A (en) | 1971-05-10 | 1974-08-06 | Tenneco Chem | ((substituted indazolyl)-n1-methyl)carbamates |
| US4154943A (en) | 1977-12-29 | 1979-05-15 | University Of Vermont | Preparation of vincadifformine |
| US4267330A (en) * | 1978-08-24 | 1981-05-12 | Omnium Chimique Societe Anonyme | Process for the synthesis of vincadifformine and related derivatives |
| FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US5416193A (en) * | 1993-04-30 | 1995-05-16 | Pfizer Inc. | Coupling reagent and method |
| MA23420A1 (fr) | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US5614551A (en) | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
| AU702661B2 (en) | 1994-06-29 | 1999-02-25 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| JPH10310582A (ja) * | 1997-03-13 | 1998-11-24 | Sankyo Co Ltd | ピペリジン環縮合カルバペネム化合物 |
| AU6870098A (en) | 1997-03-31 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US5932743A (en) | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
| ID27044A (id) * | 1997-12-24 | 2001-02-22 | Aventis Pharma Gmbh | Derivatif indole sebagai penghambat pada faktor xa |
| CA2341346A1 (en) * | 1998-08-20 | 2000-04-13 | Agouron Pharmaceuticals, Inc. | Non-peptide gnrh agents, methods and intermediates for their preparation |
| GT199900167A (es) * | 1998-10-01 | 2001-03-21 | Nuevos bis-benzimidazoles. | |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR024077A1 (es) | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| AR024158A1 (es) | 1999-06-01 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| CO5180605A1 (es) | 1999-06-23 | 2002-07-30 | Smithkline Beecham Corp | Compuestos de indol |
| US6346391B1 (en) | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
| DE60019954T2 (de) | 1999-10-08 | 2006-02-23 | Affinium Pharmaceuticals, Inc., Toronto | Fab i hemmer |
| EP1225894B1 (en) | 1999-10-08 | 2006-07-05 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| DE60017180T2 (de) | 1999-10-08 | 2005-12-08 | Affinium Pharmaceuticals, Inc., Toronto | Fab i inhibitoren |
| CA2323008C (en) | 1999-10-11 | 2005-07-12 | Pfizer Inc. | Pharmaceutically active compounds |
| US6656703B1 (en) | 1999-12-29 | 2003-12-02 | Millennium Pharamaceuticals, Inc. | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria |
| US6372752B1 (en) | 2000-02-07 | 2002-04-16 | Genzyme Corporation | Inha inhibitors and methods of use thereof |
| US6642252B2 (en) | 2000-11-07 | 2003-11-04 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| US20020107266A1 (en) | 2000-12-12 | 2002-08-08 | Marguerita Lim-Wilby | Compounds, compositions and methods for treatment of parasitic infections |
-
2000
- 2000-05-30 AR ARP000102666A patent/AR024158A1/es not_active Application Discontinuation
- 2000-05-30 CO CO00039765A patent/CO5370679A1/es unknown
- 2000-06-01 IL IL14651400A patent/IL146514A0/xx unknown
- 2000-06-01 DE DE60016198T patent/DE60016198T2/de not_active Expired - Lifetime
- 2000-06-01 NZ NZ515611A patent/NZ515611A/en not_active IP Right Cessation
- 2000-06-01 WO PCT/US2000/015154 patent/WO2000072846A1/en not_active Ceased
- 2000-06-01 EP EP00936459A patent/EP1180030B1/en not_active Expired - Lifetime
- 2000-06-01 HU HU0201206A patent/HUP0201206A3/hu unknown
- 2000-06-01 CN CN00810964A patent/CN1365280A/zh active Pending
- 2000-06-01 US US09/980,369 patent/US6573272B1/en not_active Expired - Fee Related
- 2000-06-01 CZ CZ20014290A patent/CZ20014290A3/cs unknown
- 2000-06-01 AU AU51774/00A patent/AU773550B2/en not_active Ceased
- 2000-06-01 MX MXPA01012326A patent/MXPA01012326A/es active IP Right Grant
- 2000-06-01 KR KR1020017015412A patent/KR20020005767A/ko not_active Withdrawn
- 2000-06-01 JP JP2000620958A patent/JP4733836B2/ja not_active Expired - Fee Related
- 2000-06-01 PL PL00351959A patent/PL351959A1/xx not_active Application Discontinuation
- 2000-06-01 HK HK02105376.1A patent/HK1045644A1/zh unknown
- 2000-06-01 AT AT00936459T patent/ATE283049T1/de not_active IP Right Cessation
- 2000-06-01 TR TR2001/03485T patent/TR200103485T2/xx unknown
- 2000-06-01 CA CA002375630A patent/CA2375630A1/en not_active Abandoned
- 2000-06-01 BR BR0011121-0A patent/BR0011121A/pt not_active IP Right Cessation
-
2001
- 2001-11-23 NO NO20015722A patent/NO20015722D0/no not_active Application Discontinuation
- 2001-11-27 ZA ZA200109733A patent/ZA200109733B/en unknown
-
2003
- 2003-05-05 US US10/429,923 patent/US6964970B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20015722L (no) | 2001-11-23 |
| US6573272B1 (en) | 2003-06-03 |
| CZ20014290A3 (cs) | 2002-05-15 |
| AU5177400A (en) | 2000-12-18 |
| KR20020005767A (ko) | 2002-01-17 |
| JP2003500448A (ja) | 2003-01-07 |
| EP1180030B1 (en) | 2004-11-24 |
| CA2375630A1 (en) | 2000-12-07 |
| CN1365280A (zh) | 2002-08-21 |
| HUP0201206A2 (en) | 2002-08-28 |
| ZA200109733B (en) | 2002-09-11 |
| HUP0201206A3 (en) | 2003-07-28 |
| WO2000072846A1 (en) | 2000-12-07 |
| NZ515611A (en) | 2004-05-28 |
| MXPA01012326A (es) | 2002-07-30 |
| DE60016198T2 (de) | 2005-12-01 |
| NO20015722D0 (no) | 2001-11-23 |
| JP4733836B2 (ja) | 2011-07-27 |
| BR0011121A (pt) | 2002-02-26 |
| CO5370679A1 (es) | 2004-02-27 |
| PL351959A1 (en) | 2003-07-14 |
| EP1180030A4 (en) | 2002-09-25 |
| HK1045644A1 (zh) | 2002-12-06 |
| DE60016198D1 (de) | 2004-12-30 |
| EP1180030A1 (en) | 2002-02-20 |
| ATE283049T1 (de) | 2004-12-15 |
| US6964970B2 (en) | 2005-11-15 |
| IL146514A0 (en) | 2002-07-25 |
| US20030232850A1 (en) | 2003-12-18 |
| TR200103485T2 (tr) | 2002-04-22 |
| AU773550B2 (en) | 2004-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |