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BR9813378A - Compound, process for preparing the same, and use of it, pharmaceutical composition, and process for preparing the same, and process for effecting immunosuppression - Google Patents

Compound, process for preparing the same, and use of it, pharmaceutical composition, and process for preparing the same, and process for effecting immunosuppression

Info

Publication number
BR9813378A
BR9813378A BR9813378-0A BR9813378A BR9813378A BR 9813378 A BR9813378 A BR 9813378A BR 9813378 A BR9813378 A BR 9813378A BR 9813378 A BR9813378 A BR 9813378A
Authority
BR
Brazil
Prior art keywords
same
preparing
pharmaceutical composition
compound
effecting immunosuppression
Prior art date
Application number
BR9813378-0A
Other languages
Portuguese (pt)
Inventor
Andrew Baxter
David Cheshire
Thomas Mcinally
Michael Mortimore
David Cladingboel
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of BR9813378A publication Critical patent/BR9813378A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR O MESMO, E USO DO MESMO, COMPOSIçãO FARMACêUTICA, E PROCESSO PARA A PREPARAçãO DA MESMA, E, PROCESSO DE EFETUAR A IMUNOSSUPRESSãO". A invenção fornece novos compostos, um processo para a sua preparação, composições farmacêuticas que os contenham, um processo para preparar as composições farmacêuticas e seu uso em terapia."COMPOSITE, PROCESS TO PREPARE THE SAME, AND USE OF THE SAME, PHARMACEUTICAL COMPOSITION, AND PROCESS FOR THE PREPARATION OF THE SAME, AND, PROCESS TO PERFORM IMMUNOSUPPRESSION". The invention provides new compounds, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions and their use in therapy.

BR9813378-0A 1997-12-05 1998-12-01 Compound, process for preparing the same, and use of it, pharmaceutical composition, and process for preparing the same, and process for effecting immunosuppression BR9813378A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704546A SE9704546D0 (en) 1997-12-05 1997-12-05 Novel compounds
PCT/SE1998/002190 WO1999029686A1 (en) 1997-12-05 1998-12-01 Novel compounds

Publications (1)

Publication Number Publication Date
BR9813378A true BR9813378A (en) 2000-10-10

Family

ID=20409283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813378-0A BR9813378A (en) 1997-12-05 1998-12-01 Compound, process for preparing the same, and use of it, pharmaceutical composition, and process for preparing the same, and process for effecting immunosuppression

Country Status (16)

Country Link
EP (1) EP1037889A1 (en)
JP (1) JP2001525406A (en)
KR (1) KR20010032800A (en)
CN (1) CN1284074A (en)
AU (1) AU1791599A (en)
BR (1) BR9813378A (en)
CA (1) CA2312357A1 (en)
EE (1) EE200000321A (en)
HU (1) HUP0100731A3 (en)
IL (1) IL136368A0 (en)
NO (1) NO20002787L (en)
PL (1) PL340837A1 (en)
SE (1) SE9704546D0 (en)
SK (1) SK8442000A3 (en)
TR (1) TR200001544T2 (en)
WO (1) WO1999029686A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901875D0 (en) * 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
SE9904505D0 (en) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904652D0 (en) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
JP2002330787A (en) * 2000-10-21 2002-11-19 Astrazeneca Ab Chemical substance
PA8557501A1 (en) 2001-11-12 2003-06-30 Pfizer Prod Inc BENZAMIDA, HETEROARILAMIDA AND INVESTED AMIDAS
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (en) 2002-12-31 2004-07-26 Pfizer Prod Inc BENZAMID INHIBITORS OF THE P2X7 RECEIVER.
WO2004099146A1 (en) 2003-05-12 2004-11-18 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
RU2006146675A (en) 2004-06-29 2008-07-10 Пфайзер Продактс Инк. (Us) METHOD FOR PRODUCING 5- [4- (2-HYDROXYPROPYL) -3,5-DIOXO-4,5-DIHYDRO-3H- [1,2,4] TRIAZIN-2-IL] BENZAMIDE DERIVATIVES BY REMOVING PROTECTION FROM INTERMEDIATE PRODUCTS, SODA HYDROXYL
TWI464148B (en) 2006-03-16 2014-12-11 Evotec Us Inc Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
MX2008011919A (en) 2006-03-16 2008-11-28 Renovis Inc Bicycloheteroaryl compounds as p2x7 modulators and uses thereof.
ES2569677T3 (en) 2006-03-16 2016-05-12 Second Genome, Inc. Bicycloheteroaryl compounds as modulators of P2X7 and uses thereof
TW200813018A (en) 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
PL2049478T3 (en) * 2006-07-06 2012-09-28 Glaxo Group Ltd Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use
GB0613473D0 (en) * 2006-07-06 2006-08-16 Glaxo Group Ltd Novel compounds
CA2680275C (en) 2007-03-09 2016-08-23 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
US20100168171A1 (en) * 2007-03-28 2010-07-01 Paul John Beswick Piperidinone Carboxamide Derivatives as P2X7 Modulators
US20100144727A1 (en) * 2007-03-29 2010-06-10 Paul John Beswick Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators
WO2008119825A2 (en) 2007-04-03 2008-10-09 Glaxo Group Limited Imidazolidine carboxamide derivatives as p2x7 modulators
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system
JP5506776B2 (en) 2008-03-25 2014-05-28 アフェクティス ファーマシューティカルズ アーゲー Novel P2X7R antagonist and use thereof
WO2010118921A1 (en) 2009-04-14 2010-10-21 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
EP2322149A1 (en) 2009-11-03 2011-05-18 Universidad del Pais Vasco Methods and compositions for the treatment of ischemia
EA201201548A1 (en) 2010-05-14 2013-05-30 Эффектис Фармасьютиклз Аг NEW WAYS TO GET P2X7R ANTAGONISTS
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
EP3713540B1 (en) 2017-11-21 2025-08-20 Solventum Intellectual Properties Company Plant based oil-in-water oral emulsions and methods of use
JP7341143B2 (en) 2017-12-20 2023-09-08 スリーエム イノベイティブ プロパティズ カンパニー Oral composition and method of use
US11324681B2 (en) 2017-12-20 2022-05-10 3M Innovative Properties Company Oral compositions and methods of use
CN113226287B (en) 2018-12-29 2025-10-17 舒万诺知识产权公司 Oral product and method of use

Also Published As

Publication number Publication date
AU1791599A (en) 1999-06-28
HUP0100731A3 (en) 2002-08-28
SE9704546D0 (en) 1997-12-05
KR20010032800A (en) 2001-04-25
IL136368A0 (en) 2001-06-14
EP1037889A1 (en) 2000-09-27
JP2001525406A (en) 2001-12-11
NO20002787D0 (en) 2000-05-31
SK8442000A3 (en) 2001-01-18
CN1284074A (en) 2001-02-14
NO20002787L (en) 2000-08-01
WO1999029686A1 (en) 1999-06-17
PL340837A1 (en) 2001-02-26
EE200000321A (en) 2001-08-15
HUP0100731A2 (en) 2002-05-29
CA2312357A1 (en) 1999-06-17
TR200001544T2 (en) 2000-11-21

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]