BR9810544A - Derivados de azetidinilpropilpiperidina, intermediários e uso como antagonistas de taquicinina - Google Patents
Derivados de azetidinilpropilpiperidina, intermediários e uso como antagonistas de taquicininaInfo
- Publication number
- BR9810544A BR9810544A BR9810544-2A BR9810544A BR9810544A BR 9810544 A BR9810544 A BR 9810544A BR 9810544 A BR9810544 A BR 9810544A BR 9810544 A BR9810544 A BR 9810544A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- cycloalkyl
- optionally substituted
- halogens
- fluorine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE AZETIDINILPROPILPIPERIDINA, INTERMEDIáRIOS E USO COMO ANTAGONISTAS DE TAQUICININA"<D>. Compostos da fórmula (I): sais farmaceuticamente aceitáveis dos mesmos são úteis como inibidores de taquicinina, os quais actuam nos receptores de NK~ 1~, NK~ 2~ ou NK~ 3~, ou uma sua combinação de dois ou mais na dita fórmula (I) A é CO, SO~ 2~ ou CH~ 2~; AR^ 1^ é fenila opcionalmente substituída por um ou mais substituintes independentemente selecionados dentre halogênio, alcóxi C~ 1-6~ opcionalmente substituído por um ou mais halogênios, e alquila C~ 1-6~ opcionalmente substituído por um ou mais halogênios; X^ 1^ é cicloalquila C~ 3-7~, arila ou alquila C~ 1-6~ sendo a referida alquila C~ 1-6~ opcionalmente substituída por flúor, CO~ 2~H, CO~ 2~ (alquila C~ 1-4~), cicloalquila C~ 3-7~. adamantila, arila, ou Het e sendo a referida cicloalquila C~ 3-7~ opcionalmente substituída por 1 ou 2 substituíntes cada um independentemente selecionado dentre alquila C~ 1-4~, cicloalquila C~ 3-7~, alcóxi C~ 1-4~, OH, F, flúor (alquila C~ 1-4~) e flúor (alcóxi C~ 1-4~); X é uma ligação direta ou NR^ 1^; R é SO~ 2~-arila, SO~ 2~ (alquila C~ 1-6~ opcionalmente substituída por um ou mais halogênios)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9714129.5A GB9714129D0 (en) | 1997-07-04 | 1997-07-04 | Azetidines |
| PCT/EP1998/004177 WO1999001451A1 (en) | 1997-07-04 | 1998-07-01 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810544A true BR9810544A (pt) | 2000-09-05 |
Family
ID=10815370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810544-2A BR9810544A (pt) | 1997-07-04 | 1998-07-01 | Derivados de azetidinilpropilpiperidina, intermediários e uso como antagonistas de taquicinina |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6262046B1 (pt) |
| EP (1) | EP1023285A1 (pt) |
| JP (1) | JP2000511207A (pt) |
| KR (1) | KR20010015532A (pt) |
| CN (1) | CN1261887A (pt) |
| AP (1) | AP1110A (pt) |
| AR (1) | AR013171A1 (pt) |
| AU (1) | AU726708B2 (pt) |
| BG (1) | BG103992A (pt) |
| BR (1) | BR9810544A (pt) |
| CA (1) | CA2294193A1 (pt) |
| CO (1) | CO4950604A1 (pt) |
| DZ (1) | DZ2550A1 (pt) |
| EA (1) | EA002773B1 (pt) |
| GB (1) | GB9714129D0 (pt) |
| GT (1) | GT199800106A (pt) |
| HN (1) | HN1998003689A (pt) |
| HR (1) | HRP20000002B1 (pt) |
| HU (1) | HUP0002330A3 (pt) |
| ID (1) | ID24090A (pt) |
| IL (1) | IL133433A0 (pt) |
| IS (1) | IS5295A (pt) |
| MA (1) | MA26519A1 (pt) |
| NO (1) | NO996115L (pt) |
| NZ (1) | NZ501715A (pt) |
| OA (1) | OA11236A (pt) |
| PA (1) | PA8454601A1 (pt) |
| PE (1) | PE83999A1 (pt) |
| PL (1) | PL338004A1 (pt) |
| SK (1) | SK182799A3 (pt) |
| TN (1) | TNSN98127A1 (pt) |
| TR (1) | TR200000025T2 (pt) |
| TW (1) | TW492960B (pt) |
| UY (1) | UY25079A1 (pt) |
| WO (1) | WO1999001451A1 (pt) |
| ZA (1) | ZA985875B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9714129D0 (en) | 1997-07-04 | 1997-09-10 | Pfizer Ltd | Azetidines |
| WO1999019297A1 (en) * | 1997-10-15 | 1999-04-22 | Coelacanth Chemical Corporation | Synthesis of azetidine derivatives |
| FR2787449B3 (fr) | 1998-12-15 | 2001-01-12 | Sanofi Sa | Derives de 3-phenyl-2,6-dioxopiperidin-3-yl propionamide et leur procede de preparation |
| FR2787448B3 (fr) | 1998-12-18 | 2001-01-12 | Sanofi Sa | Ester d'alkyle inferieur de l'acide 3-(3,4-dihalogenophenyl) -2,6-dioxopiperidine3-propionique et son mode de preparation |
| US6566356B2 (en) | 2000-03-03 | 2003-05-20 | Aventis Pharma S.A. | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation |
| FR2805810B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation |
| FR2805817B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation |
| CA2509406C (en) * | 2002-12-23 | 2012-07-03 | Janssen Pharmaceutica N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
| TW200508221A (en) | 2003-06-13 | 2005-03-01 | Astrazeneca Ab | New azetidine compounds |
| FR2876689B1 (fr) * | 2004-10-14 | 2008-02-22 | Aventis Pharma Sa | Nouveau procede et intermediaires de preparation de derives de n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulfonamide |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| ES2350647T3 (es) * | 2005-03-08 | 2011-01-25 | Janssen Pharmaceutica Nv | Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1). |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| WO2007118854A1 (en) | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
| US8791264B2 (en) | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| US8106208B2 (en) | 2006-05-18 | 2012-01-31 | Albireo Ab | Benzamide compounds that act as NK receptor antagonists |
| KR20090112722A (ko) | 2007-01-24 | 2009-10-28 | 글락소 그룹 리미티드 | 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물 |
| US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| MX2010001080A (es) | 2007-08-07 | 2010-03-01 | Hoffmann La Roche | Pirrolidin-aril-eteres como antagonistas de receptor de nk3. |
| WO2009040659A2 (en) | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| MX373231B (es) | 2015-06-16 | 2020-05-08 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
| KR102559211B1 (ko) | 2015-06-23 | 2023-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | (6S,9aS)-N-벤질-8-({6-[3-(4-에틸피페라진-1-일)아제티딘-1-일]피리딘-2-일}메틸)-6-(2-플루오로-4-하이드록시벤질)-4,7-디옥소-2-(프로프-2-엔-1-일)헥사하이드로-2H-피라지노[2,1-c][1,2,4]트리아진-1(6H)-카복사마이드의 결정 |
| JP6581320B2 (ja) | 2017-02-08 | 2019-09-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5625060A (en) | 1991-05-03 | 1997-04-29 | Elf Sanofi | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present |
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| TW432061B (en) | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
| FR2729951B1 (fr) | 1995-01-30 | 1997-04-18 | Sanofi Sa | Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant |
| GB9600235D0 (en) | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
| GB9601697D0 (en) * | 1996-01-27 | 1996-03-27 | Pfizer Ltd | Therapeutic agents |
| GB9714129D0 (en) | 1997-07-04 | 1997-09-10 | Pfizer Ltd | Azetidines |
-
1997
- 1997-07-04 GB GBGB9714129.5A patent/GB9714129D0/en active Pending
-
1998
- 1998-06-01 TW TW087108533A patent/TW492960B/zh active
- 1998-06-30 HN HN1998003689A patent/HN1998003689A/es unknown
- 1998-07-01 EP EP98939619A patent/EP1023285A1/en not_active Withdrawn
- 1998-07-01 KR KR1020007000013A patent/KR20010015532A/ko not_active Abandoned
- 1998-07-01 MA MA25151A patent/MA26519A1/fr unknown
- 1998-07-01 TR TR2000/00025T patent/TR200000025T2/xx unknown
- 1998-07-01 CA CA002294193A patent/CA2294193A1/en not_active Abandoned
- 1998-07-01 SK SK1827-99A patent/SK182799A3/sk unknown
- 1998-07-01 IL IL13343398A patent/IL133433A0/xx unknown
- 1998-07-01 JP JP11506382A patent/JP2000511207A/ja active Pending
- 1998-07-01 HR HR970497A patent/HRP20000002B1/xx not_active IP Right Cessation
- 1998-07-01 AU AU88062/98A patent/AU726708B2/en not_active Ceased
- 1998-07-01 PE PE1998000589A patent/PE83999A1/es not_active Application Discontinuation
- 1998-07-01 WO PCT/EP1998/004177 patent/WO1999001451A1/en not_active Ceased
- 1998-07-01 HU HU0002330A patent/HUP0002330A3/hu unknown
- 1998-07-01 DZ DZ980160A patent/DZ2550A1/xx active
- 1998-07-01 US US09/423,771 patent/US6262046B1/en not_active Expired - Fee Related
- 1998-07-01 UY UY25079A patent/UY25079A1/es not_active IP Right Cessation
- 1998-07-01 EA EA199901102A patent/EA002773B1/ru not_active IP Right Cessation
- 1998-07-01 BR BR9810544-2A patent/BR9810544A/pt not_active IP Right Cessation
- 1998-07-01 NZ NZ501715A patent/NZ501715A/en unknown
- 1998-07-01 ID IDW20000006A patent/ID24090A/id unknown
- 1998-07-01 PL PL98338004A patent/PL338004A1/xx unknown
- 1998-07-01 CN CN98806898A patent/CN1261887A/zh active Pending
- 1998-07-02 AR ARP980103228A patent/AR013171A1/es not_active Application Discontinuation
- 1998-07-02 AP APAP/P/1998/001291A patent/AP1110A/en active
- 1998-07-02 PA PA19988454601A patent/PA8454601A1/es unknown
- 1998-07-03 CO CO98037815A patent/CO4950604A1/es unknown
- 1998-07-03 ZA ZA9805875A patent/ZA985875B/xx unknown
- 1998-07-10 TN TNTNSN98127A patent/TNSN98127A1/fr unknown
- 1998-07-14 GT GT199800106A patent/GT199800106A/es unknown
-
1999
- 1999-12-10 IS IS5295A patent/IS5295A/is unknown
- 1999-12-10 NO NO996115A patent/NO996115L/no not_active Application Discontinuation
- 1999-12-13 BG BG103992A patent/BG103992A/xx unknown
- 1999-12-15 OA OA9900282A patent/OA11236A/en unknown
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