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BR9712548A - Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal. - Google Patents

Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal.

Info

Publication number
BR9712548A
BR9712548A BR9712548-2A BR9712548A BR9712548A BR 9712548 A BR9712548 A BR 9712548A BR 9712548 A BR9712548 A BR 9712548A BR 9712548 A BR9712548 A BR 9712548A
Authority
BR
Brazil
Prior art keywords
fetal
erythrocyte
identifying
kit
erythroblastic cell
Prior art date
Application number
BR9712548-2A
Other languages
English (en)
Inventor
Mitchell Golbus
Original Assignee
Applied Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Imaging Inc filed Critical Applied Imaging Inc
Publication of BR9712548A publication Critical patent/BR9712548A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"PROCESSO PARA IDENTIFICAR UMA CéLULA ERITRóCITA OU ERITROBLáSTCA FETAL EM UMA AMOSTRA SANGUìNEA, KIT PARA IDENTIFICAçãO DE UMA CéLULA ERITRóCITA OU ERITROBLáSTICA NUCLEADA FETAL, E, KIT PARA SELEçãO OU ISOLAMENTO DE UMA SEQUêNCIA DE áCIDO NUCLéICO DENTRO DE UMA CéLULA ERITRóCITA NUCLEADA FETAL". é descrito um processo in vitro de identificação ou de isolamento de células fetais de uma amostra sanguínea. Eritrócitos ou eritroblastos nucleados fetais são identificados pelo uso de um anticorpo ou de um fragmento de anticorpo específico para hemoglobina embriónica ou uma cadeia de hemoglobina embriónica. Tendo sido identicadas as células fetais, elas podem ser tratadas para tornar disponíveis as proteínas ou os ácidos nucléicos fetais para a identificação ou a amplificação. Detecção da ocorrência ou da existência de proteínas ou ácidos nucléicos fetais selecionados permite um diagnóstico qualitativo ou quantitativo ou uma avaliação pré-natal, incluindo a determinação do sexo do feto, a determinação de anormalidades cromossómicas, de único gene ou de proteína, e a determinação da presenção ou da ausência de específicos genes, sequências de ácidos nucleícos ou de proteínas.
BR9712548-2A 1996-10-21 1997-10-20 Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal. BR9712548A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/734,556 US5731156A (en) 1996-10-21 1996-10-21 Use of anti-embryonic hemoglobin antibodies to identify fetal cells
PCT/US1997/019447 WO1998018005A1 (en) 1996-10-21 1997-10-20 Use of anti-embryonic hemoglobin antibodies to identify fetal cells

Publications (1)

Publication Number Publication Date
BR9712548A true BR9712548A (pt) 1999-12-21

Family

ID=24952172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712548-2A BR9712548A (pt) 1996-10-21 1997-10-20 Processo para identificar uma célula eritrócita ou eritroblástica fetal em uma amostra sanguìnea, kit para identificação de uma célula eritrócita ou eritroblástica nucleada fetal, e, kit para seleção ou isolamento de uma sequência de ácida nucléico dentro de uma célula eritrócita ou eritroblástica nucleada fetal.

Country Status (13)

Country Link
US (1) US5731156A (pt)
EP (1) EP1007965B1 (pt)
JP (1) JP4091123B2 (pt)
KR (1) KR100523381B1 (pt)
CN (1) CN1234117A (pt)
AT (1) ATE290210T1 (pt)
AU (1) AU735380B2 (pt)
BR (1) BR9712548A (pt)
CA (1) CA2269327A1 (pt)
DE (1) DE69732662T2 (pt)
IL (1) IL129382A (pt)
RU (1) RU2178703C2 (pt)
WO (1) WO1998018005A1 (pt)

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Also Published As

Publication number Publication date
CA2269327A1 (en) 1998-04-30
IL129382A (en) 2002-09-12
EP1007965A1 (en) 2000-06-14
RU2178703C2 (ru) 2002-01-27
US5731156A (en) 1998-03-24
DE69732662T2 (de) 2005-12-29
EP1007965B1 (en) 2005-03-02
KR20000052662A (ko) 2000-08-25
JP4091123B2 (ja) 2008-05-28
CN1234117A (zh) 1999-11-03
HK1031255A1 (en) 2001-06-08
DE69732662D1 (de) 2005-04-07
ATE290210T1 (de) 2005-03-15
IL129382A0 (en) 2000-02-17
WO1998018005A1 (en) 1998-04-30
EP1007965A4 (en) 2000-06-14
KR100523381B1 (ko) 2005-10-24
AU735380B2 (en) 2001-07-05
AU4920097A (en) 1998-05-15
JP2001502805A (ja) 2001-02-27

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