BR9711586A - Compostos e uso dos mesmo - Google Patents

Compostos e uso dos mesmo

Info

Publication number: BR9711586A
Authority: BR; Brazil
Prior art keywords: compounds; medicaments; formula
Prior art date: 1996-10-04

Application number

BR9711586A

Other languages

English (en)

Inventor

Soldato Piero Del

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-02

Publication date

1999-08-24

1997-10-02 Application filed by Nicox Sa filed Critical Nicox Sa

1999-08-24 Publication of BR9711586A publication Critical patent/BR9711586A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BR9711586A 1996-10-04 1997-10-02 Compostos e uso dos mesmo BR9711586A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI002048A IT1285770B1 (it)	1996-10-04	1996-10-04	Composti corticoidei
PCT/EP1997/005426 WO1998015568A2 (en)	1996-10-04	1997-10-02	Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Publications (1)

Publication Number	Publication Date
BR9711586A true BR9711586A (pt)	1999-08-24

Family

ID=11374972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9711586A BR9711586A (pt)	1996-10-04	1997-10-02	Compostos e uso dos mesmo

Country Status (18)

Country	Link
US (8)	US6610676B1 (pt)
EP (1)	EP0929565B1 (pt)
JP (1)	JP4388600B2 (pt)
KR (1)	KR100487898B1 (pt)
CN (1)	CN1142939C (pt)
AT (1)	ATE218142T1 (pt)
AU (1)	AU719250B2 (pt)
BR (1)	BR9711586A (pt)
CA (1)	CA2267630C (pt)
DE (1)	DE69712900T2 (pt)
DK (1)	DK0929565T3 (pt)
ES (1)	ES2177952T3 (pt)
HU (1)	HUP9904149A3 (pt)
IT (1)	IT1285770B1 (pt)
PT (1)	PT929565E (pt)
RU (1)	RU2186781C2 (pt)
SI (1)	SI0929565T1 (pt)
WO (1)	WO1998015568A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824669A (en)	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1311922B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en)	2000-12-29	2002-07-03	Nicox S.A.	Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
AU2002331916B2 (en)	2001-10-03	2008-07-24	Merck Sharp & Dohme Corp.	Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it) *	2002-01-29	2003-07-29	Nicox Sa	Nuovi corticosteroidi
RU2261481C2 (ru) *	2003-03-26	2005-09-27	ФГУ Омская государственная медицинская академия	Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) *	2005-08-03	2009-07-15	中国人民解放军军事医学科学院毒物药物研究所	胆汁酸衍生物及其医药用途
EP1940863B1 (en) *	2005-09-02	2012-09-05	Nicox S.A.	Nitrooxy derivatives of glucocorticoids
US8802726B2 (en)	2006-02-03	2014-08-12	Nicox S.A.	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) *	2006-05-15	2011-02-22	Janssen Pharmaceutica Nv	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009008334A (es) *	2007-02-05	2009-08-12	Nicox Sa	Esteroides que liberan oxido nitrico.
EP2205248A2 (en) *	2007-08-10	2010-07-14	Nicox S.A.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) *	2007-08-31	2009-04-02	Topigen Pharmaceuticals Inc.	No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
AU2009277381B2 (en) *	2008-07-31	2014-04-24	Nicox S.A.	Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
JP2011529933A (ja)	2008-08-05	2011-12-15	ニコックスエスエイ	網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド
CN102186874A (zh) *	2008-08-05	2011-09-14	尼科克斯公司	新的释放no的类固醇衍生物
WO2011132171A1 (en)	2010-04-23	2011-10-27	Piramal Life Sciences Limited	Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh) *	2010-06-07	2012-10-03	刘超	糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
US9844599B2 (en)	2013-01-21	2017-12-19	Apparao Satyam	Nitric oxide releasing produgs of therapeutic agents
CN108191938B (zh) *	2018-01-11	2019-07-05	湖南新合新生物医药有限公司	9,11烯烃甾族化合物的制备方法
CN113069460B (zh) *	2021-03-24	2022-02-08	兰州大学	哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2990401A (en) *	1958-06-18	1961-06-27	American Cyanamid Co	11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (pt) *	1963-05-01
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
US3494941A (en) *	1967-12-04	1970-02-10	American Home Prod	Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (pt) *	1971-05-07	1973-12-28
NZ177056A (en) *	1974-03-27	1978-09-20	Plurichemie Anstalt	Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
CA1058161A (en) *	1975-09-08	1979-07-10	Ravi K. Varma	3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF
IT1256345B (it)	1992-08-20	1995-12-01		Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en)	1993-10-05	1995-10-10	Regents Of The University Of Minnesota	Spirovesamicols
WO1995009831A1 (en)	1993-10-06	1995-04-13	Nicox S.A.	Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
BR9507634A (pt)	1994-05-10	1997-09-23	Nicox Sa	Compostos ou suas composições e uso dos mesmos
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei

1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
1997
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 EP EP97910409A patent/EP0929565B1/en not_active Expired - Lifetime
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
2006
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP9904149A3 (en)	2001-03-28
IT1285770B1 (it)	1998-06-18
DK0929565T3 (da)	2002-09-09
US7056905B2 (en)	2006-06-06
DE69712900D1 (de)	2002-07-04
ATE218142T1 (de)	2002-06-15
JP2001501637A (ja)	2001-02-06
WO1998015568A3 (en)	1998-06-18
US20060270644A1 (en)	2006-11-30
JP4388600B2 (ja)	2009-12-24
US6610676B1 (en)	2003-08-26
KR100487898B1 (ko)	2005-05-09
HUP9904149A2 (hu)	2000-04-28
RU2186781C2 (ru)	2002-08-10
KR20000048911A (ko)	2000-07-25
EP0929565A2 (en)	1999-07-21
EP0929565B1 (en)	2002-05-29
US20050004089A1 (en)	2005-01-06
US20060154905A1 (en)	2006-07-13
DE69712900T2 (de)	2002-12-12
US20060160780A1 (en)	2006-07-20
US7157450B2 (en)	2007-01-02
ES2177952T3 (es)	2002-12-16
CA2267630C (en)	2008-01-08
PT929565E (pt)	2002-10-31
ITMI962048A1 (it)	1998-04-04
US7605151B2 (en)	2009-10-20
US7160871B2 (en)	2007-01-09
CN1253563A (zh)	2000-05-17
CN1142939C (zh)	2004-03-24
WO1998015568A2 (en)	1998-04-16
US20060160781A1 (en)	2006-07-20
US7205288B2 (en)	2007-04-17
US7368442B2 (en)	2008-05-06
SI0929565T1 (en)	2002-08-31
US20080234242A1 (en)	2008-09-25
AU4780397A (en)	1998-05-05
CA2267630A1 (en)	1998-04-16
US7196075B2 (en)	2007-03-27
AU719250B2 (en)	2000-05-04
US20070161612A1 (en)	2007-07-12

Publication	Publication Date	Title
BR9711586A (pt)	1999-08-24	Compostos e uso dos mesmo
DK1109812T3 (da)	2005-09-05	Pyrrolobenzodiazepiner
UY34152A (es)	2013-02-28	?oxazolidinonas substituidas y su uso?.
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
CY1108610T1 (el)	2014-04-09	Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
BR9611175A (pt)	1999-03-30	Compostos ou suas composições e uso dos mesmo
DE59709414D1 (de)	2003-04-03	Oxyiminopregnancarbolactone
AR010062A1 (es)	2000-05-17	Nuevos benzamidaldehidos y su utilizacion
BR9707501A (pt)	1999-07-27	Composto composição farmacêutica e uso do composto
DE69021501D1 (de)	1995-09-14	Anti-entzündende 4-aminophenol-derivate.
BR9707808A (pt)	1999-07-27	Composto composição farmacêutica e uso do composto
RU95101375A (ru)	1996-11-20	Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, их получение и применение в терапии
ATE203519T1 (de)	2001-08-15	Chinolinderivate als antimalariamittel
IS4367A (is)	1996-09-30	CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
BR9612413A (pt)	1999-07-13	Composto uso do mesmo e composição farmacêutica
DE69616074D1 (de)	2001-11-22	Ara-c derivate
BG100248A (bg)	1996-07-31	Инхибитори на скваленсинтетаза
DK1073447T3 (da)	2007-09-03	N1-modificerede glycopeptider
TR199701298T1 (xx)	1998-02-21	Tetralinler.
AR002978A1 (es)	1998-05-27	Compuestos benzamidas, composiciones farmacéuticasque los contienen, metodos para preparar los mismos y el uso de los mismos.
UY24915A1 (es)	2000-12-29	Derivados de benzoxazindiona, aplicación de los mismos y medicamentos que los contienen
BR9509055A (pt)	1998-06-23	Imidazoloquinoxalinona uso da mesma e composiçao farmacêutica
ES2158441T3 (es)	2001-09-01	Arilheterociclos con actividad herbicida.
FI963102L (fi)	1996-08-06	1,3,2-bentsoditiatsoli-1-oksidien käyttö mikrobiosideina teknisten materiaalien suojaamiseksi sekä määrätyt 1,3-bentsoditiatsoli-1-oksidit
ITGE920115A1 (it)	1994-05-04	Uso di 4 -isopropilbenzilsalicilato come antilipoperossidante cutaneo.

Legal Events

Date	Code	Title	Description
2006-10-03	B25G	Requested change of headquarter approved	Owner name: NICOX S.A. (FR) Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS NA PETICAO NO 020050046572/RJ DE 06/06/2005.
2007-09-18	B25G	Requested change of headquarter approved	Owner name: NICOX S.A. (FR) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070016104/RJ DE 07/02/2007.
2008-09-30	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2010-01-05	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2010-07-13	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 13 DA LPI.
2011-01-11	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.