BR9611175A - Compostos ou suas composições e uso dos mesmo - Google Patents

Compostos ou suas composições e uso dos mesmo

Info

Publication number: BR9611175A
Authority: BR; Brazil
Prior art keywords: pct; compositions; compounds; sec; date
Prior art date: 1995-10-31

Application number

BR9611175A

Other languages

English (en)

Other versions

BR9611175B1 (pt

Inventor

Piero Del Soldato

Francesso Sannicolo

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-31

Filing date

1996-10-29

Publication date

1999-03-30

1996-10-29 Application filed by Nicox Sa filed Critical Nicox Sa

1999-03-30 Publication of BR9611175A publication Critical patent/BR9611175A/pt

2009-01-13 Publication of BR9611175B1 publication Critical patent/BR9611175B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI9611175-5A 1995-10-31 1996-10-29 compostos e composiÇÕes farmacÊuticas. BR9611175B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI002263A IT1276071B1 (it)	1995-10-31	1995-10-31	Compositi ad attivita' anti-infiammatoria
PCT/EP1996/004696 WO1997016405A1 (en)	1995-10-31	1996-10-29	New compounds and their compositions having anti-inflammatory and anti-thrombotic activities

Publications (2)

Publication Number	Publication Date
BR9611175A true BR9611175A (pt)	1999-03-30
BR9611175B1 BR9611175B1 (pt)	2009-01-13

Family

ID=11372460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9611175-5A BR9611175B1 (pt)	1995-10-31	1996-10-29	compostos e composiÇÕes farmacÊuticas.

Country Status (18)

Country	Link
US (1)	US6040341A (pt)
EP (1)	EP0871606B1 (pt)
JP (1)	JP3880067B2 (pt)
KR (1)	KR100546038B1 (pt)
AT (1)	ATE193883T1 (pt)
AU (1)	AU709338B2 (pt)
BR (1)	BR9611175B1 (pt)
CA (1)	CA2235996C (pt)
DE (1)	DE69608916T2 (pt)
DK (1)	DK0871606T3 (pt)
ES (1)	ES2148808T3 (pt)
GR (1)	GR3033827T3 (pt)
HU (1)	HUP9802986A3 (pt)
IT (1)	IT1276071B1 (pt)
PT (1)	PT871606E (pt)
RU (1)	RU2165921C2 (pt)
SI (1)	SI0871606T1 (pt)
WO (1)	WO1997016405A1 (pt)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
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US6043232A (en) *	1997-07-23	2000-03-28	Nitromed, Inc.	Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
US7115661B1 (en)	1999-12-29	2006-10-03	Queen's University At Kingston	Methods and compositions for mitigating pain
US20050137191A1 (en) *	1996-06-04	2005-06-23	Thatcher Gregory R.	Nitrate esters and their use for mitigating cellular damage
US20040082652A1 (en) *	1996-09-04	2004-04-29	Nicox S.A.	Nitric ester derivatives and their use in treating gastrointestinal tumors
IT1288123B1 (it) *	1996-09-04	1998-09-10	Nicox Sa	Uso di nitroderivati per l'incontinenza urinaria
GB9801398D0 (en)	1998-01-22	1998-03-18	Anggard Erik E	Chemical compounds
WO1999045913A1 (en) *	1998-03-13	1999-09-16	Merck & Co., Inc.	Combination therapy and composition for acute coronary ischemic syndrome and related conditions
US6136804A (en)	1998-03-13	2000-10-24	Merck & Co., Inc.	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
ES2136581B1 (es)	1998-05-27	2000-09-16	Uriach & Cia Sa J	Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
EP1085845A2 (en) *	1998-06-08	2001-03-28	Advanced Medicine, Inc.	Multibinding inhibitors of cyclooxygenase-2
AU760735B2 (en) *	1998-09-28	2003-05-22	Merck & Co., Inc.	A method for treating inflammatory diseases by administering a thrombin inhibitor
JP2002528495A (ja)	1998-10-30	2002-09-03	ニトロメドインコーポレーテッド	ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
IT1307928B1 (it) *	1999-01-26	2001-11-29	Nicox Sa	Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
IT1308633B1 (it) *	1999-03-02	2002-01-09	Nicox Sa	Nitrossiderivati.
IT1311924B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
US6509377B1 (en) *	1999-05-26	2003-01-21	J. Uriach & Cia, S.A.	Use of a 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-κB
IT1312115B1 (it) *	1999-06-24	2002-04-04	Nicox Sa	Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it) *	1999-07-09	2001-01-09	Nicox Sa	Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
IT1313596B1 (it)	1999-08-04	2002-09-09	Nicox Sa	Processo per la preparazione di nitrossialchil esteri del naproxene
EP1246621A4 (en)	1999-12-23	2004-11-24	Nitromed Inc	NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE
US6538033B2 (en) *	2000-08-29	2003-03-25	Huntington Medical Research Institutes	Nitric oxide donor compounds
IT1319201B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per il diabete.
IT1319202B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per le malattie a base infiammatoria.
EP1406609B1 (en) *	2000-12-21	2006-09-06	Nitromed, Inc.	Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
GB0111872D0 (en) *	2001-05-15	2001-07-04	Northwick Park Inst For Medica	Therapeutic agents and methods
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011240A1 (it) *	2001-06-13	2002-12-13	Nicox Sa	Farmaci per le vasculopatie
ITMI20011307A1 (it) *	2001-06-21	2002-12-21	Nicox Sa	Farmaci per l'epilessia
ITMI20011308A1 (it)	2001-06-21	2002-12-21	Nicox Sa	Farmaci per il dolore cronico
US7968605B2 (en) *	2002-02-04	2011-06-28	ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) *	2002-02-04	2008-01-31	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
CA2475209A1 (en)	2002-02-04	2003-08-14	Alfama - Investigacao E Desenvolvimento De Produtos Farmaceuticos Lda.	Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US20050215611A1 (en) *	2002-05-10	2005-09-29	Hunt Richard H	Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
EP1505985A1 (en) *	2002-05-10	2005-02-16	Merck & Co., Inc.	Combination therapy for treating cyclooxygenase-2 mediated diseases in patients at risk of thrombotic cardiovascular events
JP2006501161A (ja) *	2002-06-11	2006-01-12	ニトロメッドインク．	ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
AU2003247622A1 (en)	2002-06-27	2004-01-19	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005535642A (ja) *	2002-06-28	2005-11-24	ニトロメッドインコーポレーティッド	オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
JP2005539089A (ja) *	2002-07-03	2005-12-22	ニトロメッドインコーポレーティッド	ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
WO2004011421A1 (en)	2002-07-26	2004-02-05	Merck Frosst Canada & Co.	Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
WO2004010945A2 (en) *	2002-07-29	2004-02-05	Nitromed, Inc.	Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) *	2002-08-29	2004-02-29	Nicox Sa	Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
EP1558559A1 (en) *	2002-09-20	2005-08-03	Nicox S.A.	Manufacturing process for no-donating compounds such as no-donating diclofenac
US20060247216A1 (en) *	2002-10-25	2006-11-02	Haj-Yehia Abdullah I	Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) *	2002-11-20	2005-09-14	Northwick Park Inst For Medica	Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
ITMI20022658A1 (it) *	2002-12-17	2004-06-18	Nicox Sa	Farmaci per il dolore cronico.
US20070207217A1 (en) *	2003-02-03	2007-09-06	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en)	2003-05-27	2007-01-23	Nicox S.A.	Statin derivatives
US7169805B2 (en)	2003-05-28	2007-01-30	Nicox S.A.	Captopril derivatives
EP1635816B1 (en)	2003-06-19	2009-03-04	NicOx S.A.	Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases
EP1709155B1 (en) *	2003-12-31	2013-10-02	Chesterford Enterprises Limited	Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
JP5198063B2 (ja)	2004-08-26	2013-05-15	アッパラオ・サティアム	新規バイオ開裂性リンカー
TW200616604A (en)	2004-08-26	2006-06-01	Nicholas Piramal India Ltd	Nitric oxide releasing prodrugs containing bio-cleavable linker
US7521435B2 (en) *	2005-02-18	2009-04-21	Pharma Diagnostics, N.V.	Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
DE602006017724D1 (de)	2005-11-23	2010-12-02	Nicox Sa	Salicylsäurederivate
GB0601394D0 (en)	2006-01-24	2006-03-01	Hemocorm Ltd	Therapeutic delivery of carbon monoxide
JP2007275193A (ja) *	2006-04-04	2007-10-25	Fujifilm Corp	光プローブおよび光断層画像化装置
PL2180788T3 (pl) *	2007-08-10	2017-06-30	Basil Rigas	Związki przeciwzapalne i ich zastosowanie
WO2010118968A1 (en)	2009-04-16	2010-10-21	Nicox S.A.	No-donor aspirin derivatives
WO2011160974A2 (en)	2010-06-21	2011-12-29	Nicox S.A.	Statin derivatives
PT2699242T (pt)	2011-04-19	2018-01-22	Alfama Inc	Moléculas de libertação de monóxido de carbono e utilizações das mesmas
EP2734235B1 (en)	2011-07-21	2017-03-22	Alfama, Inc.	Ruthenium carbon monoxide releasing molecules and uses thereof
US9844599B2 (en)	2013-01-21	2017-12-19	Apparao Satyam	Nitric oxide releasing produgs of therapeutic agents
US20140271923A1 (en)	2013-03-14	2014-09-18	Christopher Brian Reid	Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
CN117843491A (zh) *	2023-12-29	2024-04-09	陕西中医药大学	4-(2-(硝基氧基)乙基)-1,2-亚苯基二乙酸酯及其合成方法、应用和药物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256450B (it) *	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
CA2173582C (en) *	1993-10-06	2006-11-28	Piero Del Soldato	Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
DE69512232T2 (de) *	1994-05-10	2000-02-24	Nicox S.A., Paris	Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria

1995
- 1995-10-31 IT IT95MI002263A patent/IT1276071B1/it active IP Right Grant
1996
- 1996-10-29 AT AT96937282T patent/ATE193883T1/de not_active IP Right Cessation
- 1996-10-29 CA CA002235996A patent/CA2235996C/en not_active Expired - Fee Related
- 1996-10-29 US US09/066,344 patent/US6040341A/en not_active Expired - Fee Related
- 1996-10-29 RU RU98110565/04A patent/RU2165921C2/ru not_active IP Right Cessation
- 1996-10-29 DK DK96937282T patent/DK0871606T3/da active
- 1996-10-29 PT PT96937282T patent/PT871606E/pt unknown
- 1996-10-29 ES ES96937282T patent/ES2148808T3/es not_active Expired - Lifetime
- 1996-10-29 JP JP51706097A patent/JP3880067B2/ja not_active Expired - Fee Related
- 1996-10-29 AU AU74950/96A patent/AU709338B2/en not_active Ceased
- 1996-10-29 KR KR1019980703206A patent/KR100546038B1/ko not_active Expired - Fee Related
- 1996-10-29 EP EP96937282A patent/EP0871606B1/en not_active Expired - Lifetime
- 1996-10-29 SI SI9630170T patent/SI0871606T1/xx unknown
- 1996-10-29 HU HU9802986A patent/HUP9802986A3/hu unknown
- 1996-10-29 DE DE69608916T patent/DE69608916T2/de not_active Expired - Fee Related
- 1996-10-29 BR BRPI9611175-5A patent/BR9611175B1/pt not_active IP Right Cessation
- 1996-10-29 WO PCT/EP1996/004696 patent/WO1997016405A1/en not_active Ceased
2000
- 2000-06-30 GR GR20000401528T patent/GR3033827T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9611175B1 (pt)	2009-01-13
GR3033827T3 (en)	2000-10-31
DK0871606T3 (da)	2000-07-31
ITMI952263A0 (pt)	1995-10-31
KR100546038B1 (ko)	2006-10-04
PT871606E (pt)	2000-11-30
ATE193883T1 (de)	2000-06-15
SI0871606T1 (en)	2000-08-31
RU2165921C2 (ru)	2001-04-27
HUP9802986A2 (hu)	1999-04-28
WO1997016405A1 (en)	1997-05-09
EP0871606B1 (en)	2000-06-14
ITMI952263A1 (it)	1997-05-01
CA2235996C (en)	2007-01-02
DE69608916D1 (de)	2000-07-20
HUP9802986A3 (en)	1999-12-28
CA2235996A1 (en)	1997-05-09
US6040341A (en)	2000-03-21
EP0871606A1 (en)	1998-10-21
ES2148808T3 (es)	2000-10-16
DE69608916T2 (de)	2001-01-11
KR19990067247A (ko)	1999-08-16
IT1276071B1 (it)	1997-10-24
JP3880067B2 (ja)	2007-02-14
JPH11514636A (ja)	1999-12-14
AU7495096A (en)	1997-05-22
AU709338B2 (en)	1999-08-26

Publication	Publication Date	Title
BR9611175A (pt)	1999-03-30	Compostos ou suas composições e uso dos mesmo
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
BG103251A (bg)	2000-02-29	Оксадиазоли, методи за получаването им и приложението им като лекарствени средства
TR199901471T2 (xx)	1999-10-21	Pestisidal 1-aril ve piridilpirazol t�revleri.
ATE269850T1 (de)	2004-07-15	3-thiocarbamoylpyrazol-derivate als pestiziden
IL124674A0 (en)	1998-12-06	Piperazine derivatives pharmaceutical compositions containing the same and use thereof
ES2157993T3 (es)	2001-09-01	Benzoilguanidinas, su preparacion y su uso en medicamentos.
DK0695171T3 (da)	1997-06-02	Lyosfærer indeholdende gonadotropin
BG103399A (en)	2000-01-31	New heterocycle-substituted benzamides and their application for the treatment of diseases
ITMI931780A1 (it)	1995-02-05	Tropil 7-azaindolil-3-carbossiamidi
ATE126215T1 (de)	1995-08-15	Anti-entzündende 4-aminophenol-derivate.
IT1285770B1 (it)	1998-06-18	Composti corticoidei
FI973221A0 (fi)	1997-08-04	1-aryyli-2-asyyliammo-etaaniyhdisteitä ja niiden käyttö neurokiniiniantagonisteina, erityisesti neurokiniini 1 antagonisteina
RU95101375A (ru)	1996-11-20	Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, их получение и применение в терапии
MX9601112A (es)	1997-06-28	Nuevas composiciones herbicidas.
KR960703863A (ko)	1996-08-31	암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
MX9203100A (es)	1993-07-01	Nuevos peptidos, su preparacion y su aplicacion.
BG104232A (bg)	2000-10-31	Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
SE9504662D0 (sv)	1995-12-22	New compounds
TR199701298T1 (xx)	1998-02-21	Tetralinler.
ATE149159T1 (de)	1997-03-15	Heteroarylmethylbenzole-aromatasehemmer
TR200001122T2 (tr)	2000-08-21	Farmasötikler olarak bifenil türevleri.
BR9808210A (pt)	2000-05-16	Befeniloxazolinas dissubstituìdas
TR199800958A2 (xx)	1998-12-21	Herbisidal 3,5-Difloropridinleri.
NO301639B1 (no)	1997-11-24	Chinolinforbindelser og deres anvendelse

Legal Events

Date	Code	Title	Description
2002-04-23	FB36	Technical and formal requirements: requirement - article 36 of industrial property law
2005-10-25	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2006-04-18	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2006-08-08	B25G	Requested change of headquarter approved	Owner name: NICOX S.A. (FR) Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS NA PETICAO NO 020050046572/RJ DE 06/06/05.
2006-10-17	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PRESENTE PEDIDO POR NAO ATENDER AO DISPOSTO NOS ARTIGOS 24 E 25 DA LPI 9.279/96
2007-01-23	B12B	Appeal against refusal [chapter 12.2 patent gazette]
2007-06-26	B25G	Requested change of headquarter approved	Owner name: NICOX S.A. (FR) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070016104/RJ DE 07/02/2007.
2008-09-30	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2008-10-21	B09Y	Publication of grant cancelled [chapter 9.1.2 patent gazette]	Free format text: REFERENTE A RPI NO 1969 DE 30/09/2008
2009-03-10	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2009, OBSERVADAS AS CONDICOES LEGAIS.
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