PT929565E - Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas - Google Patents

Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas

Info

Publication number: PT929565E
Authority: PT; Portugal
Prior art keywords: pharmaceutical applications; nitrate esters; compounds; corticoid compounds; corticoid
Prior art date: 1996-10-04

Application number

PT97910409T

Other languages

English (en)

Inventor

Piero Del Soldato

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-04

Filing date

1997-10-02

Publication date

2002-10-31

1997-10-02 Application filed by Nicox Sa filed Critical Nicox Sa

2002-10-31 Publication of PT929565E publication Critical patent/PT929565E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT97910409T 1996-10-04 1997-10-02 Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas PT929565E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96MI002048A IT1285770B1 (it)	1996-10-04	1996-10-04	Composti corticoidei

Publications (1)

Publication Number	Publication Date
PT929565E true PT929565E (pt)	2002-10-31

Family

ID=11374972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97910409T PT929565E (pt)	1996-10-04	1997-10-02	Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas

Country Status (18)

Country	Link
US (8)	US6610676B1 (pt)
EP (1)	EP0929565B1 (pt)
JP (1)	JP4388600B2 (pt)
KR (1)	KR100487898B1 (pt)
CN (1)	CN1142939C (pt)
AT (1)	ATE218142T1 (pt)
AU (1)	AU719250B2 (pt)
BR (1)	BR9711586A (pt)
CA (1)	CA2267630C (pt)
DE (1)	DE69712900T2 (pt)
DK (1)	DK0929565T3 (pt)
ES (1)	ES2177952T3 (pt)
HU (1)	HUP9904149A3 (pt)
IT (1)	IT1285770B1 (pt)
PT (1)	PT929565E (pt)
RU (1)	RU2186781C2 (pt)
SI (1)	SI0929565T1 (pt)
WO (1)	WO1998015568A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5824669A (en)	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei
IT1311922B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) *	2000-12-22	2003-11-26	Nicox Sa	Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en)	2000-12-29	2002-07-03	Nicox S.A.	Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en)	2001-05-22	2004-02-24	Nicox-S.A.	Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
AU2002331916B2 (en)	2001-10-03	2008-07-24	Merck Sharp & Dohme Corp.	Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it) *	2002-01-29	2003-07-29	Nicox Sa	Nuovi corticosteroidi
RU2261481C2 (ru) *	2003-03-26	2005-09-27	ФГУ Омская государственная медицинская академия	Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) *	2005-08-03	2009-07-15	中国人民解放军军事医学科学院毒物药物研究所	胆汁酸衍生物及其医药用途
EP1940863B1 (en) *	2005-09-02	2012-09-05	Nicox S.A.	Nitrooxy derivatives of glucocorticoids
US8802726B2 (en)	2006-02-03	2014-08-12	Nicox S.A.	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) *	2006-05-15	2011-02-22	Janssen Pharmaceutica Nv	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009008334A (es) *	2007-02-05	2009-08-12	Nicox Sa	Esteroides que liberan oxido nitrico.
EP2205248A2 (en) *	2007-08-10	2010-07-14	Nicox S.A.	Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) *	2007-08-31	2009-04-02	Topigen Pharmaceuticals Inc.	No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
AU2009277381B2 (en) *	2008-07-31	2014-04-24	Nicox S.A.	Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
JP2011529933A (ja)	2008-08-05	2011-12-15	ニコックスエスエイ	網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド
CN102186874A (zh) *	2008-08-05	2011-09-14	尼科克斯公司	新的释放no的类固醇衍生物
WO2011132171A1 (en)	2010-04-23	2011-10-27	Piramal Life Sciences Limited	Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh) *	2010-06-07	2012-10-03	刘超	糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
US9844599B2 (en)	2013-01-21	2017-12-19	Apparao Satyam	Nitric oxide releasing produgs of therapeutic agents
CN108191938B (zh) *	2018-01-11	2019-07-05	湖南新合新生物医药有限公司	9,11烯烃甾族化合物的制备方法
CN113069460B (zh) *	2021-03-24	2022-02-08	兰州大学	哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2990401A (en) *	1958-06-18	1961-06-27	American Cyanamid Co	11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (pt) *	1963-05-01
US3183252A (en) *	1963-09-05	1965-05-11	Syntex Corp	16-nitratoalkyl-pregnanes
US3494941A (en) *	1967-12-04	1970-02-10	American Home Prod	Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (pt) *	1971-05-07	1973-12-28
NZ177056A (en) *	1974-03-27	1978-09-20	Plurichemie Anstalt	Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
CA1058161A (en) *	1975-09-08	1979-07-10	Ravi K. Varma	3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF
IT1256345B (it)	1992-08-20	1995-12-01		Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en)	1993-10-05	1995-10-10	Regents Of The University Of Minnesota	Spirovesamicols
WO1995009831A1 (en)	1993-10-06	1995-04-13	Nicox S.A.	Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
BR9507634A (pt)	1994-05-10	1997-09-23	Nicox Sa	Compostos ou suas composições e uso dos mesmos
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) *	1996-05-02	1998-11-17	G. D. Searle & Co.	Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) *	1996-05-02	1999-11-16	G.D. Searle & Co.	Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) *	1996-10-04	1998-06-18	Nicox Sa	Composti corticoidei

1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
1997
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 EP EP97910409A patent/EP0929565B1/en not_active Expired - Lifetime
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
2006
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP9904149A3 (en)	2001-03-28
IT1285770B1 (it)	1998-06-18
DK0929565T3 (da)	2002-09-09
US7056905B2 (en)	2006-06-06
DE69712900D1 (de)	2002-07-04
ATE218142T1 (de)	2002-06-15
JP2001501637A (ja)	2001-02-06
WO1998015568A3 (en)	1998-06-18
US20060270644A1 (en)	2006-11-30
JP4388600B2 (ja)	2009-12-24
US6610676B1 (en)	2003-08-26
KR100487898B1 (ko)	2005-05-09
HUP9904149A2 (hu)	2000-04-28
RU2186781C2 (ru)	2002-08-10
KR20000048911A (ko)	2000-07-25
EP0929565A2 (en)	1999-07-21
EP0929565B1 (en)	2002-05-29
US20050004089A1 (en)	2005-01-06
US20060154905A1 (en)	2006-07-13
DE69712900T2 (de)	2002-12-12
US20060160780A1 (en)	2006-07-20
US7157450B2 (en)	2007-01-02
ES2177952T3 (es)	2002-12-16
CA2267630C (en)	2008-01-08
ITMI962048A1 (it)	1998-04-04
US7605151B2 (en)	2009-10-20
US7160871B2 (en)	2007-01-09
CN1253563A (zh)	2000-05-17
CN1142939C (zh)	2004-03-24
WO1998015568A2 (en)	1998-04-16
US20060160781A1 (en)	2006-07-20
US7205288B2 (en)	2007-04-17
US7368442B2 (en)	2008-05-06
SI0929565T1 (en)	2002-08-31
US20080234242A1 (en)	2008-09-25
AU4780397A (en)	1998-05-05
CA2267630A1 (en)	1998-04-16
US7196075B2 (en)	2007-03-27
AU719250B2 (en)	2000-05-04
BR9711586A (pt)	1999-08-24
US20070161612A1 (en)	2007-07-12

Publication	Publication Date	Title
PT929565E (pt)	2002-10-31	Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas
WO1996032003A3 (en)	1997-01-03	Tetrahydroimidazopyridoindolediones and their use as medicaments
DK1193270T3 (da)	2003-09-15	Pyrrolobenzodiazepiner
ATE233274T1 (de)	2003-03-15	Oxyiminopregnancarbolactone
DK0425650T3 (da)	1995-12-27	Antiinflammatoriske 4-aminophenolderivater
BR1100860A (pt)	1999-08-31	Composto, droga antiinflamatória, composição farmacêutica, epìmero r e epìmero s do composto
MY111201A (en)	1999-09-30	New imidazopyridines
NO965516D0 (no)	1996-12-20	Sterolderivater anvendt til regulering av meiose
ATE245977T1 (de)	2003-08-15	Therapeutische substituierte guanidine
ES2150152T3 (es)	2000-11-16	Nuevos derivados de esteres de nitrito/nitrato esteroideos utiles como farmacos antiinflamatorios.
BG103219A (bg)	1999-10-29	Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие
ES2172937T3 (es)	2002-10-01	21-hidroxi-6,19-oxidoprogesterona(21oh-6op) como medicamento para tratar el exceso de glucocorticoides.
SE9801494D0 (sv)	1998-04-28	Novel use
PT736029E (pt)	2006-05-31	Sulfamatos de pseudofructopiranose anticonvulsivos
FI960658A0 (fi)	1996-02-14	Uudet bis-naftalimidit syövän hoitamiseksi
TR199900662T2 (xx)	1999-06-21	1-Hidroksi-2-piridonlar�n seborik dermatit tedavisi amac�yla kullan�m�
ES2118248T3 (es)	1998-09-16	Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
TR199701298T1 (xx)	1998-02-21	Tetralinler.
ATE270551T1 (de)	2004-07-15	Kombinationspräparat aus 2-methylthiazolidin-2,4- dicarbonsäure und paracetamol
FR2355846A1 (fr)	1978-01-20	Esters de penicillines utilisables comme medicaments
ES2134971T3 (es)	1999-10-16	Derivado de acido octahidro-2-naftaleno-carboxilico, su produccion y uso.
EP0729950A4 (en)	2001-02-07	ANTI-HIV MEDICINAL PRODUCTS
FI911616A0 (fi)	1991-04-04	Substituerade 3-tia- eller 3-oxa-alkyl -flavoner, foerfarande foer deras framstaellning, deras anvaendning, pao dessa foereningar baserade laekemedel samt mellanprodukter.
DK0779075T3 (da)	2002-02-18	Anvendelse af 3-alpha-hydroxy-5-alpha-androsta-16-en som lægemidler
SE8704049D0 (sv)	1987-10-16	Novel pharmacological compounds