BR9710918A - Método de tratamento ou redução de isquemia de miocárdio ou doença arteriocoronária ou acidentes cardiovasculares e uso de progesterona e polìmero de ácido mpolicarboxìlico de ligação cruzada. - Google Patents
Método de tratamento ou redução de isquemia de miocárdio ou doença arteriocoronária ou acidentes cardiovasculares e uso de progesterona e polìmero de ácido mpolicarboxìlico de ligação cruzada.Info
- Publication number
- BR9710918A BR9710918A BR9710918-5A BR9710918A BR9710918A BR 9710918 A BR9710918 A BR 9710918A BR 9710918 A BR9710918 A BR 9710918A BR 9710918 A BR9710918 A BR 9710918A
- Authority
- BR
- Brazil
- Prior art keywords
- progesterone
- disease
- arteriocoronary
- treatment
- cross
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 10
- 239000000186 progesterone Substances 0.000 title abstract 5
- 229960003387 progesterone Drugs 0.000 title abstract 5
- 230000002526 effect on cardiovascular system Effects 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000031225 myocardial ischemia Diseases 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 208000028867 ischemia Diseases 0.000 abstract 3
- 239000000583 progesterone congener Substances 0.000 abstract 2
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
<B>MéTODO DE TRATAMENTO OU REDUçãO DE ISQUEMIA DE MIOCáRDIO OU DOENçA ARTERIOCORONáRIA OU ACIDENTES CARDIOVASCULARES E USO DE PROGESTERONA E POLìMERO DE áCIDO POLICARBOXìLICO DE LIGAçãO CRUZADA<D>. A presente invenção compreende a administração de progesterona para tratar ou reduzir isquemia ou incidência de acidentes cardiovasculares, ou para tratar doença arterial coronária. Está demonstrado que a progesterona, à diferença das progestinas sintéticas, reduz a isquemia. Portanto, a progesterona, por exemplo, mas não as progestinas sintéticas, pode ser utilizadas em terapia de reposição de hormónio com efeitos positivos, e não negativos, no tratamento da isquemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/743,153 US5985861A (en) | 1996-11-04 | 1996-11-04 | Progesterone for treating or reducing ischemia |
| PCT/US1997/020923 WO1998019681A1 (en) | 1996-11-04 | 1997-11-04 | Progesterone for treating or reducing ischemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710918A true BR9710918A (pt) | 2000-01-11 |
Family
ID=24987712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710918-5A BR9710918A (pt) | 1996-11-04 | 1997-11-04 | Método de tratamento ou redução de isquemia de miocárdio ou doença arteriocoronária ou acidentes cardiovasculares e uso de progesterona e polìmero de ácido mpolicarboxìlico de ligação cruzada. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5985861A (pt) |
| EP (1) | EP0956023B1 (pt) |
| KR (1) | KR100434623B1 (pt) |
| CN (1) | CN100341512C (pt) |
| AR (1) | AR009407A1 (pt) |
| AT (1) | ATE321558T1 (pt) |
| AU (1) | AU715740C (pt) |
| BR (1) | BR9710918A (pt) |
| CA (1) | CA2270565C (pt) |
| DE (1) | DE69735598T2 (pt) |
| DK (1) | DK0956023T3 (pt) |
| ES (1) | ES2262196T3 (pt) |
| GE (1) | GEP20022630B (pt) |
| HU (1) | HUP9904045A3 (pt) |
| IL (1) | IL127455A (pt) |
| LV (1) | LV12342B (pt) |
| MA (1) | MA24391A1 (pt) |
| MY (1) | MY121627A (pt) |
| NO (1) | NO324278B1 (pt) |
| NZ (1) | NZ335306A (pt) |
| PE (1) | PE9899A1 (pt) |
| PT (1) | PT956023E (pt) |
| RO (1) | RO120607B1 (pt) |
| UA (1) | UA66772C2 (pt) |
| WO (1) | WO1998019681A1 (pt) |
| ZA (1) | ZA979862B (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6056972A (en) * | 1997-02-26 | 2000-05-02 | Dimera, Llc | Method for reducing coronary artery reactivity |
| US6602487B1 (en) | 1997-02-26 | 2003-08-05 | Dimera Incorporated | Methods and tests for producing and for inhibiting coronary artery vasospasms |
| DE69819748T2 (de) | 1997-09-12 | 2004-09-30 | Columbia Laboratories (Bermuda) Ltd. | Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen |
| US20040234606A1 (en) * | 1997-09-12 | 2004-11-25 | Levine Howard L. | Localized vaginal delivery without detrimental blood levels |
| GB0107383D0 (en) * | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
| US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US8425892B2 (en) | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US7572780B2 (en) | 2003-01-21 | 2009-08-11 | Dimera, Incorporated | Method and kit for reducing the symptoms of peripheral vascular disease |
| JP4898431B2 (ja) * | 2003-04-29 | 2012-03-14 | ザ ジェネラル ホスピタル コーポレイション | 複数薬物の持続放出のための方法およびデバイス |
| DE102005027004B4 (de) * | 2005-06-10 | 2020-03-19 | Continental Automotive Gmbh | Scheibenwaschvorrichtung |
| US8828981B2 (en) | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
| KR20100133969A (ko) * | 2008-02-04 | 2010-12-22 | 테바 위민즈 헬스 인코포레이티드 | 프로게스테론 함유 단일형 질내 링 및 그의 제조방법과 용도 |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| KR20170040209A (ko) | 2014-07-29 | 2017-04-12 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 경피 크림 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US11512107B2 (en) | 2018-09-07 | 2022-11-29 | Trustees Of Dartmouth College | Methods for assembly of tetracyclic compounds by stereoselective C9-C10 bond formation |
| AU2019335005A1 (en) | 2018-09-07 | 2021-03-18 | Trustees Of Dartmouth College | C19 scaffolds and steroids and methods of use and manufacture thereof |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| GB202316026D0 (en) * | 2023-10-19 | 2023-12-06 | Theramex Hq Uk Ltd | Methods of prevention or treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1124906A1 (ru) * | 1982-05-25 | 1984-11-23 | Ивановский государственный медицинский институт им.А.С.Бубнова | Способ коррекции ишемических повреждений консервированной донорской почки |
| JPH0830004B2 (ja) * | 1983-11-14 | 1996-03-27 | コロンビア ラボラトリーズ インコーポレイテッド | 生物接着性組成物およびそれにより治療する方法 |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
-
1996
- 1996-11-04 US US08/743,153 patent/US5985861A/en not_active Expired - Lifetime
-
1997
- 1997-11-03 MA MA24853A patent/MA24391A1/fr unknown
- 1997-11-03 ZA ZA9709862A patent/ZA979862B/xx unknown
- 1997-11-04 PE PE1997000985A patent/PE9899A1/es not_active Application Discontinuation
- 1997-11-04 AU AU51801/98A patent/AU715740C/en not_active Ceased
- 1997-11-04 ES ES97946681T patent/ES2262196T3/es not_active Expired - Lifetime
- 1997-11-04 WO PCT/US1997/020923 patent/WO1998019681A1/en not_active Ceased
- 1997-11-04 NZ NZ335306A patent/NZ335306A/xx not_active IP Right Cessation
- 1997-11-04 EP EP97946681A patent/EP0956023B1/en not_active Expired - Lifetime
- 1997-11-04 DK DK97946681T patent/DK0956023T3/da active
- 1997-11-04 UA UA99052985A patent/UA66772C2/uk unknown
- 1997-11-04 DE DE69735598T patent/DE69735598T2/de not_active Expired - Fee Related
- 1997-11-04 RO RO99-00508A patent/RO120607B1/ro unknown
- 1997-11-04 BR BR9710918-5A patent/BR9710918A/pt not_active Application Discontinuation
- 1997-11-04 PT PT97946681T patent/PT956023E/pt unknown
- 1997-11-04 KR KR10-1999-7003965A patent/KR100434623B1/ko not_active Expired - Fee Related
- 1997-11-04 HU HU9904045A patent/HUP9904045A3/hu unknown
- 1997-11-04 AT AT97946681T patent/ATE321558T1/de not_active IP Right Cessation
- 1997-11-04 GE GEAP19974830A patent/GEP20022630B/en unknown
- 1997-11-04 CA CA002270565A patent/CA2270565C/en not_active Expired - Fee Related
- 1997-11-04 CN CNB971994145A patent/CN100341512C/zh not_active Expired - Fee Related
- 1997-11-04 AR ARP970105144A patent/AR009407A1/es unknown
- 1997-11-04 MY MYPI97005220A patent/MY121627A/en unknown
-
1998
- 1998-12-09 IL IL12745598A patent/IL127455A/xx not_active IP Right Cessation
-
1999
- 1999-02-01 US US09/240,610 patent/US6054447A/en not_active Expired - Lifetime
- 1999-05-03 NO NO19992140A patent/NO324278B1/no unknown
- 1999-05-28 LV LVP-99-88A patent/LV12342B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADO DE INT.CL: A61K 31/57; A61K 31/565; A61P 9/10 Ipc: A61K 31/57 (2008.01), A61K 31/565 (2008.01), A61P |
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| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI |