BR9710758A - Inibidores da metaloprotease de tiol sulfona - Google Patents
Inibidores da metaloprotease de tiol sulfonaInfo
- Publication number
- BR9710758A BR9710758A BR9710758A BR9710758A BR9710758A BR 9710758 A BR9710758 A BR 9710758A BR 9710758 A BR9710758 A BR 9710758A BR 9710758 A BR9710758 A BR 9710758A BR 9710758 A BR9710758 A BR 9710758A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- metalloprotease inhibitors
- proteinase
- thiol
- sulfone
- Prior art date
Links
- -1 Thiol sulfone Chemical class 0.000 title abstract 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 abstract 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 3
- 102100027995 Collagenase 3 Human genes 0.000 abstract 2
- 108050005238 Collagenase 3 Proteins 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 102000011722 Matrix Metalloproteinase 13 Human genes 0.000 abstract 1
- 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 235000019419 proteases Nutrition 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Lubricants (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2204396P | 1996-07-22 | 1996-07-22 | |
| PCT/US1997/012874 WO1998003164A1 (en) | 1996-07-22 | 1997-07-22 | Thiol sulfone metalloprotease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9710758A true BR9710758A (pt) | 1999-08-17 |
Family
ID=21807522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9710758A BR9710758A (pt) | 1996-07-22 | 1997-07-22 | Inibidores da metaloprotease de tiol sulfona |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6013649A (pt) |
| EP (1) | EP0939628B1 (pt) |
| JP (1) | JP2001505869A (pt) |
| KR (1) | KR20000067963A (pt) |
| CN (1) | CN1230884A (pt) |
| AT (1) | ATE233552T1 (pt) |
| AU (1) | AU714687B2 (pt) |
| BR (1) | BR9710758A (pt) |
| CA (1) | CA2260859A1 (pt) |
| CZ (1) | CZ16799A3 (pt) |
| DE (1) | DE69719538T2 (pt) |
| DK (1) | DK0939628T3 (pt) |
| ES (1) | ES2194209T3 (pt) |
| IL (1) | IL128079A0 (pt) |
| NO (1) | NO990262L (pt) |
| NZ (1) | NZ333824A (pt) |
| PL (1) | PL331369A1 (pt) |
| PT (1) | PT939628E (pt) |
| RU (1) | RU2221781C2 (pt) |
| WO (1) | WO1998003164A1 (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) * | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| BR9814643A (pt) * | 1997-11-14 | 2000-10-03 | Searle & Co | Inibidor de metaloprotease de ácido sulfona hidroxâmico aromático |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| CA2344412A1 (en) | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Thiol compound, their production and use |
| US6288261B1 (en) * | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| AU766192B2 (en) * | 1999-01-27 | 2003-10-09 | Wyeth Holdings Corporation | Acetylenic sulfonamide thiol tace inhibitors |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6583299B1 (en) * | 1999-05-20 | 2003-06-24 | G.D. Searle & Co. | α-amino-β-sulfonyl hydroxamic acid compounds |
| US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| CZ20032913A3 (cs) | 2001-05-11 | 2004-05-12 | Pharmaciaácorporation | Aromatické sulfonhydroxamáty a jejich použití jako inhibitorů proteázy |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| JP2003081838A (ja) * | 2001-09-11 | 2003-03-19 | Rohto Pharmaceut Co Ltd | グルコサミン製剤 |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| DE10201392A1 (de) * | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| EP1501827A2 (en) * | 2002-04-25 | 2005-02-02 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acid and their use as protease inhibitors |
| CA2490646A1 (en) * | 2002-06-25 | 2003-12-31 | Pharmacia Corporation | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
| BR0317715A (pt) * | 2002-12-27 | 2005-11-22 | Angiotech Int Ag | Composições e processos de uso de collajolie |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| UY29223A1 (es) | 2004-11-23 | 2006-06-30 | Astrazeneca Ab | Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación |
| US8148572B2 (en) * | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
| CA2698928A1 (en) * | 2007-09-28 | 2009-04-09 | Absolute Science, Inc. | Compounds and methods for treating zinc matrix metalloprotease dependent diseases |
| US20110190285A1 (en) * | 2008-09-19 | 2011-08-04 | Absolute Science, Inc. | Methods of treating a botulinum toxin related condition in a subject |
| PL2442647T3 (pl) * | 2009-06-15 | 2016-09-30 | Związki ditiolowe, pochodne i ich zastosowania | |
| FR2950890B1 (fr) * | 2009-10-06 | 2011-12-30 | Tetrahedron | Procede de synthese de la 2-thiohistidine et analogues |
| GB201313238D0 (en) * | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| AU2018229277B2 (en) | 2017-02-28 | 2025-03-20 | Immunogen, Inc. | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| WO1993001169A2 (en) * | 1991-07-05 | 1993-01-21 | Merck Sharp & Dohme Limited | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5376664A (en) * | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| EP0720601B1 (en) * | 1993-08-10 | 2000-10-25 | James Black Foundation Limited | Gastrin and cck receptor ligands |
| JPH09511216A (ja) * | 1993-11-04 | 1997-11-11 | ザ リポソーム カンパニー、インコーポレーテッド | ユニラメラリポソーム性のアラキドン酸代謝物剤を用いる治療の方法 |
| GB9323162D0 (en) * | 1993-11-10 | 1994-01-05 | British Bio Technology | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| JP3787605B2 (ja) * | 1994-10-05 | 2006-06-21 | ダーウィン・ディスカバリー・リミテッド | ペプチジル化合物および金属プロテアーゼのインヒビターとしてのその治療的使用 |
| CN1198096A (zh) * | 1995-08-08 | 1998-11-04 | 菲布洛根有限公司 | 用于治疗与胶原蛋白过量产生有关的疾病的c－蛋白酶抑制剂 |
| KR19990072009A (ko) * | 1995-08-12 | 1999-09-27 | 게리 이. 프리드만 | 메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체 |
-
1997
- 1997-07-22 CN CN97198098A patent/CN1230884A/zh active Pending
- 1997-07-22 DK DK97936169T patent/DK0939628T3/da active
- 1997-07-22 CA CA002260859A patent/CA2260859A1/en not_active Abandoned
- 1997-07-22 AU AU38904/97A patent/AU714687B2/en not_active Ceased
- 1997-07-22 PL PL97331369A patent/PL331369A1/xx unknown
- 1997-07-22 WO PCT/US1997/012874 patent/WO1998003164A1/en not_active Ceased
- 1997-07-22 BR BR9710758A patent/BR9710758A/pt not_active IP Right Cessation
- 1997-07-22 US US08/900,028 patent/US6013649A/en not_active Expired - Fee Related
- 1997-07-22 CZ CZ99167A patent/CZ16799A3/cs unknown
- 1997-07-22 KR KR1019997000465A patent/KR20000067963A/ko not_active Ceased
- 1997-07-22 RU RU99103642/04A patent/RU2221781C2/ru not_active IP Right Cessation
- 1997-07-22 IL IL12807997A patent/IL128079A0/xx unknown
- 1997-07-22 JP JP50719698A patent/JP2001505869A/ja not_active Abandoned
- 1997-07-22 DE DE69719538T patent/DE69719538T2/de not_active Expired - Fee Related
- 1997-07-22 AT AT97936169T patent/ATE233552T1/de not_active IP Right Cessation
- 1997-07-22 ES ES97936169T patent/ES2194209T3/es not_active Expired - Lifetime
- 1997-07-22 NZ NZ333824A patent/NZ333824A/xx unknown
- 1997-07-22 PT PT97936169T patent/PT939628E/pt unknown
- 1997-07-22 EP EP97936169A patent/EP0939628B1/en not_active Expired - Lifetime
-
1999
- 1999-01-21 NO NO990262A patent/NO990262L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0939628A1 (en) | 1999-09-08 |
| DE69719538D1 (en) | 2003-04-10 |
| AU3890497A (en) | 1998-02-10 |
| US6013649A (en) | 2000-01-11 |
| NZ333824A (en) | 2000-08-25 |
| KR20000067963A (ko) | 2000-11-25 |
| JP2001505869A (ja) | 2001-05-08 |
| PT939628E (pt) | 2003-07-31 |
| EP0939628A4 (en) | 1999-12-22 |
| EP0939628B1 (en) | 2003-03-05 |
| AU714687B2 (en) | 2000-01-06 |
| NO990262D0 (no) | 1999-01-21 |
| RU2221781C2 (ru) | 2004-01-20 |
| DK0939628T3 (da) | 2003-07-07 |
| IL128079A0 (en) | 1999-11-30 |
| CZ16799A3 (cs) | 1999-06-16 |
| DE69719538T2 (de) | 2004-02-19 |
| PL331369A1 (en) | 1999-07-05 |
| NO990262L (no) | 1999-03-17 |
| WO1998003164A1 (en) | 1998-01-29 |
| ES2194209T3 (es) | 2003-11-16 |
| CN1230884A (zh) | 1999-10-06 |
| ATE233552T1 (de) | 2003-03-15 |
| CA2260859A1 (en) | 1998-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9710758A (pt) | Inibidores da metaloprotease de tiol sulfona | |
| MX9804262A (es) | Inhibidores derivados de d-aminoacidos de proteasas de cisteina y serina. | |
| BR9815469A (pt) | Inibidores de protease | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| NZ335981A (en) | Ketobenzamides as calpain inhibitors | |
| DE69526330D1 (de) | Serin-protease-inhibitoren: derivate des isothiazolidin-3-on-1,1-dioxids und des 3-oxo-1,2,5-thiadiazolidin-1,1-dioxids | |
| ES2059295T3 (es) | Inhibidores de las proteasas retrovirales. | |
| NO990855D0 (no) | Substituerte sykliske amin-metallprotease-inhibitorer | |
| DE69832268D1 (en) | Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren | |
| BR9507237A (pt) | Protease altamente alcalina e sua aplicação | |
| BR9908280A (pt) | Inibidores de enzimas de fosfolipase | |
| TR200003028T2 (tr) | Yeni ikame edilmiş amidler, bunların üretimi ve kullanımı. | |
| MA24136A1 (fr) | Fabrication d'agents de surface . | |
| MY113489A (en) | Reversible protease inhibitors | |
| AR009816A1 (es) | Detergentes liquidos que contienen enzima proteolitica, aldehido peptido e iones de calcio | |
| WO2002076939A3 (en) | Cysteine protease inhibitors | |
| SE9602263D0 (sv) | New amino acid derivatives | |
| ATE170868T1 (de) | Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen | |
| EA200100804A1 (ru) | Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз | |
| DE69835532D1 (de) | Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease | |
| TR200003071T2 (tr) | Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler | |
| DK0871454T3 (da) | Phosphorholdige inhibitorer af cystein- og serinprotease | |
| DE3683170D1 (de) | Peptid-derivate, renin- und saeureprotease hemmende mittel. | |
| CA2342985A1 (en) | Hydroxamate-containing cysteine and serine protease inhibitors | |
| ATE354591T1 (de) | Mittel zur behandlung und/oder prophylaxe von mikrozirkulationsstörungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1898 DE 22/05/2007. |