NO990262D0 - Tiosulfon-metallproteaseinhibitorer - Google Patents
Tiosulfon-metallproteaseinhibitorerInfo
- Publication number
- NO990262D0 NO990262D0 NO990262A NO990262A NO990262D0 NO 990262 D0 NO990262 D0 NO 990262D0 NO 990262 A NO990262 A NO 990262A NO 990262 A NO990262 A NO 990262A NO 990262 D0 NO990262 D0 NO 990262D0
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- proteinase
- mmp
- tiosulfon
- metalloprotease
- Prior art date
Links
- 229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 abstract 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 3
- 102100027995 Collagenase 3 Human genes 0.000 abstract 2
- 108050005238 Collagenase 3 Proteins 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 102000011722 Matrix Metalloproteinase 13 Human genes 0.000 abstract 1
- 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 235000019419 proteases Nutrition 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- -1 thiol sulfone Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Lubricants (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2204396P | 1996-07-22 | 1996-07-22 | |
| PCT/US1997/012874 WO1998003164A1 (en) | 1996-07-22 | 1997-07-22 | Thiol sulfone metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO990262D0 true NO990262D0 (no) | 1999-01-21 |
| NO990262L NO990262L (no) | 1999-03-17 |
Family
ID=21807522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO990262A NO990262L (no) | 1996-07-22 | 1999-01-21 | Tiosulfon-metallproteaseinhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6013649A (no) |
| EP (1) | EP0939628B1 (no) |
| JP (1) | JP2001505869A (no) |
| KR (1) | KR20000067963A (no) |
| CN (1) | CN1230884A (no) |
| AT (1) | ATE233552T1 (no) |
| AU (1) | AU714687B2 (no) |
| BR (1) | BR9710758A (no) |
| CA (1) | CA2260859A1 (no) |
| CZ (1) | CZ16799A3 (no) |
| DE (1) | DE69719538T2 (no) |
| DK (1) | DK0939628T3 (no) |
| ES (1) | ES2194209T3 (no) |
| IL (1) | IL128079A0 (no) |
| NO (1) | NO990262L (no) |
| NZ (1) | NZ333824A (no) |
| PL (1) | PL331369A1 (no) |
| PT (1) | PT939628E (no) |
| RU (1) | RU2221781C2 (no) |
| WO (1) | WO1998003164A1 (no) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) * | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| RU2250105C2 (ru) * | 1997-11-14 | 2005-04-20 | Дж.Д.Сёрл ЛЛС | Ароматическая сульфонгидроксамовая кислота в качестве ингибитора металлопротеаз |
| WO2000017162A1 (en) | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Novel thiol derivatives, process for producing the same and utilization thereof |
| US6288261B1 (en) * | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| PL350420A1 (en) * | 1999-01-27 | 2002-12-16 | American Cyanamid Co | Acetylenic sulfonamide thiol tace inhibitors |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6583299B1 (en) * | 1999-05-20 | 2003-06-24 | G.D. Searle & Co. | α-amino-β-sulfonyl hydroxamic acid compounds |
| US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| YU85403A (sh) | 2001-05-11 | 2006-03-03 | Pharmacia Corporation | Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) * | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| JP2003081838A (ja) * | 2001-09-11 | 2003-03-19 | Rohto Pharmaceut Co Ltd | グルコサミン製剤 |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| DE10201392A1 (de) * | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| MXPA04010555A (es) * | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| MXPA05000171A (es) * | 2002-06-25 | 2005-04-08 | Pharmacia Corp | Acido arilsulfonilhidroxamico y derivados de amida y su uso como inhibidores de la proteasa. |
| EP1585555A2 (en) * | 2002-12-27 | 2005-10-19 | Angiotech International Ag | Compositions and methods of using collagen and mmpi |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| UY29223A1 (es) | 2004-11-23 | 2006-06-30 | Astrazeneca Ab | Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación |
| EP1937632A1 (en) * | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
| EP2190293A4 (en) * | 2007-09-28 | 2011-11-09 | Absolute Science Inc | COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES MEDIATED BY ZINC MATRIX METALLOPROTEASE |
| EP2337778A4 (en) * | 2008-09-19 | 2012-05-09 | Absolute Science Inc | METHODS OF TREATING BOTULINUM TOXIN-RELATED DISEASE IN A SUBJECT |
| DK2442647T3 (en) * | 2009-06-15 | 2016-05-30 | Encore Health Llc | Dithiolforbindelser, derivatives thereof, and the uses of these |
| FR2950890B1 (fr) * | 2009-10-06 | 2011-12-30 | Tetrahedron | Procede de synthese de la 2-thiohistidine et analogues |
| GB201313238D0 (en) | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| TWI781145B (zh) | 2017-02-28 | 2022-10-21 | 美商伊繆諾金公司 | 具有自分解肽連接子之類美登素衍生物及其結合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5274094A (en) * | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| JPH06509087A (ja) * | 1991-07-05 | 1994-10-13 | メルク シヤープ エンド ドーム リミテツド | 芳香族化合物、それらを含む医薬組成物、及び治療におけるそれらの使用 |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5376664A (en) * | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| GB9307956D0 (en) * | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| ATE197146T1 (de) * | 1993-08-10 | 2000-11-15 | Black James Foundation | Gastrin-und cck-rezeptorligande |
| AU8130894A (en) * | 1993-11-04 | 1995-05-23 | Liposome Company, Inc., The | Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations |
| GB9323162D0 (en) * | 1993-11-10 | 1994-01-05 | British Bio Technology | 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf |
| GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| BR9509237A (pt) * | 1994-10-05 | 1997-10-21 | Chiroscience Ltd | Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases |
| BR9609883A (pt) * | 1995-08-08 | 1999-03-23 | Fibrogen Inc | Composto tendo efeito inibidor em proteinase c composição farmacéutica e processo para tratar doenças relacionadas com a produção inapropriada ou desregulada de colágeno |
| DE69626684T2 (de) * | 1995-12-08 | 2004-04-29 | Agouron Pharmaceuticals, Inc., La Jolla | Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung |
-
1997
- 1997-07-22 PL PL97331369A patent/PL331369A1/xx unknown
- 1997-07-22 CN CN97198098A patent/CN1230884A/zh active Pending
- 1997-07-22 AT AT97936169T patent/ATE233552T1/de not_active IP Right Cessation
- 1997-07-22 CA CA002260859A patent/CA2260859A1/en not_active Abandoned
- 1997-07-22 RU RU99103642/04A patent/RU2221781C2/ru not_active IP Right Cessation
- 1997-07-22 KR KR1019997000465A patent/KR20000067963A/ko not_active Ceased
- 1997-07-22 JP JP50719698A patent/JP2001505869A/ja not_active Abandoned
- 1997-07-22 WO PCT/US1997/012874 patent/WO1998003164A1/en not_active Ceased
- 1997-07-22 ES ES97936169T patent/ES2194209T3/es not_active Expired - Lifetime
- 1997-07-22 BR BR9710758A patent/BR9710758A/pt not_active IP Right Cessation
- 1997-07-22 AU AU38904/97A patent/AU714687B2/en not_active Ceased
- 1997-07-22 NZ NZ333824A patent/NZ333824A/xx unknown
- 1997-07-22 CZ CZ99167A patent/CZ16799A3/cs unknown
- 1997-07-22 EP EP97936169A patent/EP0939628B1/en not_active Expired - Lifetime
- 1997-07-22 PT PT97936169T patent/PT939628E/pt unknown
- 1997-07-22 DK DK97936169T patent/DK0939628T3/da active
- 1997-07-22 US US08/900,028 patent/US6013649A/en not_active Expired - Fee Related
- 1997-07-22 IL IL12807997A patent/IL128079A0/xx unknown
- 1997-07-22 DE DE69719538T patent/DE69719538T2/de not_active Expired - Fee Related
-
1999
- 1999-01-21 NO NO990262A patent/NO990262L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2260859A1 (en) | 1998-01-29 |
| EP0939628B1 (en) | 2003-03-05 |
| KR20000067963A (ko) | 2000-11-25 |
| DE69719538T2 (de) | 2004-02-19 |
| WO1998003164A1 (en) | 1998-01-29 |
| NZ333824A (en) | 2000-08-25 |
| PT939628E (pt) | 2003-07-31 |
| IL128079A0 (en) | 1999-11-30 |
| EP0939628A1 (en) | 1999-09-08 |
| EP0939628A4 (en) | 1999-12-22 |
| NO990262L (no) | 1999-03-17 |
| CZ16799A3 (cs) | 1999-06-16 |
| ATE233552T1 (de) | 2003-03-15 |
| AU3890497A (en) | 1998-02-10 |
| JP2001505869A (ja) | 2001-05-08 |
| US6013649A (en) | 2000-01-11 |
| RU2221781C2 (ru) | 2004-01-20 |
| CN1230884A (zh) | 1999-10-06 |
| AU714687B2 (en) | 2000-01-06 |
| DK0939628T3 (da) | 2003-07-07 |
| ES2194209T3 (es) | 2003-11-16 |
| BR9710758A (pt) | 1999-08-17 |
| DE69719538D1 (en) | 2003-04-10 |
| PL331369A1 (en) | 1999-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0939628T3 (da) | Thiolsulfon-metalloproteaseinhibitorer | |
| BR9815469A (pt) | Inibidores de protease | |
| ATE215938T1 (de) | Serin-protease-inhibitoren: derivate des isothiazolidin-3-on-1,1-dioxids und des 3-oxo-1,2,5-thiadiazolidin-1,1-dioxids | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| ATE377006T1 (de) | Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer | |
| NZ335981A (en) | Ketobenzamides as calpain inhibitors | |
| ES2059295T3 (es) | Inhibidores de las proteasas retrovirales. | |
| DK0968182T3 (da) | Hydroxam- og carboxylsyrederivater med MMP- og TNF-inhiberende aktivitet | |
| DE69536064D1 (de) | Bizyklischer Lactaminhibitor des Interleukin-1-beta-konvertierenden Enzyms | |
| EP0677048A1 (en) | CYCLIC SULPHONES AS INHIBITORS RETROVIRAL PROTEASES. | |
| MXPA04010555A (es) | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. | |
| ATE170868T1 (de) | Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen | |
| EP0975353A4 (en) | PEPTIDYL-2-AMINO-1HYDROXYALKANESULPHONIC ACIDS AS CYSTEIN PROTEASE INHIBITORS | |
| DE3683170D1 (de) | Peptid-derivate, renin- und saeureprotease hemmende mittel. | |
| DE69835532D1 (de) | Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease | |
| TR200003071T2 (tr) | Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler | |
| AU6458396A (en) | Phosphorous-containing cysteine and serine protease inhibitors | |
| DK0941975T3 (da) | Injiceringscement indeholdende korrosionshæmmere | |
| CA2342985A1 (en) | Hydroxamate-containing cysteine and serine protease inhibitors | |
| BRPI0415885A (pt) | ácidos piperidinil-e piperazinil-sulfonilmetilidroxámicos e sua utilização como inibidores de protease | |
| TR200000954T2 (tr) | Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde. | |
| TW200505910A (en) | Heteroarylsulfonylmethyl hydroxamic acids and amides and their use as protease inhibitors | |
| DK1141337T3 (da) | Gram-positive bakterier, som mangler HtrA-proteaseaktivitet, samt deres anvendelser | |
| MY141460A (en) | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | |
| PT1119351E (pt) | Utilizacao de derivados de catecol como inibidores de proteinases |