BR9611479A - Acidos alfa-iminoidroxâmicos e carboxílicos N-substituídos cíclicos e heterocíclicos - Google Patents

Acidos alfa-iminoidroxâmicos e carboxílicos N-substituídos cíclicos e heterocíclicos

Info

Publication number: BR9611479A
Authority: BR; Brazil
Prior art keywords: iminohydroxamic; alpha; carboxylic acids; substituted cyclic; heterocyclic carboxylic
Prior art date: 1995-11-13

Application number

BR9611479A

Other languages

English (en)

Other versions

BR9611479B1 (pt

Inventor

Werner Thorwart

Wilfried Schwab

Manfred Schudok

Burkhard Haase

Eckart Bartnik

Klaus-Ulrich Weithmann

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-13

Filing date

1996-11-04

Publication date

1999-07-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26020318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9611479(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-11-13 Priority claimed from DE1995142189 external-priority patent/DE19542189A1/de

1996-03-28 Priority claimed from DE1996112298 external-priority patent/DE19612298A1/de

1996-11-04 Application filed by Hoechst Ag filed Critical Hoechst Ag

1999-07-13 Publication of BR9611479A publication Critical patent/BR9611479A/pt

2009-01-13 Publication of BR9611479B1 publication Critical patent/BR9611479B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Pyridine Compounds (AREA)

BRPI9611479-7A 1995-11-13 1996-11-04 Ácidos alfa-iminoidroxÂmicos e carboxÍlicos n-substituÍdos cÍclicos e heterocÍclicos. BR9611479B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE1995142189 DE19542189A1 (de)	1995-11-13	1995-11-13	Cyclische N-substituierte alpha-Iminohydroxamsäuren
DE1996112298 DE19612298A1 (de)	1996-03-28	1996-03-28	Heterocyclische N-substituierte alpha-Iminohydroxamsäuren
PCT/EP1996/004776 WO1997018194A1 (de)	1995-11-13	1996-11-04	CYCLISCHE UND HETEROCYCLISCHE N-SUBSTITUIERTE α-IMINOHYDROXAM- UND CARBONSÄUREN

Publications (2)

Publication Number	Publication Date
BR9611479A true BR9611479A (pt)	1999-07-13
BR9611479B1 BR9611479B1 (pt)	2009-01-13

Family

ID=26020318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9611479-7A BR9611479B1 (pt)	1995-11-13	1996-11-04	Ácidos alfa-iminoidroxÂmicos e carboxÍlicos n-substituÍdos cÍclicos e heterocÍclicos.

Country Status (20)

Country	Link
US (3)	US6207672B1 (pt)
EP (1)	EP0861236B2 (pt)
JP (1)	JP4638560B2 (pt)
KR (1)	KR100475206B1 (pt)
CN (1)	CN1131215C (pt)
AT (1)	ATE213232T1 (pt)
AU (1)	AU707707B2 (pt)
BR (1)	BR9611479B1 (pt)
CA (1)	CA2237590C (pt)
CZ (1)	CZ297550B6 (pt)
DE (1)	DE59608740D1 (pt)
DK (1)	DK0861236T4 (pt)
ES (1)	ES2170884T5 (pt)
HU (1)	HU223086B1 (pt)
MX (1)	MX9803753A (pt)
PL (1)	PL186869B1 (pt)
PT (1)	PT861236E (pt)
RU (1)	RU2164914C2 (pt)
TR (1)	TR199800849T2 (pt)
WO (1)	WO1997018194A1 (pt)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR19990072009A (ko) *	1995-08-12	1999-09-27	게리 이. 프리드만	메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
FR2748026B1 (fr) *	1996-04-26	1998-06-05	Adir	Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR199900382T2 (xx) *	1996-08-28	1999-05-21	The Procter & Gamble Company	Heterosiklik metaloproteaz inhibit�rleri.
US5929097A (en) *	1996-10-16	1999-07-27	American Cyanamid Company	Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5962481A (en)	1996-10-16	1999-10-05	American Cyanamid Company	Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6228869B1 (en)	1996-10-16	2001-05-08	American Cyanamid Company	Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US5977408A (en) *	1996-10-16	1999-11-02	American Cyanamid Company	Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US6548524B2 (en)	1996-10-16	2003-04-15	American Cyanamid Company	Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
AU4812697A (en) *	1996-10-22	1998-05-15	Pharmacia & Upjohn Company	Alpha-amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
SG88737A1 (en) *	1996-10-30	2002-05-21	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
ZA98376B (en) *	1997-01-23	1998-07-23	Hoffmann La Roche	Sulfamide-metalloprotease inhibitors
WO1998032748A1 (en) *	1997-01-23	1998-07-30	F. Hoffmann-La Roche Ag	Sulfamide-metalloprotease inhibitors
US6376506B1 (en)	1997-01-23	2002-04-23	Syntex (U.S.A.) Llc	Sulfamide-metalloprotease inhibitors
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
JP2003524572A (ja) *	1997-08-04	2003-08-19	アムジエン・インコーポレーテツド	ヒドロキサム酸置換縮合複素環メタロプロテイナーゼ阻害剤
BR9812727A (pt) *	1997-10-06	2000-08-22	American Cyanamid Co	Preparação e uso de ácidos orto-sulfonamido bicìclico hetero aril hidroxâmicos como metalo proteinase matriz e inibidores de tace
US6130220A (en) *	1997-10-16	2000-10-10	Syntex (Usa) Inc.	Sulfamide-metalloprotease inhibitors
FR2771095B1 (fr) *	1997-11-14	1999-12-17	Adir	Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6335329B1 (en)	1997-12-19	2002-01-01	Amgen Inc.	Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
US6107291A (en) *	1997-12-19	2000-08-22	Amgen Inc.	Azepine or larger medium ring derivatives and methods of use
HUP0100277A3 (en) *	1998-01-27	2002-03-28	American Cyanamid Company Madi	2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as metalloproteinase inhibitors, process for their preparation and pharmaceutical compositions containing them
US6071903A (en) *	1998-01-27	2000-06-06	American Cyanamid Company	2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
AU3982599A (en) *	1998-05-14	1999-11-29	Du Pont Pharmaceuticals Company	Novel substituted aryl hydroxamic acids as metalloproteinase inhibitors
AU6228499A (en) *	1998-10-22	2000-05-08	Akzo Nobel N.V.	Tetrahydropyridopyridine derivatives and intermediates for producing the same
US20040122011A1 (en) *	1998-12-23	2004-06-24	Pharmacia Corporation	Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6200996B1 (en)	1999-01-27	2001-03-13	American Cyanamid Company	Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
US6946473B2 (en)	1999-01-27	2005-09-20	Wyeth Holdings Corporation	Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6326516B1 (en)	1999-01-27	2001-12-04	American Cyanamid Company	Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
US6313123B1 (en)	1999-01-27	2001-11-06	American Cyanamid Company	Acetylenic sulfonamide thiol tace inhibitors
US6225311B1 (en)	1999-01-27	2001-05-01	American Cyanamid Company	Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6753337B2 (en)	1999-01-27	2004-06-22	Wyeth Holdings Corporation	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6544984B1 (en)	1999-01-27	2003-04-08	American Cyanamid Company	2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
US6340691B1 (en)	1999-01-27	2002-01-22	American Cyanamid Company	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6358980B1 (en)	1999-01-27	2002-03-19	American Cyanamid Company	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6277885B1 (en)	1999-01-27	2001-08-21	American Cyanamid Company	Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6762178B2 (en)	1999-01-27	2004-07-13	Wyeth Holdings Corporation	Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
AR022423A1 (es) *	1999-01-27	2002-09-04	American Cyanamid Co	Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
GB9903598D0 (en) *	1999-02-18	1999-04-07	Univ Manchester	Connective tissue healing
CO5261615A1 (es)	1999-12-01	2003-03-31	Agouron Pharma	Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas
GB0011409D0 (en) *	2000-05-11	2000-06-28	Smithkline Beecham Plc	Novel compounds
MXPA01013172A (es)	2001-02-14	2002-08-21	Warner Lambert Co	Inhibidores sulfonamida de metaloproteinasa de matriz.
FR2821842B1 (fr) *	2001-03-07	2003-05-09	Servier Lab	Nouveaux derives d'inhibiteurs de mettalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002324716A1 (en)	2001-08-17	2003-03-03	Bristol-Myers Squibb Company Patent Department	Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
MXPA04004010A (es)	2001-11-01	2004-07-23	Wyeth Corp	Acidos hidroxamicos de aril sulfonamida alenicos como inhibidores de tace y metaloproteinasa de matriz.
RU2223703C2 (ru) *	2002-02-13	2004-02-20	Иркутский государственный институт усовершенствования врачей	Способ лечения передней хронической нестабильности коленного сустава
DE10209299A1 (de) *	2002-03-02	2003-09-18	Aventis Pharma Gmbh	Cyclische N-substituierte alpha-Iminocarbonsäuren zur selektiven Inhibierung von Kollagenase
US6716853B2 (en)	2002-03-02	2004-04-06	Aventis Pharma Deutschland Gmbh	Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
AU2003304456A1 (en)	2002-12-23	2005-03-16	Wyeth Holdings Corporation	Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
WO2004060892A1 (ja) *	2002-12-27	2004-07-22	Japan Tobacco Inc.	縮合ｎ含有ヘテロ環化合物及びその医薬用途
DE10300015A1 (de) *	2003-01-03	2004-07-15	Aventis Pharma Deutschland Gmbh	Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen
DE10344936A1 (de)	2003-09-27	2005-04-21	Aventis Pharma Gmbh	Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen
US7205315B2 (en)	2003-09-27	2007-04-17	Sanofi-Aventis Deutschland Gmbh	Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases
DE10351904A1 (de) *	2003-11-06	2005-06-09	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von cyclischen N-substituierten alpha-Iminocarbonsäure
US7244845B2 (en) *	2003-11-06	2007-07-17	Sanofi-Aventis Deutschland Gmbh	Process for preparing cyclic N-substituted alpha-imino carboxylic acids
DE102004004974A1 (de) *	2004-01-31	2005-08-18	Aventis Pharma Deutschland Gmbh	Thieno-Iminosäure-Derivate als Inhibitoren von Matrix-Metalloproteinasen
US7705017B2 (en) *	2004-05-03	2010-04-27	En Vivo Pharmaceuticals, Inc.	Compounds for treatment of neurodegenerative diseases
DE102004031620A1 (de) *	2004-06-30	2006-02-02	Sanofi-Aventis Deutschland Gmbh	4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln
DE102004031850A1 (de) *	2004-06-30	2006-01-26	Sanofi-Aventis Deutschland Gmbh	Substituirte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
US7601838B2 (en) *	2004-12-28	2009-10-13	Council Of Scientific And Industrial Research	2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents
DE102005002500A1 (de) *	2005-01-19	2006-07-27	Sanofi-Aventis Deutschland Gmbh	Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
DE102005015040A1 (de) *	2005-03-31	2006-10-05	Sanofi-Aventis Deutschland Gmbh	Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
BRPI0610128B1 (pt)	2005-05-13	2021-12-07	Topotarget Uk Limited	Composição farmacêutica, e, uso de uma composição
WO2007045661A1 (en) *	2005-10-20	2007-04-26	Nordic Bioscience Diagnostics A/S	Detection or quantification of aggrecan and its fragments
GB0526257D0 (en) *	2005-12-22	2006-02-01	Novartis Ag	Organic compounds
ATE509956T1 (de) *	2006-06-08	2011-06-15	Helmholtz Zentrum Muenchen	Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie
CA2695504C (en)	2007-08-03	2017-05-30	Nucitec S.A. De C.V.	Compositions and methods for treatment and prevention of osteoarthritis
JP5501230B2 (ja)	2007-08-07	2014-05-21	アボットゲーエムベーハーウントカンパニーカーゲー	セロトニン５−ｈｔ６受容体の調節に応答する障害の治療に好適なキノリン化合物
BRPI0821247A2 (pt)	2007-12-14	2015-06-16	Univ Georgetown	Inibidores de histona deacetilase
ES2527589T3 (es) *	2008-04-24	2015-01-27	Msd K.K.	Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo
KR20110040911A (ko) *	2008-07-14	2011-04-20	노파르티스 아게	선택적 히드록삼산계 ｍｍｐ-12 및 ｍｍｐ-13 억제제
FR2947268B1 (fr)	2009-06-30	2011-08-26	Galderma Res & Dev	Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2947270B1 (fr)	2009-06-30	2011-08-26	Galderma Res & Dev	Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
US20140275108A1 (en)	2013-03-15	2014-09-18	Galderma Research & Development	Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
WO2017117130A1 (en)	2015-12-28	2017-07-06	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Methods for inhibiting human immunodeficiency virus (hiv) release from infected cells
EP3199534B1 (en)	2016-02-01	2018-09-05	Galderma Research & Development	Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
EP3717481B1 (en)	2017-11-27	2023-03-01	Council of Scientific & Industrial Research	Indole (sulfomyl) n-hydroxy benzamide derivatives as selective hdac inhibitors
WO2025224168A1 (en)	2024-04-24	2025-10-30	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators
CN119565781B (zh) *	2024-12-20	2026-01-02	中南大学	一种金属离子-含氮芳杂环配合物捕收剂及其制备方法和在钨矿浮选中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2125778A1 (en) †	1970-06-02	1971-12-16	Hokuriku Seiyaku Co Ltd , Katsuyama, Fukui (Japan)	Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids
TW201303B (pt) *	1990-07-05	1993-03-01	Hoffmann La Roche
JPH04210675A (ja) †	1990-12-13	1992-07-31	Otsuka Pharmaceut Co Ltd	ベンゼン誘導体
US5219851A (en) †	1991-03-05	1993-06-15	Warner-Lambert Company	Tetrahydroisoquinoline-type renin inhibiting peptides
US5284957A (en) *	1992-09-03	1994-02-08	Eli Lilly And Company	Excitatory amino acid receptor antagonists
US5455258A (en) *	1993-01-06	1995-10-03	Ciba-Geigy Corporation	Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) *	1993-01-06	1996-04-09	Ciba-Geigy Corporation	Arylsufonamido-substituted hydroxamic acids
FR2701480B1 (fr) *	1993-02-15	1995-05-24	Sanofi Elf	Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.
CA2193691A1 (en) †	1994-06-22	1995-12-28	Andrew Miller	Metalloproteinase inhibitors
DE10003007C2 (de) *	2000-01-25	2002-06-13	Schunk Metall & Kunststoff	Erdungskontakt

1996
- 1996-11-04 CN CN96198294A patent/CN1131215C/zh not_active Expired - Fee Related
- 1996-11-04 AU AU75624/96A patent/AU707707B2/en not_active Ceased
- 1996-11-04 DK DK96938052T patent/DK0861236T4/da active
- 1996-11-04 JP JP51854297A patent/JP4638560B2/ja not_active Expired - Fee Related
- 1996-11-04 RU RU98111153/04A patent/RU2164914C2/ru not_active IP Right Cessation
- 1996-11-04 PT PT96938052T patent/PT861236E/pt unknown
- 1996-11-04 PL PL96326702A patent/PL186869B1/pl not_active IP Right Cessation
- 1996-11-04 WO PCT/EP1996/004776 patent/WO1997018194A1/de not_active Ceased
- 1996-11-04 ES ES96938052T patent/ES2170884T5/es not_active Expired - Lifetime
- 1996-11-04 KR KR10-1998-0703715A patent/KR100475206B1/ko not_active Expired - Fee Related
- 1996-11-04 TR TR1998/00849T patent/TR199800849T2/xx unknown
- 1996-11-04 EP EP96938052A patent/EP0861236B2/de not_active Expired - Lifetime
- 1996-11-04 DE DE59608740T patent/DE59608740D1/de not_active Expired - Lifetime
- 1996-11-04 US US09/068,497 patent/US6207672B1/en not_active Expired - Lifetime
- 1996-11-04 HU HU9903405A patent/HU223086B1/hu not_active IP Right Cessation
- 1996-11-04 CZ CZ0145398A patent/CZ297550B6/cs not_active IP Right Cessation
- 1996-11-04 AT AT96938052T patent/ATE213232T1/de active
- 1996-11-04 BR BRPI9611479-7A patent/BR9611479B1/pt not_active IP Right Cessation
- 1996-11-04 CA CA2237590A patent/CA2237590C/en not_active Expired - Fee Related
1998
- 1998-05-12 MX MX9803753A patent/MX9803753A/es unknown
2001
- 2001-02-12 US US09/780,514 patent/US6573277B2/en not_active Expired - Fee Related
2003
- 2003-03-03 US US10/376,287 patent/US6815440B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TR199800849T2 (xx)	1998-07-21
US6207672B1 (en)	2001-03-27
HU223086B1 (hu)	2004-03-29
BR9611479B1 (pt)	2009-01-13
EP0861236B1 (de)	2002-02-13
PL186869B1 (pl)	2004-03-31
ES2170884T5 (es)	2007-04-01
RU2164914C2 (ru)	2001-04-10
ES2170884T3 (es)	2002-08-16
US6815440B2 (en)	2004-11-09
US20010011134A1 (en)	2001-08-02
CN1202156A (zh)	1998-12-16
AU707707B2 (en)	1999-07-15
PT861236E (pt)	2002-07-31
CZ145398A3 (cs)	1998-08-12
CA2237590A1 (en)	1997-05-22
HUP9903405A1 (hu)	2000-04-28
WO1997018194A1 (de)	1997-05-22
CN1131215C (zh)	2003-12-17
EP0861236A1 (de)	1998-09-02
JP2000500145A (ja)	2000-01-11
US20030176432A1 (en)	2003-09-18
KR100475206B1 (ko)	2005-12-16
DK0861236T3 (da)	2002-05-21
MX9803753A (es)	1998-10-31
DE59608740D1 (de)	2002-03-21
EP0861236B2 (de)	2006-08-16
CZ297550B6 (cs)	2007-02-07
DK0861236T4 (da)	2006-12-18
JP4638560B2 (ja)	2011-02-23
ATE213232T1 (de)	2002-02-15
HUP9903405A3 (en)	2000-12-28
KR19990067685A (ko)	1999-08-25
US6573277B2 (en)	2003-06-03
CA2237590C (en)	2011-07-19
AU7562496A (en)	1997-06-05
PL326702A1 (en)	1998-10-26

Publication	Publication Date	Title
BR9611479A (pt)	1999-07-13	Acidos alfa-iminoidroxâmicos e carboxílicos N-substituídos cíclicos e heterocíclicos
ATE301651T1 (de)	2005-08-15	Substituierte benzimidazole
ATE427300T1 (de)	2009-04-15	Heterocyclisch substituierte amide als calpainhemmer
BR9810841A (pt)	2001-07-10	Inibidores de metaloprotease alicìclicos
ATE230757T1 (de)	2003-01-15	Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
EA200100524A1 (ru)	2002-02-28	Амиды антраниловой кислоты и их применение в качестве лекарственных средств
DK1030836T3 (da)	2003-05-26	Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet
NO963499L (no)	1996-10-14	Hydroksaminsyre- og karboksylsyrederivater, fremgangsmåte for deres fremstilling og anvendelse derav
DE69941429D1 (de)	2009-10-29	1-deoxy-galactonojirimycin-derivate zur vewendung bei der behandlung von lysosomalen speicherkrankheiten mittels steigerung der lysosomalen alpha galactosidase a
NO990279L (no)	1999-01-22	Isobutylgaba og dets derivater for behandling av smerte
BR9712085A (pt)	2000-10-24	Inibidores de metaloprotease heterocìclicos
NO20030724D0 (no)	2003-02-14	Anvendelse av derivater av valproinsyreamider og 2- valproensyreamider for terapi eller prevensjon av smerte- og/eller hodepinelidelser
DE60032795D1 (de)	2007-02-15	Nordihydroguaiaretinsäurederivate zur behandlung von tumoren
ATE321548T1 (de)	2006-04-15	Verwendung von statin zur behandlung von hauterkrankungen
DE69613693D1 (de)	2001-08-09	2-heteroarylalkenylderivate der cyclopentano-heptan(heptaen)säure als therapeutisches mittel zur behandlung des erhöhten augeninnendruckes
YU48698A (sh)	2001-09-28	Karboksamidni derivati pirolidina, piperidina i heksahidroazepina za lečenje oboljenja na bazi tromboze
ATE264321T1 (de)	2004-04-15	Zyklisch imid-substituierte pyridylalkan-, alken-,und alkin- carboxamid-derivate, verwendbar als zytostatische und immunosuppressive mittel
ATE260653T1 (de)	2004-03-15	Verwendung von naaladase inhibitoren zur behandlung von angstzuständen und gedächtnisstörungen
DE69834500D1 (de)	2006-06-14	Xanthinderivative zur behandlung von hirnischämie
ATE225171T1 (de)	2002-10-15	Aminosäurederivate zur behandlung von schlaganfall
ATE222491T1 (de)	2002-09-15	Melatonin-derivate zur verwendung in der behandlung von schlafstörungen
CY1106155T1 (el)	2011-06-08	Χρηση παραγωγων 3-βενζολοφαινυλοξικων οξεων για την αντιμετωπιση διαταραχων του αμφιβληστροειδους
DE69736180D1 (de)	2006-08-03	Behandlung von manischen erkrankungen
DE60024969D1 (de)	2006-01-26	2-methyl-3-butenyl-1-pyrophosphorsäuresalze und mittel zur behandlung von lymphozyten
ES2160102T3 (es)	2001-11-01	Tratamiento del eritema provocado por uv.

Legal Events

Date	Code	Title	Description
2005-11-01	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-04-04	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PEDIDO DE PATENTE COM BASE NOS ARTIGOS 8,13,24 E 25 DA LPI NO. 9.279 DE 14/05/1996.
2006-07-25	B12B	Appeal against refusal [chapter 12.2 patent gazette]
2009-01-13	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/01/2009, OBSERVADAS AS CONDICOES LEGAIS.
2013-10-08	B22O	Other matters related to patents and certificates of addition of invention: legal action concerning patent	Free format text: INPI-52400.061552/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132261-03.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: ELI LILLY AND COMPANY (NZ) LIMITED, ELI LILLY AND COMPANY, F. HOFFMANN-LA ROCHE AG., GENENTECH, INC. E HOECHST AKTIENGESELLSCHAFT
2013-10-29	B24H	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)	Free format text: EXTINCAO DEFINITIVA - ART. 78 INCISO IV DA LPI
2020-11-24	B24F	Patent annual fee: publication cancelled	Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2234 DE 29/10/2013 POR TER SIDO INDEVIDA.
2021-09-14	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 16O, 17O, 18O, 19O E 20O RETRIBUICAO ANUAL.