BRPI0821247A2 - Inibidores de histona deacetilase - Google Patents
Inibidores de histona deacetilaseInfo
- Publication number
- BRPI0821247A2 BRPI0821247A2 BRPI0821247-3A BRPI0821247A BRPI0821247A2 BR PI0821247 A2 BRPI0821247 A2 BR PI0821247A2 BR PI0821247 A BRPI0821247 A BR PI0821247A BR PI0821247 A2 BRPI0821247 A2 BR PI0821247A2
- Authority
- BR
- Brazil
- Prior art keywords
- histone deacetylase
- deacetylase inhibitors
- inhibitors
- histone
- deacetylase
- Prior art date
Links
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1386607P | 2007-12-14 | 2007-12-14 | |
| PCT/US2008/086603 WO2009079375A1 (en) | 2007-12-14 | 2008-12-12 | Histone deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0821247A2 true BRPI0821247A2 (pt) | 2015-06-16 |
Family
ID=40795877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0821247-3A BRPI0821247A2 (pt) | 2007-12-14 | 2008-12-12 | Inibidores de histona deacetilase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8293513B2 (pt) |
| EP (1) | EP2231596A4 (pt) |
| CN (1) | CN101970399A (pt) |
| AU (1) | AU2008338631A1 (pt) |
| BR (1) | BRPI0821247A2 (pt) |
| CA (1) | CA2709383A1 (pt) |
| WO (1) | WO2009079375A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010027641A2 (en) * | 2008-08-15 | 2010-03-11 | Georgetown University | Na channels, disease, and related assays and compositions |
| US9221773B2 (en) * | 2009-12-22 | 2015-12-29 | The Translational Genomics Research Institute | Benzamide derivatives |
| WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| US10166241B2 (en) * | 2012-07-13 | 2019-01-01 | Turun Yliopisto | Combination Therapy III |
| US9670236B2 (en) | 2012-10-31 | 2017-06-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
| WO2015058106A1 (en) | 2013-10-18 | 2015-04-23 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| US10478431B2 (en) | 2014-11-26 | 2019-11-19 | The J. David Gladstone Institutes | Methods for treating a cytomegalovirus infection |
| WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| WO2022011174A1 (en) * | 2020-07-08 | 2022-01-13 | Klotho Therapeutics, Inc. | Water soluble prodrugs of ptba for use in hdac inhibition and enhancing renal recovery following acute kidney injury |
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| CA417501A (en) | 1944-01-04 | B. Clark Joel | Oil filter cartridge | |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5387681A (en) | 1992-08-19 | 1995-02-07 | Eli Lilly And Company | Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US5354566A (en) | 1993-06-02 | 1994-10-11 | Kraft General Foods, Inc. | Preparation of yeast-leavened dough crusts |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6140505A (en) | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
| EP0861236B2 (de) | 1995-11-13 | 2006-08-16 | Sanofi-Aventis Deutschland GmbH | Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren |
| CN1378450A (zh) | 1999-09-08 | 2002-11-06 | 斯隆-凯特林癌症研究院 | 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法 |
| EP1233958B1 (en) | 1999-11-23 | 2011-06-29 | MethylGene Inc. | Inhibitors of histone deacetylase |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7288567B2 (en) * | 2000-03-24 | 2007-10-30 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1170008A1 (en) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| EP1598067B1 (en) | 2000-09-29 | 2009-05-06 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage for the treatment of malaria |
| GB0023983D0 (en) | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| AU2001290131B2 (en) | 2000-09-29 | 2007-11-15 | Topotarget Uk Limited | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors |
| AR035417A1 (es) | 2001-01-27 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US7193105B2 (en) | 2002-05-22 | 2007-03-20 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on trihalomethylcarbonyl compounds |
| US7057057B2 (en) | 2002-05-22 | 2006-06-06 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US20030134423A1 (en) | 2002-01-04 | 2003-07-17 | Chu Yong Liang | Compounds for delivering substances into cells |
| WO2003070754A1 (fr) | 2002-02-20 | 2003-08-28 | Minoru Yoshida | Inhibiteurs d'histone desacetylase et procede de production de ces inhibiteurs |
| WO2003070691A1 (en) | 2002-02-21 | 2003-08-28 | Osaka Industrial Promotion Organization | N-hydroxycarboxamide derivative |
| MXPA04009490A (es) | 2002-04-03 | 2005-06-08 | Topo Target Uk Ltd | Compuesto de acido carbamico que comprenden un enlace de piperazina como inhibidores de histona desacetilasa. |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| AU2003219595A1 (en) | 2002-04-11 | 2003-10-27 | In2Gen Co., Ltd. | Alpha,Beta-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS |
| NO20032183L (no) | 2002-05-15 | 2003-11-17 | Schering Ag | Histon-deacetylase-inhibitor og anvendelse derav |
| EP1511729A4 (en) | 2002-05-22 | 2006-09-06 | Errant Gene Therapeutics Llc | HISTONDEACETYLASEINHIBITORS BASED ON ALPHACHALCOGEN METHYL CARBONYL COMPOUNDS |
| US20030224473A1 (en) | 2002-05-23 | 2003-12-04 | Mccafferty Dewey G. | Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors |
| US20050176686A1 (en) | 2002-07-23 | 2005-08-11 | 4Sc Ag | Novel compounds as histone deacetylase inhibitors |
| JP2005539001A (ja) | 2002-08-02 | 2005-12-22 | アージェンタ・ディスカバリー・リミテッド | ヒストンデアセチラーゼインヒビターとしての置換チエニルヒドロキサム酸 |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| AU2004205372B2 (en) | 2003-01-17 | 2011-02-24 | Topotarget Uk Limited | Hydroxamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| AU2004215624B2 (en) | 2003-02-25 | 2011-06-02 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| US7169801B2 (en) | 2003-03-17 | 2007-01-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| PE20050206A1 (es) | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
| ATE460425T1 (de) | 2003-06-20 | 2010-03-15 | Riken | Histondeacetylaseinhibitor und verfahren zu dessen herstellung |
| US7842835B2 (en) | 2003-07-07 | 2010-11-30 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| GB0316889D0 (en) | 2003-07-18 | 2003-08-20 | Univ London | Pharmaceutical agents |
| US20050159470A1 (en) | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
| WO2005066151A2 (en) | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| PT1735274E (pt) | 2004-03-22 | 2009-12-11 | Southern Res Inst | Inibidores não peptídicos de metaloproteinases da matriz |
| US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| WO2005108367A1 (en) | 2004-05-03 | 2005-11-17 | Envivo Pharmaceuticals, Inc. | Compounds for treatment of neurodegenerative diseases |
| CA2573509A1 (en) | 2004-07-12 | 2006-02-16 | Merck & Co., Inc. | Histone deacetylase inhibitors |
| AU2005271841A1 (en) | 2004-07-12 | 2006-02-16 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| US20060018921A1 (en) | 2004-07-16 | 2006-01-26 | Baylor College Of Medicine | Histone deacetylase inhibitors and cognitive applications |
| EP1776357A1 (en) | 2004-08-09 | 2007-04-25 | Astellas Pharma Inc. | Hydroxyamide compounds having activity as inhibitors of histone deacetylase (hdac) |
| AR050552A1 (es) | 2004-09-02 | 2006-11-01 | Osi Pharm Inc | Mercaptoamidas como inhibidores de histona desacetilasa |
| US20060160902A1 (en) | 2004-11-08 | 2006-07-20 | Wiech Norbert L | Histone deacetylase inhibitors |
| US20060106049A1 (en) | 2004-11-17 | 2006-05-18 | The University Of Chicago | Histone deacetylase inhibitors and methods of use |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20070088043A1 (en) | 2005-10-18 | 2007-04-19 | Orchid Research Laboratories Limited. | Novel HDAC inhibitors |
| EP3006424A1 (en) | 2005-11-11 | 2016-04-13 | The Scripps Research Institute | Histone deacetylase inhibitors as therapeutics for neurological diseases |
| JP2009525955A (ja) | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
-
2008
- 2008-12-12 CA CA2709383A patent/CA2709383A1/en not_active Abandoned
- 2008-12-12 EP EP08862332A patent/EP2231596A4/en not_active Withdrawn
- 2008-12-12 US US12/747,365 patent/US8293513B2/en not_active Expired - Fee Related
- 2008-12-12 BR BRPI0821247-3A patent/BRPI0821247A2/pt not_active IP Right Cessation
- 2008-12-12 CN CN2008801248083A patent/CN101970399A/zh active Pending
- 2008-12-12 AU AU2008338631A patent/AU2008338631A1/en not_active Abandoned
- 2008-12-12 WO PCT/US2008/086603 patent/WO2009079375A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101970399A (zh) | 2011-02-09 |
| US8293513B2 (en) | 2012-10-23 |
| AU2008338631A1 (en) | 2009-06-25 |
| WO2009079375A1 (en) | 2009-06-25 |
| US20100317739A1 (en) | 2010-12-16 |
| EP2231596A4 (en) | 2012-06-06 |
| CA2709383A1 (en) | 2009-06-25 |
| EP2231596A1 (en) | 2010-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |