[go: up one dir, main page]

BR9609653A - Compostos e composições farmacêuticas contendo os mesmos - Google Patents

Compostos e composições farmacêuticas contendo os mesmos

Info

Publication number
BR9609653A
BR9609653A BR9609653-5A BR9609653A BR9609653A BR 9609653 A BR9609653 A BR 9609653A BR 9609653 A BR9609653 A BR 9609653A BR 9609653 A BR9609653 A BR 9609653A
Authority
BR
Brazil
Prior art keywords
same
compositions containing
pharmaceutical compounds
amphophosphonates
alpha
Prior art date
Application number
BR9609653-5A
Other languages
English (en)
Inventor
Lan Mong Nguyen
Original Assignee
Symphar Sa
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa, Smithkline Beecham Plc filed Critical Symphar Sa
Publication of BR9609653A publication Critical patent/BR9609653A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTOS E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS". Aminofosfonatos alfa substituídos por grupos fenóis de fórmula (I) possuindo atividade reduzida de lipoproteína.
BR9609653-5A 1995-06-30 1996-06-26 Compostos e composições farmacêuticas contendo os mesmos BR9609653A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01920/95A CH690264A5 (fr) 1995-06-30 1995-06-30 Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
PCT/EP1996/002842 WO1997002037A1 (en) 1995-06-30 1996-06-26 Compounds and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR9609653A true BR9609653A (pt) 1999-12-21

Family

ID=4221681

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9609653-5A BR9609653A (pt) 1995-06-30 1996-06-26 Compostos e composições farmacêuticas contendo os mesmos

Country Status (27)

Country Link
US (2) US6060464A (pt)
EP (1) EP0835116A1 (pt)
JP (1) JPH11508576A (pt)
KR (1) KR19990028542A (pt)
CN (1) CN1113654C (pt)
AP (1) AP778A (pt)
AR (1) AR004498A1 (pt)
AU (1) AU705206B2 (pt)
BG (1) BG102215A (pt)
BR (1) BR9609653A (pt)
CA (1) CA2225391A1 (pt)
CH (1) CH690264A5 (pt)
CZ (1) CZ422097A3 (pt)
EA (1) EA199800106A1 (pt)
HU (1) HUP9901684A3 (pt)
IL (1) IL122717A0 (pt)
MA (1) MA24340A1 (pt)
MX (1) MX9800189A (pt)
NO (1) NO976128L (pt)
NZ (1) NZ312696A (pt)
OA (1) OA10554A (pt)
PL (1) PL187024B1 (pt)
SK (1) SK178397A3 (pt)
TR (1) TR199701700T1 (pt)
TW (1) TW413681B (pt)
WO (1) WO1997002037A1 (pt)
ZA (1) ZA965505B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
GB9626616D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626536D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626615D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
DE19748659A1 (de) * 1997-11-04 1999-05-06 Hoechst Ag Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen
US6017918A (en) * 1998-08-06 2000-01-25 Warner-Lambert Company Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
US6284795B1 (en) 1998-09-04 2001-09-04 Warner-Lambert Company Sulfonamide compounds and methods of treating atherosclerosis and restenosis
CA2387394C (en) 1999-10-27 2009-08-18 Teva Pharmaceutical Industries, Ltd. Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder
WO2001060805A1 (en) 2000-02-16 2001-08-23 Smithkline Beecham P.L.C. Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
JP2004513891A (ja) * 2000-09-27 2004-05-13 アイレックス　オンコロジー　リサーチ　エス．エイ． α−置換β−アミノエチルホスホネート
US20030114421A1 (en) * 2000-09-27 2003-06-19 Phan Hieu Trung Alpha-substituted beta-aminoethyl phosphonate derivatives
GB0024808D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0025849D0 (en) * 2000-10-23 2000-12-06 Smithkline Beecham Plc Novel compounds
WO2003068240A1 (en) * 2002-02-11 2003-08-21 Ilex Products, Inc. Alpha-substituted heteroarylalkyl phosphonate derivattives
WO2003094852A2 (en) * 2002-05-11 2003-11-20 Ilex Products, Inc. Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
CA2496452A1 (en) * 2002-08-30 2004-03-11 Biostratum, Inc. Inhibitors of post-amadori advanced glycation end products
MX2013006342A (es) 2010-12-06 2013-08-26 Glaxo Group Ltd Compuestos de pirimidinona para usarse en el tratamiento de enfermedades o afecciones mediadas por fosfolipasa asociada con lipoproteinas a2 (lp-pla2).
KR20140059203A (ko) 2011-07-27 2014-05-15 글락소 그룹 리미티드 2,3-디히드로이미다조[1,2-c]피리미딘-5(1h)-온 화합물의 lp-pla2 억제제로서의 용도
AU2012288865B2 (en) 2011-07-27 2015-10-01 Glaxo Group Limited Bicyclic pyrimidone compounds
JP6199291B2 (ja) 2011-09-01 2017-09-20 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 新規な結晶形態
JP2016505053A (ja) 2013-01-25 2016-02-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｌｐ‐ＰＬＡ２の阻害剤としての二環式ピリミドン化合物
CA2899124A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
AU2014209949B2 (en) 2013-01-25 2016-09-08 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
BR112022008786A2 (pt) 2019-11-09 2022-07-26 Shanghai Simr Biotechnology Co Ltd Composto, composição, uso do composto ou da composição, e, método para tratar ou prevenir uma complicação diabética, doença relacionada à neuroinflamação ou aterosclerose
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683996A5 (fr) * 1992-03-05 1994-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de) * 1994-09-19 1996-03-28 Hoechst Ag Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen

Also Published As

Publication number Publication date
CN1113654C (zh) 2003-07-09
US6060464A (en) 2000-05-09
NO976128D0 (no) 1997-12-29
HUP9901684A2 (hu) 1999-09-28
SK178397A3 (en) 1998-06-03
AP9701160A0 (en) 1998-01-31
NZ312696A (en) 1999-10-28
AP778A (en) 1999-10-29
AU705206B2 (en) 1999-05-20
OA10554A (en) 2002-05-29
KR19990028542A (ko) 1999-04-15
EP0835116A1 (en) 1998-04-15
IL122717A0 (en) 1998-08-16
US6660724B1 (en) 2003-12-09
TR199701700T1 (xx) 1998-03-21
NO976128L (no) 1998-02-10
HUP9901684A3 (en) 2000-04-28
AR004498A1 (es) 1998-12-16
MA24340A1 (fr) 1998-07-01
PL324341A1 (en) 1998-05-25
PL187024B1 (pl) 2004-04-30
CN1193913A (zh) 1998-09-23
CH690264A5 (fr) 2000-06-30
EA199800106A1 (ru) 1998-08-27
ZA965505B (en) 1998-03-30
CZ422097A3 (cs) 1998-10-14
WO1997002037A1 (en) 1997-01-23
TW413681B (en) 2000-12-01
AU6418596A (en) 1997-02-05
JPH11508576A (ja) 1999-07-27
BG102215A (en) 1998-09-30
MX9800189A (es) 1998-04-30
CA2225391A1 (en) 1997-01-23

Similar Documents

Publication Publication Date Title
BR9609653A (pt) Compostos e composições farmacêuticas contendo os mesmos
TR199800019T1 (xx) Trombosit topaklanmas�n� �nleyici yeni maddeler.
MX9204661A (es) Compuestos intermedios derivados de eter y procedimiento para su preparacion.
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
PT1140993E (pt) Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
BR9911488A (pt) Composto, uso do mesmo, composição farmacêutica, e, processos para tratamento ou de profilaxia de doenças inflamatórias, e para a preparação de um composto
NO307336B1 (no) 2-[(Dihydro)pyrazolyl-3'-oksylmetylen]anilider, anvendelse derav, samt middel inneholdende forbindelsen og mellomprodukter for fremstilling av forbindelsen
TR200101961T2 (tr) 1,2-halkalı kinolin türevleri
ATE206409T1 (de) N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide
BR9711586A (pt) Compostos e uso dos mesmo
AU674378B2 (en) Use of 2-amino-6-A-propylamino-4,5,6, 7-tetrahydrobenzothiazole (pramipexol) as an anti-depressantdrug
KR960006915A (ko) 췌장염의 치료 조성물
SE9801494D0 (sv) Novel use
ES2103440T3 (es) Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen.
KR960703863A (ko) 암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
EA200000242A1 (ru) Применение фанхинона для лечения болезни альцгеймера
NO982229D0 (no) Svovelholdige di-tert-butylfenol-forbindelser anvendbare som antiinflammatoriske midler
DE69936052D1 (de) N1 modifizierte glycopeptide
DK319785A (da) Acetyleniske phenoxypropanolderivater
YU49316B (sh) Novi intermedijari, njihova primena u sintezi n,n'-premoštenih bisindolilmaleimida i farmaceutske formulacije
PT1000067E (pt) Tiazolobenzo-heterociclos sua preparacao e medicamentos que os contem
IT1216056B (it) Composizioni farmaceutiche contenenti timosina alfa 1.
DE69614552D1 (de) MODIFIZIERTE ALPHA-D-GLCP-(1,2)-ALPHA-D-Glcp-(1,3)-ALPHA-D-Glcp-ANALOGE
FI853506L (fi) Nya antibioter, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska kompositioner.

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI.