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BR9609399A - Elements of streptococcal heat shock proteins of the hsp70 family - Google Patents

Elements of streptococcal heat shock proteins of the hsp70 family

Info

Publication number
BR9609399A
BR9609399A BR9609399-4A BR9609399A BR9609399A BR 9609399 A BR9609399 A BR 9609399A BR 9609399 A BR9609399 A BR 9609399A BR 9609399 A BR9609399 A BR 9609399A
Authority
BR
Brazil
Prior art keywords
seq
heat shock
shock proteins
hsp70
hsps
Prior art date
Application number
BR9609399-4A
Other languages
Portuguese (pt)
Inventor
Josee Hamel
Bernard R Brodeur
Denis Martin
Clement Rioux
Original Assignee
Biochem Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/472,534 external-priority patent/US5919620A/en
Application filed by Biochem Vaccines Inc filed Critical Biochem Vaccines Inc
Publication of BR9609399A publication Critical patent/BR9609399A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ELEMENTOS DE PROTEìNAS DE CHOQUE TéRMICO ESTREPTOCóCICOS DA FAMìLIA HSP70. São descritas novas proteínas de choque térmico (HSPs) de Streptococcus pneumoniae, Sterptococcus pyogenes e Streptococcus agalactiae tendo massas moleculares aparentes de 70 a 72 KDa, polipeptídeos imunologicamente relacionados, o nucleotídeo e seq³ências de aminoácido derivadas de HSP72 de S. pneumoniae (SEQ ID NO: 4; SEQ ID NO: 5), o nucleotídeo e sequências de aminoácido derivadas de HSP70 de S. pyogenes (SEQ ID NO: 19; SEQ ID NO:20), o nucleotídeo e as sequências de aminoácido derivadas de HSP70 de S. agalactiae (SEQ ID NO:21; SEQ ID NO:22), anticorpos se ligam às HSPs e métodos de DNA recombinante para a produção das HSPs e polipeptídeos imunologicamente relacionados. Os polipeptídeos, as seq³ências de DNA e os anticorpos desta invenção proporcionam novos meios de diagnóstico, prevenção e/ou tratamento de doença estreptocócica.ELEMENTS OF STREPTOCOCCIC HEAT SHOCK PROTEINS FROM THE HSP70 FAMILY. New heat shock proteins (HSPs) from Streptococcus pneumoniae, Sterptococcus pyogenes and Streptococcus agalactiae are described having apparent molecular weights of 70 to 72 KDa, immunologically related polypeptides, the nucleotide and amino acid sequences derived from HSP72 of S. pneumoniae (SEQ ID NO. : 4; SEQ ID NO: 5), the S. pyogenes-derived HSP70 nucleotide and amino acid sequences (SEQ ID NO: 19; SEQ ID NO: 20), the S. HSP70-derived nucleotide and amino acid sequences agalactiae (SEQ ID NO: 21; SEQ ID NO: 22), antibodies bind to HSPs and recombinant DNA methods for the production of immunologically related HSPs and polypeptides. The polypeptides, DNA sequences and antibodies of this invention provide new means of diagnosing, preventing and / or treating streptococcal disease.

BR9609399-4A 1995-06-07 1996-05-17 Elements of streptococcal heat shock proteins of the hsp70 family BR9609399A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/472,534 US5919620A (en) 1995-06-07 1995-06-07 Heat shock protein HSP72 of Streptococcus pneumoniae
US180595P 1995-08-04 1995-08-04
PCT/CA1996/000322 WO1996040928A1 (en) 1995-06-07 1996-05-17 Streptococcal heat shock proteins members of the hsp70 family

Publications (1)

Publication Number Publication Date
BR9609399A true BR9609399A (en) 2001-08-28

Family

ID=26669494

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9609399-4A BR9609399A (en) 1995-06-07 1996-05-17 Elements of streptococcal heat shock proteins of the hsp70 family

Country Status (18)

Country Link
EP (1) EP0832238A1 (en)
JP (1) JPH11507214A (en)
KR (1) KR19990022742A (en)
CN (1) CN1192241A (en)
AP (1) AP9701163A0 (en)
AR (1) AR003124A1 (en)
AU (1) AU700080B2 (en)
BR (1) BR9609399A (en)
CA (1) CA2224015A1 (en)
CZ (1) CZ394297A3 (en)
EA (1) EA199800046A1 (en)
HU (1) HUP0600442A3 (en)
IL (1) IL118329A0 (en)
NO (1) NO975752L (en)
PL (1) PL323781A1 (en)
SK (1) SK168497A3 (en)
TR (1) TR199701537T1 (en)
WO (1) WO1996040928A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253252A1 (en) * 1996-05-01 1997-11-06 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
JP2002508156A (en) * 1997-12-31 2002-03-19 ストレスジェン バイオテクノロジーズ コーポレイション Streptococcus heat shock proteins of the Hsp60 family
US6497880B1 (en) 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
KR100802198B1 (en) * 1998-12-23 2008-02-11 샤이어 바이오켐 인코포레이티드 Novel Streptococcus Antigens
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
HU229968B1 (en) 1999-03-19 2015-03-30 Smithkline Beecham Biologicals S.A Streptococcus vaccine
US7015309B1 (en) 1999-06-23 2006-03-21 The Wistar Institute Of Anatomy And Biology Pyrrhocoricin-derived peptides, and methods of use thereof
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
AU2005204321B2 (en) * 1999-08-19 2008-07-10 Immunobiology Limited Vaccines from Infectious Agents
GB9919734D0 (en) * 1999-08-19 1999-10-20 Colaco Camilo Vaccines from infectious agents
EP1252517A4 (en) * 2000-01-21 2004-10-20 Wistar Inst BIOCIDAL MOLECULES, MACROMOLECULAR TARGETS, AND METHODS OF PRODUCTION AND USE
US6833134B2 (en) 2000-06-12 2004-12-21 University Of Saskacthewan Immunization of dairy cattle with GapC protein against Streptococcus infection
EP1294771B1 (en) 2000-06-12 2008-10-29 University Of Saskatchewan Chimeric GapC protein from Streptococcus and its use in vaccination and diagnosis
US6866855B2 (en) 2000-06-12 2005-03-15 University Of Saskatchewan Immunization of dairy cattle with GapC protein against Streptococcus infection
GB0021757D0 (en) * 2000-09-04 2000-10-18 Colaco Camilo Vaccine against microbial pathogens
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
JP4740738B2 (en) 2002-08-02 2011-08-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム vaccine
JP4579156B2 (en) 2002-11-01 2010-11-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Immunogenic composition
EP2287311A1 (en) * 2003-03-04 2011-02-23 Intercell AG Streptococcus pyogenes antigens
EP2336357A1 (en) * 2003-04-15 2011-06-22 Intercell AG S. pneumoniae antigens
WO2005032584A2 (en) 2003-10-02 2005-04-14 Glaxosmithkline Biologicals S.A. Pertussis antigens and use thereof in vaccination
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
CN104436180B (en) 2006-01-17 2021-08-31 阿恩·福斯格伦 Novel surface-exposed Haemophilus influenzae protein (Protein E; pE)
CN102869377A (en) 2010-03-10 2013-01-09 葛兰素史密丝克莱恩生物有限公司 Immunogenic composition
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
CN103146734B (en) * 2013-03-12 2014-10-01 中国人民解放军军事医学科学院军事兽医研究所 Anti-burn and scald infection multiple organ failure Pseudomonas aeruginosa toxin vaccine
CN104001164A (en) * 2014-04-23 2014-08-27 杭州师范大学 Aeromonas hydrophila heat shock protein subunit vaccine and preparation method thereof
CN114805567B (en) * 2022-06-27 2022-09-16 和元生物技术（上海）股份有限公司 Monoclonal antibody, method and application of marker protein HSPA1A for recognizing exosomes
CN116258247A (en) * 2022-12-26 2023-06-13 三峡大学 A Power Load Forecasting Method Based on SAINet Neural Network Model

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571538B1 (en) * 1991-02-15 1998-07-08 The Uab Research Foundation Structural gene of pneumococcal protein
IT1262896B (en) * 1992-03-06 1996-07-22 CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES.

Also Published As

Publication number Publication date
TR199701537T1 (en) 1998-03-21
EA199800046A1 (en) 1998-06-25
EP0832238A1 (en) 1998-04-01
AU700080B2 (en) 1998-12-17
PL323781A1 (en) 1998-04-27
KR19990022742A (en) 1999-03-25
WO1996040928A1 (en) 1996-12-19
AP9701163A0 (en) 1998-01-31
JPH11507214A (en) 1999-06-29
CA2224015A1 (en) 1996-12-19
HUP0600442A3 (en) 2007-03-28
SK168497A3 (en) 1998-07-08
CZ394297A3 (en) 1998-04-15
AU5682896A (en) 1996-12-30
CN1192241A (en) 1998-09-02
NO975752D0 (en) 1997-12-05
IL118329A0 (en) 1996-09-12
HUP0600442A2 (en) 2006-08-28
NO975752L (en) 1998-02-06
AR003124A1 (en) 1998-07-08

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