AR003124A1 - STREPTOCOCCAL PROTEINS OF THERMAL SHOCK MEMBERS OF THE HSP7270 FAMILY, DNA SEQUENCE CODING FOR SUCH POLYPEPTIDES, VECTOR OF EXPRESSION, METHOD OF MAKING A POLIPEPTIDE OR FRAGMENTO MOST OF THE MOST - Google Patents
STREPTOCOCCAL PROTEINS OF THERMAL SHOCK MEMBERS OF THE HSP7270 FAMILY, DNA SEQUENCE CODING FOR SUCH POLYPEPTIDES, VECTOR OF EXPRESSION, METHOD OF MAKING A POLIPEPTIDE OR FRAGMENTO MOST OF THE MOSTInfo
- Publication number
- AR003124A1 AR003124A1 ARP960102631A AR10263196A AR003124A1 AR 003124 A1 AR003124 A1 AR 003124A1 AR P960102631 A ARP960102631 A AR P960102631A AR 10263196 A AR10263196 A AR 10263196A AR 003124 A1 AR003124 A1 AR 003124A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptides
- seq
- hsp72
- pneumoniae
- immunologically related
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 229920001184 polypeptide Polymers 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000035939 shock Effects 0.000 title 1
- 108010027814 HSP72 Heat-Shock Proteins Proteins 0.000 abstract 4
- 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 abstract 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 4
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 101710163595 Chaperone protein DnaK Proteins 0.000 abstract 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 abstract 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 abstract 2
- 241000193985 Streptococcus agalactiae Species 0.000 abstract 2
- 241000193996 Streptococcus pyogenes Species 0.000 abstract 2
- 108020003215 DNA Probes Proteins 0.000 abstract 1
- 239000003298 DNA probe Substances 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 241000193998 Streptococcus pneumoniae Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Nuevas proteinas de shock por calor (HSPs) Streptococcus pneumoniae, Streptococcus pyogenes y Streptococcus agalactiae que tienen masas molecularesaparentes de 70-72 kDa, polipéptidos inmunológicamente relacionados, las secuencias de nucleótidos y aminoácidos derivadas de HSP72 de S.pneumoniae (SECID Ns: 4, SEC ID Ns: 5), las secuencias de nucleótidos y aminoácidos derivados de HSP70 de S. pyogenes (SEC ID Ns: 19; SEC ID Ns: 20), las secuencias denucleótidos y aminoácidos derivadas HSP70 de S. agalactiae (SEC ID Ns: 21; SEC ID Ns: 22), anticuerpos que se ligan con HSPs y métodos de ADN recombinantes,vectores de expresión y huéspedes recombinantes para la producción de los HSPs y los polipéptidos inmunológicamente relacionados. Los polipéptidos, lassecuencias de ADN y los anticuerpos de esta invención proveen nuevos medios para el diagnóstico, prevención y/o tratamiento de las enfermedades causadaspor estreptococos. Se describe un nuevo método para producir anticuerpos contra HSP72 y péptidos inmunológicamente relacionados. Estos péptidos son usados enla preparación de una vacuna y en un método de prevención de una infección causada por S. pneumoniae. Finalmente, también se describen métodos dedetección dela presencia de S. pneumoniae en muestras biológicas, haciendo uso de los polipéptidos bacterianos HSP72 y polipéptidos inmunológicamenterelacionados, de anticuerpos dirigidos contra el mismo o de una sonda de ADN contra los ácidos nucleicos quecodifican para los polipéptidos HSP72.New heat shock proteins (HSPs) Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae having apparent molecular masses of 70-72 kDa, immunologically related polypeptides, nucleotide and amino acid sequences derived from S. pneumoniae HSP72 (SECID Ns: 4, Ns: 4, SEQ ID Ns: 5), the nucleotide and amino acid sequences derived from S. pyogenes HSP70 (SEQ ID Ns: 19; SEQ ID Ns: 20), the nucleotide and amino acid sequences derived HSP70 from S. agalactiae (SEQ ID Ns: 21; SEQ ID Ns: 22), antibodies that bind to HSPs and recombinant DNA methods, expression vectors and recombinant hosts for the production of the HSPs and immunologically related polypeptides. The polypeptides, DNA sequences, and antibodies of this invention provide new means for the diagnosis, prevention, and / or treatment of diseases caused by streptococci. A new method for producing antibodies against HSP72 and immunologically related peptides is described. These peptides are used in the preparation of a vaccine and in a method of preventing an infection caused by S. pneumoniae. Finally, methods for detecting the presence of S. pneumoniae in biological samples are also described, making use of the bacterial HSP72 polypeptides and immunologically related polypeptides, of antibodies directed against it or of a DNA probe against the nucleic acids that encode for the HSP72 polypeptides.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/472,534 US5919620A (en) | 1995-06-07 | 1995-06-07 | Heat shock protein HSP72 of Streptococcus pneumoniae |
| US180595P | 1995-08-04 | 1995-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003124A1 true AR003124A1 (en) | 1998-07-08 |
Family
ID=26669494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102631A AR003124A1 (en) | 1995-06-07 | 1996-05-20 | STREPTOCOCCAL PROTEINS OF THERMAL SHOCK MEMBERS OF THE HSP7270 FAMILY, DNA SEQUENCE CODING FOR SUCH POLYPEPTIDES, VECTOR OF EXPRESSION, METHOD OF MAKING A POLIPEPTIDE OR FRAGMENTO MOST OF THE MOST |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0832238A1 (en) |
| JP (1) | JPH11507214A (en) |
| KR (1) | KR19990022742A (en) |
| CN (1) | CN1192241A (en) |
| AP (1) | AP9701163A0 (en) |
| AR (1) | AR003124A1 (en) |
| AU (1) | AU700080B2 (en) |
| BR (1) | BR9609399A (en) |
| CA (1) | CA2224015A1 (en) |
| CZ (1) | CZ394297A3 (en) |
| EA (1) | EA199800046A1 (en) |
| HU (1) | HUP0600442A3 (en) |
| IL (1) | IL118329A0 (en) |
| NO (1) | NO975752L (en) |
| PL (1) | PL323781A1 (en) |
| SK (1) | SK168497A3 (en) |
| TR (1) | TR199701537T1 (en) |
| WO (1) | WO1996040928A1 (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2253252A1 (en) * | 1996-05-01 | 1997-11-06 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| US6245335B1 (en) | 1996-05-01 | 2001-06-12 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| JP2002508156A (en) * | 1997-12-31 | 2002-03-19 | ストレスジェン バイオテクノロジーズ コーポレイション | Streptococcus heat shock proteins of the Hsp60 family |
| US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| KR100802198B1 (en) * | 1998-12-23 | 2008-02-11 | 샤이어 바이오켐 인코포레이티드 | Novel Streptococcus Antigens |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| HU229968B1 (en) | 1999-03-19 | 2015-03-30 | Smithkline Beecham Biologicals S.A | Streptococcus vaccine |
| US7015309B1 (en) | 1999-06-23 | 2006-03-21 | The Wistar Institute Of Anatomy And Biology | Pyrrhocoricin-derived peptides, and methods of use thereof |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| AU2005204321B2 (en) * | 1999-08-19 | 2008-07-10 | Immunobiology Limited | Vaccines from Infectious Agents |
| GB9919734D0 (en) * | 1999-08-19 | 1999-10-20 | Colaco Camilo | Vaccines from infectious agents |
| EP1252517A4 (en) * | 2000-01-21 | 2004-10-20 | Wistar Inst | BIOCIDAL MOLECULES, MACROMOLECULAR TARGETS, AND METHODS OF PRODUCTION AND USE |
| US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| EP1294771B1 (en) | 2000-06-12 | 2008-10-29 | University Of Saskatchewan | Chimeric GapC protein from Streptococcus and its use in vaccination and diagnosis |
| US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
| GB0021757D0 (en) * | 2000-09-04 | 2000-10-18 | Colaco Camilo | Vaccine against microbial pathogens |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| JP4740738B2 (en) | 2002-08-02 | 2011-08-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | vaccine |
| JP4579156B2 (en) | 2002-11-01 | 2010-11-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Immunogenic composition |
| EP2287311A1 (en) * | 2003-03-04 | 2011-02-23 | Intercell AG | Streptococcus pyogenes antigens |
| EP2336357A1 (en) * | 2003-04-15 | 2011-06-22 | Intercell AG | S. pneumoniae antigens |
| WO2005032584A2 (en) | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
| GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
| TWI457133B (en) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
| CN104436180B (en) | 2006-01-17 | 2021-08-31 | 阿恩·福斯格伦 | Novel surface-exposed Haemophilus influenzae protein (Protein E; pE) |
| CN102869377A (en) | 2010-03-10 | 2013-01-09 | 葛兰素史密丝克莱恩生物有限公司 | Immunogenic composition |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| CN103146734B (en) * | 2013-03-12 | 2014-10-01 | 中国人民解放军军事医学科学院军事兽医研究所 | Anti-burn and scald infection multiple organ failure Pseudomonas aeruginosa toxin vaccine |
| CN104001164A (en) * | 2014-04-23 | 2014-08-27 | 杭州师范大学 | Aeromonas hydrophila heat shock protein subunit vaccine and preparation method thereof |
| CN114805567B (en) * | 2022-06-27 | 2022-09-16 | 和元生物技术（上海）股份有限公司 | Monoclonal antibody, method and application of marker protein HSPA1A for recognizing exosomes |
| CN116258247A (en) * | 2022-12-26 | 2023-06-13 | 三峡大学 | A Power Load Forecasting Method Based on SAINet Neural Network Model |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0571538B1 (en) * | 1991-02-15 | 1998-07-08 | The Uab Research Foundation | Structural gene of pneumococcal protein |
| IT1262896B (en) * | 1992-03-06 | 1996-07-22 | CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES. |
-
1996
- 1996-05-17 JP JP9500026A patent/JPH11507214A/en active Pending
- 1996-05-17 AP APAP/P/1997/001163A patent/AP9701163A0/en unknown
- 1996-05-17 CA CA002224015A patent/CA2224015A1/en not_active Abandoned
- 1996-05-17 HU HU0600442A patent/HUP0600442A3/en unknown
- 1996-05-17 EP EP96914821A patent/EP0832238A1/en not_active Withdrawn
- 1996-05-17 SK SK1684-97A patent/SK168497A3/en unknown
- 1996-05-17 EA EA199800046A patent/EA199800046A1/en unknown
- 1996-05-17 BR BR9609399-4A patent/BR9609399A/en not_active Application Discontinuation
- 1996-05-17 KR KR1019970709184A patent/KR19990022742A/en not_active Withdrawn
- 1996-05-17 PL PL96323781A patent/PL323781A1/en unknown
- 1996-05-17 WO PCT/CA1996/000322 patent/WO1996040928A1/en not_active Ceased
- 1996-05-17 CN CN96195891A patent/CN1192241A/en active Pending
- 1996-05-17 TR TR97/01537T patent/TR199701537T1/en unknown
- 1996-05-17 CZ CZ973942A patent/CZ394297A3/en unknown
- 1996-05-17 AU AU56828/96A patent/AU700080B2/en not_active Ceased
- 1996-05-20 AR ARP960102631A patent/AR003124A1/en unknown
- 1996-05-20 IL IL11832996A patent/IL118329A0/en unknown
-
1997
- 1997-12-05 NO NO975752A patent/NO975752L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9609399A (en) | 2001-08-28 |
| TR199701537T1 (en) | 1998-03-21 |
| EA199800046A1 (en) | 1998-06-25 |
| EP0832238A1 (en) | 1998-04-01 |
| AU700080B2 (en) | 1998-12-17 |
| PL323781A1 (en) | 1998-04-27 |
| KR19990022742A (en) | 1999-03-25 |
| WO1996040928A1 (en) | 1996-12-19 |
| AP9701163A0 (en) | 1998-01-31 |
| JPH11507214A (en) | 1999-06-29 |
| CA2224015A1 (en) | 1996-12-19 |
| HUP0600442A3 (en) | 2007-03-28 |
| SK168497A3 (en) | 1998-07-08 |
| CZ394297A3 (en) | 1998-04-15 |
| AU5682896A (en) | 1996-12-30 |
| CN1192241A (en) | 1998-09-02 |
| NO975752D0 (en) | 1997-12-05 |
| IL118329A0 (en) | 1996-09-12 |
| HUP0600442A2 (en) | 2006-08-28 |
| NO975752L (en) | 1998-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR003124A1 (en) | STREPTOCOCCAL PROTEINS OF THERMAL SHOCK MEMBERS OF THE HSP7270 FAMILY, DNA SEQUENCE CODING FOR SUCH POLYPEPTIDES, VECTOR OF EXPRESSION, METHOD OF MAKING A POLIPEPTIDE OR FRAGMENTO MOST OF THE MOST | |
| BR9916477A (en) | Isolated polynucleotide, chimeric polynucleotide, vaccine composition and use of this composition comprising polynucleotides | |
| DE60139690D1 (en) | IMMUNIZATION AGAINST CHLAMYDIA PNEUMONIAE | |
| WO2000034317A2 (en) | Method for reducing immunogenicity of proteins | |
| DK0942983T3 (en) | Streptococcus pneumoniae antigens and vaccines | |
| BR9813841A (en) | Hmw protein of the isolated chlamydia species, isolated nucleic acid molecule, recombinant expression vector, transformed host cell, isolated recombinant protein or fragment or analog thereof, immunogenic composition, antigenic composition, processes to produce an immune response in an animal, anti- serum, antibodies, diagnostic reagent, to detect anti-chlamydia antibodies in a test sample, to detect the presence of chlamydia in a test sample, to prevent, treat or ameliorate a chlamydia-related disorder in a host in need of this treatment , and to determine the presence of nucleic acid encoding an hmw protein or a fragment or analog thereof in a sample, diagnostic kits to detect antibodies to chlamydia, and to determine the presence of nucleic acid encoding an hmw protein or fragment or analog thereof in a sample, vaccine composition, and pharmaceutical composition The | |
| NL930012I1 (en) | Recombinant DNA, host proteins transformed therewith by hosts produced polypeptides; methods of preparation thereof, detection methods using the polypeptides; compositions and agents containing the polypeptides; DNS sequences | |
| EA199700248A1 (en) | ESSENTIALLY DETERMINED PURIFIED SURFACE ANTIGEN OF PROTEIN NATURE NEISSERIA AND FRAGMENT OF THIS ANTIGEN | |
| BR0208944A (en) | streptococus pneumoniae open reading frames encoding polypeptide antigens and their uses | |
| JP3245298B2 (en) | Epitope region of pneumococcal surface protein A | |
| JP2009542196A (en) | Small Streptococcus pyogenes antigens and their use | |
| ATE360640T1 (en) | GROUP-B STREPTOCOCCUS POLYPEPTIDES, NUCLEIC ACIDS, THERAPEUTIC COMPOSITIONS AND VACCINES THEREOF | |
| DE60120621D1 (en) | Lawsonia intracellular vaccine | |
| DE69733944D1 (en) | VMP-Similar Sequences of Pathogen Borrelia | |
| NZ500540A (en) | Purified proteins, fusion proteins, recombinant vector, vaccine, kit, comprising proteins from Actinobacillus pleuropneumoniae | |
| EP0369825B1 (en) | Streptolysin o antigen derivative, its production and uses | |
| RU2006134631A (en) | IMMUNOGENIC COMPOSITIONS AGAINST CHLAMIDIA PNEUMONIAE | |
| US5354846A (en) | Streptolysin O antigen derivatives, its production and uses | |
| BR9810288A (en) | Species-specific diagnostic test to identify infection of a mammal, such as a human, with chlamydia pneumoniae, fragment of nucleic acid derived from chlamydia pneumoniae, protein derived from chlamydia pneumoniae, polyclonal monospecific antibody, diagnostic kit for the diagnosis of infection of a mammal, as a human, with chlamydia pneumoniae, composition to immunize a mammal as a human, against chlamydia pneumoniae, use of a protein, and use of a nucleic acid fragment. | |
| ES2110996T3 (en) | BALLICO POLLEN ALLERGEN. | |
| BR9908476A (en) | Peptide, therapeutic composition, and, process to confer protective immunity to a patient, against s infection. pneumoniae | |
| CA2338886A1 (en) | Expression and characterization of hiv-1 envelope protein associated with a broadly reactive neutralizing antibody response | |
| JP2001505534A (en) | Treatment and diagnosis of Gram-positive bacterial infections | |
| DE60035485D1 (en) | IDENTIFICATION OF SPECIFIC DIFFERENTIALLY EXPRESSED ANTIGENES FROM MYCOBACTERIUM AND MEDICAL USE OF MYCOBACTERIUM PROTEINS Rv0068 AND Rv3407 | |
| AR015393A1 (en) | ISOLATED POLINUCLEOTIDE MOLECULA, OLIGONUCLEOTIDE MOLECULAR THAT HYBRIDES, RECOMBINATING EXPRESSION VECTOR, TRANSFORMED HOSPED CELL, ISOLATED POLYPEPTIDE, PROCEDURE TO PREPARE IT, ANALOGS OR COMBINED VACCINATION, WINNING PROCESS |