[go: up one dir, main page]

BR9607772A - Derivados de ácido hidroxâmico contendo lactama sua preparação e seu uso como inibidores de metaloprotease de matriz - Google Patents

Derivados de ácido hidroxâmico contendo lactama sua preparação e seu uso como inibidores de metaloprotease de matriz

Info

Publication number
BR9607772A
BR9607772A BR9607772A BR9607772A BR9607772A BR 9607772 A BR9607772 A BR 9607772A BR 9607772 A BR9607772 A BR 9607772A BR 9607772 A BR9607772 A BR 9607772A BR 9607772 A BR9607772 A BR 9607772A
Authority
BR
Brazil
Prior art keywords
preparation
acid derivatives
hydroxamic acid
derivatives containing
matrix metalloprotease
Prior art date
Application number
BR9607772A
Other languages
English (en)
Inventor
Christopher Thomas Wahl
Michael George Natchus
Biswanath De
Menyen Cheng
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9607772A publication Critical patent/BR9607772A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR9607772A 1995-03-21 1996-03-19 Derivados de ácido hidroxâmico contendo lactama sua preparação e seu uso como inibidores de metaloprotease de matriz BR9607772A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/407,839 US5672598A (en) 1995-03-21 1995-03-21 Lactam-containing hydroxamic acids
PCT/US1996/003726 WO1996029313A1 (en) 1995-03-21 1996-03-19 Lactam-containing hydroxamic acid derivatives, their preparation and their use as inhibitors of matrix metalloprotease

Publications (1)

Publication Number Publication Date
BR9607772A true BR9607772A (pt) 1998-07-07

Family

ID=23613737

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9607772A BR9607772A (pt) 1995-03-21 1996-03-19 Derivados de ácido hidroxâmico contendo lactama sua preparação e seu uso como inibidores de metaloprotease de matriz

Country Status (17)

Country Link
US (1) US5672598A (pt)
EP (1) EP0815084B1 (pt)
JP (1) JPH11502523A (pt)
KR (1) KR19980703151A (pt)
AR (1) AR002718A1 (pt)
AT (1) ATE248150T1 (pt)
AU (1) AU711889B2 (pt)
BR (1) BR9607772A (pt)
CA (1) CA2216129C (pt)
CZ (1) CZ295197A3 (pt)
DE (1) DE69629670T2 (pt)
HU (1) HUP9800813A3 (pt)
IL (1) IL117527A (pt)
NO (1) NO974335L (pt)
NZ (1) NZ304689A (pt)
WO (1) WO1996029313A1 (pt)
ZA (1) ZA962253B (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0925287T3 (da) * 1996-08-28 2003-05-12 Procter & Gamble Heterocykliske metalloproteaseinhibitorer
NZ334490A (en) * 1996-09-19 2000-08-25 Hoechst Marion Roussel Inc 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives as inhibitors of matrix metalloproteinase
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
ATE224364T1 (de) * 1996-10-16 2002-10-15 American Cyanamid Co Beta-sulfonamido hydroxamsäure als matrix metalloproteinase und als tace inhibitoren
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US20030206874A1 (en) * 1996-11-21 2003-11-06 The Proctor & Gamble Company Promoting whole body health
US6191166B1 (en) * 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US20050058709A1 (en) * 1997-06-04 2005-03-17 Fisher Gary J. Methods for inhibiting photoaging of human skin using orally-administered agent
ZA988967B (en) * 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
US6403632B1 (en) 2000-03-01 2002-06-11 Bristol Myers Squibb Pharma Co Lactam metalloprotease inhibitors
US6335329B1 (en) 1997-12-19 2002-01-01 Amgen Inc. Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
US6569636B2 (en) * 1998-05-29 2003-05-27 Hawaii Biotechnology Group, Inc. Assay for modulators of metallo-enzyme activity
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU2003203805B8 (en) * 1998-08-07 2007-02-15 Bristol-Myers Squibb Pharma Company Succinoylamino lactams as inhibitors of ABeta protein production
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ509241A (en) * 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
US6737038B1 (en) * 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
DE69926254D1 (de) * 1998-11-12 2005-08-25 Bristol Myers Squibb Pharma Co Verwendung von radioliganden zum screening von inhibitoren der herstellung von beta-amyloid peptiden
IL142816A0 (en) * 1998-12-24 2002-03-10 Du Pont Pharm Co SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
CA2358955A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
PT1150976E (pt) * 1998-12-31 2003-07-31 Aventis Pharma Inc Lactamas 3-(tio amido substituidas) uteis como inibidores da metaloproteinase da matriz
US6262080B1 (en) * 1998-12-31 2001-07-17 Avantis Pharmaceuticals Inc. 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
US6344450B1 (en) 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
CA2361919A1 (en) * 1999-02-09 2000-08-17 Bristol-Myers Squibb Company Lactam inhibitors of fxa and method
EP1156803A4 (en) 1999-02-09 2004-03-17 Bristol Myers Squibb Co FXA LACTAM INHIBITORS AND METHOD
GB9929527D0 (en) * 1999-12-14 2000-02-09 Smithkline Beecham Plc Novel compounds
US6509330B2 (en) * 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
EP1268433A1 (en) * 2000-04-03 2003-01-02 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of a-beta-protein production
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
WO2001085716A1 (en) * 2000-05-11 2001-11-15 Kyowa Hakko Kogyo Co., Ltd 2-piperidone compounds for the treatment of cancer
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
WO2001092235A1 (en) 2000-06-01 2001-12-06 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
PE20020102A1 (es) * 2000-06-30 2002-03-06 Procter & Gamble Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales
AU2001271545A1 (en) * 2000-06-30 2002-01-14 The Procter And Gamble Company Promoting whole body health
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
WO2003033018A1 (en) * 2001-10-18 2003-04-24 Warner-Lambert Company Llc Method for preparing purified matrix metalloproteinase
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
KR100838852B1 (ko) * 2003-09-09 2008-06-16 에프. 호프만-라 로슈 아게 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US4771038A (en) * 1986-01-21 1988-09-13 Ici Americas Inc. Hydroxamic acids
GB8601368D0 (en) * 1986-01-21 1986-02-26 Ici America Inc Hydroxamic acids
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
CA2002021A1 (en) * 1988-11-03 1990-05-03 Ann E. Aulabaugh Inhibition of ketol-acid reductoisomerase by oxalylhydroxamate derivatives
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
WO1991008737A2 (en) * 1989-12-16 1991-06-27 Fisons Plc Pharmacologically active amide carboxylate derivatives
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
JPH04217950A (ja) * 1990-03-28 1992-08-07 Asahi Chem Ind Co Ltd ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤
DE4011172A1 (de) * 1990-04-06 1991-10-10 Degussa Verbindungen zur bekaempfung von pflanzenkrankheiten
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5239078A (en) * 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
GB9107368D0 (en) * 1991-04-08 1991-05-22 Smithkline Beecham Plc Novel compounds
IL98681A (en) * 1991-06-30 1997-06-10 Yeda Rehovot And Dev Company L Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
DE4127842A1 (de) * 1991-08-22 1993-02-25 Rhone Poulenc Rorer Gmbh 5-((omega)-arylalky)-2-thienyl alkansaeuren, ihre salze und/oder ihre derivate
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
NZ249202A (en) * 1992-02-20 1996-06-25 Black James Foundation Bicyclo[2.2.2.]octane derivatives, preparation and pharmaceutical compositions thereof
WO1993020047A1 (en) * 1992-04-07 1993-10-14 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors
AU4267293A (en) * 1992-05-01 1993-11-29 British Biotech Pharmaceuticals Limited Use of MMP inhibitors
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
WO1994021612A1 (en) * 1993-03-18 1994-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as matrix metalloproteinases inhibitors

Also Published As

Publication number Publication date
HUP9800813A2 (hu) 1998-07-28
DE69629670T2 (de) 2004-06-17
HUP9800813A3 (en) 1998-09-28
WO1996029313A1 (en) 1996-09-26
CA2216129A1 (en) 1996-09-26
EP0815084B1 (en) 2003-08-27
US5672598A (en) 1997-09-30
AR002718A1 (es) 1998-04-29
CA2216129C (en) 2002-08-20
KR19980703151A (ko) 1998-10-15
NO974335L (no) 1997-11-21
IL117527A (en) 1999-12-22
CZ295197A3 (cs) 1998-05-13
MX9707214A (es) 1997-11-29
ZA962253B (en) 1996-09-30
ATE248150T1 (de) 2003-09-15
JPH11502523A (ja) 1999-03-02
NZ304689A (en) 1999-05-28
AU5255896A (en) 1996-10-08
AU711889B2 (en) 1999-10-21
NO974335D0 (no) 1997-09-19
DE69629670D1 (de) 2003-10-02
EP0815084A1 (en) 1998-01-07
IL117527A0 (en) 1996-07-23

Similar Documents

Publication Publication Date Title
BR9607772A (pt) Derivados de ácido hidroxâmico contendo lactama sua preparação e seu uso como inibidores de metaloprotease de matriz
BR9611929A (pt) Inibidores de metaloproteinase composições farmacéuticas contendo os mesmos e seus usos farmacéuticos e métodos e intermediários úteis
DE69820906D1 (de) Hydroxamsäure-derivate als matrix metalloproteinaseinhibitoren
BR9509802A (pt) Inibidores de metaloproteases de matriz
FI965036A7 (fi) Interleukiini-beta:aa muuttavan entsyymin inhibiittoreita sekä niitä sisältävät farmaseuttiset koostumukset
FI973278A7 (fi) Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
BR9510175A (pt) Inibidores contendo ácido hidroxâmico de metaloproteases de matriz
ATE219058T1 (de) Alpha-substituierte arylsulphonamidohydroxamsaüre als tnf-alpha und matrix-metalloproteinase- inhibitoren
FI971412A7 (fi) Peptididyyliyhdisteet ja niiden terapeuttinen käyttö metalloproteaasie n estäjinä
FI960042L (fi) Farmaseuttisia valmisteita niukkaliukoisia aktiivisia aineita varten
FI964920A7 (fi) Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
FI973733L (fi) Farmaseuttinen valmiste ja menetelmä sen valmistamiseksi
FI955091A7 (fi) Parannetut farmaseuttisesti hyväksyttävät seokset, jotka sisältävät al koholia ja hydrofobista lääkettä
AU5493598A (en) N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
KR950704251A (ko) 프롤릴 엔도펩티다아제 억제 활성을 갖는 화합물 및 그 약학적 용도(compound with prolyl endopeptdase inhibitor activity and pharmaceutical use thereof)
FI972542L (fi) Transdermaalijärjestelmä useamman aktiivisen aineen samanaikaista antamista varten
PT1119557E (pt) Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos
FI954990L (fi) Aktiiviainetta sisältävä transdermaalinen valmiste
FI961857A7 (fi) Matriksin metalloproteaasien inhibiittorit
PT864559E (pt) Compostos amino substituidos e sua utilizacao como substancias activas analgesicas
BR9602915A (pt) Medicamentos uso e formulação farmacêutica
BR9610821A (pt) Derivado de aminoácido uso de um composto e medicamento contendo o mesmo
FI960482A7 (fi) Matriksin metalloproteaasien inhibiittorit
EE9900180A (et) Asendatud 4-bifenüül-4-hüdroksübutaanhappe derivaadid metalloproteaasimaatriksi inhibiitoritena
EE04371B1 (et) Fenüülamidiini derivaadid, meetodid nende valmistamiseks ja nende kasutamine arstimitena

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]