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PT1119557E - Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos - Google Patents

Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos

Info

Publication number
PT1119557E
PT1119557E PT99969717T PT99969717T PT1119557E PT 1119557 E PT1119557 E PT 1119557E PT 99969717 T PT99969717 T PT 99969717T PT 99969717 T PT99969717 T PT 99969717T PT 1119557 E PT1119557 E PT 1119557E
Authority
PT
Portugal
Prior art keywords
hydrotiazole
anorectical
nafto
benzocyclohepta
indene
Prior art date
Application number
PT99969717T
Other languages
English (en)
Inventor
Martin Bickel
Heiner Glombik
Gerhard Jaehne
Karl Geisen
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PT1119557E publication Critical patent/PT1119557E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT99969717T 1998-09-29 1999-09-16 Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos PT1119557E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19844547A DE19844547C2 (de) 1998-09-29 1998-09-29 Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PT1119557E true PT1119557E (pt) 2004-04-30

Family

ID=7882588

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99969717T PT1119557E (pt) 1998-09-29 1999-09-16 Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos

Country Status (25)

Country Link
US (2) US6090833A (pt)
EP (1) EP1119557B1 (pt)
JP (1) JP3542078B2 (pt)
KR (1) KR20010079952A (pt)
CN (1) CN1143852C (pt)
AR (1) AR020662A1 (pt)
AT (1) ATE255569T1 (pt)
AU (1) AU755158B2 (pt)
BR (1) BR9915014A (pt)
CA (1) CA2345359A1 (pt)
DE (2) DE19844547C2 (pt)
DK (1) DK1119557T3 (pt)
ES (1) ES2212673T3 (pt)
HK (1) HK1040080B (pt)
HU (1) HUP0103504A3 (pt)
ID (1) ID29578A (pt)
IL (1) IL142096A0 (pt)
NO (1) NO318388B1 (pt)
NZ (1) NZ510399A (pt)
PL (1) PL347072A1 (pt)
PT (1) PT1119557E (pt)
RU (1) RU2217427C2 (pt)
TR (1) TR200100868T2 (pt)
WO (1) WO2000018749A1 (pt)
ZA (1) ZA200102446B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
HUP0203290A3 (en) * 1999-11-05 2004-12-28 Sanofi Aventis Deutschland Indeno-, naphto-, and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments
CA2400698A1 (en) 2000-02-23 2001-08-30 Aventis Pharma Deutschland Gmbh 8,8a-dihydro-indeno[1,2-d]thiazole derivatives, substituted in position 8a, a method for their production and their use as medicaments, e.g. anorectic agents
DE10008274A1 (de) 2000-02-23 2001-08-30 Aventis Pharma Gmbh Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2001062747A1 (de) * 2000-02-26 2001-08-30 Aventis Pharma Deutschland Gmbh 8,8a-dihydro-indeno[1,2-d]thiazol-derivate, die in 2-stellung einen substituenten mit einer sulfonamidstruktur oder sulfonstruktur tragen; verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE10142665B4 (de) * 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
DE10142722A1 (de) * 2001-08-31 2003-03-27 Aventis Pharma Deutschland GmbH, 65929 Frankfurt C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
BRPI0716134A2 (pt) 2006-09-07 2013-09-17 Nycomed Gmbh tratamento de combinaÇço para diabetes mellitus
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008149345A2 (en) 2007-06-04 2008-12-11 Ben-Gurion University Of The Negev Research And Development Authority Tri-aryl compounds and compositions comprising the same
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2741125A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112013021236B1 (pt) 2011-02-25 2021-05-25 Merck Sharp & Dohme Corp composto derivado de benzimidazol, e, composição
KR102034748B1 (ko) 2011-03-01 2019-10-21 시너지 파마슈티컬즈 인코포레이티드 구아닐레이트 사이클라제 c 작용제의 제조 방법
US9527875B2 (en) 2012-08-02 2016-12-27 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2015010935A (es) 2013-02-22 2015-10-29 Merck Sharp & Dohme Compuestos biciclicos antidiabeticos.
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CN106061940A (zh) 2013-11-05 2016-10-26 本古里安大学内盖夫研究发展局 治疗糖尿病和由其引发的并发疾病的化合物
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2942003A (en) * 1957-06-06 1960-06-21 Gen Aniline & Film Corp Process for preparing naphtho [1, 2-d]-thiazoles
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
JPH0514068A (ja) * 1991-07-03 1993-01-22 Shimada Phys & Chem Ind Co Ltd 並列増幅部切換型高周波低雑音増幅装置
JP3197602B2 (ja) * 1992-02-17 2001-08-13 久光製薬株式会社 チアゾール類縁化合物及び皮膚外用剤
KR970701705A (ko) * 1994-03-11 1997-04-12 오노다 마사요시 5-HT₃ 수용체 효능제, 신규한 티아졸 유도체 및 이의 중간체(5-HT₃receptor agonist, novel thiazole derivative, and intermediate therefor)
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use

Also Published As

Publication number Publication date
AU5978799A (en) 2000-04-17
ID29578A (id) 2001-09-06
HK1040080A1 (en) 2002-05-24
ES2212673T3 (es) 2004-07-16
DE19844547C2 (de) 2002-11-07
CN1143852C (zh) 2004-03-31
IL142096A0 (en) 2002-03-10
HUP0103504A2 (hu) 2002-07-29
DK1119557T3 (da) 2004-04-13
US6090833A (en) 2000-07-18
HUP0103504A3 (en) 2002-10-28
DE59907961D1 (de) 2004-01-15
RU2217427C2 (ru) 2003-11-27
EP1119557A1 (de) 2001-08-01
NO20011503D0 (no) 2001-03-23
KR20010079952A (ko) 2001-08-22
JP3542078B2 (ja) 2004-07-14
WO2000018749A1 (de) 2000-04-06
ZA200102446B (en) 2001-09-28
EP1119557B1 (de) 2003-12-03
NO318388B1 (no) 2005-03-14
DE19844547A1 (de) 2000-03-30
TR200100868T2 (tr) 2001-09-21
NZ510399A (en) 2003-10-31
ATE255569T1 (de) 2003-12-15
HK1040080B (zh) 2004-08-20
BR9915014A (pt) 2001-08-07
NO20011503L (no) 2001-03-23
US6291486B1 (en) 2001-09-18
PL347072A1 (en) 2002-03-11
AU755158B2 (en) 2002-12-05
JP2002525363A (ja) 2002-08-13
CA2345359A1 (en) 2000-04-06
AR020662A1 (es) 2002-05-22
CN1320120A (zh) 2001-10-31

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