BR9607638A - Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido - Google Patents

Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido

Info

Publication number: BR9607638A
Authority: BR; Brazil
Prior art keywords: retroviral; amino acid; protease inhibitors; retroviral protease; protease
Prior art date: 1995-03-10

Application number

BR9607638A

Other languages

English (en)

Inventor

Daniel P Getman

Gary A Decrescenzo

John N Freskos

Michael L Vazquez

David L Brown

James A Sikorski

Joseph J Mcdonald

Balekudru Devadas

Srinivasan Nagarajan

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1996-03-07

Publication date

1998-05-26

1996-03-07 Application filed by Searle & Co filed Critical Searle & Co

1998-05-26 Publication of BR9607638A publication Critical patent/BR9607638A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)

BR9607638A 1995-03-10 1996-03-07 Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido BR9607638A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40228795A	1995-03-10	1995-03-10
PCT/US1996/002684 WO1996028463A1 (en)	1995-03-10	1996-03-07	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number	Publication Date
BR9607638A true BR9607638A (pt)	1998-05-26

Family

ID=23591303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9607638A BR9607638A (pt)	1995-03-10	1996-03-07	Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido

Country Status (23)

Country	Link
US (3)	US5756533A (pt)
EP (2)	EP0813542B1 (pt)
JP (1)	JP4091111B2 (pt)
KR (1)	KR100377855B1 (pt)
CN (1)	CN1204144C (pt)
AT (1)	ATE226213T1 (pt)
AU (1)	AU705268B2 (pt)
BR (1)	BR9607638A (pt)
CA (1)	CA2215061A1 (pt)
CZ (1)	CZ297719B6 (pt)
DE (1)	DE69624346T2 (pt)
DK (1)	DK0813542T3 (pt)
EA (1)	EA000470B1 (pt)
EE (1)	EE04349B1 (pt)
ES (1)	ES2187640T3 (pt)
HU (1)	HUP9801562A3 (pt)
NO (1)	NO974148L (pt)
NZ (1)	NZ303861A (pt)
PL (1)	PL184748B1 (pt)
PT (1)	PT813542E (pt)
SK (1)	SK285688B6 (pt)
UA (1)	UA56130C2 (pt)
WO (1)	WO1996028463A1 (pt)

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AU4828199A (en) *	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
US7470506B1 (en)	1998-06-23	2008-12-30	The United States Of America As Represented By The Department Of Health And Human Services	Fitness assay and associated methods
US6538006B1 (en)	1998-07-08	2003-03-25	Pharmacia Corporation	Retroviral protease inhibitors
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
AUPR034000A0 (en) *	2000-09-25	2000-10-19	Fujisawa Pharmaceutical Co., Ltd.	Aminoalcohol derivatives
NZ527391A (en) *	2001-02-14	2005-04-29	Tibotec Pharm Ltd	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
IL158092A0 (en) *	2001-04-09	2004-03-28	Tibotec Pharm Ltd	Broadspectrum 2- (substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CZ304524B6 (cs) *	2001-05-11	2014-06-18	Tibotec Pharmaceuticals Ltd.	Derivát 2-aminobenzoxazolsulfonamidu, farmaceutická kompozice s jeho obsahem a léčivo pro léčení infekce retroviry
TWI336621B (en)	2001-12-21	2011-02-01	Tibotec Pharm Ltd	Broad spectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
US7011678B2 (en) *	2002-01-31	2006-03-14	Radi Medical Systems Ab	Biodegradable stent
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ME01059B (me)	2003-12-23	2012-10-20	Janssen Sciences Ireland Uc	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
BRPI0417272B8 (pt)	2003-12-23	2021-05-25	Janssen R&D Ireland	processo para a preparação de (3r, 3as, 6ar)-hexahidrofuro [2,3-b] furan-3-il (1s, 2r)-3-[[(4-aminofenil) sulfonil] (isobutil) amino]-1-benzil-2-hidroxipropilcarbamato
EP1732891A4 (en)	2004-03-11	2009-05-06	Sequoia Pharmaceuticals Inc	RESISTANT PREVENTIVE INHIBITORS FOR RETROVIRAL PROTEASES
CN101674822A (zh) *	2006-08-18	2010-03-17	塞阔伊亚药品公司	抑制细胞色素p450的组合物和方法
CN101965186A (zh)	2007-11-28	2011-02-02	塞阔伊亚药品公司	抑制细胞色素p450 2d6的化合物和方法
US8163953B2 (en) *	2008-04-18	2012-04-24	University Of Connecticut	Compounds for lysosomal modulation and methods of use
WO2011010524A1 (ja) *	2009-07-24	2011-01-27	住友精化株式会社	アルコキシベンゼンスルホニルクロライドの製造方法
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CN104387299B (zh) *	2014-10-23	2016-08-17	凯莱英医药集团（天津）股份有限公司	4-氨基-n-[(2r, 3s)-3-氨基-2-羟基-4-苯丁基]-n-异丁基苯磺酰胺的制备方法
CN111205206B (zh) *	2020-02-13	2021-10-22	中国医学科学院医药生物技术研究所	一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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DE3912829A1 (de) *	1989-04-19	1990-10-25	Bayer Ag	Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
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DE69118907T2 (de) *	1990-11-19	1996-11-14	Monsanto Co	Retrovirale proteaseinhibitoren
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IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
ATE167669T1 (de) *	1992-10-30	1998-07-15	Searle & Co	Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen
CA2164703A1 (en) *	1993-06-21	1995-01-05	Patrick Henry Terry	Catalytic cracking system
DE69415326T2 (de) *	1993-08-24	1999-06-02	G.D. Searle & Co., Chicago, Ill.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

1995
- 1995-06-07 US US08/474,052 patent/US5756533A/en not_active Expired - Fee Related
1996
- 1996-03-07 EA EA199700221A patent/EA000470B1/ru not_active IP Right Cessation
- 1996-03-07 SK SK1224-97A patent/SK285688B6/sk unknown
- 1996-03-07 CZ CZ0282497A patent/CZ297719B6/cs not_active IP Right Cessation
- 1996-03-07 WO PCT/US1996/002684 patent/WO1996028463A1/en not_active Ceased
- 1996-03-07 BR BR9607638A patent/BR9607638A/pt not_active Application Discontinuation
- 1996-03-07 DK DK96907135T patent/DK0813542T3/da active
- 1996-03-07 ES ES96907135T patent/ES2187640T3/es not_active Expired - Lifetime
- 1996-03-07 KR KR1019970706313A patent/KR100377855B1/ko not_active Expired - Fee Related
- 1996-03-07 AU AU50294/96A patent/AU705268B2/en not_active Ceased
- 1996-03-07 US US08/894,900 patent/US5968970A/en not_active Expired - Fee Related
- 1996-03-07 EP EP96907135A patent/EP0813542B1/en not_active Expired - Lifetime
- 1996-03-07 JP JP52764896A patent/JP4091111B2/ja not_active Expired - Fee Related
- 1996-03-07 AT AT96907135T patent/ATE226213T1/de not_active IP Right Cessation
- 1996-03-07 PL PL96322784A patent/PL184748B1/pl not_active IP Right Cessation
- 1996-03-07 NZ NZ303861A patent/NZ303861A/xx unknown
- 1996-03-07 EP EP02011526A patent/EP1258491A1/en not_active Withdrawn
- 1996-03-07 CA CA002215061A patent/CA2215061A1/en not_active Abandoned
- 1996-03-07 EE EE9700201A patent/EE04349B1/xx not_active IP Right Cessation
- 1996-03-07 DE DE69624346T patent/DE69624346T2/de not_active Expired - Fee Related
- 1996-03-07 CN CNB961936207A patent/CN1204144C/zh not_active Expired - Fee Related
- 1996-03-07 PT PT96907135T patent/PT813542E/pt unknown
- 1996-03-07 HU HU9801562A patent/HUP9801562A3/hu unknown
- 1996-07-03 UA UA97104995A patent/UA56130C2/uk unknown
1997
- 1997-09-09 NO NO974148A patent/NO974148L/no unknown
1998
- 1998-03-03 US US09/033,897 patent/US5965601A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR19980702905A (ko)	1998-09-05
EP0813542A1 (en)	1997-12-29
DE69624346T2 (de)	2003-06-26
NO974148L (no)	1997-10-27
HUP9801562A3 (en)	2001-02-28
CN1186499A (zh)	1998-07-01
EA199700221A1 (ru)	1998-04-30
CN1204144C (zh)	2005-06-01
UA56130C2 (uk)	2003-05-15
PT813542E (pt)	2003-01-31
EE9700201A (et)	1998-02-16
AU705268B2 (en)	1999-05-20
ES2187640T3 (es)	2003-06-16
WO1996028463A1 (en)	1996-09-19
KR100377855B1 (ko)	2003-07-23
PL322784A1 (en)	1998-02-16
SK122497A3 (en)	1998-03-04
US5968970A (en)	1999-10-19
JP2001513746A (ja)	2001-09-04
SK285688B6 (sk)	2007-06-07
NZ303861A (en)	1999-02-25
CA2215061A1 (en)	1996-09-19
JP4091111B2 (ja)	2008-05-28
HUP9801562A2 (hu)	1998-11-30
CZ282497A3 (cs)	1998-02-18
NO974148D0 (no)	1997-09-09
PL184748B1 (pl)	2002-12-31
EP1258491A1 (en)	2002-11-20
DE69624346D1 (de)	2002-11-21
ATE226213T1 (de)	2002-11-15
EA000470B1 (ru)	1999-08-26
US5965601A (en)	1999-10-12
CZ297719B6 (cs)	2007-03-14
AU5029496A (en)	1996-10-02
US5756533A (en)	1998-05-26
EE04349B1 (et)	2004-08-16
DK0813542T3 (da)	2003-02-17
EP0813542B1 (en)	2002-10-16

Publication	Publication Date	Title
BR9607638A (pt)	1998-05-26	Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido
BR9607543A (pt)	1997-12-23	Inibidores de protease retroviral sulfonamida hidroxietilamino de bis-amino ácido
BR9607450A (pt)	1998-06-30	Inibidores de protease retroviral sulfonilalcanoilamino hidroxietilamino sulfonamida
BR9607625A (pt)	1999-06-15	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
MX9706912A (es)	1998-01-31	Inhibidores de protesa retroviral de sulfonamida de hidroxietilamino de amino acido y uso de los mismos.

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2007-06-12	B09S	Decision of refusal: publication cancelled [chapter 9.2.2 patent gazette]	Free format text: ANULADA A PUBLICACAO DE INDEFERIMENTO POR TER SIDO INDEVIDA.
2007-09-18	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-12-02	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-05-19	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements