[go: up one dir, main page]

BR9510498A - Derivados de nucleosìdeos com grupos de proteção fotolábeis - Google Patents

Derivados de nucleosìdeos com grupos de proteção fotolábeis

Info

Publication number
BR9510498A
BR9510498A BR9510498-4A BR9510498A BR9510498A BR 9510498 A BR9510498 A BR 9510498A BR 9510498 A BR9510498 A BR 9510498A BR 9510498 A BR9510498 A BR 9510498A
Authority
BR
Brazil
Prior art keywords
och
halogen
nucleoside derivatives
amino
derivatives
Prior art date
Application number
BR9510498-4A
Other languages
English (en)
Inventor
Wolfgang Pfleiderer
Heiner Giegrich
Original Assignee
Wolfgang Pfleiderer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wolfgang Pfleiderer filed Critical Wolfgang Pfleiderer
Publication of BR9510498A publication Critical patent/BR9510498A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção:<B>"DERIVADOS DE NUCLEOSìDEOS COM GRUPOS DE PROTEçãO FOTOLáBEIS"<D>. A invenção refere-se a derivados de nucleosídeo tendo grupos de proteção fotolábeis de fórmula geral (I) em que R^ 1^= H, NO~ 2~, CN, OCH~ 3~, halogênio ou alquila ou alcoxialquila com átomos de 1 a 4 C R^ 2^= H, OCH~ 3~ R^ 3^= H, F, Cl, Br, NO~ 2~ R^ 4^ H, halogênio, OCH~ 3~, ou um metal radical alquila tendo 1 a 4 átomos C, R^ 5^ H ou um grupo funcional comum para preparar oligonucleotídeos, R^ 6^ H, OH, halogênio ou XR^ 8^, em que X = O ou S e R^ 8^ representa um grupo de proteção comum em química de nucleotídeos, B adenina, citosina, guanina, timina, uracil, 2,6-diaminopurin-9-ila, hipoxantin-9-ila, 5-metilcitosina-1-ila, 5-amino-4-imidazol carboxamid-1-ila ou 5-amino-4-imidazolcaboxamid-3-ila, onde no caso de B = adenina, citosina ou guanina, a função amino primária opcionalmente demonstra um grupo de proteção permanente. Estes derivados podem ser usados para a síntese controlada por luz de oligonucleotídeos em um chip de DNA.
BR9510498-4A 1994-12-16 1995-12-15 Derivados de nucleosìdeos com grupos de proteção fotolábeis BR9510498A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4444996A DE4444996A1 (de) 1994-12-16 1994-12-16 Nucleosid-Derivate mit photolabilen Schutzgruppen
PCT/EP1995/004976 WO1996018634A2 (de) 1994-12-16 1995-12-15 Nucleosid-derivate mit photolabilen schutzgruppen

Publications (1)

Publication Number Publication Date
BR9510498A true BR9510498A (pt) 1999-11-30

Family

ID=6536071

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9510498-4A BR9510498A (pt) 1994-12-16 1995-12-15 Derivados de nucleosìdeos com grupos de proteção fotolábeis

Country Status (17)

Country Link
US (1) US5763599A (pt)
EP (1) EP0797580B1 (pt)
JP (1) JPH11501287A (pt)
KR (1) KR100395290B1 (pt)
AT (1) ATE215957T1 (pt)
AU (1) AU692658B2 (pt)
BR (1) BR9510498A (pt)
CA (1) CA2207912A1 (pt)
CZ (1) CZ292296B6 (pt)
DE (2) DE4444996A1 (pt)
DK (1) DK0797580T3 (pt)
ES (1) ES2174976T3 (pt)
FI (1) FI973643A7 (pt)
HU (1) HU215543B (pt)
IL (1) IL116407A (pt)
NO (1) NO307382B1 (pt)
WO (1) WO1996018634A2 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147205A (en) * 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US20110028350A1 (en) * 1995-12-15 2011-02-03 Affymetrix, Inc. Photocleavable protecting groups
EP0898575B1 (en) 1996-04-17 2004-12-29 KÖSTER, Hubert, Dr. A combinatorial protecting group strategy for multifunctional molecules
DE19620170A1 (de) * 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
US6222030B1 (en) * 1998-08-03 2001-04-24 Agilent Technologies, Inc. Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
AU5492499A (en) 1998-08-21 2000-03-14 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
US6187540B1 (en) 1998-11-09 2001-02-13 Identigene, Inc. Method of newborn identification and tracking
DE19858440A1 (de) * 1998-12-17 2000-06-21 Deutsches Krebsforsch Verfahren zur photolithografischen Biochip-Synthese
AU2998800A (en) 1999-03-24 2000-10-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The N-acylphosphoramidites and their use in oligonucleotide synthesis
WO2000061594A2 (de) * 1999-04-08 2000-10-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Nucleosid-derivate mit photolabilen schutzgruppen
DE19952113A1 (de) 1999-10-29 2001-05-03 Nigu Chemie Gmbh Nucleosid-Derivate mit photolabilen Schutzgruppen
EP1176151B1 (en) * 2000-07-28 2014-08-20 Agilent Technologies, Inc. Synthesis of polynucleotides using combined oxidation/deprotection chemistry
AU2001292142A1 (en) * 2000-09-11 2002-03-22 Affymetrix, Inc. Photocleavable protecting groups
DE10105079A1 (de) * 2001-02-05 2002-08-08 Febit Ferrarius Biotech Gmbh Fotolabile Schutzgruppen für die Synthese von Biopolymeren
DE10105077A1 (de) * 2001-02-05 2002-08-08 Febit Ferrarius Biotech Gmbh Hybrid-Schutzgruppe
EP1401851B8 (de) * 2001-07-03 2008-09-10 febit holding GmbH Zweistufige schutzgruppen für die synthese von biopolymeren
DE10152147A1 (de) * 2001-10-25 2003-05-15 Chemogenix Gmbh Verfahren zum Aufbringen von Nukleosiden und/oder Nukleotiden auf funktionalisierten Oberflächen sowie Verfahren zur Bestimmung von Kopplungsausbeuten bei der Synthese von Nukleotiden
DE10156467A1 (de) * 2001-11-16 2003-06-05 Micronas Gmbh Träger zur Synthese sowie Verfahren zur Herstellung von Biopolymeren
WO2003048179A2 (en) * 2001-12-03 2003-06-12 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
DE10209203A1 (de) 2002-03-04 2003-09-25 Ulrich Steiner Verfahren zur Abspaltung von labilen funktionellen Gruppen aus chemischen Verbindungen
EP1480927B1 (en) 2002-03-04 2012-12-26 Universität Konstanz A method for cleavage of labile functional groups from chemical compounds
WO2004058392A2 (de) * 2002-12-23 2004-07-15 Febit Ag Intramolekular triplettsensibilisierte o-nitrophenylethyl-photoschutzgruppen
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
US7759513B2 (en) * 2003-02-21 2010-07-20 Nigu Chemie Gmbh Photolabile protective groups for improved processes to prepare oligonucleotide arrays
DE10315772A1 (de) * 2003-04-07 2004-11-04 Ulrich Prof. Dr. Steiner Chemische Verbindung und Verfahren für den intramolekularen Energietransfer zur Abspaltung von labilen funktionellen Gruppen aus chemischen Verbindungen
WO2004101582A2 (en) * 2003-05-09 2004-11-25 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
DE102004019098A1 (de) * 2004-04-20 2005-11-10 Chemogenix Gmbh Photolabile Schutzgruppen
WO2006065751A2 (en) * 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
US8338093B2 (en) * 2004-12-31 2012-12-25 Affymetrix, Inc. Primer array synthesis and validation
US7547775B2 (en) 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
US8343710B1 (en) 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
WO2012102616A1 (en) 2011-01-28 2012-08-02 Flexgen B.V. Heterodirectional polynucleotides
US9139874B2 (en) 2011-07-07 2015-09-22 Life Technologies Corporation Bi-directional sequencing compositions and methods
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5449094A (en) * 1992-11-02 1994-05-24 Affymax Technologies N.V. Novel photoreactive protecting groups

Also Published As

Publication number Publication date
AU692658B2 (en) 1998-06-11
NO972754L (no) 1997-08-11
JPH11501287A (ja) 1999-02-02
FI973643A0 (fi) 1997-09-09
ES2174976T3 (es) 2002-11-16
EP0797580B1 (de) 2002-04-10
IL116407A0 (en) 1996-03-31
WO1996018634A3 (de) 1996-08-22
CZ183697A3 (en) 1997-12-17
DE59510162D1 (de) 2002-05-16
FI973643L (fi) 1997-09-09
HU215543B (hu) 1999-01-28
DK0797580T3 (da) 2002-06-17
DE4444996A1 (de) 1996-06-20
AU4386596A (en) 1996-07-03
NO972754D0 (no) 1997-06-13
HUT77176A (hu) 1998-03-02
WO1996018634A2 (de) 1996-06-20
ATE215957T1 (de) 2002-04-15
KR100395290B1 (ko) 2004-03-24
CA2207912A1 (en) 1996-06-20
CZ292296B6 (cs) 2003-08-13
NO307382B1 (no) 2000-03-27
IL116407A (en) 2001-09-13
FI973643A7 (fi) 1997-09-09
US5763599A (en) 1998-06-09
EP0797580A2 (de) 1997-10-01

Similar Documents

Publication Publication Date Title
BR9510498A (pt) Derivados de nucleosìdeos com grupos de proteção fotolábeis
DZ3487A1 (fr) Derives de nucleoside comme inhibiteurs de l&#39;arn polymerase virale d&#39;arn-dependant
WO2002069903A3 (en) Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
DE69815342D1 (de) Sulfonatfreie cyaninfarbstoffe zur markierung von nukleosiden und nukleotiden
ATE373671T1 (de) Aminooxy-modifizierte oligonukleotide
NZ513402A (en) Novel nucleosides and oligonucleotide analogues
BRPI9506596B8 (pt) composto l-nucleosídeo.
NZ507913A (en) Novel nucleosides having bicyclic sugar moiety
DE3751947D1 (de) Nucleosidderivate und ihre Verwendung in der Oligonucleotid-Synthese
KR950032263A (ko) 2&#39;-에테르 그룹을 갖는 뉴클레오사이드 및 올리고 뉴클레오타이드
PT1280813E (pt) Analogos de nucleosidos de pirimidina antivirais
DE59704973D1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
SE8406484D0 (sv) Syntes av aminoderivat av oligonukleotider
BR9911491A (pt) Processo de tratamento de uma superfìcie metálica para aumentar a resistência contra corrosão, e, uso de uma solução de tratamento
DE50001917D1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
EP0034424A3 (en) Seven-membered ring compounds as inhibitors of cytidine deaminase
NO965017D0 (no) Oligonukleotider med anti-cytomegalovirus aktivitet
BR9916849A (pt) Análogos de nucleosìdeos antivirais
WO2003028712A3 (en) Purinergic and pyrimidinergic receptor agonists for the treatment of activated cd4+ t lymphocyte-mediated immune diseases
RU97119150A (ru) Ингибитор репродукции вируса иммунодефицита человека
RU2001106467A (ru) Синтетические олигонуклеотиды - праймеры, используемые для выявления днк вируса простого герпеса 2 типа (впг-2) человека

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements