BR9509155A - Apilcação de inibidores de aromatase para preparação de um medicamento para tratamento de uma deficiência relativa de andrôgeno no homem - Google Patents

Apilcação de inibidores de aromatase para preparação de um medicamento para tratamento de uma deficiência relativa de andrôgeno no homem

Info

Publication number: BR9509155A
Authority: BR; Brazil
Prior art keywords: men; pct; aromatase inhibitors; apilcation; androgen deficiency
Prior art date: 1994-09-22

Application number

BR9509155A

Other languages

English (en)

Inventor

Albert Radlmaier

Ursula-Friederike Habenicht

Friedmund Neumann

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-22

Filing date

1995-09-22

Publication date

1997-10-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6529877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9509155(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-09-22 Application filed by Schering Ag filed Critical Schering Ag

1997-10-14 Publication of BR9509155A publication Critical patent/BR9509155A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

BR9509155A 1994-09-22 1995-09-22 Apilcação de inibidores de aromatase para preparação de um medicamento para tratamento de uma deficiência relativa de andrôgeno no homem BR9509155A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4435368A DE4435368A1 (de)	1994-09-22	1994-09-22	Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
PCT/EP1995/003733 WO1996009057A1 (de)	1994-09-22	1995-09-22	Verwendung von aromatasehemmern zur herstellung eines arzneimittels zur behandlung eines relativen androgenmangels beim mann

Publications (1)

Publication Number	Publication Date
BR9509155A true BR9509155A (pt)	1997-10-14

Family

ID=6529877

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9509155A BR9509155A (pt)	1994-09-22	1995-09-22	Apilcação de inibidores de aromatase para preparação de um medicamento para tratamento de uma deficiência relativa de andrôgeno no homem

Country Status (21)

Country	Link
US (1)	US5861389A (pt)
EP (1)	EP0782450B1 (pt)
JP (1)	JPH10505848A (pt)
KR (1)	KR100387345B1 (pt)
CN (1)	CN1104243C (pt)
AT (1)	ATE241989T1 (pt)
AU (1)	AU707997B2 (pt)
BR (1)	BR9509155A (pt)
CA (1)	CA2200195C (pt)
CZ (1)	CZ76097A3 (pt)
DE (2)	DE4435368A1 (pt)
DK (1)	DK0782450T3 (pt)
ES (1)	ES2199255T3 (pt)
FI (1)	FI971207A7 (pt)
HU (1)	HUT76981A (pt)
MX (1)	MX9702170A (pt)
NO (1)	NO971349L (pt)
PL (1)	PL182909B1 (pt)
PT (1)	PT782450E (pt)
SK (1)	SK36397A3 (pt)
WO (1)	WO1996009057A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19610645A1 (de) *	1996-03-06	1997-09-11	Schering Ag	Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann
US5972921A (en)	1997-12-12	1999-10-26	Hormos Medical Oy Ltd.	Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
US7067557B2 (en) *	2000-05-26	2006-06-27	Harry Fisch	Methods of treating androgen deficiency in men using selective antiestrogens
AU2001261684B2 (en)	2000-05-26	2006-01-12	Harry Fisch	Methods of treating androgen deficiency in men using selective antiestrogens
US6607755B2 (en)	2001-06-21	2003-08-19	Michael Donald Farley	Anti-aromatase pharmaceutical composition for controlling testosterone/estrone ratios
ATE406153T1 (de) *	2001-07-09	2008-09-15	Repros Therapeutics Inc	Verfahren und materialien für die behandlung des testosteron-mangels bei männern
US7737185B2 (en) *	2001-07-09	2010-06-15	Repros Therapeutics Inc.	Methods and compositions with trans-clomiphene
US7173064B2 (en) *	2001-07-09	2007-02-06	Repros Therapeutics Inc.	Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
HRP20040588A2 (en) *	2001-12-06	2004-10-31	Gtx Inc	Treating muscle wasting with selective androgen receptor modulators
US6586417B1 (en)	2002-04-22	2003-07-01	Nutrisport Pharmacal, Inc.	Ester and ether derivatives of 4-hydroxy 4-androstene-3,17-dione and a method for the regulation of athletic function in humans
WO2004064814A1 (en) *	2003-01-13	2004-08-05	Michael Donald Farley	Improvements in or relating to anti-aromatase composition
AU2003203010A1 (en) *	2003-01-13	2004-08-13	Michael Donald Farley	Improvements in or relating to anti-aromatase composition
US20040248989A1 (en)	2003-06-05	2004-12-09	Risto Santti	Method for the treatment or prevention of lower urinary tract symptoms
EP1776098A1 (en) *	2004-07-14	2007-04-25	Repros Therapeutics Inc.	Trans-clomiphene for the treatment of benign prostate hypertrophy, prostate cancer, hypogonadism, elevated triglycerides and high cholesterol
EP1848416A4 (en) *	2005-02-04	2008-09-24	Repros Therapeutics Inc	METHOD AND MATERIALS USING TRANS-CLOMIPHES FOR TREATING MALE INACCURIBILITY
CA3071412A1 (en) *	2005-03-22	2006-09-28	Allergan Pharmaceuticals International Limited	Dosing regimes for trans-clomiphene
JP5123935B2 (ja)	2006-05-22	2013-01-23	ホルモスメディカルリミテッド	選択的エストロゲン受容体モジュレーターまたはアロマターゼ阻害剤を用いた慢性非細菌性前立腺炎の治療方法
JP5558358B2 (ja)	2007-10-16	2014-07-23	レプロスセラピューティクスインコーポレイティド	メタボリック症候群用のｔｒａｎｓ−クロミフェン
WO2009066712A1 (ja) *	2007-11-21	2009-05-28	Kracie Pharma, Ltd.	アロマターゼ阻害剤
US20090215738A1 (en) *	2008-02-26	2009-08-27	Michael Charles Scally	Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake
US20090306031A1 (en) *	2009-08-07	2009-12-10	Kneller Bruce W	5alpha-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
WO2011016814A1 (en) *	2009-08-07	2011-02-10	Kneller Bruce W	5α-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
UA113291C2 (xx)	2011-08-04	2017-01-10		Метаболіти транскломіфену і їх застосування
CA2881604C (en) *	2011-08-09	2021-09-14	Kenneth W. Adams	Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males
DK2753312T3 (da) *	2011-09-08	2017-02-13	Mereo Biopharma 2 Ltd	Anvendelse af en aromatase-inhibitor i behandlingen af hypogonadisme og relaterede sygdomme
CN102641502A (zh) *	2012-04-25	2012-08-22	中国农业大学	芳香酶抑制剂的新用途
MX2015005160A (es)	2012-11-02	2015-07-17	Repros Therapeutics Inc	Trans-clomifeno para uso en terapia de cancer.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4289762A (en) *	1980-06-27	1981-09-15	Merrell Dow Pharmaceuticals Inc.	10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) *	1980-06-27	1982-03-30	Merrell Dow Pharmaceuticals Inc.	10-Alkynyl steroids
EP0100566B1 (en) *	1982-07-14	1986-02-19	Akzo N.V.	Novel 19-thio-androstane derivatives
DE3322285A1 (de) *	1983-06-18	1984-12-20	Schering AG, 1000 Berlin und 4709 Bergkamen	1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3539244A1 (de) *	1985-11-01	1987-05-07	Schering Ag	1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8531745D0 (en) *	1985-12-24	1986-02-05	Erba Farmitalia	10beta-alkynyl-4-9(11)-estradiene derivatives
GB8615092D0 (en) *	1986-06-20	1986-07-23	Erba Farmitalia	Androst-4-ene-317-diones
DE3705990A1 (de) *	1987-02-20	1988-09-01	Schering Ag	1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3926365A1 (de) *	1989-08-04	1991-02-07	Schering Ag	Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
GB9226620D0 (en) *	1992-12-21	1993-02-17	Fujisawa Pharmaceutical Co	A new compound fr 901537,production thereof and use thereof

1994
- 1994-09-22 DE DE4435368A patent/DE4435368A1/de not_active Withdrawn
1995
- 1995-09-22 WO PCT/EP1995/003733 patent/WO1996009057A1/de not_active Ceased
- 1995-09-22 ES ES95934094T patent/ES2199255T3/es not_active Expired - Lifetime
- 1995-09-22 CA CA002200195A patent/CA2200195C/en not_active Expired - Fee Related
- 1995-09-22 BR BR9509155A patent/BR9509155A/pt not_active Application Discontinuation
- 1995-09-22 AT AT95934094T patent/ATE241989T1/de not_active IP Right Cessation
- 1995-09-22 PT PT95934094T patent/PT782450E/pt unknown
- 1995-09-22 MX MX9702170A patent/MX9702170A/es not_active IP Right Cessation
- 1995-09-22 JP JP8510608A patent/JPH10505848A/ja active Pending
- 1995-09-22 PL PL95319299A patent/PL182909B1/pl not_active IP Right Cessation
- 1995-09-22 DK DK95934094T patent/DK0782450T3/da active
- 1995-09-22 DE DE59510714T patent/DE59510714D1/de not_active Expired - Fee Related
- 1995-09-22 KR KR1019970701850A patent/KR100387345B1/ko not_active Expired - Fee Related
- 1995-09-22 US US08/809,582 patent/US5861389A/en not_active Expired - Fee Related
- 1995-09-22 HU HU9701697A patent/HUT76981A/hu unknown
- 1995-09-22 EP EP95934094A patent/EP0782450B1/de not_active Expired - Lifetime
- 1995-09-22 FI FI971207A patent/FI971207A7/fi not_active IP Right Cessation
- 1995-09-22 SK SK363-97A patent/SK36397A3/sk unknown
- 1995-09-22 CZ CZ97760A patent/CZ76097A3/cs unknown
- 1995-09-22 AU AU36518/95A patent/AU707997B2/en not_active Ceased
- 1995-09-22 CN CN95195216A patent/CN1104243C/zh not_active Expired - Fee Related
1997
- 1997-03-21 NO NO971349A patent/NO971349L/no unknown

Also Published As

Publication number	Publication date
CN1158570A (zh)	1997-09-03
DE59510714D1 (de)	2003-07-10
ES2199255T3 (es)	2004-02-16
MX9702170A (es)	1998-04-30
FI971207L (fi)	1997-03-21
NO971349L (no)	1997-05-16
CN1104243C (zh)	2003-04-02
FI971207A0 (fi)	1997-03-21
EP0782450B1 (de)	2003-06-04
EP0782450A1 (de)	1997-07-09
CZ76097A3 (en)	1997-07-16
KR100387345B1 (ko)	2003-08-30
CA2200195A1 (en)	1996-03-28
AU3651895A (en)	1996-04-09
CA2200195C (en)	2008-04-22
PT782450E (pt)	2003-09-30
FI971207A7 (fi)	1997-03-21
DK0782450T3 (da)	2003-08-18
NO971349D0 (no)	1997-03-21
ATE241989T1 (de)	2003-06-15
HUT76981A (hu)	1998-01-28
SK36397A3 (en)	1997-08-06
AU707997B2 (en)	1999-07-29
DE4435368A1 (de)	1996-03-28
PL182909B1 (pl)	2002-04-30
WO1996009057A1 (de)	1996-03-28
PL319299A1 (en)	1997-08-04
KR970706002A (ko)	1997-11-03
US5861389A (en)	1999-01-19
JPH10505848A (ja)	1998-06-09

Publication	Publication Date	Title
BR9509155A (pt)	1997-10-14	Apilcação de inibidores de aromatase para preparação de um medicamento para tratamento de uma deficiência relativa de andrôgeno no homem
NO20003546L (no)	1995-06-16	Anvendelse av progestin og en farmasøytisk sammensetning samt et kit inneholdende disse
IL139681A0 (en)	2002-02-10	Pharmaceutical compositions containing vitamin b6
TR200200406T2 (tr)	2002-06-21	Kadınlara oral olmayan yollarla androjenik steroidlerin uygulanması
Miller et al.	1954	Cortisone treatment in advanced carcinoma of the prostate
CA2467237A1 (en)	2003-05-22	Method of preventing or treating benign gynaecological disorders
BR9912466A (pt)	2001-04-17	Utilização de sulfamatos de estrogênio biogênicos na terapia de reposição hormonal
EA200301022A1 (ru)	2004-02-26	Гормональная заместительная терапия
Pinkerton et al.	1999	Alternatives to the use of estrogen in postmenopausal women
ITRM920900A1 (it)	1994-06-17	Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale.
AR009113A1 (es)	2000-03-08	UN PRODUCTO ANTICONCEPTIVO PARA DETENER LA OVULACIoN EN MUJERES DURANTE SU PERIODO DE ACTIVIDAD OVÁRICA
DK1227814T3 (da)	2005-04-11	Hormonal sammensætning baseret på nomegestrolacetat og et östrogen samt anvendelse heraf
ATE198707T1 (de)	2001-02-15	Prostaglandinanaloga zur oralen oder vaginalen verabreichung in der routinebehandlung des dritten stadiums der geburtswehen
IL159241A0 (en)	2004-06-01	Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
HUP9901505A2 (hu)	1999-09-28	Dehidroepiandroszteron és aromatázgátlók kombinációja és e kombináció felhasználása férfiak relatív és abszolút androgénhiányának kezelésére szolgáló gyógyszerkészítmények előállítására
Miwa et al.	1990	Drug-induced hypertrichosis: case report and review of the literature
BR0208968A (pt)	2004-04-27	Inibição de aromatase para aumentar a reprodução assistida
BR0208920A (pt)	2004-04-20	Inibidor de aromatase em dose única para tratamento de infertilidade
Nachtigall et al.	1992	Hormone replacement therapy
DK0648117T3 (da)	1998-02-23	Lægemiddel til at forebygge udvikling af tolerance ved behandling med benzodiazepin-receptor-bindende aktive forbindelser
Stoll	1969	Hormonal management of advanced breast cancer
Wells Jr et al.	1982	Comparison of surgical adrenalectomy to medical adrenalectomy in patients with metastatic carcinoma of the breast
EP0968717B1 (fr)	2006-06-07	Préparation sous forme galénique simple visant à limiter les effects induits durant la ménopause et postérieurement et traitement avec cette préparation
Oral et al.	2003	The effect of sodium monofluorophosphate therapy on lipid and lipoprotein metabolism in postmenopausal women
Sismondi et al.	1994	Hormone replacement therapy and gynecologic cancers

Legal Events

Date	Code	Title	Description
2004-08-03	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2005-01-18	B09B	Patent application refused [chapter 9.2 patent gazette]