BR9106665A - Derivados de quinuclidina - Google Patents

Derivados de quinuclidina

Info

Publication number: BR9106665A
Authority: BR; Brazil
Prior art keywords: quinuclidine derivatives; quinuclidine; derivatives; migraine; antagonists
Prior art date: 1990-07-23

Application number

BR919106665A

Other languages

English (en)

Inventor

John A Lowe Iii

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-23

Filing date

1991-05-14

Publication date

1993-06-08

1991-05-14 Application filed by Pfizer filed Critical Pfizer

1993-06-08 Publication of BR9106665A publication Critical patent/BR9106665A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Soft Magnetic Materials (AREA)
Paper (AREA)
Control Of Electric Motors In General (AREA)

BR919106665A 1990-07-23 1991-05-14 Derivados de quinuclidina BR9106665A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55744290A	1990-07-23	1990-07-23
PCT/US1991/003369 WO1992001688A1 (en)	1990-07-23	1991-05-14	Quinuclidine derivatives

Publications (1)

Publication Number	Publication Date
BR9106665A true BR9106665A (pt)	1993-06-08

Family

ID=24225412

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR919106665A BR9106665A (pt)	1990-07-23	1991-05-14	Derivados de quinuclidina

Country Status (25)

Country	Link
US (5)	US5422354A (pt)
EP (1)	EP0540526B1 (pt)
JP (1)	JP2514137B2 (pt)
CN (1)	CN1058405A (pt)
AT (1)	ATE116317T1 (pt)
AU (1)	AU660416B2 (pt)
BR (1)	BR9106665A (pt)
CA (1)	CA2086434C (pt)
DE (1)	DE69106365T2 (pt)
DK (1)	DK0540526T3 (pt)
ES (1)	ES2065691T3 (pt)
FI (1)	FI114473B (pt)
GR (1)	GR3015144T3 (pt)
HU (1)	HUT62584A (pt)
IE (1)	IE65000B1 (pt)
IL (1)	IL98860A (pt)
MX (1)	MX9100308A (pt)
MY (1)	MY107157A (pt)
NO (1)	NO302172B1 (pt)
NZ (1)	NZ239063A (pt)
PL (1)	PL167568B1 (pt)
PT (1)	PT98393B (pt)
WO (1)	WO1992001688A1 (pt)
YU (1)	YU128091A (pt)
ZA (1)	ZA915727B (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2514137B2 (ja) *	1990-07-23	1996-07-10	フアイザー・インコーポレイテツド	キヌクリジン誘導体
US5716965A (en) *	1991-05-22	1998-02-10	Pfizer Inc.	Substituted 3-aminoquinuclidines
US5773450A (en) *	1991-06-20	1998-06-30	Pfizer Inc.	Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
TW202432B (pt) *	1991-06-21	1993-03-21	Pfizer
JP2535134B2 (ja) *	1991-09-16	1996-09-18	ファイザー・インコーポレーテッド	縮合三環式窒素含有複素環
CA2324959C (en) *	1991-11-12	2002-11-12	Pfizer Limited	Phthalimido compounds as intermediates for producing substance p receptor antagonists
ES2164657T3 (es) *	1992-05-18	2002-03-01	Pfizer	Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
AU4396193A (en) *	1992-08-04	1994-03-03	Pfizer Inc.	3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
EP1114823A3 (en) *	1992-08-19	2001-07-18	Pfizer Inc.	Substituted benzylamino nitrogen containing non-aromatic heterocycles
JP2722279B2 (ja) *	1992-12-10	1998-03-04	ファイザー・インク．	アミノメチレンで置換した非芳香族複素環式化合物及びサブスタンスｐのアンタゴニストとしての使用
US5830854A (en) *	1992-12-14	1998-11-03	Merck Sharp & Dohme, Limited	Method of treating cystic fibrosis using a tachykinin receptor antagonist
US5340826A (en) *	1993-02-04	1994-08-23	Pfizer Inc.	Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis
EP0655246A1 (en) *	1993-11-30	1995-05-31	Pfizer Inc.	Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
FR2725900B1 (fr) *	1994-10-21	1997-07-18	Sanofi Sa	Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
IL116249A (en) *	1994-12-12	2003-07-06	Pfizer	Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
GB9502582D0 (en) *	1995-02-10	1995-03-29	Smithkline Beecham Plc	Novel process
GB9510459D0 (en)	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
CZ287821B6 (en) *	1996-05-13	2001-02-14	Zeneca Ltd	Bicyclic amines, process of their preparation and insecticidal, acaricidal and nematocidal agent containing thereof
WO1998006720A1 (fr) *	1996-08-09	1998-02-19	Eisai Co., Ltd.	Derives de benzopiperidine
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
EA199900502A1 (ru)	1996-11-26	2000-02-28	Зенека Лимитед	8-азабицикло[3.2.1]октан-, 8-азабицикло[3.2.1]окт-6-ен-, 9-азабицикло[3.3.1]нонан-, 9-аза-3-оксабицикло[3.3.1]нонан- и 9-аза-3-тиабицикло[3.3.1]нонанпроизводные, их получение и их применение в качестве инсектицидов
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
AU7723300A (en)	1999-09-27	2001-04-30	Georgetown University	Novel tropane analogs
CA2324116A1 (en) *	1999-10-25	2001-04-25	Susan Beth Sobolov-Jaynes	Nk-1 receptor antagonists and eletriptan for the treatment of migraine
WO2001032625A1 (en)	1999-11-03	2001-05-10	Du Pont Pharmaceuticals Company	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
CA2415532C (en)	2000-07-11	2010-05-11	Albany Molecular Research, Inc.	Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
US20020049211A1 (en) *	2000-09-06	2002-04-25	Sobolov-Jaynes Susan Beth	Combination treatment for depression and anxiety
EP1192952A3 (en) *	2000-09-28	2003-03-26	Pfizer Products Inc.	Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
WO2006123182A2 (en)	2005-05-17	2006-11-23	Merck Sharp & Dohme Limited	Cyclohexyl sulphones for treatment of cancer
NZ565111A (en)	2005-07-15	2011-10-28	Amr Technology Inc	Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2007041052A2 (en)	2005-09-29	2007-04-12	Merck & Co., Inc.	Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
WO2008039327A2 (en)	2006-09-22	2008-04-03	Merck & Co., Inc.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (en)	2007-01-10	2019-04-03	MSD Italia S.r.l.	Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
KR20090112722A (ko)	2007-01-24	2009-10-28	글락소 그룹 리미티드	3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
AU2008269154B2 (en)	2007-06-27	2014-06-12	Merck Sharp & Dohme Llc	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CA2717509A1 (en)	2008-03-03	2009-09-11	Tiger Pharmatech	Tyrosine kinase inhibitors
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
EA020553B1 (ru)	2009-05-12	2014-12-30	Олбани Молекьюлар Рисерч, Инк.	7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ
KR20120023072A (ko)	2009-05-12	2012-03-12	브리스톨-마이어스 스큅 컴퍼니	（Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
EP2429295B1 (en)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102638981B (zh)	2009-10-14	2015-07-22	默沙东公司	提高p53活性的取代的哌啶和其用途
US8999957B2 (en)	2010-06-24	2015-04-07	Merck Sharp & Dohme Corp.	Heterocyclic compounds as ERK inhibitors
EP2601293B1 (en)	2010-08-02	2017-12-06	Sirna Therapeutics, Inc.	RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2012024170A2 (en)	2010-08-17	2012-02-23	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012030685A2 (en)	2010-09-01	2012-03-08	Schering Corporation	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
IN2013MN02170A (pt)	2011-04-21	2015-06-12	Piramal Entpr Ltd
US9023865B2 (en)	2011-10-27	2015-05-05	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
CA2858720A1 (en) *	2011-12-12	2013-06-20	University Of Florida Research Foundation	Nicotinic receptor targeted compounds and compositions
EP3919620A1 (en)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
RU2660429C2 (ru)	2012-09-28	2018-07-06	Мерк Шарп И Доум Корп.	Новые соединения, которые являются ингибиторами erk
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
PL2925888T3 (pl)	2012-11-28	2018-03-30	Merck Sharp & Dohme Corp.	Kompozycje i sposoby do stosowania w leczeniu nowotworów
KR102196882B1 (ko)	2012-12-20	2020-12-30	머크 샤프 앤드 돔 코포레이션	Hdm2 억제제로서의 치환된 이미다조피리딘
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en)	2013-09-03	2016-07-07	Moderna Therapeutics, Inc.	Circular polynucleotides
DK3344628T5 (da)	2015-09-04	2021-07-26	Janssen Pharmaceutica Nv	Terapeutiske forbindelser og syntese
EP3525785B1 (en)	2016-10-12	2025-08-27	Merck Sharp & Dohme LLC	Kdm5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3706747B1 (en)	2017-11-08	2025-09-03	Merck Sharp & Dohme LLC	Prmt5 inhibitors
MA53287A (fr)	2018-08-07	2022-05-11	Merck Sharp & Dohme	Inhibiteurs de prmt5
EP3833668B1 (en)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Prmt5 inhibitors
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2455949A (en) *	1947-06-02	1948-12-14	Parke Davis & Co	Dialkylaminoalkyl benzahydryl ethers and salts thereof
US3560510A (en) *	1969-03-05	1971-02-02	Aldrich Chem Co Inc	2-benzhydrylquinuclidines
GB1527489A (en) *	1976-08-05	1978-10-04	Andreu Sa Dr	Amine compound
US4246201A (en) *	1979-06-11	1981-01-20	Alfa Farmaceutici, S.P.A.	Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists
UA41251C2 (uk) *	1990-01-04	2001-09-17	Пфайзер, Інк.	Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
AU648317B2 (en) *	1990-06-01	1994-04-21	Pfizer Inc.	3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
JP2514137B2 (ja) *	1990-07-23	1996-07-10	フアイザー・インコーポレイテツド	キヌクリジン誘導体

1991
- 1991-05-14 JP JP3509439A patent/JP2514137B2/ja not_active Expired - Fee Related
- 1991-05-14 US US07/988,125 patent/US5422354A/en not_active Expired - Fee Related
- 1991-05-14 BR BR919106665A patent/BR9106665A/pt not_active Application Discontinuation
- 1991-05-14 AT AT91909987T patent/ATE116317T1/de not_active IP Right Cessation
- 1991-05-14 DE DE69106365T patent/DE69106365T2/de not_active Expired - Fee Related
- 1991-05-14 CA CA002086434A patent/CA2086434C/en not_active Expired - Fee Related
- 1991-05-14 DK DK91909987.9T patent/DK0540526T3/da active
- 1991-05-14 AU AU78948/91A patent/AU660416B2/en not_active Ceased
- 1991-05-14 HU HU93188A patent/HUT62584A/hu unknown
- 1991-05-14 ES ES91909987T patent/ES2065691T3/es not_active Expired - Lifetime
- 1991-05-14 PL PL91297654A patent/PL167568B1/pl unknown
- 1991-05-14 WO PCT/US1991/003369 patent/WO1992001688A1/en not_active Ceased
- 1991-05-14 EP EP91909987A patent/EP0540526B1/en not_active Expired - Lifetime
- 1991-07-15 IL IL9886091A patent/IL98860A/en not_active IP Right Cessation
- 1991-07-19 PT PT98393A patent/PT98393B/pt not_active IP Right Cessation
- 1991-07-19 MX MX9100308A patent/MX9100308A/es not_active IP Right Cessation
- 1991-07-22 YU YU128091A patent/YU128091A/sh unknown
- 1991-07-22 NZ NZ239063A patent/NZ239063A/en unknown
- 1991-07-22 ZA ZA915727A patent/ZA915727B/xx unknown
- 1991-07-22 CN CN91104961A patent/CN1058405A/zh active Pending
- 1991-07-22 MY MYPI91001322A patent/MY107157A/en unknown
- 1991-07-22 IE IE256091A patent/IE65000B1/en not_active IP Right Cessation
1993
- 1993-01-22 FI FI930262A patent/FI114473B/fi not_active IP Right Cessation
- 1993-01-22 NO NO930222A patent/NO302172B1/no unknown
1995
- 1995-02-22 GR GR950400364T patent/GR3015144T3/el unknown
- 1995-03-14 US US08/403,987 patent/US5641786A/en not_active Expired - Fee Related
- 1995-03-14 US US08/403,967 patent/US5698568A/en not_active Expired - Fee Related
1997
- 1997-03-21 US US08/821,487 patent/US5821248A/en not_active Expired - Fee Related
- 1997-03-21 US US08/821,500 patent/US5854256A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI930262L (fi)	1993-01-22
FI114473B (fi)	2004-10-29
MX9100308A (es)	1992-02-28
NZ239063A (en)	1995-09-26
PL167568B1 (pl)	1995-09-30
NO302172B1 (no)	1998-02-02
ATE116317T1 (de)	1995-01-15
CA2086434C (en)	1998-09-22
NO930222D0 (no)	1993-01-22
DE69106365D1 (de)	1995-02-09
CA2086434A1 (en)	1992-01-24
US5422354A (en)	1995-06-06
US5641786A (en)	1997-06-24
ES2065691T3 (es)	1995-02-16
DK0540526T3 (da)	1995-04-18
YU128091A (sh)	1994-01-20
US5854256A (en)	1998-12-29
HU9300188D0 (en)	1993-04-28
PT98393B (pt)	1999-01-29
NO930222L (no)	1993-01-22
CN1058405A (zh)	1992-02-05
DE69106365T2 (de)	1995-05-04
WO1992001688A1 (en)	1992-02-06
US5821248A (en)	1998-10-13
IL98860A0 (en)	1992-07-15
FI930262A0 (fi)	1993-01-22
IE65000B1 (en)	1995-10-04
JPH05507687A (ja)	1993-11-04
IE912560A1 (en)	1992-01-29
IL98860A (en)	1995-11-27
HUT62584A (en)	1993-05-28
EP0540526B1 (en)	1994-12-28
PT98393A (pt)	1992-05-29
AU660416B2 (en)	1995-06-29
MY107157A (en)	1995-09-30
EP0540526A1 (en)	1993-05-12
JP2514137B2 (ja)	1996-07-10
GR3015144T3 (en)	1995-05-31
ZA915727B (en)	1993-02-24
US5698568A (en)	1997-12-16
AU7894891A (en)	1992-02-18

Publication	Publication Date	Title
MX9100308A (es)	1992-02-28	Derivados de quinuclidina
FI963450A0 (fi)	1996-09-03	Morfoliinitakykiniinireseptoriantagonistien lääke-esiastetta
MX9202449A (es)	1993-03-01	3-aminoquinuclidinas substituidas.
YU56492A (sh)	1995-03-27	Derivati hinuklidina
GR3026231T3 (en)	1998-05-29	3-aminopiperidine derivatives and related nitrogen containing heterocycles.
ATE165830T1 (de)	1998-05-15	Dihydro pyrazolopyrrole
BR9206500A (pt)	1995-10-03	Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P
DE69523155D1 (de)	2001-11-15	Benzimidazolonderivate mit zentraler dopaminerger aktivität
DE69925160D1 (de)	2005-06-09	Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
YU140491A (sh)	1994-01-20	6-supstituisani-tetrahidrobenz(c,d) indoli
PT889044E (pt)	2005-01-31	Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central

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Date	Code	Title	Description
1998-11-24	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-08-17	FC	Decision: refusal