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BR9206500A - Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P - Google Patents

Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P

Info

Publication number
BR9206500A
BR9206500A BR9206500A BR9206500A BR9206500A BR 9206500 A BR9206500 A BR 9206500A BR 9206500 A BR9206500 A BR 9206500A BR 9206500 A BR9206500 A BR 9206500A BR 9206500 A BR9206500 A BR 9206500A
Authority
BR
Brazil
Prior art keywords
pct
antagonists
heterocycles containing
containing condensed
condensed tricyclic
Prior art date
Application number
BR9206500A
Other languages
English (en)
Inventor
John A Lowe Iii
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9206500A publication Critical patent/BR9206500A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BR9206500A 1991-09-26 1992-08-20 Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P BR9206500A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76648891A 1991-09-26 1991-09-26
PCT/US1992/006819 WO1993006099A1 (en) 1991-09-16 1992-08-20 Fused tricyclic nitrogen containing heterocycles as substance p receptor antagonists

Publications (1)

Publication Number Publication Date
BR9206500A true BR9206500A (pt) 1995-10-03

Family

ID=25076576

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9206500A BR9206500A (pt) 1991-09-26 1992-08-20 Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P

Country Status (19)

Country Link
US (1) US5527808A (pt)
EP (1) EP0607164B1 (pt)
JP (1) JP2535134B2 (pt)
CN (1) CN1071168A (pt)
AT (1) ATE216996T1 (pt)
AU (1) AU2481292A (pt)
BR (1) BR9206500A (pt)
CA (1) CA2118704C (pt)
CZ (1) CZ59394A3 (pt)
DE (1) DE69232588T2 (pt)
DK (1) DK0607164T3 (pt)
ES (1) ES2174836T3 (pt)
FI (1) FI941212A0 (pt)
HU (1) HU9400728D0 (pt)
MX (1) MX9205242A (pt)
NO (1) NO940927D0 (pt)
PT (1) PT100901A (pt)
WO (1) WO1993006099A1 (pt)
ZA (1) ZA927370B (pt)

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IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728265A1 (fr) * 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p dans une composition pharmaceutique
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
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EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5319518B2 (ja) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 インドールジオン誘導体
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
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US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
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EA020553B1 (ru) 2009-05-12 2014-12-30 Олбани Молекьюлар Рисерч, Инк. 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ
EP2429295B1 (en) 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102638981B (zh) 2009-10-14 2015-07-22 默沙东公司 提高p53活性的取代的哌啶和其用途
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EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
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EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
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KR102196882B1 (ko) 2012-12-20 2020-12-30 머크 샤프 앤드 돔 코포레이션 Hdm2 억제제로서의 치환된 이미다조피리딘
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US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
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US3506673A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4'halo)-benzhydryl-3-quinuclidinols
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
JP2514137B2 (ja) * 1990-07-23 1996-07-10 フアイザー・インコーポレイテツド キヌクリジン誘導体

Also Published As

Publication number Publication date
DE69232588T2 (de) 2002-08-22
US5527808A (en) 1996-06-18
HU9400728D0 (en) 1994-06-28
ES2174836T3 (es) 2002-11-16
WO1993006099A1 (en) 1993-04-01
NO940927L (no) 1994-03-15
CA2118704A1 (en) 1993-04-01
DE69232588D1 (de) 2002-06-06
CZ59394A3 (en) 1994-11-16
FI941212L (fi) 1994-03-15
ATE216996T1 (de) 2002-05-15
JPH06507179A (ja) 1994-08-11
FI941212A7 (fi) 1994-03-15
JP2535134B2 (ja) 1996-09-18
PT100901A (pt) 1994-02-28
CA2118704C (en) 1997-01-21
DK0607164T3 (da) 2002-06-17
MX9205242A (es) 1993-03-01
NO940927D0 (no) 1994-03-15
CN1071168A (zh) 1993-04-21
EP0607164B1 (en) 2002-05-02
FI941212A0 (fi) 1994-03-15
ZA927370B (en) 1994-03-25
AU2481292A (en) 1993-04-27
EP0607164A1 (en) 1994-07-27

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Legal Events

Date Code Title Description
EE Request for examination
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
FC Decision: refusal