BR9105136A - Complexo de inclusao de n-etoxicarbonil-3-morfolino-sidnon imina ou de seu sal,processo para sua preparacao,composicao farmaceutica,processo para sua preparacao,e,processo de tratamento de doencas anginicas e isquemicas em humanos - Google Patents

Complexo de inclusao de n-etoxicarbonil-3-morfolino-sidnon imina ou de seu sal,processo para sua preparacao,composicao farmaceutica,processo para sua preparacao,e,processo de tratamento de doencas anginicas e isquemicas em humanos

Info

Publication number: BR9105136A
Authority: BR; Brazil
Prior art keywords: preparation; cyclodextrin; sidnon; etoxicarbonil; anginic
Prior art date: 1990-03-28

Application number

BR919105136A

Other languages

English (en)

Inventor

Maria Vikmon

Jozsef Szejtli

Jozsef Gaal

Istvan Hermecz

Agnes Horvath

Katalin Marmarosi

Gabor Horvath

Iren Munkacsi

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-28

Filing date

1991-03-28

Publication date

1992-08-04

1991-03-28 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1992-08-04 Publication of BR9105136A publication Critical patent/BR9105136A/pt

Links

150000003839 salts Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title 3
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000000302 ischemic effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229920000858 Cyclodextrin Polymers 0.000 abstract 7
XLFWDASMENKTKL-UHFFFAOYSA-N molsidomine Chemical compound O1C(N=C([O-])OCC)=C[N+](N2CCOCC2)=N1 XLFWDASMENKTKL-UHFFFAOYSA-N 0.000 abstract 4
239000001116 FEMA 4028 Substances 0.000 abstract 3
229960004853 betadex Drugs 0.000 abstract 3
206010002383 Angina Pectoris Diseases 0.000 abstract 2
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 2
235000011175 beta-cyclodextrine Nutrition 0.000 abstract 2
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
230000002253 anti-ischaemic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229960004027 molsidomine Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Materials Engineering (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BR919105136A 1990-03-28 1991-03-28 Complexo de inclusao de n-etoxicarbonil-3-morfolino-sidnon imina ou de seu sal,processo para sua preparacao,composicao farmaceutica,processo para sua preparacao,e,processo de tratamento de doencas anginicas e isquemicas em humanos BR9105136A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU901868A HU210921B (en)	1990-03-28	1990-03-28	Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
PCT/HU1991/000012 WO1991014680A1 (en)	1990-03-28	1991-03-28	Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same

Publications (1)

Publication Number	Publication Date
BR9105136A true BR9105136A (pt)	1992-08-04

Family

ID=10956592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR919105136A BR9105136A (pt)	1990-03-28	1991-03-28	Complexo de inclusao de n-etoxicarbonil-3-morfolino-sidnon imina ou de seu sal,processo para sua preparacao,composicao farmaceutica,processo para sua preparacao,e,processo de tratamento de doencas anginicas e isquemicas em humanos

Country Status (34)

Country	Link
US (1)	US5403840A (pt)
EP (1)	EP0477315B1 (pt)
JP (1)	JP2582497B2 (pt)
KR (1)	KR950004705B1 (pt)
CN (1)	CN1051080C (pt)
AT (1)	ATE138656T1 (pt)
AU (1)	AU638824B2 (pt)
BG (1)	BG61689B1 (pt)
BR (1)	BR9105136A (pt)
CA (1)	CA2054188C (pt)
CZ (1)	CZ287353B6 (pt)
DE (1)	DE69119853T2 (pt)
DK (1)	DK0477315T3 (pt)
ES (1)	ES2090320T3 (pt)
FI (1)	FI102460B1 (pt)
GE (1)	GEP19991832B (pt)
GR (1)	GR3020684T3 (pt)
HR (1)	HRP920561B1 (pt)
HU (1)	HU210921B (pt)
IL (1)	IL97714A (pt)
LT (1)	LT3394B (pt)
LV (1)	LV10245B (pt)
MC (1)	MC2185A1 (pt)
MD (1)	MD679G2 (pt)
NO (1)	NO179611C (pt)
OA (1)	OA10029A (pt)
PL (1)	PL165868B1 (pt)
RO (1)	RO109649B1 (pt)
RU (1)	RU2111216C1 (pt)
SI (1)	SI9110908A (pt)
SK (1)	SK279891B6 (pt)
TJ (1)	TJ231R3 (pt)
UA (1)	UA27226C2 (pt)
WO (1)	WO1991014680A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA949182B (en) *	1993-12-02	1995-07-26	South African Druggists Ltd	Pharmaceutical composition
GB2290964A (en) *	1994-07-08	1996-01-17	Arto Olavi Urtti	Transdermal drug delivery system
US6046177A (en) *	1997-05-05	2000-04-04	Cydex, Inc.	Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
GB9915231D0 (en)	1999-06-29	1999-09-01	Pfizer Ltd	Pharmaceutical complex
FR2805462B1 (fr)	2000-02-24	2003-08-15	Therabel Res	Nouvelle forme galenique orale a liberation prolongee de la molsidomine
ITTO20120056A1 (it) *	2012-01-24	2013-07-25	Borla Ind	Connettore per linee medicali di infusione, trasfusione e simili
ITTO20130433A1 (it) *	2013-05-29	2014-11-30	Borla Ind	Connettore per linee medicali
BE1028879B1 (fr)	2020-12-11	2022-07-12	Europharmaceuticals	Comprimé à libération prolongée de la molsidomine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1695897C3 (de) *	1966-07-04	1979-02-15	Takeda Chemical Industries Ltd	N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3221425A1 (de) *	1982-06-07	1983-12-08	Boehringer Ingelheim KG, 6507 Ingelheim	Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette
DK243084A (da) *	1983-05-26	1984-11-27	Takeda Chemical Industries Ltd	Perkutane farmaceutiske praeparater til udvortes brug
DE3346614A1 (de) *	1983-12-23	1985-07-04	Anton Hummel Gmbh Metallwarenfabrik, 7808 Waldkirch	Entlueftungsventil insbesondere zum entlueften von heizsystemen
GB8506792D0 (en) *	1985-03-15	1985-04-17	Janssen Pharmaceutica Nv	Derivatives of y-cyclodextrin
DE3522191A1 (de) *	1985-06-21	1987-01-15	Cassella Ag	Photostabilisierung von sydnoniminen
GB8613688D0 (en) *	1986-06-05	1986-07-09	Euro Celtique Sa	Pharmaceutical composition
JPH0819004B2 (ja) *	1986-12-26	1996-02-28	日清製粉株式会社	徐放性医薬製剤
IT1204725B (it) *	1987-06-17	1989-03-10	Edmond Pharma Srl	Complessi di inclusione del dipiridamolo con ciclodestrine
ES2037385T3 (es) *	1988-01-14	1993-06-16	Akzo N.V.	Un procedimiento de manufactura de una preparacion farmaceutica para administracion local.
US5120732A (en) *	1988-06-14	1992-06-09	Cassella Aktiengesellschaft	Substituted 3-aminosyndone imines, a process for their preparation and their use
IT1227626B (it) *	1988-11-28	1991-04-23	Vectorpharma Int	Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
SE8904296D0 (sv) *	1989-12-21	1989-12-21	Pharmacia Ab	Transdermal system
HU212730B (en) *	1990-03-28	1996-10-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them

1990
- 1990-03-28 HU HU901868A patent/HU210921B/hu unknown
1991
- 1991-03-28 IL IL9771491A patent/IL97714A/en not_active IP Right Cessation
- 1991-03-28 PL PL91293022A patent/PL165868B1/pl unknown
- 1991-03-28 CA CA002054188A patent/CA2054188C/en not_active Expired - Lifetime
- 1991-03-28 AU AU75745/91A patent/AU638824B2/en not_active Expired
- 1991-03-28 SI SI9110908A patent/SI9110908A/sl unknown
- 1991-03-28 ES ES91906726T patent/ES2090320T3/es not_active Expired - Lifetime
- 1991-03-28 CN CN91102687A patent/CN1051080C/zh not_active Expired - Fee Related
- 1991-03-28 RO RO148827A patent/RO109649B1/ro unknown
- 1991-03-28 UA UA5010581A patent/UA27226C2/uk unknown
- 1991-03-28 BR BR919105136A patent/BR9105136A/pt not_active Application Discontinuation
- 1991-03-28 CZ CS1991851A patent/CZ287353B6/cs not_active IP Right Cessation
- 1991-03-28 JP JP3507012A patent/JP2582497B2/ja not_active Expired - Lifetime
- 1991-03-28 EP EP91906726A patent/EP0477315B1/en not_active Expired - Lifetime
- 1991-03-28 WO PCT/HU1991/000012 patent/WO1991014680A1/en not_active Ceased
- 1991-03-28 KR KR1019910701670A patent/KR950004705B1/ko not_active Expired - Fee Related
- 1991-03-28 SK SK851-91A patent/SK279891B6/sk unknown
- 1991-03-28 AT AT91906726T patent/ATE138656T1/de not_active IP Right Cessation
- 1991-03-28 MC MC@@@@D patent/MC2185A1/xx unknown
- 1991-03-28 DK DK91906726.4T patent/DK0477315T3/da active
- 1991-03-28 DE DE69119853T patent/DE69119853T2/de not_active Expired - Lifetime
- 1991-03-28 US US07/807,852 patent/US5403840A/en not_active Expired - Lifetime
- 1991-03-28 RU SU5010581A patent/RU2111216C1/ru active
- 1991-11-08 OA OA60094A patent/OA10029A/en unknown
- 1991-11-26 FI FI915569A patent/FI102460B1/fi active
- 1991-11-27 NO NO914649A patent/NO179611C/no not_active IP Right Cessation
- 1991-11-27 BG BG95531A patent/BG61689B1/bg unknown
1992
- 1992-09-28 HR HRP-908/91A patent/HRP920561B1/xx not_active IP Right Cessation
- 1992-12-30 LV LVP-92-590A patent/LV10245B/en unknown
1993
- 1993-03-05 LT LTIP386A patent/LT3394B/lt not_active IP Right Cessation
- 1993-06-16 GE GEAP1993884A patent/GEP19991832B/en unknown
1994
- 1994-08-25 MD MD94-0333A patent/MD679G2/ro not_active IP Right Cessation
- 1994-11-28 TJ TJ94000007A patent/TJ231R3/xx unknown
1996
- 1996-07-31 GR GR960402042T patent/GR3020684T3/el unknown

Also Published As

Publication number	Publication date
JP2582497B2 (ja)	1997-02-19
PL165868B1 (pl)	1995-02-28
DK0477315T3 (da)	1996-09-30
ATE138656T1 (de)	1996-06-15
HU210921B (en)	1995-09-28
CS85191A3 (en)	1991-11-12
SK279891B6 (sk)	1999-05-07
NO179611B (no)	1996-08-05
KR950004705B1 (ko)	1995-05-04
HRP920561B1 (en)	1999-12-31
EP0477315A1 (en)	1992-04-01
NO179611C (no)	1996-11-13
CN1056688A (zh)	1991-12-04
KR920701182A (ko)	1992-08-11
FI102460B (fi)	1998-12-15
LTIP386A (en)	1994-12-27
HRP920561A2 (hr)	1994-04-30
DE69119853T2 (de)	1996-10-10
HUT58109A (en)	1992-01-28
FI915569A0 (fi)	1991-11-26
AU638824B2 (en)	1993-07-08
UA27226C2 (uk)	2000-08-15
NO914649L (no)	1991-11-27
WO1991014680A1 (en)	1991-10-03
NO914649D0 (no)	1991-11-27
GEP19991832B (en)	1999-11-05
BG61689B1 (bg)	1998-03-31
LV10245A (lv)	1994-10-20
PL293022A1 (en)	1992-12-28
US5403840A (en)	1995-04-04
LV10245B (en)	1995-08-20
BG95531A (bg)	1993-12-24
IL97714A (en)	1995-03-30
ES2090320T3 (es)	1996-10-16
CN1051080C (zh)	2000-04-05
SI9110908A (sl)	1998-06-30
MD679F1 (en)	1997-02-28
AU7574591A (en)	1991-10-21
OA10029A (en)	1996-10-14
FI102460B1 (fi)	1998-12-15
TJ231R3 (en)	1999-11-24
GR3020684T3 (en)	1996-10-31
CZ287353B6 (cs)	2000-11-15
RO109649B1 (ro)	1995-04-28
LT3394B (en)	1995-09-25
JPH04506362A (ja)	1992-11-05
IL97714A0 (en)	1992-06-21
MC2185A1 (fr)	1992-09-16
EP0477315B1 (en)	1996-05-29
HU901868D0 (en)	1990-08-28
MD679G2 (ro)	1997-11-30
CA2054188C (en)	1996-07-23
DE69119853D1 (de)	1996-07-04
CA2054188A1 (en)	1991-09-29
RU2111216C1 (ru)	1998-05-20

Publication	Publication Date	Title
BR9105136A (pt)	1992-08-04	Complexo de inclusao de n-etoxicarbonil-3-morfolino-sidnon imina ou de seu sal,processo para sua preparacao,composicao farmaceutica,processo para sua preparacao,e,processo de tratamento de doencas anginicas e isquemicas em humanos
RU94028890A (ru)	1995-11-10	Композиции производных циклодекстрина, композиции, содержащие лекарство и производные циклодекстринов
ATE87319T1 (de)	1993-04-15	Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate.
ATE228013T1 (de)	2002-12-15	Hochlösliche multikomponenten-inklusionskomplexe, welche ein basisches arzneimittel, eine säure und ein zyklodextrin enthalten
DK0513072T3 (da)	1994-08-01	Forbedret cyclodextrinbaseret erythropoietinformulering
ATE247486T1 (de)	2003-09-15	Pharmazeutische zusammensetzungen, enthaltend diclofenac und 2-hydroxypropyl-beta-cyclodextrin
DE69428334D1 (de)	2001-10-25	Wässrige Lösungen enthaltend Inklusionskomplexe aus Benzothiophenderivaten und Cyclodextrinen
AU3854095A (en)	1996-06-06	Novel complexes and their compositions
DK0465535T3 (da)	1999-03-01	Regioselektive substitutioner i cyclodextriner
EP0931545A3 (en)	2000-08-23	Droloxifene pharmaceutical compositions
DE69025691D1 (de)	1996-04-11	Einschlusskomplexe mit Silybinin, ihre Herstellung und pharmazeutische Präparate, die diese enthalten
ATE363214T1 (de)	2007-06-15	Löslicher natamycin-proteinkomplex
FI102462B1 (fi)	1998-12-15	Menetelmä nimesulidin syklodekstriinikompleksin valmistamiseksi
Maaroufi et al.	1997	Mechanism of thrombin inhibition by heparin cofactor II in the presence of dermatan sulphates, native or oversulphated, and a heparin-like dextran derivative
Kirschfink et al.	1988	Binding and activation of C4 and C3 on the red cell surface by non-complement enzymes
KR920701183A (ko)	1992-08-11	3-모르폴리노-시드노니민 또는 그 염들 또는 그 토우토머(tautomer)이 성질체를 함유하는 복합체들 및 그 제조방법과 이들을 함유하는 약제학적 조성물
ES2166754T3 (es)	2002-05-01	Procedimiento para la obtencion de complejos de principio activo.
ES2107460T3 (es)	1997-12-01	Tratamiento de la trombosis.
KR960705587A (ko)	1996-11-08	개선된 약제학적 성질을 가진 에스트라무스틴 제제(Estramustine formulations with improved pharmaceutical properties)
IT1223122B (it)	1990-09-12	Derivati proteici del ferro altamente biodisponibile e tollerabili, loro preparazione e composizioni farmaceutiche che li contengono
RU96113045A (ru)	1998-09-27	Составы эстрамустина с улучшенными фармацевтическими свойствами
ES2094080B1 (es)	1997-08-01	Procedimiento de preparacion de complejos de inclusion de tenoxicam con ciclodextrinas.
HUT57582A (en)	1991-12-30	Process for producing n-acylated amino-containing compositions suitable for treating burns

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