IT1204725B - Complessi di inclusione del dipiridamolo con ciclodestrine - Google Patents
Complessi di inclusione del dipiridamolo con ciclodestrineInfo
- Publication number
- IT1204725B IT1204725B IT20925/87A IT2092587A IT1204725B IT 1204725 B IT1204725 B IT 1204725B IT 20925/87 A IT20925/87 A IT 20925/87A IT 2092587 A IT2092587 A IT 2092587A IT 1204725 B IT1204725 B IT 1204725B
- Authority
- IT
- Italy
- Prior art keywords
- inclusion complexes
- cyclodestrine
- dipyridamol
- dipyridamole
- cyclodextrins
- Prior art date
Links
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002768 dipyridamole Drugs 0.000 title abstract 4
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20925/87A IT1204725B (it) | 1987-06-17 | 1987-06-17 | Complessi di inclusione del dipiridamolo con ciclodestrine |
| AT88108536T ATE71633T1 (de) | 1987-06-17 | 1988-05-27 | Einschlusskomplexe von dipyridamol und cyclodextrinen. |
| DE8888108536T DE3867718D1 (de) | 1987-06-17 | 1988-05-27 | Einschlusskomplexe von dipyridamol und cyclodextrinen. |
| EP88108536A EP0295476B1 (en) | 1987-06-17 | 1988-05-27 | Inclusion complexes of dipyridamole with cyclodextrins |
| ES198888108536T ES2038241T3 (es) | 1987-06-17 | 1988-05-27 | Complejos de inclusion de dipiridamol con ciclodextrinas. |
| US07/201,038 US5010064A (en) | 1987-06-17 | 1988-06-01 | Inclusion complexes of dipyridamole with cyclodextrins |
| JP63149249A JPH0193587A (ja) | 1987-06-17 | 1988-06-16 | ジピリダモルとシクロデキストリンとの包接複合体及びその製造方法並びに該複合体を有効成分とする医薬組成物 |
| KR1019880007278A KR890000094A (ko) | 1987-06-17 | 1988-06-17 | 시클로덱스트린과 디피리다몰의 봉입복합체 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20925/87A IT1204725B (it) | 1987-06-17 | 1987-06-17 | Complessi di inclusione del dipiridamolo con ciclodestrine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8720925A0 IT8720925A0 (it) | 1987-06-17 |
| IT1204725B true IT1204725B (it) | 1989-03-10 |
Family
ID=11174168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT20925/87A IT1204725B (it) | 1987-06-17 | 1987-06-17 | Complessi di inclusione del dipiridamolo con ciclodestrine |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5010064A (it) |
| EP (1) | EP0295476B1 (it) |
| JP (1) | JPH0193587A (it) |
| KR (1) | KR890000094A (it) |
| AT (1) | ATE71633T1 (it) |
| DE (1) | DE3867718D1 (it) |
| ES (1) | ES2038241T3 (it) |
| IT (1) | IT1204725B (it) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1237509B (it) * | 1989-10-31 | 1993-06-08 | Magis Farmaceutici | Complessi con le ciclodestrine indicati per il trattamento di tutte leforme anemiche da carenza di folati, loro preparazione e relative composizioni farmaceutiche |
| EP0518930A4 (en) * | 1990-03-02 | 1993-09-15 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
| HU210921B (en) * | 1990-03-28 | 1995-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them |
| HU212730B (en) * | 1990-03-28 | 1996-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them |
| IT1239064B (it) * | 1990-05-14 | 1993-09-20 | Fidia Spa | Uso terapeutico del dipiridamolo |
| US5302393A (en) * | 1991-07-11 | 1994-04-12 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method for inhibiting biological degradation of implantation polymeric material, inhibitor thereof and implantation polymeric material containing the inhibitor |
| SI9300470A (en) * | 1993-09-10 | 1995-04-30 | Lek Tovarna Farmacevtskih | Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use |
| ATE359827T1 (de) * | 2002-06-17 | 2007-05-15 | Chiesi Farma Spa | Prozess für die vorbereitung von piroxicam: beta- cyclodextrin einschlusskomplexe |
| KR100466250B1 (ko) * | 2002-09-30 | 2005-01-14 | 한국과학기술원 | 다양한 형태의 콜로이드 결정 및 다공성 구조체의 제조방법 |
| AU2005268972A1 (en) * | 2004-08-02 | 2006-02-09 | Chiesi Farmaceutici S.P.A. | A process for the preparation of a piroxicam: betacyclodextrin inclusion compound |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054736A (en) * | 1970-06-10 | 1977-10-18 | Ono Pharmaceutical Co., Ltd. | Clathrate compounds of prostaglandins or their analogues with cyclodextrin |
| HU176215B (en) * | 1978-01-27 | 1981-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1 |
| HU183430B (en) * | 1981-05-12 | 1984-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing cyclodextrine inclusion complexes of n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine or n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine-hydrochloride |
| JPS5813541A (ja) * | 1981-07-16 | 1983-01-26 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はドコサヘキサエン酸のシクロデキストリン包接化合物 |
| JPS5782754A (en) * | 1981-09-17 | 1982-05-24 | Matsushita Electric Ind Co Ltd | Inspection device for printed wiring substrate |
| JPS5920230A (ja) * | 1982-07-19 | 1984-02-01 | チバ−ガイギ−・アクチエンゲゼルシヤフト | ピルプロフエン含有薬剤 |
| IT1196033B (it) * | 1984-02-22 | 1988-11-10 | Chiesi Farma Spa | Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche |
| DE3427786A1 (de) * | 1984-07-27 | 1986-01-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Inklusionskomplexe von benzimidazolderivaten mit cyclodextrinen, deren herstellung und arzneimittel |
-
1987
- 1987-06-17 IT IT20925/87A patent/IT1204725B/it active
-
1988
- 1988-05-27 DE DE8888108536T patent/DE3867718D1/de not_active Expired - Fee Related
- 1988-05-27 AT AT88108536T patent/ATE71633T1/de not_active IP Right Cessation
- 1988-05-27 EP EP88108536A patent/EP0295476B1/en not_active Expired - Lifetime
- 1988-05-27 ES ES198888108536T patent/ES2038241T3/es not_active Expired - Lifetime
- 1988-06-01 US US07/201,038 patent/US5010064A/en not_active Expired - Fee Related
- 1988-06-16 JP JP63149249A patent/JPH0193587A/ja active Pending
- 1988-06-17 KR KR1019880007278A patent/KR890000094A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2038241T3 (es) | 1993-07-16 |
| ATE71633T1 (de) | 1992-02-15 |
| EP0295476A2 (en) | 1988-12-21 |
| DE3867718D1 (de) | 1992-02-27 |
| JPH0193587A (ja) | 1989-04-12 |
| EP0295476A3 (en) | 1989-06-07 |
| US5010064A (en) | 1991-04-23 |
| IT8720925A0 (it) | 1987-06-17 |
| KR890000094A (ko) | 1989-03-11 |
| EP0295476B1 (en) | 1992-01-15 |
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