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BR0312948A - Pramipexole em forma de dosagem uma vez ao dia - Google Patents

Pramipexole em forma de dosagem uma vez ao dia

Info

Publication number
BR0312948A
BR0312948A BR0312948-9A BR0312948A BR0312948A BR 0312948 A BR0312948 A BR 0312948A BR 0312948 A BR0312948 A BR 0312948A BR 0312948 A BR0312948 A BR 0312948A
Authority
BR
Brazil
Prior art keywords
pramipexole
hours
average
composition
absorption
Prior art date
Application number
BR0312948-9A
Other languages
English (en)
Inventor
Ernest J Lee
Gerard M Bredael
John R Baldwin
Steven R Cox
Mark J Heintz
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31192088&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0312948(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0312948A publication Critical patent/BR0312948A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PRAMIPEXOLE EM FORMA DE DOSAGEM UMA VEZ AO DIA". Uma composição farmacológica de administração oral inclui uma quantidade terapeuticamente efectiva de pramipexole ou um seu sal farmacologicamente aceitável e pelo menos excipiente farmacologicamente aceitável. Exibindo a referida composição pelo menos um de (a) um perfil de libertação in vitro em que em média não mais do que cerca de 20 % de pramipexole está dissolvido dentro de 2 horas depois de se colocar a composição em um teste de dissolução normalizado e (b) um perfil de absorção de pramipexole in vivo seguido a administração de dose única em humanos adultos saudáveis em que o tempo de alcançar uma média de 20 % de absorção é superior a cerca de 2 horas e/ou o tempo para alcançar uma média de 40 % de absorção é superior a cerca de 4 horas. A composição é útil para administração oral, não mais do que uma vez ao dia, a um sujeito tendo uma condição ou distúrbio para o qual é indicado um agonista do receptor dopamina.
BR0312948-9A 2002-07-25 2003-07-25 Pramipexole em forma de dosagem uma vez ao dia BR0312948A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39844702P 2002-07-25 2002-07-25
US39842702P 2002-07-25 2002-07-25
US47951403P 2003-06-18 2003-06-18
PCT/US2003/023522 WO2004010999A1 (en) 2002-07-25 2003-07-25 Pramipexole once-daily dosage form

Publications (1)

Publication Number Publication Date
BR0312948A true BR0312948A (pt) 2005-06-14

Family

ID=31192088

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312948-9A BR0312948A (pt) 2002-07-25 2003-07-25 Pramipexole em forma de dosagem uma vez ao dia

Country Status (39)

Country Link
US (2) US8679533B2 (pt)
EP (2) EP2289514B9 (pt)
JP (1) JP4607584B2 (pt)
KR (2) KR101066374B1 (pt)
CN (1) CN1671381B (pt)
AP (1) AP2223A (pt)
AR (1) AR040682A1 (pt)
AU (1) AU2003256921B2 (pt)
BR (1) BR0312948A (pt)
CA (1) CA2493629C (pt)
CU (1) CU23468B7 (pt)
CY (2) CY1114263T1 (pt)
DE (1) DE20321906U1 (pt)
DK (2) DK1536792T3 (pt)
EA (1) EA017595B1 (pt)
EC (1) ECSP055569A (pt)
ES (2) ES2436745T3 (pt)
GE (1) GEP20074047B (pt)
HR (1) HRP20041234B1 (pt)
IL (1) IL166076A0 (pt)
IS (1) IS7613A (pt)
MA (1) MA27372A1 (pt)
ME (1) ME00347B (pt)
MX (1) MXPA05000980A (pt)
MY (1) MY142204A (pt)
NO (1) NO20050481L (pt)
NZ (1) NZ562681A (pt)
OA (1) OA12889A (pt)
PA (1) PA8578501A1 (pt)
PE (1) PE20040134A1 (pt)
PL (1) PL375444A1 (pt)
PT (2) PT2289514E (pt)
RS (1) RS52764B (pt)
SG (1) SG177011A1 (pt)
SI (2) SI2289514T1 (pt)
TW (1) TWI351955B (pt)
UY (1) UY27913A1 (pt)
WO (1) WO2004010999A1 (pt)
ZA (1) ZA200500015B (pt)

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