BR0312250A - Uso de inibidores de vasopeptidase no tratamento de nefropatia - Google Patents
Uso de inibidores de vasopeptidase no tratamento de nefropatiaInfo
- Publication number
- BR0312250A BR0312250A BR0312250A BR0312250A BR0312250A BR 0312250 A BR0312250 A BR 0312250A BR 0312250 A BR0312250 A BR 0312250A BR 0312250 A BR0312250 A BR 0312250A BR 0312250 A BR0312250 A BR 0312250A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetic
- nephropathy
- treatment
- vasopeptidase inhibitors
- vasopeptidase
- Prior art date
Links
- 208000017169 kidney disease Diseases 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 3
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010048554 Endothelial dysfunction Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 206010027525 Microalbuminuria Diseases 0.000 abstract 1
- 206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 1
- 208000028208 end stage renal disease Diseases 0.000 abstract 1
- 201000000523 end stage renal failure Diseases 0.000 abstract 1
- 230000008694 endothelial dysfunction Effects 0.000 abstract 1
- 206010061989 glomerulosclerosis Diseases 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 201000009925 nephrosclerosis Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"USO DE INIBIDORES DE VASOPEPTIDASE NO TRATAMENTO DE NEFROPATIA". A presente invenção descreve o uso de inibidores de vasopeptidase da fórmula (I) para o tratamento e/ou profilaxia de nefropatia em pacientes diabéticos ou não-diabéticos, inclusive nefropatia diabética ou não-diabética, glomerulonefrite, esclerose glomerular, síndrome nefrótica, nefroesclerose hipertensiva, microalbuminúria ou doença renal de estágio terminal, ou resistência à insulina ou de doenças metabólicas associadas a produtos finais de glicação avançada, tal como complicações diabéticas, neuropatia diabética, nefropatia, retinopatia diabética, catarata, enfarte do miocárdio e/ou cardiomiopatia diabética ou aterosclerose ou disfunção endotelial.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2002129180 DE10229180A1 (de) | 2002-06-28 | 2002-06-28 | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
| PCT/EP2003/006276 WO2004002492A1 (en) | 2002-06-28 | 2003-06-13 | Use of vasopeptidase inhibitors in the treatment of nephropathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312250A true BR0312250A (pt) | 2005-04-26 |
Family
ID=29795983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312250A BR0312250A (pt) | 2002-06-28 | 2003-06-13 | Uso de inibidores de vasopeptidase no tratamento de nefropatia |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US6930103B2 (pt) |
| EP (1) | EP1519732B1 (pt) |
| JP (1) | JP4564354B2 (pt) |
| KR (1) | KR101072235B1 (pt) |
| CN (1) | CN100366254C (pt) |
| AR (1) | AR040343A1 (pt) |
| AT (1) | ATE548040T1 (pt) |
| AU (1) | AU2003280440B2 (pt) |
| BR (1) | BR0312250A (pt) |
| CA (1) | CA2490277C (pt) |
| CR (1) | CR7667A (pt) |
| CY (1) | CY1112905T1 (pt) |
| DE (1) | DE10229180A1 (pt) |
| DK (1) | DK1519732T3 (pt) |
| EC (1) | ECSP045513A (pt) |
| ES (1) | ES2383889T3 (pt) |
| HN (1) | HN2003000193A (pt) |
| HR (1) | HRP20041212B1 (pt) |
| IL (2) | IL165935A0 (pt) |
| MA (1) | MA27281A1 (pt) |
| MX (1) | MXPA04012230A (pt) |
| NO (1) | NO334811B1 (pt) |
| NZ (1) | NZ537480A (pt) |
| OA (1) | OA12871A (pt) |
| PA (1) | PA8576501A1 (pt) |
| PE (1) | PE20040582A1 (pt) |
| PL (1) | PL218070B1 (pt) |
| PT (1) | PT1519732E (pt) |
| RS (1) | RS52478B (pt) |
| RU (1) | RU2336080C2 (pt) |
| SI (1) | SI1519732T1 (pt) |
| SV (1) | SV2004001560A (pt) |
| TN (1) | TNSN04262A1 (pt) |
| TW (1) | TWI326215B (pt) |
| UA (1) | UA82845C2 (pt) |
| UY (1) | UY27869A1 (pt) |
| WO (1) | WO2004002492A1 (pt) |
| ZA (1) | ZA200409382B (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2482546C2 (ru) * | 2011-04-28 | 2013-05-20 | Общество С Ограниченной Ответственностью "Научно-Производственная Фирма "Материа Медика Холдинг" | Способ коррекции эндотелиальной дисфункции раствором гомеопатических разведений антител к с-концевому фрагменту рецептора ангиотензина ii |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| JP2558208B2 (ja) * | 1991-03-01 | 1996-11-27 | ゼリア新薬工業株式会社 | インダン誘導体及び該化合物を含有するトロンボキサン拮抗剤 |
| RU2098411C1 (ru) * | 1991-08-02 | 1997-12-10 | Иституто Лусо Фармако д Италия С.п.А. | Производные пиримидина, способ их получения, фармацевтическая композиция на их основе |
| EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| EP0625987B1 (en) * | 1992-02-14 | 1998-04-01 | Merrell Pharmaceuticals Inc. | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| CA2184696C (en) * | 1994-03-24 | 2001-01-02 | Gary A. Flynn | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
| EP0835106A4 (en) * | 1995-06-30 | 1998-09-30 | Merck & Co Inc | METHOD OF TREATING NEPHROPATHIES USING AN ACE INHIBITOR AND AN A II ANTAGONIST |
| JP3448869B2 (ja) | 1995-12-27 | 2003-09-22 | 三菱ウェルファーマ株式会社 | 糖尿病性合併症の予防・治療剤 |
| NZ517468A (en) * | 1999-08-30 | 2004-02-27 | Aventis Pharma Gmbh | Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events |
| US6149915A (en) | 1999-09-29 | 2000-11-21 | Shiva Biomedical, Llc | Treatment of diabetic nephropathy and microalbuminuria |
| PL209338B1 (pl) * | 2001-04-12 | 2011-08-31 | Sanofi Aventis Deutschland | Pochodne merkaptoacetyloamidu, ich zastosowanie oraz kompozycja farmaceutyczna zawierająca te pochodne |
| US20030040509A1 (en) * | 2001-08-06 | 2003-02-27 | Genomed, Llc | Methods and compositions for treating diseases associated with excesses in ACE |
-
2002
- 2002-06-28 DE DE2002129180 patent/DE10229180A1/de not_active Ceased
-
2003
- 2003-06-13 AT AT03740247T patent/ATE548040T1/de active
- 2003-06-13 HR HRP20041212AA patent/HRP20041212B1/hr not_active IP Right Cessation
- 2003-06-13 BR BR0312250A patent/BR0312250A/pt not_active IP Right Cessation
- 2003-06-13 PT PT03740247T patent/PT1519732E/pt unknown
- 2003-06-13 AU AU2003280440A patent/AU2003280440B2/en not_active Ceased
- 2003-06-13 MX MXPA04012230A patent/MXPA04012230A/es active IP Right Grant
- 2003-06-13 CA CA 2490277 patent/CA2490277C/en not_active Expired - Fee Related
- 2003-06-13 UA UA2005000743A patent/UA82845C2/xx unknown
- 2003-06-13 EP EP20030740247 patent/EP1519732B1/en not_active Expired - Lifetime
- 2003-06-13 NZ NZ537480A patent/NZ537480A/en not_active IP Right Cessation
- 2003-06-13 CN CNB038153491A patent/CN100366254C/zh not_active Expired - Fee Related
- 2003-06-13 IL IL16593503A patent/IL165935A0/xx unknown
- 2003-06-13 OA OA1200400333A patent/OA12871A/en unknown
- 2003-06-13 RS YUP100704 patent/RS52478B/sr unknown
- 2003-06-13 DK DK03740247T patent/DK1519732T3/da active
- 2003-06-13 WO PCT/EP2003/006276 patent/WO2004002492A1/en not_active Ceased
- 2003-06-13 RU RU2005102087A patent/RU2336080C2/ru not_active IP Right Cessation
- 2003-06-13 SI SI200332139T patent/SI1519732T1/sl unknown
- 2003-06-13 PL PL372992A patent/PL218070B1/pl unknown
- 2003-06-13 KR KR1020047021259A patent/KR101072235B1/ko not_active Expired - Fee Related
- 2003-06-13 JP JP2004516596A patent/JP4564354B2/ja not_active Expired - Fee Related
- 2003-06-13 ES ES03740247T patent/ES2383889T3/es not_active Expired - Lifetime
- 2003-06-20 PE PE2003000623A patent/PE20040582A1/es not_active Application Discontinuation
- 2003-06-23 SV SV2003001560A patent/SV2004001560A/es not_active Application Discontinuation
- 2003-06-24 PA PA8576501A patent/PA8576501A1/es unknown
- 2003-06-26 TW TW92117352A patent/TWI326215B/zh not_active IP Right Cessation
- 2003-06-26 HN HN2003000193A patent/HN2003000193A/es unknown
- 2003-06-26 AR ARP030102293 patent/AR040343A1/es unknown
- 2003-06-26 US US10/607,521 patent/US6930103B2/en not_active Expired - Lifetime
- 2003-06-27 UY UY27869A patent/UY27869A1/es unknown
-
2004
- 2004-11-22 ZA ZA2004/09382A patent/ZA200409382B/en unknown
- 2004-12-08 MA MA27991A patent/MA27281A1/fr unknown
- 2004-12-22 IL IL16593504A patent/IL165935A/en not_active IP Right Cessation
- 2004-12-27 TN TNP2004000262A patent/TNSN04262A1/en unknown
- 2004-12-27 EC ECSP045513 patent/ECSP045513A/es unknown
-
2005
- 2005-01-25 NO NO20050425A patent/NO334811B1/no not_active IP Right Cessation
- 2005-01-28 CR CR7667A patent/CR7667A/es unknown
- 2005-04-01 US US11/096,790 patent/US7514423B2/en not_active Expired - Lifetime
-
2012
- 2012-05-30 CY CY20121100488T patent/CY1112905T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 13A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |