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BR0204588A - Derivados de n-alquil-adamantil-triazinil-benzamida - Google Patents

Derivados de n-alquil-adamantil-triazinil-benzamida

Info

Publication number
BR0204588A
BR0204588A BR0204588-5A BR0204588A BR0204588A BR 0204588 A BR0204588 A BR 0204588A BR 0204588 A BR0204588 A BR 0204588A BR 0204588 A BR0204588 A BR 0204588A
Authority
BR
Brazil
Prior art keywords
benzamide derivatives
triazinyl
alkyl
alkyl adamantyl
preparation
Prior art date
Application number
BR0204588-5A
Other languages
English (en)
Inventor
Allen Jacob Duplatier
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0204588A publication Critical patent/BR0204588A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)

Abstract

"DERIVADOS DE N-ALQUIL-ADAMANTILTRIAZINIL-BENZAMIDA". A presente invenção refere-se com novos derivados de N-alquil-adamantil-triazinil-benzamida de fórmula I e com processos para a sua preparação, com intermediários proveitosos na sua preparação, com as composições farmacêuticas que os contêm, e com a sua utilização em terapia. Os compostos ativos da presente invenção são úteis no tratamento da inflamação, osteoartrite, artrite reumatóide, câncer, reperfusão ou isquemia na apoplexia ou ataque cardíaco, doenças auto-imunes e outros distúrbios.
BR0204588-5A 2001-11-12 2002-11-07 Derivados de n-alquil-adamantil-triazinil-benzamida BR0204588A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33689201P 2001-11-12 2001-11-12

Publications (1)

Publication Number Publication Date
BR0204588A true BR0204588A (pt) 2003-09-16

Family

ID=23318138

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0204588-5A BR0204588A (pt) 2001-11-12 2002-11-07 Derivados de n-alquil-adamantil-triazinil-benzamida

Country Status (10)

Country Link
US (1) US6927219B2 (pt)
EP (1) EP1310493B1 (pt)
JP (1) JP4001542B2 (pt)
AT (1) ATE302196T1 (pt)
BR (1) BR0204588A (pt)
CA (1) CA2411544C (pt)
DE (1) DE60205564T2 (pt)
ES (1) ES2244733T3 (pt)
MX (1) MXPA02009783A (pt)
WO (1) WO2003042190A1 (pt)

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EP1644042A1 (en) * 2003-05-29 2006-04-12 AstraZeneca AB A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
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EP1906960A4 (en) * 2005-07-11 2010-03-10 Astrazeneca Ab NEW COMBINATION 1
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JP4850912B2 (ja) 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ３ｘ２／３モジュレーターとしてのジアミノピリミジン
CN101300235B (zh) 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
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