BR0112362B1 - Processo para a preparação de octanoil amidas substituídas e compostos intermediários - Google Patents
Processo para a preparação de octanoil amidas substituídas e compostos intermediáriosInfo
- Publication number
- BR0112362B1 BR0112362B1 BRPI0112362-9B1A BR0112362A BR0112362B1 BR 0112362 B1 BR0112362 B1 BR 0112362B1 BR 0112362 A BR0112362 A BR 0112362A BR 0112362 B1 BR0112362 B1 BR 0112362B1
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- intermediate compounds
- substituted
- amides
- octanoyl amides
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- LTHCSWBWNVGEFE-UHFFFAOYSA-N octanamide Chemical class CCCCCCCC(N)=O LTHCSWBWNVGEFE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH13292000 | 2000-07-05 | ||
| CH24502000 | 2000-12-15 | ||
| PCT/CH2001/000399 WO2002002508A1 (en) | 2000-07-05 | 2001-06-26 | Process for the preparation of substituted octanoyl amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0112362A BR0112362A (pt) | 2003-05-13 |
| BR0112362B1 true BR0112362B1 (pt) | 2013-12-31 |
Family
ID=25738979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0112362-9B1A BR0112362B1 (pt) | 2000-07-05 | 2001-06-26 | Processo para a preparação de octanoil amidas substituídas e compostos intermediários |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6730798B2 (pt) |
| EP (1) | EP1296935B1 (pt) |
| JP (1) | JP4900755B2 (pt) |
| KR (1) | KR100690471B1 (pt) |
| CN (1) | CN100482636C (pt) |
| AR (1) | AR029564A1 (pt) |
| AT (1) | ATE426592T1 (pt) |
| AU (2) | AU2001273763B2 (pt) |
| BR (1) | BR0112362B1 (pt) |
| CA (1) | CA2414847C (pt) |
| CY (1) | CY1109110T1 (pt) |
| DE (1) | DE60138099D1 (pt) |
| DK (1) | DK1296935T3 (pt) |
| ES (1) | ES2322547T3 (pt) |
| HU (1) | HU228526B1 (pt) |
| IL (4) | IL153717A0 (pt) |
| MX (1) | MXPA02012628A (pt) |
| NO (1) | NO328105B1 (pt) |
| NZ (1) | NZ523088A (pt) |
| PL (1) | PL212898B1 (pt) |
| PT (1) | PT1296935E (pt) |
| TW (1) | TWI289551B (pt) |
| WO (1) | WO2002002508A1 (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003103653A1 (en) * | 2002-06-11 | 2003-12-18 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
| GB0511686D0 (en) | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| KR20080023730A (ko) * | 2005-07-11 | 2008-03-14 | 노파르티스 아게 | 신규한 피로카테킨 유도체 |
| GB0519764D0 (en) | 2005-09-28 | 2005-11-09 | Novartis Ag | Organic compounds |
| GB2431645A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431649A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| GB0605688D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| AR063560A1 (es) * | 2006-11-07 | 2009-02-04 | Novartis Ag | Compuestos organicos |
| MX2009004628A (es) * | 2006-11-09 | 2009-05-15 | Novartis Ag | Sal de alisquireno con acido orotico. |
| EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| JP2011503185A (ja) | 2007-11-13 | 2011-01-27 | テバ ファーマシューティカル インダストリーズ リミティド | ヘミフマル酸アリスキレンの多形形態及びその調製プロセス |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| KR20100135936A (ko) * | 2008-05-23 | 2010-12-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 알리스키렌 모노푸마레이트 및 이의 제조 방법 |
| EP2189442B1 (en) | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| CN102046162A (zh) * | 2009-02-05 | 2011-05-04 | 特瓦制药工业有限公司 | 阿利吉仑化合物的固态形式 |
| EP2393489B1 (en) | 2009-02-05 | 2014-10-08 | Krka, tovarna zdravil, d.d., Novo mesto | Moisture-activated granulation process |
| US20120220663A1 (en) | 2009-09-03 | 2012-08-30 | Teva Pharmaceuticals Usa, Inc. | Solid forms of aliskiren hemifumarate and processes for preparation thereof |
| WO2011051853A1 (en) | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| US20110113995A1 (en) * | 2009-11-13 | 2011-05-19 | Lindsay Corporation | Method and apparatus for planting and irrigation |
| WO2011148392A1 (en) * | 2010-05-28 | 2011-12-01 | Msn Laboratories Limited | Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof |
| HRP20150068T1 (hr) | 2010-10-19 | 2015-04-10 | Mylan Laboratories Limited | Sinteza aliskirena |
| ITMI20110893A1 (it) * | 2011-05-19 | 2012-11-20 | Chemelectiva S R L | Processi ed intermedi per la sintesi di aliskiren |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| WO2013118138A1 (en) | 2011-12-13 | 2013-08-15 | Laboratories Ltd Mylan | Novel process for the preparation of renin inhibitors |
| US9090537B2 (en) | 2012-02-17 | 2015-07-28 | Mylan Laboratories Limited | Process for the preparation of aliskiren |
| WO2013124868A2 (en) | 2012-02-21 | 2013-08-29 | Mylan Laboratories Limited | Solid form of aliskiren intermediate |
| WO2013144979A1 (en) | 2012-03-28 | 2013-10-03 | Maylan Laboratories Ltd | Process for the preparation of aliskiren |
| WO2013171767A1 (en) | 2012-05-18 | 2013-11-21 | Mylan Laboratories Limited | An improved process for the preparation of aliskiren |
| CN104876832B (zh) * | 2014-02-28 | 2016-12-07 | 华润双鹤药业股份有限公司 | 阿利吉仑的4-位差向异构体、其制备方法及用途 |
| CN106146339B (zh) * | 2015-04-23 | 2018-02-23 | 华润双鹤药业股份有限公司 | 阿利吉仑的5‑位差向异构体、其制备方法及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4492799A (en) * | 1979-07-02 | 1985-01-08 | Union Carbide Corporation | Halo-4-alkenoic acids and their use as pesticidal intermediates |
| FR2666757B1 (fr) * | 1990-09-14 | 1992-12-18 | Usinor Sacilor | Virole pour cylindre de coulee continue des metaux, notamment de l'acier, entre cylindres ou sur un cylindre. |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5659065A (en) | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
| DE59504502D1 (de) * | 1994-07-18 | 1999-01-21 | Siemens Ag | Giesswalzen-verschleissschutzschicht |
| WO1998052706A1 (de) * | 1997-05-23 | 1998-11-26 | Voest-Alpine Industrieanlagenbau Gmbh | Giesswalze für eine dünnband-stranggiessanlage |
| JP4580606B2 (ja) | 1999-07-29 | 2010-11-17 | シュペーデル・ファルマ・アーゲー | ２−アルキル−５−ハロゲノ−ペンタ−４−エンカルボン酸およびそれの製造 |
-
2001
- 2001-06-26 PL PL358887A patent/PL212898B1/pl unknown
- 2001-06-26 IL IL15371701A patent/IL153717A0/xx unknown
- 2001-06-26 HU HU0301463A patent/HU228526B1/hu not_active IP Right Cessation
- 2001-06-26 DK DK01940047T patent/DK1296935T3/da active
- 2001-06-26 JP JP2002507765A patent/JP4900755B2/ja not_active Expired - Lifetime
- 2001-06-26 BR BRPI0112362-9B1A patent/BR0112362B1/pt not_active IP Right Cessation
- 2001-06-26 CA CA002414847A patent/CA2414847C/en not_active Expired - Fee Related
- 2001-06-26 US US10/312,987 patent/US6730798B2/en not_active Expired - Lifetime
- 2001-06-26 AU AU2001273763A patent/AU2001273763B2/en not_active Ceased
- 2001-06-26 AU AU7376301A patent/AU7376301A/xx active Pending
- 2001-06-26 WO PCT/CH2001/000399 patent/WO2002002508A1/en not_active Ceased
- 2001-06-26 NZ NZ523088A patent/NZ523088A/en not_active IP Right Cessation
- 2001-06-26 CN CNB018122817A patent/CN100482636C/zh not_active Expired - Lifetime
- 2001-06-26 KR KR1020027017207A patent/KR100690471B1/ko not_active Expired - Fee Related
- 2001-06-26 PT PT01940047T patent/PT1296935E/pt unknown
- 2001-06-26 MX MXPA02012628A patent/MXPA02012628A/es active IP Right Grant
- 2001-06-26 ES ES01940047T patent/ES2322547T3/es not_active Expired - Lifetime
- 2001-06-26 AT AT01940047T patent/ATE426592T1/de active
- 2001-06-26 EP EP01940047A patent/EP1296935B1/en not_active Expired - Lifetime
- 2001-06-26 DE DE60138099T patent/DE60138099D1/de not_active Expired - Lifetime
- 2001-06-29 TW TW090115929A patent/TWI289551B/zh not_active IP Right Cessation
- 2001-07-04 AR ARP010103194A patent/AR029564A1/es active IP Right Grant
-
2002
- 2002-12-27 IL IL153717A patent/IL153717A/en not_active IP Right Cessation
-
2003
- 2003-01-02 NO NO20030012A patent/NO328105B1/no not_active IP Right Cessation
-
2007
- 2007-11-29 IL IL187795A patent/IL187795A/en not_active IP Right Cessation
- 2007-11-29 IL IL187796A patent/IL187796A/en not_active IP Right Cessation
-
2009
- 2009-05-28 CY CY20091100571T patent/CY1109110T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/12/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25A | Requested transfer of rights approved | ||
| B25A | Requested transfer of rights approved | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 19A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2594 DE 24-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |