[go: up one dir, main page]

BR0015440A - Compostos 5-aril-1h-1,2,4-triazol como inibidores de ciclooxigenase-2 e composições farmacêuticas contendo os mesmos - Google Patents

Compostos 5-aril-1h-1,2,4-triazol como inibidores de ciclooxigenase-2 e composições farmacêuticas contendo os mesmos

Info

Publication number
BR0015440A
BR0015440A BR0015440-7A BR0015440A BR0015440A BR 0015440 A BR0015440 A BR 0015440A BR 0015440 A BR0015440 A BR 0015440A BR 0015440 A BR0015440 A BR 0015440A
Authority
BR
Brazil
Prior art keywords
inhibitors
pharmaceutical compositions
aryl
same
compositions containing
Prior art date
Application number
BR0015440-7A
Other languages
English (en)
Inventor
Jean-Claude Pascal
Denis Carniato
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of BR0015440A publication Critical patent/BR0015440A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção para: "COMPOSTOS 5-APIL-1H-1,2,4-TRIAZOL COMO INIBIDORES DE CICLOOXIGENASE-2 E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS". A invenção se refere aos compostos 5-aril-IH-1,2,4-triazol da fórmula (I): onde R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são conforme definidos na descrição. Estes compostos são inibidores potentes e seletivos de COX-2. A invenção também se refere às composições farmacêuticas compreendendo estes compostos.
BR0015440-7A 1999-11-09 2000-11-06 Compostos 5-aril-1h-1,2,4-triazol como inibidores de ciclooxigenase-2 e composições farmacêuticas contendo os mesmos BR0015440A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (en) 1999-11-09 1999-11-09 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
PCT/EP2000/010956 WO2001034577A1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR0015440A true BR0015440A (pt) 2002-07-02

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015440-7A BR0015440A (pt) 1999-11-09 2000-11-06 Compostos 5-aril-1h-1,2,4-triazol como inibidores de ciclooxigenase-2 e composições farmacêuticas contendo os mesmos

Country Status (24)

Country Link
US (1) US6803380B1 (pt)
EP (2) EP1099695A1 (pt)
JP (1) JP4786846B2 (pt)
CN (1) CN1198807C (pt)
AT (1) ATE245148T1 (pt)
AU (1) AU778819B2 (pt)
BR (1) BR0015440A (pt)
CA (1) CA2390649C (pt)
CZ (1) CZ20021591A3 (pt)
DE (1) DE60003949T2 (pt)
DK (1) DK1246809T3 (pt)
ES (1) ES2203538T3 (pt)
HU (1) HUP0203376A3 (pt)
IL (2) IL149370A0 (pt)
MX (1) MXPA01012903A (pt)
NO (1) NO328008B1 (pt)
NZ (1) NZ518682A (pt)
PL (1) PL204230B1 (pt)
PT (1) PT1246809E (pt)
RU (1) RU2249588C2 (pt)
SI (1) SI1246809T1 (pt)
TW (1) TWI268925B (pt)
WO (1) WO2001034577A1 (pt)
ZA (1) ZA200203165B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
ATE298749T1 (de) 2001-07-05 2005-07-15 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
ES2240661T3 (es) 2001-07-05 2005-10-16 Pfizer Products Inc. Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos.
KR100824233B1 (ko) 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) * 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
CN101171239B (zh) * 2005-04-28 2013-08-14 西巴特殊化学品控股有限公司 场致发光器件
WO2008017932A2 (en) * 2006-08-09 2008-02-14 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
KR101893624B1 (ko) * 2010-11-26 2018-08-30 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기금속 착물, 발광 엘리먼트, 발광 디바이스, 전자 디바이스 및 조명 디바이스
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
BR112020016946A2 (pt) 2018-03-08 2020-12-15 Bayer Aktiengesellschaft Uso de compostos de heteroaril-triazol e heteroaril-tetrazol como pesticidas na proteção de plantas
BR112020018006A2 (pt) 2018-04-12 2021-01-12 Bayer Aktiengesellschaft Derivados de n-(ciclopropilmetil)-5-(metilsulfonil)-n-{1-[1-(pirimidin-2-il)-1h-1,2,4-triazol-5-il]etil}benzamida e os derivados correspondentes de piridina-carboxamida como pesticidas
AU2019260016B2 (en) 2018-04-25 2022-11-17 Bayer Aktiengesellschaft Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
WO2021013720A1 (en) 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
CN114423748A (zh) 2019-07-23 2022-04-29 拜耳公司 作为农药的新的杂芳基三唑化合物
PH12022550874A1 (en) 2019-10-09 2023-03-27 Bayer Ag Novel heteroaryl-triazole compounds as pesticides
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
US20230148601A1 (en) 2020-02-18 2023-05-18 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (pt) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
JP3682075B2 (ja) * 1993-04-16 2005-08-10 クミアイ化学工業株式会社 トリアゾール誘導体及び殺虫、殺ダニ剤
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
HUP0203376A3 (en) 2004-12-28
MXPA01012903A (es) 2002-11-07
AU1998501A (en) 2001-06-06
CA2390649A1 (en) 2001-05-17
WO2001034577A1 (en) 2001-05-17
HUP0203376A2 (hu) 2003-01-28
EP1099695A1 (en) 2001-05-16
NZ518682A (en) 2003-07-25
DE60003949T2 (de) 2004-05-27
ZA200203165B (en) 2003-06-25
NO20022202D0 (no) 2002-05-08
PL356120A1 (en) 2004-06-14
PL204230B1 (pl) 2009-12-31
DK1246809T3 (da) 2003-10-20
US6803380B1 (en) 2004-10-12
AU778819B2 (en) 2004-12-23
ES2203538T3 (es) 2004-04-16
DE60003949D1 (de) 2003-08-21
CZ20021591A3 (cs) 2002-07-17
CA2390649C (en) 2008-05-06
CN1387517A (zh) 2002-12-25
JP4786846B2 (ja) 2011-10-05
RU2249588C2 (ru) 2005-04-10
EP1246809B1 (en) 2003-07-16
CN1198807C (zh) 2005-04-27
TWI268925B (en) 2006-12-21
ATE245148T1 (de) 2003-08-15
JP2003513961A (ja) 2003-04-15
IL149370A0 (en) 2002-11-10
EP1246809A1 (en) 2002-10-09
IL149370A (en) 2007-06-17
NO20022202L (no) 2002-05-08
NO328008B1 (no) 2009-11-09
PT1246809E (pt) 2003-11-28
SI1246809T1 (en) 2004-02-29

Similar Documents

Publication Publication Date Title
BR0015440A (pt) Compostos 5-aril-1h-1,2,4-triazol como inibidores de ciclooxigenase-2 e composições farmacêuticas contendo os mesmos
WO2001087846A3 (en) Tricyclic pyrazole derivatives as protein kinase inhibitors
NO20005535D0 (no) Pyrazol-derivater som P-38 MAP kinase-inhibitorer
DK1117736T3 (da) Modificerede stivelsessammensætninger til film
BR9807824A (pt) Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
BR9807508A (pt) Inibidores de sulfamida da metaloprotease
IS6002A (is) Pýrazólkarboxýlsýruafleiður, framleiðsla þeirra, lyfjasamsetningar sem innihalda þær
EE200300259A (et) Mandelhappe derivaadid, nende valmistamise meetod, nende kasutamine trombiini inhibiitoritena ja neid sisaldavad ravimkoostised
DZ3402A1 (fr) Cyclopentanoindoles, compositions contenant ces composes et methodes de traitement
IS6658A (is) Ný efnasambönd
ATE316083T1 (de) Adamantanderivate
PA8582801A1 (es) Nuevos derivados espirotricíclicos y su uso como inhibidores de la fosfodiesterasa
ES2243579T3 (es) Derivados de pirazolopirideno.
PT1105114E (pt) Composicoes farmaceuticas topicas contendo nimesulide
BR0208205A (pt) Derivados de benzimidazol moduladores de receptores de quimocinas
AU2001286003A1 (en) Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
AU2002357740A1 (en) Pyrazolo-pyridine derivatives as antiherpes agents
AU2002248531A1 (en) Pyrazolopyriadine derivatives
SE9904128D0 (sv) Novel compounds
WO2004072037A8 (en) 2,3'-bipyridines derivatives as selective cox-2 inhibitors
AU2001284154A1 (en) Aminoalkenylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
WO2002018363A3 (en) 3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
WO2004054983A3 (en) 1-n-phenylamino-1h-imidazole derivatives as aromatase inhibitors
HK1048117A1 (zh) 2-苯基吡喃-4-酮衍生物
WO2002083641A3 (en) Amino-aza-cyclohexanes for the treatment of malaria

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements