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BR0013781A - Pirazolo [4,3-d]pirimidinas - Google Patents

Pirazolo [4,3-d]pirimidinas

Info

Publication number
BR0013781A
BR0013781A BR0013781-2A BR0013781A BR0013781A BR 0013781 A BR0013781 A BR 0013781A BR 0013781 A BR0013781 A BR 0013781A BR 0013781 A BR0013781 A BR 0013781A
Authority
BR
Brazil
Prior art keywords
pyrimidines
pyrazolo
treatment
disorders
pirazole
Prior art date
Application number
BR0013781-2A
Other languages
English (en)
Inventor
Rochus Jonas
Hans-Michael Eggenweiler
Pierre Schelling
Maria Christadler
Norbert Beier
Original Assignee
Merc Patent Ges Mit Beschraenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merc Patent Ges Mit Beschraenk filed Critical Merc Patent Ges Mit Beschraenk
Publication of BR0013781A publication Critical patent/BR0013781A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "PIRAZOLO[4,3-d]PIRIMIDINAS". Pirazolo[4,3-d]pirimidinas da fórmula I e seus sais fisiologicamente aceitáveis. onde R^ 1^, R^ 2^, R^ 3^, R^ 4^ e X têm os significados indicados na reivindicação 1, exibem inibição de fosfodiesterase e podem ser empregados para o tratamento de distúrbios do sistema cardiovascular e para o tratamento e/ou terapia de distúrbios de potência.
BR0013781-2A 1999-09-06 2000-08-24 Pirazolo [4,3-d]pirimidinas BR0013781A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19942474A DE19942474A1 (de) 1999-09-06 1999-09-06 Pyrazolo[4,3-d]pyrimidine
PCT/EP2000/008257 WO2001018004A2 (de) 1999-09-06 2000-08-24 PYRAZOLO[4,3-d]PYRIMIDINE

Publications (1)

Publication Number Publication Date
BR0013781A true BR0013781A (pt) 2002-05-14

Family

ID=7920966

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013781-2A BR0013781A (pt) 1999-09-06 2000-08-24 Pirazolo [4,3-d]pirimidinas

Country Status (23)

Country Link
US (1) US6777419B1 (pt)
EP (1) EP1210349B1 (pt)
JP (1) JP4975921B2 (pt)
KR (1) KR20020025253A (pt)
CN (1) CN1145627C (pt)
AR (1) AR025569A1 (pt)
AT (1) ATE231866T1 (pt)
AU (1) AU773878B2 (pt)
BR (1) BR0013781A (pt)
CA (1) CA2384037C (pt)
CZ (1) CZ294587B6 (pt)
DE (2) DE19942474A1 (pt)
DK (1) DK1210349T3 (pt)
ES (1) ES2189766T3 (pt)
HU (1) HUP0202624A3 (pt)
MX (1) MXPA02002383A (pt)
NO (1) NO20021083L (pt)
PL (1) PL353366A1 (pt)
PT (1) PT1210349E (pt)
RU (1) RU2249594C2 (pt)
SK (1) SK3132002A3 (pt)
WO (1) WO2001018004A2 (pt)
ZA (1) ZA200202653B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
HUP0303315A2 (hu) * 2000-12-19 2004-01-28 Merck Patent Gmbh. Pirazolo [4,3-d] pirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
DE10148883A1 (de) 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
AU2004234158B2 (en) * 2003-04-29 2010-01-28 Pfizer Inc. 5,7-diaminopyrazolo[4,3-D]pyrimidines useful in the treatment of hypertension
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
WO2005097799A1 (en) * 2004-04-07 2005-10-20 Pfizer Limited Pyrazolo`4,3-d! pyrimidines
MX2007013215A (es) 2005-05-12 2007-12-12 Pfizer Formas cristalinas anhidras de la n-[1-(2-etoxietil)-5-(n-etil-n- metilamino)-7-(4-metilpiridin-2-il-amino)-1h-pirazolo[4,3-d] pirimidina -3-carbonil] metanosulfonamida.
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
TWI606049B (zh) * 2011-04-21 2017-11-21 原真股份有限公司 新穎激酶抑制劑
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
PL3723807T3 (pl) 2017-12-14 2022-01-24 H. Lundbeck A/S Leczenie skojarzone obejmujące podawanie 1h-pirazolo­[4,3-b]pirydyn
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
WO2019121840A1 (en) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
KR100441229B1 (ko) * 1997-04-25 2004-07-22 화이자 인코포레이티드 타입 5 시클릭 구아노신 3',5'-모노포스페이트 포스포디에스테라제(ｃＧＭＰ ＰＤＥ5)를 억제하는 성기능 장애 치료용 피라졸로피리미디논
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates

Also Published As

Publication number Publication date
DK1210349T3 (da) 2003-05-19
KR20020025253A (ko) 2002-04-03
RU2249594C2 (ru) 2005-04-10
MXPA02002383A (es) 2002-09-02
ES2189766T3 (es) 2003-07-16
AU773878B2 (en) 2004-06-10
AU7279300A (en) 2001-04-10
CN1145627C (zh) 2004-04-14
NO20021083D0 (no) 2002-03-05
ATE231866T1 (de) 2003-02-15
DE50001191D1 (de) 2003-03-06
WO2001018004A2 (de) 2001-03-15
US6777419B1 (en) 2004-08-17
CZ294587B6 (cs) 2005-02-16
WO2001018004A3 (de) 2001-08-09
PL353366A1 (en) 2003-11-17
EP1210349A2 (de) 2002-06-05
CA2384037A1 (en) 2001-03-15
CA2384037C (en) 2009-10-13
HUP0202624A3 (en) 2004-11-29
PT1210349E (pt) 2003-06-30
JP4975921B2 (ja) 2012-07-11
SK3132002A3 (en) 2002-07-02
JP2003508534A (ja) 2003-03-04
HUP0202624A2 (hu) 2002-12-28
CN1377357A (zh) 2002-10-30
DE19942474A1 (de) 2001-03-15
EP1210349B1 (de) 2003-01-29
ZA200202653B (en) 2003-09-23
CZ2002736A3 (cs) 2002-05-15
AR025569A1 (es) 2002-12-04
NO20021083L (no) 2002-03-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.