BR0010599A - Compostos de heteroarila bicìclicos substituìdos como antagonistas de integrina - Google Patents
Compostos de heteroarila bicìclicos substituìdos como antagonistas de integrinaInfo
- Publication number
- BR0010599A BR0010599A BR0010599-6A BR0010599A BR0010599A BR 0010599 A BR0010599 A BR 0010599A BR 0010599 A BR0010599 A BR 0010599A BR 0010599 A BR0010599 A BR 0010599A
- Authority
- BR
- Brazil
- Prior art keywords
- bond
- alkylene
- compounds
- heterocycloalkylene
- cycloalkylene
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 2
- 125000006588 heterocycloalkylene group Chemical group 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005724 cycloalkenylene group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- -1 heteroaryldiyl Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Semiconductor Integrated Circuits (AREA)
Abstract
Patente de Invenção: "COMPOSTOS DE HETEROARILA BICìCLICOS SUBSTITUìDOS COMO ANTAGONISTAS DE INTEGRINA". A invenção refere-se a compostos fisiologicamente ativos da fórmula geral (1) R^ 1^Z^ 1^-Het-L^ 1^-Ar^ 1^-L^ 2^-Y onde Het representa um sistema de anel bicíclico de 8 a 10 membros saturados, parcialmente saturado ou completamente insaturado contendo pelo menos um heteroátomo selecionado de O, S ou N; R^ 1^ é arila, heteroarila, alquila, alquenila, alquinila, cicloalquila ou heterocicloalquila opcionalmente substituída; Z^ 1^ representa uma ligação direta, uma cadeia alquileno ou NR^ 4^, O ou S(O)~ n~; L^ 1^ é uma ligação onde R^ 5^ é alquileno, alquenileno ou alquinileno e R6 é uma ligação direta, cicloalquileno, heterocicloalquileno, arileno, heteroarildila, C(=Z^ 3^)-NR^ 4^-,-NR^ 4^-C(=Z^ 3^),-Z^ 3^-C(=O)-, -G(=NOR^ 4^)-, -NR^ 4^, -NR^ 4^-C(=Z^ 3^)-NR^ 4^, -SO~ 2~-NR^ 4^,NR~ 4~-SO~ 2~-, -O-C(=O)-, -C(=O)-O-, -NR^ 4^-C(=O)-O- ou -O-C(=O)-NR^ 4^-; L^ 2^ é uma ligação direta; uma ligação alquileno, alquenileno, alquinileno, cicloal-quenileno, cicloalquileno, heteroarildiíla, heterocicloalquileno ou arileno opcionalmente substituída; uma ligação -[C(=O)-N(R^ 9^)-C(R^ 4^)(R^ 10^)]~ p~-; uma ligação -Z^ 4^-R^ 11^-; uma ligação -C(=O)-CH~ 2~-C(=O); uma ligação -R^ 11^-Z^ 4^-R^ 11^-; ou uma ligação -L^ 3^-L^ 4^-L^ 5^-; e Y é carbóxi ou um bioisoéster ácido; e os N-óxidos correspondentes, e suas pró-drogas; e sais e solvatos farmaceuticamente aceitáveis (por exemplo, hidratos) de tais compostos e seus N-óxido e pródrogas. Tais compostos têm propriedades farmacêuticas valiosas, em particular, a habilidade em regular a interação de VCAM-1 e fibronectina com a integrina VLA-4 (<244>4<225>1).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9908355.2A GB9908355D0 (en) | 1999-04-12 | 1999-04-12 | Chemical compounds |
| US14147099P | 1999-06-29 | 1999-06-29 | |
| PCT/GB2000/001393 WO2000061580A1 (en) | 1999-04-12 | 2000-04-12 | Substituted bicyclic heteroaryl compounds as integrin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010599A true BR0010599A (pt) | 2002-02-13 |
Family
ID=26315408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010599-6A BR0010599A (pt) | 1999-04-12 | 2000-04-12 | Compostos de heteroarila bicìclicos substituìdos como antagonistas de integrina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6706738B2 (pt) |
| EP (1) | EP1183254B1 (pt) |
| KR (1) | KR20010110750A (pt) |
| CN (1) | CN1350534A (pt) |
| AT (1) | ATE286896T1 (pt) |
| AU (1) | AU769554B2 (pt) |
| BG (1) | BG106083A (pt) |
| BR (1) | BR0010599A (pt) |
| CA (1) | CA2369728A1 (pt) |
| CZ (1) | CZ20013661A3 (pt) |
| DE (1) | DE60017389T2 (pt) |
| EE (1) | EE200100528A (pt) |
| ES (1) | ES2231179T3 (pt) |
| HK (1) | HK1044937A1 (pt) |
| HR (1) | HRP20010732A2 (pt) |
| HU (1) | HUP0200803A3 (pt) |
| IL (2) | IL145748A0 (pt) |
| MX (1) | MXPA01010231A (pt) |
| NO (1) | NO20014951L (pt) |
| NZ (1) | NZ514602A (pt) |
| PL (1) | PL351433A1 (pt) |
| SK (1) | SK14372001A3 (pt) |
| TR (1) | TR200102959T2 (pt) |
| WO (1) | WO2000061580A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2430978C (en) | 2000-12-28 | 2012-05-15 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| ATE447404T1 (de) * | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
| CA2528586A1 (en) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
| KR20070026390A (ko) | 2004-01-23 | 2007-03-08 | 암젠 인코포레이션 | 화합물 및 사용방법 |
| US7626030B2 (en) | 2004-01-23 | 2009-12-01 | Amgen Inc. | Compounds and methods of use |
| WO2006023435A1 (en) * | 2004-08-16 | 2006-03-02 | The Procter & Gamble Company | 2-(amino or substituted amino)-5, 6-substituted phenol compounds, dyeing compositions containing them, and use thereof |
| DE102004041137A1 (de) * | 2004-08-25 | 2006-03-02 | Wella Ag | o-Aminophenol-Derivate und diese Verbindungen enthaltende Färbemittel |
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
| JP2008521900A (ja) | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| US7514460B2 (en) | 2004-12-22 | 2009-04-07 | 4Sc Ag | Benzazole analogues and uses thereof |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| PE20070427A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
| SI2010528T1 (en) | 2006-04-19 | 2018-02-28 | Novartis Ag | 6-O-substituted benzoxazole and benzothiazole compounds and procedures for inhibiting CSF-1R signaling |
| US7931838B2 (en) * | 2006-08-31 | 2011-04-26 | Virginia Tech Intellectual Properties, Inc. | Method for making oriented single-walled carbon nanotube/polymer nano-composite membranes |
| CA2703257C (en) * | 2007-10-29 | 2013-02-19 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8674113B2 (en) | 2010-12-10 | 2014-03-18 | Boehringer Ingelheim International Gmbh | Compounds |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| PT2968443T (pt) | 2013-03-15 | 2021-12-28 | Protagonist Therapeutics Inc | Análogos de hepcidina e seus usos |
| SG10201810321PA (en) * | 2014-05-16 | 2018-12-28 | Protagonist Therapeutics Inc | α4β7 INTEGRIN THIOETHER PEPTIDE ANTAGONISTS |
| BR112017001010A2 (pt) | 2014-07-17 | 2017-11-14 | Protagonist Therapeutics Inc | inibidores peptídicos orais do receptor de interleucina-23 e seu uso para tratar doenças inflamatórias intestinais |
| US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
| JP2017535527A (ja) | 2014-10-01 | 2017-11-30 | プロタゴニスト セラピューティクス， インコーポレイテッド | 新規のα４β７ペプチド単量体及び二量体拮抗薬 |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| WO2017117411A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| CN115925790A (zh) | 2016-03-23 | 2023-04-07 | 领导医疗有限公司 | 用于合成α4β7肽拮抗剂的方法 |
| EP4092038A1 (en) | 2017-09-11 | 2022-11-23 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
| US11753443B2 (en) | 2018-02-08 | 2023-09-12 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097396A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof |
| CN116082455A (zh) | 2019-07-10 | 2023-05-09 | 领导医疗有限公司 | 白细胞介素-23受体的肽抑制剂及其用于治疗炎症性疾病的用途 |
| EP4090669A4 (en) | 2020-01-15 | 2024-11-20 | Janssen Biotech, Inc. | PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR AND THEIR USE IN TREATING INFLAMMATORY DISEASES |
| CR20220332A (es) | 2020-01-15 | 2022-11-28 | Janssen Biotech Inc | Inhibidores de péptidos del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias |
| WO2021226261A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| JP7397239B2 (ja) | 2020-11-20 | 2023-12-12 | ヤンセン ファーマシューティカ エヌ．ベー． | インターロイキン－２３受容体のペプチド阻害剤の組成物 |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| PE20240595A1 (es) | 2021-07-14 | 2024-03-21 | Janssen Biotech Inc | Inhibidores peptidicos lipidicos del receptor de iinterleucina-23 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11510814A (ja) * | 1995-08-30 | 1999-09-21 | ジー．ディー．サール アンド カンパニー | インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体 |
| CN1304406A (zh) * | 1998-04-10 | 2001-07-18 | G·D·瑟尔公司 | 作为玻连蛋白拮抗剂的杂环甘氨酰β－丙氨酸衍生物 |
| AU775208B2 (en) * | 1999-02-16 | 2004-07-22 | Aventis Pharma Limited | Bicyclic compounds and their use as integrin receptor ligands |
-
2000
- 2000-04-12 CA CA002369728A patent/CA2369728A1/en not_active Abandoned
- 2000-04-12 NZ NZ514602A patent/NZ514602A/xx unknown
- 2000-04-12 KR KR1020017013055A patent/KR20010110750A/ko not_active Withdrawn
- 2000-04-12 EP EP00919064A patent/EP1183254B1/en not_active Expired - Lifetime
- 2000-04-12 MX MXPA01010231A patent/MXPA01010231A/es unknown
- 2000-04-12 AU AU39816/00A patent/AU769554B2/en not_active Expired
- 2000-04-12 CN CN00807512A patent/CN1350534A/zh active Pending
- 2000-04-12 TR TR2001/02959T patent/TR200102959T2/xx unknown
- 2000-04-12 CZ CZ20013661A patent/CZ20013661A3/cs unknown
- 2000-04-12 HU HU0200803A patent/HUP0200803A3/hu unknown
- 2000-04-12 PL PL00351433A patent/PL351433A1/xx not_active Application Discontinuation
- 2000-04-12 HR HR20010732A patent/HRP20010732A2/hr not_active Application Discontinuation
- 2000-04-12 AT AT00919064T patent/ATE286896T1/de not_active IP Right Cessation
- 2000-04-12 SK SK1437-2001A patent/SK14372001A3/sk unknown
- 2000-04-12 BR BR0010599-6A patent/BR0010599A/pt not_active Application Discontinuation
- 2000-04-12 HK HK02105579.6A patent/HK1044937A1/zh unknown
- 2000-04-12 DE DE60017389T patent/DE60017389T2/de not_active Expired - Lifetime
- 2000-04-12 WO PCT/GB2000/001393 patent/WO2000061580A1/en not_active Ceased
- 2000-04-12 EE EEP200100528A patent/EE200100528A/xx unknown
- 2000-04-12 IL IL14574800A patent/IL145748A0/xx active IP Right Grant
- 2000-04-12 ES ES00919064T patent/ES2231179T3/es not_active Expired - Lifetime
-
2001
- 2001-10-04 IL IL145748A patent/IL145748A/en not_active IP Right Cessation
- 2001-10-11 US US09/975,721 patent/US6706738B2/en not_active Expired - Lifetime
- 2001-10-11 NO NO20014951A patent/NO20014951L/no not_active Application Discontinuation
- 2001-11-05 BG BG106083A patent/BG106083A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6706738B2 (en) | 2004-03-16 |
| WO2000061580A1 (en) | 2000-10-19 |
| CA2369728A1 (en) | 2000-10-19 |
| HUP0200803A2 (hu) | 2002-07-29 |
| US20020173506A1 (en) | 2002-11-21 |
| PL351433A1 (en) | 2003-04-22 |
| IL145748A (en) | 2007-02-11 |
| KR20010110750A (ko) | 2001-12-13 |
| DE60017389T2 (de) | 2006-03-02 |
| EE200100528A (et) | 2003-02-17 |
| NO20014951D0 (no) | 2001-10-11 |
| AU3981600A (en) | 2000-11-14 |
| EP1183254B1 (en) | 2005-01-12 |
| NO20014951L (no) | 2001-12-11 |
| DE60017389D1 (de) | 2005-02-17 |
| HRP20010732A2 (en) | 2002-12-31 |
| SK14372001A3 (sk) | 2002-06-04 |
| TR200102959T2 (tr) | 2002-04-22 |
| CN1350534A (zh) | 2002-05-22 |
| MXPA01010231A (es) | 2003-07-21 |
| HK1044937A1 (zh) | 2002-11-08 |
| AU769554B2 (en) | 2004-01-29 |
| IL145748A0 (en) | 2002-07-25 |
| HUP0200803A3 (en) | 2002-12-28 |
| ES2231179T3 (es) | 2005-05-16 |
| CZ20013661A3 (cs) | 2002-01-16 |
| NZ514602A (en) | 2003-06-30 |
| BG106083A (en) | 2002-05-31 |
| ATE286896T1 (de) | 2005-01-15 |
| EP1183254A1 (en) | 2002-03-06 |
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