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BR0009074A - Proteìna para bloquear adesão de plaqueta - Google Patents

Proteìna para bloquear adesão de plaqueta

Info

Publication number
BR0009074A
BR0009074A BR0009074-3A BR0009074A BR0009074A BR 0009074 A BR0009074 A BR 0009074A BR 0009074 A BR0009074 A BR 0009074A BR 0009074 A BR0009074 A BR 0009074A
Authority
BR
Brazil
Prior art keywords
protein
collagen
platelet adhesion
useful
naturally occurring
Prior art date
Application number
BR0009074-3A
Other languages
English (en)
Inventor
Wolfgang Strittmatter
Detlef Guessow
Uwe Hofmann
Juergen Hemberger
Zisi Fotev
Bernhard Scheuble
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0009074A publication Critical patent/BR0009074A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Patente de Invenção: "PROTEìNA PARA BLOQUEAR ADESãO DE PLAQUETA". Uma proteína de ocorrência natural isolada da saliva da sanguessuga medicinal Hirudo medicinalis é descrita que fortemente liga-se a colágeno, desse modo atuando como um inibidor de adesão de plaqueta natural ao colágeno. A proteína tem um peso molecular de cerca de 12.000, um ponto isoelétrico acídico e contém seis cisteínas. A proteína foi seq³ênciada e o gene foi clonado de uma biblioteca de cDNA H. medicinalis. Os procedimentos para produzir tal polipeptídeo por técnicas recombinantes são divulgados. As proteínas recombinantes e as de ocorrência natural são inibidores potentes de adesão de plaqueta dependente de colágeno e portanto úteis para o tratamento terapêutico de várias condições relacionadas a doenças graves e doenças do sistema de circulação. Além disso a proteína é útil para revestir superfícies de colágeno natural ou artificial a fim de torná-las não adesivas às células e prevenir a ativação de células.
BR0009074-3A 1999-03-18 2000-03-10 Proteìna para bloquear adesão de plaqueta BR0009074A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99105530 1999-03-18
EP99109503 1999-05-12
PCT/EP2000/002117 WO2000056885A1 (en) 1999-03-18 2000-03-10 Protein for blocking platelet adhesion

Publications (1)

Publication Number Publication Date
BR0009074A true BR0009074A (pt) 2002-01-02

Family

ID=26152935

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009074-3A BR0009074A (pt) 1999-03-18 2000-03-10 Proteìna para bloquear adesão de plaqueta

Country Status (27)

Country Link
US (3) US6774107B1 (pt)
EP (1) EP1161530B1 (pt)
JP (1) JP4805461B2 (pt)
KR (1) KR100788219B1 (pt)
CN (1) CN1185344C (pt)
AR (1) AR023099A1 (pt)
AT (1) ATE295883T1 (pt)
AU (1) AU767172B2 (pt)
BR (1) BR0009074A (pt)
CA (1) CA2367457C (pt)
CO (1) CO5241328A1 (pt)
CZ (1) CZ301524B6 (pt)
DE (1) DE60020220T2 (pt)
DK (1) DK1161530T3 (pt)
ES (1) ES2240067T3 (pt)
HK (1) HK1045330B (pt)
HU (1) HU228068B1 (pt)
MX (1) MXPA01009363A (pt)
MY (1) MY123371A (pt)
NO (1) NO330769B1 (pt)
PL (1) PL200384B1 (pt)
PT (1) PT1161530E (pt)
RU (1) RU2292351C2 (pt)
SI (1) SI1161530T1 (pt)
SK (1) SK287496B6 (pt)
TR (1) TR200102729T2 (pt)
WO (1) WO2000056885A1 (pt)

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PL200384B1 (pl) 1999-03-18 2008-12-31 Merck Patent Gmbh Polipeptyd blokujący adhezję płytek krwi, sposób jego otrzymywania, zastosowanie i zawierający go preparat farmaceutyczny
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
EP1406929A2 (en) * 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
US7053051B2 (en) 2003-10-28 2006-05-30 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
BRPI0515994A (pt) * 2004-10-12 2008-08-19 Univ Michigan State biossìntese de floroglucinol e preparo de 1, 3-dihidróxibenzeno a partir do mesmo
US8999370B2 (en) * 2005-05-26 2015-04-07 Thomas Jefferson University Method to treat and prevent posterior capsule opacification
US7691839B2 (en) * 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
EP2379084B1 (en) 2008-10-15 2017-11-22 Ionis Pharmaceuticals, Inc. Modulation of factor 11 expression
WO2012003461A2 (en) 2010-07-02 2012-01-05 Draths Corporation Phloroglucinol synthases and methods of making and using the same
WO2012006244A1 (en) 2010-07-06 2012-01-12 Draths Corporation Method for producing phloroglucinol and dihydrophloroglucinol
WO2012006245A1 (en) 2010-07-06 2012-01-12 Draths Corporation Phloroglucinol reductase and methods of making and using the same
LT3333188T (lt) 2010-08-19 2022-06-10 Zoetis Belgium S.A. Anti-ngf antikūnai ir jų panaudojimas
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
DE202012012998U1 (de) 2011-08-31 2014-06-13 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
EP2859018B1 (en) 2012-06-06 2021-09-22 Zoetis Services LLC Caninized anti-ngf antibodies and methods thereof
CA2879443A1 (en) 2012-07-19 2014-01-23 Zoetis Llc Bovine influenza virus compositions
WO2014018724A1 (en) 2012-07-27 2014-01-30 Zoetis Llc Tick toxin compositions
EP3500292B1 (en) 2016-08-17 2024-10-16 Pharmaq AS Sea lice vaccine
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
KR20200130696A (ko) 2018-03-12 2020-11-19 조에티스 서비시즈 엘엘씨 항-ngf 항체 및 이의 방법
KR20250026872A (ko) 2018-03-16 2025-02-25 조에티스 서비시즈 엘엘씨 수의학적 용도를 위한 인터류킨-31 단클론성 항체
JP7497293B2 (ja) 2018-03-16 2024-06-10 ゾエティス・サービシーズ・エルエルシー インターロイキン－３１に対するペプチドワクチン
BR112020020957B1 (pt) 2018-05-09 2022-05-10 Ionis Pharmaceuticals, Inc Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
JP2022547975A (ja) 2019-09-11 2022-11-16 ゾエティス・サービシーズ・エルエルシー 鳥病原体の抗原を発現する組換えシチメンチョウヘルペスウイルスベクターおよびそれらの使用
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US12440556B2 (en) 2020-06-15 2025-10-14 Zoetis Services Llc Genetically modified cell line for production of Marek's disease virus vaccine and methods of making and using the same
CN116568708A (zh) 2020-10-07 2023-08-08 硕腾服务有限责任公司 抗ngf抗体和其使用方法
TWI904261B (zh) 2020-10-19 2025-11-11 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
KR20240049832A (ko) 2021-09-27 2024-04-17 조에티스 서비시즈 엘엘씨 항-TGFβ1,2,3 항체 및 이의 치료적 용도

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US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
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US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
DE4136513A1 (de) * 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
SK282961B6 (sk) * 1993-07-01 2003-01-09 Merck Patent Gesellschaft Mit Beschr�Nkter Haftung Purifikovaný proteín, spôsob jeho výroby a použitia a farmaceutický prostriedok na jeho báze
ATE314845T1 (de) 1993-07-29 2006-02-15 Us Health Verwendung von paclitaxel und seinen derivaten zur herstellung eines medikaments für die behandlung von restenose
CZ76297A3 (cs) * 1994-09-12 1998-01-14 Schering Aktiengesellschaft Způsob výroby modifikovaného pallidipinu - inhibitoru agregace krevních destiček vyvolané kolagenem
DK0789764T3 (da) * 1994-10-28 2002-04-22 Vitaleech Bioscience N V Ny familie af proteaseinhibitorer og andre biologisk aktive substanser
PL200384B1 (pl) 1999-03-18 2008-12-31 Merck Patent Gmbh Polipeptyd blokujący adhezję płytek krwi, sposób jego otrzymywania, zastosowanie i zawierający go preparat farmaceutyczny
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen

Also Published As

Publication number Publication date
NO20014506D0 (no) 2001-09-17
CA2367457C (en) 2010-09-21
CZ20013341A3 (cs) 2002-01-16
PT1161530E (pt) 2005-09-30
CZ301524B6 (cs) 2010-03-31
TR200102729T2 (tr) 2002-04-22
CN1344318A (zh) 2002-04-10
US6962801B2 (en) 2005-11-08
KR100788219B1 (ko) 2007-12-26
CO5241328A1 (es) 2003-01-31
WO2000056885A1 (en) 2000-09-28
JP2002539788A (ja) 2002-11-26
KR20020008131A (ko) 2002-01-29
SI1161530T1 (en) 2005-10-31
DE60020220D1 (de) 2005-06-23
EP1161530A1 (en) 2001-12-12
PL200384B1 (pl) 2008-12-31
CN1185344C (zh) 2005-01-19
CA2367457A1 (en) 2000-09-28
NO20014506L (no) 2001-11-16
DK1161530T3 (da) 2005-08-08
AU767172B2 (en) 2003-11-06
HUP0200353A2 (hu) 2002-05-29
US20050065084A1 (en) 2005-03-24
US6774107B1 (en) 2004-08-10
MXPA01009363A (es) 2002-06-04
AR023099A1 (es) 2002-09-04
HUP0200353A3 (en) 2003-12-29
MY123371A (en) 2006-05-31
RU2292351C2 (ru) 2007-01-27
AU3166200A (en) 2000-10-09
US20060094079A1 (en) 2006-05-04
HU228068B1 (en) 2012-09-28
ES2240067T3 (es) 2005-10-16
NO330769B1 (no) 2011-07-11
US7090986B2 (en) 2006-08-15
ATE295883T1 (de) 2005-06-15
JP4805461B2 (ja) 2011-11-02
SK287496B6 (sk) 2010-12-07
EP1161530B1 (en) 2005-05-18
HK1045330B (zh) 2005-09-09
SK12902001A3 (sk) 2002-03-05
HK1045330A1 (en) 2002-11-22
PL350147A1 (en) 2002-11-04
DE60020220T2 (de) 2006-05-24

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10 (IX), 18 (III), 24 E 25 DA LPI.

B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]

Free format text: REF. A RPI NO 2070 DE 08/09/2010.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 15A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.