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BR0008130A - Composto, composição farmacêutica, e, uso do composto ou de seu sal farmaceuticamente aceitável - Google Patents

Composto, composição farmacêutica, e, uso do composto ou de seu sal farmaceuticamente aceitável

Info

Publication number
BR0008130A
BR0008130A BR0008130-2A BR0008130A BR0008130A BR 0008130 A BR0008130 A BR 0008130A BR 0008130 A BR0008130 A BR 0008130A BR 0008130 A BR0008130 A BR 0008130A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
thrombotic
Prior art date
Application number
BR0008130-2A
Other languages
English (en)
Inventor
Peter William Rodney Caulkett
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0008130A publication Critical patent/BR0008130A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO OU DE SEU SAL FARMACEUTICAMENTE ACEITáVEL". A invenção refere-se a derivados heterocíclicos, ou seus sais farmaceuticamente aceitáveis, de fórmula (1): em que: A é um anel monocíclico aromático de 5- ou 6-membros opcionalmente substituídos contendo 1, 2 ou 3 heteroátomos no anel selecionados de átomos de oxigênio, nitrogênio e enxofre; o qual possui propriedades anti-trombóticas e anti-coagulantes e são conseq³entemente úteis em processos de tratamento de humanos ou animais. A invenção também refere-se a processos para a preparação dos derivados heterocíclicos, a composições farmacêuticas contendo eles e a seu uso na fabricação de medicamentos para uso na produção de efeito anti-trombótico ou anticoagulante.
BR0008130-2A 1999-02-11 2000-02-08 Composto, composição farmacêutica, e, uso do composto ou de seu sal farmaceuticamente aceitável BR0008130A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9902989.4A GB9902989D0 (en) 1999-02-11 1999-02-11 Heterocyclic derivatives
PCT/GB2000/000354 WO2000047573A1 (en) 1999-02-11 2000-02-08 Heterocyclic derivatives as inhibitors of factor xa

Publications (1)

Publication Number Publication Date
BR0008130A true BR0008130A (pt) 2002-02-05

Family

ID=10847476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008130-2A BR0008130A (pt) 1999-02-11 2000-02-08 Composto, composição farmacêutica, e, uso do composto ou de seu sal farmaceuticamente aceitável

Country Status (24)

Country Link
US (1) US6723723B1 (pt)
EP (1) EP1150974B1 (pt)
JP (1) JP2002536443A (pt)
KR (1) KR20010102072A (pt)
AT (1) ATE223402T1 (pt)
AU (1) AU757738B2 (pt)
BR (1) BR0008130A (pt)
CA (1) CA2362392A1 (pt)
CZ (1) CZ20012867A3 (pt)
DE (1) DE60000410T2 (pt)
DK (1) DK1150974T3 (pt)
ES (1) ES2181637T3 (pt)
GB (1) GB9902989D0 (pt)
HU (1) HUP0105102A3 (pt)
IL (1) IL144792A0 (pt)
NO (1) NO20013921L (pt)
NZ (1) NZ513350A (pt)
PL (1) PL349220A1 (pt)
PT (1) PT1150974E (pt)
RU (1) RU2226193C2 (pt)
SK (1) SK11462001A3 (pt)
TR (1) TR200102306T2 (pt)
WO (1) WO2000047573A1 (pt)
ZA (1) ZA200106337B (pt)

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AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
EP1870401A4 (en) * 2005-04-06 2011-06-15 Msd Kk 1,4-SUBSTITUTED PIPERAZINE DERIVATIVE
JP5214096B2 (ja) * 2005-06-17 2013-06-19 富士フイルムファインケミカルズ株式会社 新規なビピリジン誘導体
JP7775080B2 (ja) 2019-07-01 2025-11-25 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
MX2023008055A (es) 2021-01-06 2023-08-22 Tonix Pharma Ltd Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

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Also Published As

Publication number Publication date
JP2002536443A (ja) 2002-10-29
HUP0105102A2 (hu) 2002-05-29
PL349220A1 (en) 2002-07-01
US6723723B1 (en) 2004-04-20
TR200102306T2 (tr) 2001-12-21
NZ513350A (en) 2003-01-31
WO2000047573A1 (en) 2000-08-17
PT1150974E (pt) 2003-01-31
RU2226193C2 (ru) 2004-03-27
KR20010102072A (ko) 2001-11-15
NO20013921L (no) 2001-10-10
HUP0105102A3 (en) 2003-01-28
EP1150974A1 (en) 2001-11-07
DK1150974T3 (da) 2002-12-02
AU2447000A (en) 2000-08-29
NO20013921D0 (no) 2001-08-10
GB9902989D0 (en) 1999-03-31
AU757738B2 (en) 2003-03-06
DE60000410D1 (de) 2002-10-10
ZA200106337B (en) 2002-11-01
SK11462001A3 (sk) 2001-12-03
EP1150974B1 (en) 2002-09-04
DE60000410T2 (de) 2003-06-05
ES2181637T3 (es) 2003-03-01
IL144792A0 (en) 2002-06-30
CZ20012867A3 (cs) 2001-10-17
CA2362392A1 (en) 2000-08-17
ATE223402T1 (de) 2002-09-15

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.